Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, Wan Seok, SriRamaratnam, Rohitha, Welsch, Matthew E., Shimada, Kenichi, Skouta, Rachid, Viswanathan, Vasanthi S., Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan F., Clish, Clary B., Brown, Lewis M., Girotti, Albert W., Cornish, Virginia W., Schreiber, Stuart L., Stockwell, Brent R.·2014·Cell

DOI 10.1016/j.cell.2013.12.010

Cited by (1,027)

Items 201–300 of 1,027

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Yi Liu, Yicong Wan, Yi Jiang, Lin Zhang, Wenjun Cheng · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review
Pengxu Lei, Tao Bai, Yuling Sun · 2019 · Frontiers in Physiology
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
Annadurai Anandhan, Matthew B. Dodson, Aryatara Shakya, Jinjing Chen, Pengfei Liu, Yongyi Wei, Huı Tan, Qian Wang, Ziyan Jiang, Kevin B. Yang et al. · 2023 · Science Advances
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Min Wang, Chao Mao, Lianlian Ouyang, Yating Liu, Weiwei Lai, Na Liu, Ying Shi, Ling Chen, Desheng Xiao, Fenglei Yu et al. · 2019 · Cell Death and Differentiation
Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis
Tsurusaki, Shinya, Tsuchiya, Yuichi, Koumura, Tomoko, Nakasone, Misaki, Sakamoto, Taro, Matsuoka, Masaki, Imai, Hirotaka, Yuet-Yin Kok, Cindy, Okochi, Hitoshi, Nakano, Hiroyasu et al. · 2019 · Cell Death & Disease
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Chengxian Xu, Shaogang Sun, Travis S. Johnson, Rong Amy Qi, Siyuan Zhang, Jie Zhang, Kai Yang · 2021 · Cell Reports
Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy
Tao Liu, Wenlong Liu, Mingkang Zhang, Wuyang Yu, Fan Gao, Chuxin Li, Shibo Wang, Jun Xiang Feng, Xian‐Zheng Zhang · 2018 · ACS Nano
Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers
Ling F. Ye, Kunal R. Chaudhary, Fereshteh Zandkarimi, Andrew D. Harken, Connor Jarrett Kinslow, Pavan S. Upadhyayula, Athanassios Dovas, Dominique M. O. Higgins, Huı Tan, Yan Zhang et al. · 2020 · ACS Chemical Biology
Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells
Eling, Nils, Reuter, Lukas, Hazin, John, Hamacher-Brady, Anne, Brady, Nathan R. · 2015 · Oncoscience
Regulated cell death and inflammation: an auto-amplification loop causes organ failure
Linkermann, Andreas, Stockwell, Brent R., Krautwald, Stefan, Anders, Hans-Joachim · 2014 · Nature Reviews Immunology
Ferroptosis, radiotherapy, and combination therapeutic strategies
Guang Lei, Chao Mao, Yuelong Yan, Li Zhuang, Boyi Gan · 2021 · Protein & Cell
Characteristics and Biomarkers of Ferroptosis
Xin Chen, Paul Burdett Comish, Daolin Tang, Rui Kang · 2021 · Frontiers in Cell and Developmental Biology
Inhibiting Ferroptosis through Disrupting the NCOA4–FTH1 Interaction: A New Mechanism of Action
Yuying Fang, Xiu‐Cai Chen, Qingyun Tan, Huihao Zhou, Jun Xu, Qiong Gu · 2021 · ACS Central Science
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Haoxin Li, Shaoyang Ning, Mahmoud Ghandi, Gregory V. Kryukov, Shuba Gopal, Amy Deik, Amanda Souza, Kerry A. Pierce, Paula Keskula, Desiree Hernandez et al. · 2019 · Nature Medicine
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
Guoqing Chen, Fahad A. Benthani, Jiao Wu, Deguang Liang, Zhaoxiang Bian, Xuejun Jiang · 2019 · Cell Death and Differentiation
Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury
Yingchuan Li, Yongmei Cao, Jian Xiao, Jiawei Shang, Qin Tan, Ping Feng, Wei-Feng Huang, Fang Wu, Haijun Zhang, Xiaoping Zhang · 2020 · Cell Death and Differentiation
Lipid storage and lipophagy regulates ferroptosis
Yuansong Bai, Lingjun Meng, Leng Han, Yuanyuan Jia, Yanan Zhao, Huan Gao, Rui Kang, Xiaofeng Wang, Daolin Tang, Enyong Dai · 2018 · Biochemical and Biophysical Research Communications
Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
John K. Eaton, Laura Furst, Richard A. Ruberto, Dieter Moosmayer, André Hilpmann, Matthew J. Ryan, Katja C. Zimmermann, Luke L. Cai, Michael Niehues, Volker Badock et al. · 2020 · Nature Chemical Biology
Iron and cancer: recent insights
Manz, David H., Blanchette, Nicole L., Paul, Bibbin T., Torti, Frank M., Torti, Suzy V. · 2016 · Annals of the New York Academy of Sciences
CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation
Hua Yuan, Xuemei Li, Xiuying Zhang, Rui Kang, Daolin Tang · 2016 · Biochemical and Biophysical Research Communications
Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer
Shumin Ouyang, Huaxuan Li, Linlin Lou, Qiuyao Huang, Zhenhua Zhang, Jianshan Mo, Min Li, Jiaye Lu, Kai Zhu, Yunjie Chu et al. · 2022 · Redox Biology
Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis
Chen, Liuji, Hambright, William Sealy, Na, Ren, Ran, Qitao · 2015 · Journal of Biological Chemistry
Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
Gloria E. Villalpando-Rodriguez, Spencer Bruce Gibson · 2021 · Oxidative Medicine and Cellular Longevity
The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
Tong Liu, Le Jiang, Omid Tavana, Wei Jun Gu · 2019 · Cancer Research
A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53
Chao Mao, Xiang Wang, Yating Liu, Min Wang, Bin Yan, Yiqun Jiang, Ying Shi, Yi Shen, Xiaoli Liu, Weiwei Lai et al. · 2018 · Cancer Research
Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation
Wenjun Li, Guoshuai Feng, Jason M. Gauthier, Inessa Lokshina, Ryuji Higashikubo, Sarah Evans, Xinping Liu, Adil Hassan, Satona Tanaka, Markus Cicka et al. · 2019 · Journal of Clinical Investigation
Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis
Yuan Yuan, Yanyu Zhai, Jingjiong Chen, Xiaofeng Xu, Hongmei Wang · 2021 · Biomolecules
Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
Miao Yu, Yiwei Chen, Feng Xue, Kexin Liu, Bin Zhu, Junjie Gao, Junhui Yin, Changqing Zhang, Guangyi Li · 2022 · EBioMedicine
Clockophagy is a novel selective autophagy process favoring ferroptosis
Minghua Yang, Pan Chen, Jiao Liu, Shan Zhu, Guido Kroemer, Daniel J. Klionsky, Michael T. Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang · 2019 · Science Advances
DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin
Du, Jing, Wang, Tongtong, Li, Yanchun, Zhou, Yi, Wang, Xin, Yu, Xingxing, Ren, Xueying, An, Yihan, Wu, Yi, Sun, Weidong et al. · 2019 · Free Radical Biology and Medicine
Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
Shashank Masaldan, Ashley Ian Bush, David Devos, Anne‐Sophie Rolland, Caroline Moreau · 2018 · Free Radical Biology and Medicine
Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma
Yongfei Yang, Meiying Luo, Kexin Zhang, Jun Zhang, Tongtong Gao, Douglas O’ Connell, Fengping Yao, Changwen Mu, Bingyu Cai, Yuxue Shang et al. · 2020 · Nature Communications
Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture
Michelle Riegman, Liran Sagie, Chen Galed, Tom Levin, Noah J. Steinberg, Scott J. Dixon, Ulrich B. Wiesner, Michelle S. Bradbury, Philipp Niethammer, Assaf Zaritsky et al. · 2020 · Nature Cell Biology
Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
Chainika Khatana, Neeraj Kumar Saini, Sasanka Chakrabarti, Vipin Saini, Anil Kumar Sharma, Reena Vohra Saini, Adesh Kumar Saini · 2020 · Oxidative Medicine and Cellular Longevity
A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers
Pranavi Koppula, Guang Lei, Yilei Zhang, Yuelong Yan, Chao Mao, Lavanya Kondiparthi, Jiejun Shi, Xiaoguang Liu, Amber D. Horbath, Molina Das et al. · 2022 · Nature Communications
Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer
