The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Regulation of Ferroptotic Cancer Cell Death by GPX4
Open accessAbstract
Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules. We used targeted metabolomic profiling to discover that depletion of glutathione causes inactivation of glutathione peroxidases (GPXs) in response to one class of compounds and a chemoproteomics strategy to discover that GPX4 is directly inhibited by a second class of compounds. GPX4 overexpression and knockdown modulated the lethality of 12 ferroptosis inducers, but not of 11 compounds with other lethal mechanisms. In addition, two representative ferroptosis inducers prevented tumor growth in xenograft mouse tumor models. Sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPX4-regulated ferroptosis. Thus, GPX4 is an essential regulator of ferroptotic cancer cell death.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Cell lysates prepared from (1S, 3R)-RSL3-treated cells could not reduce phosphatidylcholine hydroperoxides into the corresponding alcohols, demonstrating that RSL3 inhibits GPX4 enzyme activity [24].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Inhibitors of this transporter have been found to deplete intracellular glutathione in cancer cells, resulting in iron-dependent accumulation of ROS and a form of cell death termed ferroptosis (Dixon et al., 2012; Dixon et al., 2014; Yang et al., 2014).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Yang et al., 2014
The cited source says what the claim attributes to it.
In the citing paper
“In addition, the depletion of GPX4 can promote the accumulation of lipid peroxide and lipid free radicals, causing ferroptosis (Yang et al., 2014).”
From MiR-378a-3p/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure (2022) · cites this paper as Yang et al., 2014
The cited source says what the claim attributes to it.
In the citing paper
“Lipid peroxidation is an important characteristic of ferroptosis and is strongly regulated by GPX4 and GSH (Chen et al., 2015;Yang et al., 2014).”
From MiR-378a-3p/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure (2022) · cites this paper as Yang et al., 2014
In the citing paper
“the reduced glutathione (GSH)-dependent enzyme glutathione peroxidase 4 (GPX4)—which is directly targeted by RSL3—has emerged as the main endogenous inhibitor of ferroptosis by virtue of its ability to limit lipid peroxidation by catalyzing the GSH-dependent reduction of lipid hydroperoxides to lipid alcohols [547–550].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [548]
In the citing paper
“erastin triggers ferroptosis by (indirectly) affecting the catalytic cycle of GPX4 via a mechanism that involves the inhibition of the cystine/glutamate antiporter system xc− and consequent decrease in intracellular cysteine (which derives from cystine reduction in the cytoplasm) and GSH (which is synthesized from cysteine) [539, 548, 549, 551].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [548]
In the citing paper
“the ferroptosis-inhibiting effect of iron depletion by either chelators [539, 543, 548] or phosphorylase kinase catalytic subunit gamma 2 (PHKG2) knockdown [566]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [548]
In the citing paper
“Among these genes, we identified known regulators of apoptosis, such as TP53, IKBIP, and factors specifically of neuronal survival, such as XIAP17–20, GDPGP121 and MAP3K123,22–24, as well as genes not previously implicated in neuronal survival, such as IGF2BP1 and IGF2BP3.”
From Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis (2021) · cites this paper as [19]
In the citing paper
“Moreover, glutathione is not depleted during RSL3-induced cell death [24], supporting the presence of an alternative ferroptosis-initiating mechanism for RSL3.”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
In the citing paper
“Analysis of mass spectrometry-based proteomic data from an affinity pulldown experiment ranked GPX4 (glutathione peroxidase 4, PHGPx) as the top protein target for (1S,3R)-RSL3 [24]; western blotting further confirmed binding between (1S,3R)-RSL3 and GPX4.”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
In the citing paper
“Glutathione depletion causes loss of cellular antioxidant capacity, as well as inhibition of glutathione-dependent enzymes, such as glutathione peroxidases [24, 25].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
In the citing paper
“Moreover, knockdown of GPX4 expression generates lipid ROS and induces ferroptosis, supporting the hypothesis that (1S, 3R)-RSL3 induces ferroptosis through inhibition of GPX4 [24].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
In the citing paper
“This glutathione depletion is sufficient for erastin-dependent cell death, as glutathione depletion by another reagent, buthionine sulfoxamine (BSO), also initiated ferroptosis [24].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
In the citing paper
“The screening assay in which erastin and RSL3 were identified later revealed ten additional compounds that induce ferroptosis [24, 26]. All but one compound (DPI2) inhibited GPX4 directly, similar to RSL3. In contrast, DPI2 depleted GSH, like erastin [24].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
In the citing paper
“Overexpression of GPX4 suppressed cell death induced by these compounds [24], but not other lethal agents, indicating that GPX4 is a specific and robust central regulator of ferroptotic cell death, akin to BCL-2 in apoptosis.”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
In the citing paper
“Indeed, a metabolite profiling assay revealed that glutathione was the most decreased cellular metabolite during erastin-induced ferroptosis [24].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
In the citing paper
“Although erastin displayed selective lethality in engineered cells overexpressing HRASG12V , there was no consistent difference in erastin sensitivity between wild-type and mutated RAS cells.”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
In the citing paper
“Tubular cells in the kidney are also particularly susceptible to ferroptosis induction by Gpx4 deletion in vivo [15], which is intriguing in light of the enhanced sensitivity of renal cell carcinoma cell lines in culture to erastin [24].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
In the citing paper
“Moreover, RCC was found to be particularly susceptible to erastin-induced ferroptosis compared to other tissues in the NCI-60 panel, a panel of cancer cell lines derived from eight different tissues [24].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Self-citationChemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068
Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,032
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
The NCI60 human tumour cell line anticancer drug screen
Shoemaker, R. H. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1951 · Cited by 2,673
Production of large amounts of hydrogen peroxide by human tumor cells.
Szatrowski, T. P., & Nathan, C. (1991) · PubMed · Cited by 2,504
Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421
Brigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904
Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876
Self-citation
Cited by
Sorted by citations
Items 801–900 of 1,027
Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy
Li, Y., Liu, J., Chen, Y., Weichselbaum, R. R., & Lin, W. (2024) · Advanced Science · doi:10.1002/advs.202310309 · Cited by 144
Glutathione, Glutaredoxins, and Iron
Berndt, C., & Lillig, C. H. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7132 · Cited by 148
A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering
To, T., Cuadros, A. M., Shah, H., Hung, W. H. W., Yang, L., Kim, S. H., Rubin, D. H. F., Boe, R. H., Rath, S. P., Eaton, J. K., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.032 · Cited by 141
Self-citationThe emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?
Mao, L., Zhao, T., Song, Y., Lin, L., Fan, X., Cui, B., Feng, H., Wang, X., Yu, Q., Zhang, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2732-5 · Cited by 141
Role of ferroptosis in the process of diabetes-induced endothelial dysfunction
Luo, E., Li, H.-X., Qin, Y., Qiao, Y., Yan, G., Yao, Y., Li, L., Hou, J., Tang, C., & Wang, D. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i2.124 · Cited by 141
Apatinib induced ferroptosis by lipid peroxidation in gastric cancer
Zhao, L., Peng, Y., He, S., Li, R., Wang, Z., Huang, J., Lei, X., Li, G., & Ma, Q. (2021) · Gastric Cancer · doi:10.1007/s10120-021-01159-8 · Cited by 141
Zhang, J., Qiu, Q., Wang, H., Chen, C., & Luo, D. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112800 · Cited by 141
Ferroptosis in colorectal cancer: Potential mechanisms and effective therapeutic targets
Wang, Y., Zhang, Z., Sun, W., Zhang, J., Xu, Q., Zhou, X., & Mao, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113524 · Cited by 143
Hydropersulfides Inhibit Lipid Peroxidation and Protect Cells from Ferroptosis
Wu, Z., Khodade, V. S., Chauvin, J. R., Rodriguez, D., Toscano, J. P., & Pratt, D. A. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c06804 · Cited by 142
Human hematopoietic stem cell vulnerability to ferroptosis
Zhao, J., Jia, Y., Mahmut, D., Deik, A., Jeanfavre, S., Clish, C. B., & Sankaran, V. G. (2023) · Cell · doi:10.1016/j.cell.2023.01.020 · Cited by 147
Self-citationTargeting GPX4 in ferroptosis and cancer: chemical strategies and challenges
Liu, J., Tang, D., & Kang, R. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.05.006 · Cited by 143
Targeting ferroptosis in pancreatic cancer: a double-edged sword
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.04.005 · Cited by 143
Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation
Müller, F., Lim, J. K. M., Bebber, C. M., Seidel, E., Tishina, S., Dahlhaus, A., Stroh, J., Beck, J., Yapici, F. I., Nakayama, K., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01096-8 · Cited by 140
MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells
Bai, T., Liang, R., Zhu, R., Wang, W., Zhou, L., & Sun, Y. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29496 · Cited by 125
Zhang, C., Liu, Z., Zhang, Y., Ma, L., Song, E., & Song, Y. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2384-5 · Cited by 140
IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer
Zhang, L., Liu, W., Liu, F., Wang, Q., Song, M., Yu, Q., Tang, K., Teng, T., Wu, D., Wang, X.-J., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1675613 · Cited by 139
Zhang, Y., Ren, X., Wang, Y., Chen, D., Jiang, L., Li, X., Li, T., Huo, M., & Li, Q. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c18061 · Cited by 141
Induction and application of ferroptosis in cancer therapy
Nie, Q. H., Hu, Y., Yu, X. H., Li, X., & Fang, X. (2022) · Cancer Cell International · doi:10.1186/s12935-021-02366-0 · Cited by 146
USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy
Li, H., Sun, Y., Yao, Y., Ke, S., Zhang, N., Xiong, W., Shi, J., He, C., Xiao, X., Yu, H., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315541121 · Cited by 152
Klasson, T. D., LaGory, E. L., Zhao, H., Huynh, S. K., Papandreou, I., Moon, E. J., & Giaccia, A. J. (2022) · Cancer & Metabolism · doi:10.1186/s40170-022-00290-z · Cited by 145
STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury
Jin, L., Yu, B., Wang, H., Shi, L., Yang, J., Wu, L., Gao, C., Pan, H., Han, F., Lin, W., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.08.025 · Cited by 140
Liang, F. G., Zandkarimi, F., Lee, J., Axelrod, J. L., Pekson, R., Yoon, Y., Stockwell, B. R., & Kitsis, R. N. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.07.020 · Cited by 139
Self-citationTherapies targeting lipid peroxidation in traumatic brain injury
Anthonymuthu, T. S., Kenny, E., & Bayır, H. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.006 · Cited by 141
Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells
Bai, T., Wang, S., Zhao, Y., Zhu, R., Wang, W., & Sun, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.136 · Cited by 138
Dong, B., Song, W., Lu, Y., Sun, Y., & Lin, W. (2020) · ACS Sensors · doi:10.1021/acssensors.0c02015 · Cited by 137
Transsulfuration, minor player or crucial for cysteine homeostasis in cancer
Zhang, H., Geltink, R. I. K., Parker, S. J., & Sorensen, P. H. B. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.02.009 · Cited by 143