Ji-Yoon Lee, Miso Nam, Hye Young Son, Kwangbeom Hyun, Seo Young Jang, Jong Woo Kim, Min Wook Kim, Youngae Jung, Eunji Jang, Seon‐Jin Yoon et al. · 2020 · Proceedings of the National Academy of Sciences
Iron and ferroptosis: A still ill‐defined liaison
Sebastian G. Doll, Marcus Conrad · 2017 · IUBMB Life
The diversified role of mitochondria in ferroptosis in cancer
Yue Liu, Shi-Ping Lu, Lei‐Lei Wu, Liang Yang, Jinghan Wang, Jinghan Wang · 2023 · Cell Death and Disease
Iron addiction: a novel therapeutic target in ovarian cancer
Debargha Basuli, Lia Tesfay, Zhao Deng, B Paul, Yusuke Yamamoto, Gang Ning, Wa Xian, Frank McKeon, Miranda L. Lynch, Christopher P. Crum et al. · 2017 · Oncogene
Ferroptosis and Its Role in Diverse Brain Diseases
Abigail Weiland, Yamei Wang, Weihua Wu, Xi Lan, Xiaoning Han, Qian Li, Jian Wang · 2018 · Molecular Neurobiology
The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents
Yu Yan, Yangchun Xie, Lizhi Cao, Liangchun Yang, Minghua Yang, Michael T. Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang · 2015 · Molecular & Cellular Oncology
A Dual Role of Heme Oxygenase-1 in Cancer Cells
Shih-Kai Chiang, Shuen‐Ei Chen, Ling‐Chu Chang · 2018 · International Journal of Molecular Sciences
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate
Yiliang Chen, Jue Zhang, Weiguo Cui, Roy L. Silverstein · 2022 · The Journal of Experimental Medicine
Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
Miki Hayano, Wushuang Yang, C K Corn, Nen C. Pagano, Brent R. Stockwell · 2015 · Cell Death and Differentiation
System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
Feng‐Jiao Li, Hui‐Zhi Long, Zi-Wei Zhou, Hongyu Luo, Shuo‐Guo Xu, Lichen Gao · 2022 · Frontiers in Pharmacology
The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy
Yue‐Chen Zhao, Yanqing Li, Ruifeng Zhang, Feng Wang, Tiejun Wang, Yan Jiao · 2020 · OncoTargets and Therapy
Regulated cell death in myocardial ischemia–reperfusion injury
Qi Xiang, Xin Yi, Xue‐Hai Zhu, Xiang Wei, Ding‐Sheng Jiang · 2023 · Trends in Endocrinology and Metabolism
The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma
Wen‐Hsuan Yang, Chien‐Kuang Cornelia Ding, Tianai Sun, Gabrielle Rupprecht, Chao‐Chieh Lin, David S. Hsu, Jen‐Tsan Chi · 2019 · Cell Reports
miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma
Luo, Meiying, Wu, Longfei, Zhang, Kexin, Wang, Hong, Zhang, Tian, Gutierrez, Lucas, O’Connell, Douglas, Zhang, Peng, Li, Yu, Gao, Tongtong et al. · 2018 · Cell Death & Differentiation
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Cai, Yeyu, Chai, Tian, Nguyen, William, Liu, Jiayi, Xiao, Enhua, Ran, Xin, Ran, Yuping, Du, Dan, Chen, Wei, Chen, Xiangyu · 2025 · Signal Transduction and Targeted Therapy
Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3
Ryosuke Shintoku, Yuta Takigawa, Keiichi Yamada, Chisato Kubota, Yuhei Yoshimoto, Toshiyuki Takeuchi, Ichiro Koshiishi, Seiji Torii · 2017 · Cancer Science
The multifaceted role of reactive oxygen species in tumorigenesis
Kirtonia, Anuradha, Sethi, Gautam, Garg, Manoj · 2020 · Cellular and Molecular Life Sciences
GPX4, ferroptosis, and diseases
Wangzheqi Zhang, Yang Liu, Liao Yan, Chenglong Zhu, Zui Zou · 2024 · Biomedicine & Pharmacotherapy
Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells
Ruiran Wei, Yueqin Zhao, Juan Wang, Yang Xu, Shun‐Lin Li, Yinyuan Wang, Xing‐Zhi Yang, Jimin Fei, Xiao‐Jiang Hao, Yuhan Zhao et al. · 2021 · International Journal of Biological Sciences
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity
Pengchong Li, Mengdi Jiang, Ketian Li, Hao Li, Yangzhong Zhou, Xinyue Xiao, Yue Xu, Suzanne Krishfield, Peter E. Lipsky, George C. Tsokos et al. · 2021 · Nature Immunology
The Role of Ferroptosis in Cancer Development and Treatment Response
Lu, Bin, Chen, Xiao Bing, Ying, Mei Dan, He, Qiao Jun, Cao, Ji, Yang, Bo · 2018 · Frontiers in Pharmacology
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity
Bartosz Wiernicki, Sophia Maschalidi, Jonathan J. Pinney, Sandy Adjemian, Tom Vanden Berghe, Kodi S. Ravichandran, Peter Vandenabeele · 2022 · Nature Communications
ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury
Yue Wang, Menghan Zhang, Ran Bi, Yali Su, Fei Quan, Yanting Lin, Chongxiu Yue, Xinmeng Cui, Qixiang Zhao, Siliang Liu et al. · 2022 · Redox Biology
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis
Annadurai Anandhan, Matthew B. Dodson, Cody J. Schmidlin, Pengfei Liu, Donna D. Zhang · 2020 · Cell chemical biology
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Youwei Ai, Yutong Meng, Bo Yan, Qinyi Zhou, Xiaodong Wang · 2024 · Molecular Cell
Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells
Xia Qin, Jun Zhang, Bin Wang, Ge Xu, Xi Yang, Zhen Zou, Chao Yu · 2021 · Autophagy
Switching Apoptosis to Ferroptosis: Metal–Organic Network for High-Efficiency Anticancer Therapy
Diwei Zheng, Qi Lei, Jingyi Zhu, Jin‐Xuan Fan, Chu‐Xin Li, Cao Li, Zushun Xu, Si‐Xue Cheng, Xian‐Zheng Zhang · 2016 · Nano Letters
Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis
Young‐Sun Lee, Dae-Hee Lee, Haroon Asif Choudry, David L. Bartlett, Yong Jun Lee · 2018 · Molecular Cancer Research
Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis
Minyi Xu, Jin Tao, Yidong Yang, Siwei Tan, Huiling Liu, Jie Jiang, Fengping Zheng, Bin Wu · 2020 · Cell Death and Disease
Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy
Yuyan Jiang, Xuhui Zhao, Jiaguo Huang, Jing Li, Paul Kumar Upputuri, He Sun, Xiao Han, Manojit Pramanik, Yansong Miao, Hongwei Duan et al. · 2020 · Nature Communications
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
Yue Wang, Lixin Zheng, Wenjing Shang, Zongcheng Yang, Tongyu Li, Fen Liu, Wei Shao, Lin Li Lv, Li Chai, Lingxin Qu et al. · 2022 · Cell Death and Differentiation
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Chun‐Yan Kong, Zhen Guo, Peng Kun Song, Xin Zhang, Yu‐Pei Yuan, Teng Teng, Ling Yan, Qi‐Zhu Tang · 2021 · International Journal of Biological Sciences
The chemistry and biology of ferroptosis
Stockwell, Brent R., Jiang, Xuejun · 2020 · Cell chemical biology
Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
Enyong Dai, Leng Han, Jiao Liu, Yangchun Xie, Herbert J. Zeh, Rui Kang, Lulu Bai, Daolin Tang · 2020 · Nature Communications
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Jiang, Qin, Wang, Kuang, Zhang, Xingyu, Ouyang, Boshu, Liu, Haixia, Pang, Zhiqing, Yang, Wuli · 2020 · Small
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Mutian Jia, Danhui Qin, Chunyuan Zhao, Li Chai, Zhongxia Yu, Wenwen Wang, Tong Li, Lin Lv, Yuanyuan Wang, Jan Rehwinkel et al. · 2020 · Nature Immunology
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
Javier García‐Bermúdez, Lou Baudrier, Erol Can Bayraktar, Yihui Shen, Konnor La, Rohiverth Guarecuco, Burcu Yücel, Danilo Fiore, Bernardo Tavora, Elizaveta Freinkman et al. · 2019 · Nature
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A. Nikolai von Krusenstiern, Ryan N. Robson, Naixin Qian, Baiyu Qiu, Fanghao Hu, Eduard Reznik, Nailah Smith, Fereshteh Zandkarimi, Verna M. Estes, Marcel M. Dupont et al. · 2023 · Nature Chemical Biology
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
Moataz Abdalkader, Riikka Lampinen, Katja M. Kanninen, Tarja Malm, Jeffrey R. Liddell · 2018 · Frontiers in Neuroscience
Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells
Yahui Ding, Xiaoping Chen, Can Liu, Weizhi Ge, Qin Wang, Xin Hao, Mengmeng Wang, Yue Chen, Quan Zhang · 2021 · Journal of Hematology & Oncology