Lee, J., & Hyun, D. (2023) · Antioxidants · doi:10.3390/antiox12040918 · Cited by 142
The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context
Xing, F., Hu, Q., Qin, Y., Xu, J., Zhang, B., Yu, X., & Wang, W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.862743 · Cited by 142
Deng, H., Zhang, J., Yang, Y., Yang, J., Wei, Y., Ma, S., & Shen, Q. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c00574 · Cited by 136
Intracellular Delivery of Glutathione Peroxidase Degrader Induces Ferroptosis In Vivo
Luo, T., Zheng, Q., Shao, L., Ma, T., Mao, L., & Wang, M. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202206277 · Cited by 136
Ferroptosis of immune cells in the tumor microenvironment
Kim, R., Taylor, D. K., Vonderheide, R. H., & Gabrilovich, D. I. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.06.005 · Cited by 143
Ferroptosis: Mechanisms and role in diabetes mellitus and its complications
Liu, P., Zhang, Z., Cai, Y., Li, Z., Zhou, Q., & Chen, Q. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102201 · Cited by 137
Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1
Zhang, Y., Koppula, P., & Gan, B. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1597506 · Cited by 138
Ferroptosis Signaling and Regulators in Atherosclerosis
Wang, Y., Zhao, Y., Ye, T., Yang, L. M., Shen, Y., & Li, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.809457 · Cited by 136
Yue, R., Zhang, C., Xu, L. J., Wang, Y., Guan, G., Lei, L., Zhang, X., & Song, G. (2022) · Chem · doi:10.1016/j.chempr.2022.03.009 · Cited by 135
Nie, T., Zou, W., Meng, Z., Wang, L., Ying, T., Cai, X., Wu, J., Zheng, Y., & Hu, B. Q. (2022) · Advanced Materials · doi:10.1002/adma.202206286 · Cited by 135
Glutamine metabolism in breast cancer and possible therapeutic targets
Li, S., Zeng, H., Fan, J., Wang, X., Xu, C., Li, Y., Tu, J., Nephew, K. P., & Long, X. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115464 · Cited by 143
The significant role of amino acid metabolic reprogramming in cancer
Liu, X., Ren, B., Ren, J., Gu, M., You, L., & Zhao, Y.-P. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01760-1 · Cited by 147
Larraufie, M., Yang, W. S., Jiang, E., Thomas, A. G., Slusher, B. S., & Stockwell, B. R. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.07.018 · Cited by 135
Self-citationRibosome stalling during selenoprotein translation exposes a ferroptosis vulnerability
Li, Z., Ferguson, L., Deol, K. K., Roberts, M. A., Magtanong, L., Hendricks, J. M., Mousa, G. A., Kilinc, S., Schaefer, K., Wells, J. A., et al. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01033-3 · Cited by 134
A Mechanistic Review of Cell Death in Alcohol‐Induced Liver Injury
Wang, S., Pacher, P., Lisle, R. C. D., Huang, H., & Ding, W. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13078 · Cited by 135
Non-Canonical Cell Death Induced by p53
Ranjan, A., & Iwakuma, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122068 · Cited by 140
Iron and Ferroptosis as Therapeutic Targets in Alzheimer's Disease
Gleason, A. J., & Bush, A. I. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00954-y · Cited by 134
Ferroptosis: A Novel Therapeutic Target for Ischemia-Reperfusion Injury
Chen, Y., Fan, H., Wang, S., Tang, G., Zhai, C., & Shen, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.688605 · Cited by 139
Sestrin2 protects dendrite cells against ferroptosis induced by sepsis
Li, J., Ren, C., Wang, L., Yao, R.-Q., Dong, N., Wu, Y., Tian, Y., & Yao, Y.-M. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04122-8 · Cited by 134
Fundamental mechanisms of the cell death caused by Nitrosative stress
Wang, F., Yuan, Q., Chen, F., Pang, J., Pan, C., Xu, F., & Chen, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.742483 · Cited by 133
Cold stress‐induced ferroptosis involves the ASK1‐p38 pathway
Hattori, K., Ishikawa, H., Sakauchi, C., Takayanagi, S., Naguro, I., & Ichijo, H. (2017) · EMBO Reports · doi:10.15252/embr.201744228 · Cited by 134
Wu, J., Ye, J., Kong, W., Zhang, S., & Zheng, Y. (2020) · Cell Proliferation · doi:10.1111/cpr.12915 · Cited by 137
Deng, S., Wu, D., Li, L., Liu, T., Zhang, T., Li, J., Yu, Y., He, M., Zhao, Y., Han, R., et al. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.02.077 · Cited by 133
Implication of ferroptosis in aging
Mazhar, M., Din, A. U., Ali, H., Yang, G., Ren, W., Wang, L., Fan, X., & Yang, S. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00553-6 · Cited by 138
Chen, W., Teo, J. M. N., Yau, S. W., Wong, M. Y., Lok, C., Che, C., Javed, A., Huang, Y., Ma, S., & Ling, G. S. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111647 · Cited by 142
Mei, H., Zhao, L., Li, W., Zheng, Z., Tang, D., Lu, X., & He, Y. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15839 · Cited by 133
Novel insights into ferroptosis: Implications for age-related diseases
Zhou, R., Chen, Y., Wei, X., Yu, B., Xiong, Z., Lu, C., & Hu, W. M. (2020) · Theranostics · doi:10.7150/thno.50663 · Cited by 134
Gu, Z., Liu, T., Liu, C., Yang, Y., Tang, J., Song, H., Wang, Y., Yang, Y., & Yu, C. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01401 · Cited by 132
David, S., Jhelum, P., Ryan, F., Jeong, S. Y., & Kroner, A. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0218 · Cited by 134
The role of ferroptosis in lung cancer
Wu, S., Zhu, C., Tang, D., Dou, Q. P., Shen, J., & Chen, X. (2021) · Biomarker Research · doi:10.1186/s40364-021-00338-0 · Cited by 137
A self-amplifying nanodrug to manipulate the Janus-faced nature of ferroptosis for tumor therapy
Zhang, M., Qin, X., Zhao, Z., Du, Q., Li, Q., Jiang, Y., & Luan, Y. (2021) · Nanoscale Horizons · doi:10.1039/d1nh00506e · Cited by 132
Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application
Liu, N., & Chen, M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116115 · Cited by 139
Zheng, H., Liu, J., Cheng, Q., Zhang, Q., Zhang, Y., Jiang, L., Huang, Y., Li, W., Zhao, Y., Chen, G., et al. (2024) · Nature Cancer · doi:10.1038/s43018-023-00715-8 · Cited by 134
RetractedHe, J., Qiu, Z., Fan, J., Xie, X., Sheng, Q., & Sui, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01891-4 · Cited by 134
Orian, L., Mauri, P., Roveri, A., Toppo, S., Benazzi, L., Bosello-Travain, V., Palma, A. D., Maiorino, M., Miotto, G., Zaccarin, M., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.011 · Cited by 135
Wang, L., Cai, H., Hu, Y., Liu, F., Huang, S., Zhou, Y., Yu, J. Q., Xu, J., & Wu, F. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1063-2 · Cited by 131
Oxidative Stress in Cell Death and Cardiovascular Diseases
Xu, T., Ding, W., Ji, X., Ao, X., Liu, Y., Yu, W., & Wang, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9030563 · Cited by 135
Anthonymuthu, T. S., Tyurina, Y. Y., Sun, W., Mikulska‐Ruminska, K., Shrivastava, I. H., Tyurin, V. A., Cinemre, F. B. S., Dar, H. H., VanDemark, A. P., Holman, T. R., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101744 · Cited by 133
Self-citationClinical and Biological Significances of a Ferroptosis-Related Gene Signature in Glioma
Zhuo, S., Chen, Z., Yang, Y., Zhang, J., Tang, J., & Yang, K. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.590861 · Cited by 133
Mammary adipocytes protect triple-negative breast cancer cells from ferroptosis
Xie, Y., Wang, B., Zhao, Y., Tao, Z., Wang, Y., Chen, G., & Hu, X. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01297-1 · Cited by 134
The Role of Ferritin in Health and Disease: Recent Advances and Understandings
Kotla, N. K., Dutta, P., Parimi, S., & Das, N. K. (2022) · Metabolites · doi:10.3390/metabo12070609 · Cited by 141
Li, C., Wu, Z., Xue, H., Gao, Q., Zhang, Y., Wang, C., & Zhao, P. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13973 · Cited by 132
Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism
Yang, X. P., Wang, Z., Zandkarimi, F., Liu, Y., Duan, S., Li, Z., Kon, N., Zhang, Z., Jiang, X., Stockwell, B. R., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.014 · Cited by 135
Self-citationMechanisms and regulations of ferroptosis
Zhang, X.-D., Liu, Z., Wang, M.-S., Guo, Y.-X., Wang, X., Luo, K., Huang, S., & Li, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1269451 · Cited by 138
Sassano, M. L., Tyurina, Y. Y., Diokmetzidou, A., Vervoort, E., Tyurin, V. A., More, S., Rovere, R. L., Giordano, F., Bultynck, G., Pavie, B., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01668-z · Cited by 138
Progress in Understanding Ferroptosis and Challenges in Its Targeting for Therapeutic Benefit
Zou, Y., & Schreiber, S. L. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.03.015 · Cited by 132
Self-citationWu, T., Xue, L., Liu, X., Li, Y., Wang, Y., Kong, L., & Tang, M. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00363-1 · Cited by 131
Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?
Sena-dos-Santos, C., Braga-da-Silva, C., Marques, D., Pinheiro, J. A. D. S., Ribeiro‐dos‐Santos, Â., & Cavalcante, G. C. (2021) · Cells · doi:10.3390/cells10020479 · Cited by 132
Chen, Y., Su, L., Yin, M., Li, Y., Chen, C., Zhang, J., Sun, K., Kong, X., Chen, Z., & Qian, J. (2022) · Diabetes · doi:10.2337/db22-0553 · Cited by 130
Bertrand, R. L. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.02.017 · Cited by 132
Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists
Morris, G., Walker, A. J., Berk, M., Maes, M. H. J., & Puri, B. K. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0793-y · Cited by 134
Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently
Eaton, J. K., Ruberto, R. A., Kramm, A., Viswanathan, V. S., & Schreiber, S. L. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10769 · Cited by 131
Self-citationMarkowitsch, S. D., Schupp, P., Lauckner, J., Vakhrusheva, O., Slade, K. S., Mager, R., Efferth, T., Haferkamp, A., & Juengel, E. (2020) · Cancers · doi:10.3390/cancers12113150 · Cited by 129
Targeting Ferroptosis as a Promising Therapeutic Strategy for Ischemia-Reperfusion Injury
Pan, Y., Wang, X., Liu, X., Shen, L., Chen, Q., & Shu, Q. (2022) · Antioxidants · doi:10.3390/antiox11112196 · Cited by 129
Ferroptosis in immunostimulation and immunosuppression
Tang, D., Kroemer, G., & Kang, R. (2023) · Immunological Reviews · doi:10.1111/imr.13235 · Cited by 129
Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage
Barrett, C. W., Reddy, V. K., Short, S. P., Motley, A. K., Lintel, M. K., Bradley, A. M., Freeman, T. J., Vallance, J. E., Wei, N., Parang, B., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76099 · Cited by 128
Chan, D. W., Yung, M. M. H., Chan, Y.-S., Yang, X., Yang, H., Xu, D., Zhan, J., Chan, K. K. L., Ng, T., & Ngan, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105157 · Cited by 128
Moosmayer, D., Hilpmann, A., Hoffmann, J., Schnirch, L., Zimmermann, K. C., Badock, V., Furst, L., Eaton, J. K., Viswanathan, V. S., Schreiber, S. L., et al. (2021) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798320016125 · Cited by 131
Self-citationZinc transporter ZIP7 is a novel determinant of ferroptosis
Chen, P., Wu, J., Xu, Y., Ding, C. C., Mestre, A. A., Lin, C., Yang, W., & Chi, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03482-5 · Cited by 128
Self-citationUnderstanding the role of cysteine in ferroptosis: progress & paradoxes
Poltorack, C. D., & Dixon, S. J. (2021) · FEBS Journal · doi:10.1111/febs.15842 · Cited by 130
PPARG-mediated ferroptosis in dendritic cells limits antitumor immunity
Han, L., Bai, L., Qu, C., Dai, E., Liu, J., Kang, R., Zhou, D., Tang, D., & Zhao, Y. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.08.082 · Cited by 128
Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis
Chen, X., Song, X., Li, J., Zhang, R., Yu, C., Zhou, Z., Liu, J., Liao, S., Klionsky, D. J., Kroemer, G., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2059170 · Cited by 128
An osmium-peroxo complex for photoactive therapy of hypoxic tumors
Lu, N., Deng, Z., Gao, J., Liang, C., Xia, H., & Zhang, P. (2022) · Nature Communications · doi:10.1038/s41467-022-29969-z · Cited by 129
Ferritinophagy: research advance and clinical significance in cancers
Wang, J., Wu, N., Peng, M., Oyang, L., Jiang, X., Peng, Q., Zhou, Y., He, Z., & Liao, Q. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01753-y · Cited by 128
Jin, M., Shi, C., Tian, L., Wu, Y., Hu, C., & Huang, G. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110282 · Cited by 127
Novel insights on targeting ferroptosis in cancer therapy
Zuo, S., Yu, J., Pan, H., & Lu, L. (2020) · Biomarker Research · doi:10.1186/s40364-020-00229-w · Cited by 128
Shi, L., Liu, Y., Li, M., & Luo, Z. Y. (2021) · FEBS Journal · doi:10.1111/febs.16034 · Cited by 127
Chen, H., Qian, Y., Jiang, C., Tang, L., Yu, J., Zhang, L., Dai, Y., & Jiang, G. Z. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166984 · Cited by 136
Mitophagy-related regulated cell death: molecular mechanisms and disease implications
Yang, M., Wei, X., Yi, X., & Jiang, D. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06804-5 · Cited by 132
Hatem, E., Banna, N. E., & Huang, M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7134 · Cited by 127
Gong, Y., Wang, N., Liu, N., & Dong, H. (2019) · DNA and Cell Biology · doi:10.1089/dna.2018.4541 · Cited by 126
Zhou, L., Chen, J., Li, R., Wei, L., Haitao, X., Wang, C., Chai, K., Chen, M., Zhu, Z., Yao, T., et al. (2021) · Small · doi:10.1002/smll.202103919 · Cited by 126
Nagasaki, T., Schuyler, A. J., Zhao, J., Samovich, S. N., Yamada, K., Deng, Y., Ginebaugh, S. P., Christenson, S. A., Woodruff, P. G., Fahy, J. V., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci151685 · Cited by 129
Chen, Y., Li, L., Lan, J., Cui, Y., Rao, X., Zhao, J., Xing, T., Ju, G., Song, G., Lou, J., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01466-9 · Cited by 126
Metadata
- Authors
- Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., Brown, L. M., Girotti, A. W., Cornish, V. W., Schreiber, S. L., & Stockwell, B. R.
- Affiliations
- Columbia University (US)
- Broad Institute (US)
- Medical College of Wisconsin (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Stockwell, Brent R.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 156
- Issue
- 1-2
- Pages
- 317-331
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4076414
- OpenAlex
- W2002490399
- Cited by
- 7,713
- References
- 48
- Citations by year
- 2026: 1070 · 2025: 1226 · 2024: 1343 · 2023: 1164 · 2022: 1041 · 2021: 759 · 2020: 421 · 2019: 256 · 2018: 151 · 2017: 115 · 2016: 86 · 2015: 53 · 2014: 25
- FWCI
- 74.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (CHE 0840451)
- New York State Stem Cell Science (C026715)
- Empire State Development's Division of Science, Technology and Innovation
- Arnold and Mabel Beckman Foundation
- National Institutes of Health (R01CA161061, 5R01CA097061, 5R01GM085081, 1S10RR025431-01A1)
- Broad Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- ferroptosis, GPX4, glutathione peroxidase, glutathione depletion, ferroptosis inducers, non-apoptotic cell death, cancer cell death, chemoproteomics, targeted metabolomics, diffuse large B-cell lymphoma, renal cell carcinoma, tumor growth inhibition
- MeSH terms
- Phospholipid Hydroperoxide Glutathione Peroxidase, Animals, Carbolines, Carcinoma, Renal Cell, Glutathione, Glutathione Peroxidase, Humans, Neoplasm Transplantation, Neoplasms, Piperazines, Lymphoma, B-Cell, Cell Death, Cell Line, Tumor, Mice, Gene Knockdown Techniques, Heterografts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