Redox homeostasis: The Golden Mean of healthy living
Fulvio Ursini, Matilde Maiorino, Henry Jay Forman · 2016 · Redox Biology
The application of Ferroptosis in diseases
Qiu, Yangmin, Cao, Yue, Cao, Wangjia, Jia, Yifei, Lu, Na · 2020 · Pharmacological Research
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis
Tian, Ruilin, Abarientos, Anthony, Hong, Jason, Hashemi, Sayed Hadi, Yan, Rui, Dräger, Nina, Leng, Kun, Nalls, Mike A., Singleton, Andrew B., Xu, Ke et al. · 2021 · Nature Neuroscience
Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
Baiyu Qiu, Fereshteh Zandkarimi, Carla T. Bezjian, Eduard Reznik, Rajesh Kumar Soni, Wei Jun Gu, Xuejun Jiang, Brent R. Stockwell · 2024 · Cell
Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
Patricia P. Yee, Yiju Wei, Soo Yeon Kim, Tong Lu, Stephen Y. Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, Krishnamoorthy Thamburaj et al. · 2020 · Nature Communications
Tumour fatty acid metabolism in the context of therapy resistance and obesity
Andrew J. Hoy, Shilpa R. Nagarajan, Lisa M. Butler · 2021 · Nature reviews. Cancer
Altered metabolite levels in cancer: implications for tumour biology and cancer therapy
Sullivan, Lucas B., Gui, Dan Y., Heiden, Matthew G. Vander · 2016 · Nature Reviews Cancer
Molecular mechanisms of ferroptosis and their involvement in brain diseases
Costa, Inês, Barbosa, Daniel José, Benfeito, Sofia, Silva, Vera, Chavarria, Daniel, Borges, Fernanda, Remião, Fernando, Silva, Renata · 2023 · Pharmacology & Therapeutics
Regulatory Phenomena in the Glutathione Peroxidase Superfamily
Regina Brigelius‐Flohé, Leopold Flohé · 2019 · Antioxidants and Redox Signaling
Inhibition of ferroptosis attenuates tissue damage and improves long‐term outcomes after traumatic brain injury in mice
Baoshu Xie, Yi‐Qin Wang, Yong Lin, Qing Mao, Junfeng Feng, Guoyi Gao, Jiyao Jiang · 2018 · CNS Neuroscience & Therapeutics
Improving the metabolic fidelity of cancer models with a physiological cell culture medium
Johan Vande Voorde, Tobias Ackermann, Nadja Pfetzer, David P. Sumpton, Gillian Mackay, Gabriela Kalna, Colin Nixon, Karen Blyth, Eyal Gottlieb, Saverio Tardito · 2019 · Science Advances
Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress
Wenyuan Li, Wei Li, Yan Leng, Yonghong Xiong, Zhongyuan Xia · 2019 · DNA and Cell Biology
Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer
Jingjing Yang, Yulu Zhou, Shuduo Xie, Ji Wang, Zhaoqing Li, Lini Chen, Misha Mao, Cong Chen, Aihua Huang, Yongxia Chen et al. · 2021 · Journal of Experimental & Clinical Cancer Research
Immunological impact of cell death signaling driven by radiation on the tumor microenvironment
Rodriguez-Ruiz, Maria Esperanza, Vitale, Ilio, Harrington, Kevin J., Melero, Ignacio, Galluzzi, Lorenzo · 2020 · Nature Immunology
Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics
Shuaifei Wang, Fangyuan Li, Ruirui Qiao, Xi Hu, Hongwei Liao, Lumin Chen, Jiahe Wu, Haibin Wu, Meng Liang Zhao, Jianan Liu et al. · 2018 · ACS Nano
PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer
Ting Hong, Guang Lei, Xue Chen, He Li, Xiaoye Zhang, Nayiyuan Wu, Yu Zhao, Yilei Zhang, Jing Wang · 2021 · Redox Biology
7-Dehydrocholesterol dictates ferroptosis sensitivity
Yaxu Li, Ran Qiao, Qiuhui Duan, Jiali Jin, Yanjin Wang, Lei Yu, Chaojie Wang, Zhenyun Zhu, Xin Chen, Linjun Weng et al. · 2024 · Nature
Ferroptosis and necroinflammation, a yet poorly explored link
Bettina Proneth, Marcus Conrad · 2018 · Cell Death and Differentiation
Modes of Regulated Cell Death in Cancer
Elle Koren, Yaron Fuchs · 2021 · Cancer Discovery
Understanding and targeting resistance mechanisms in cancer
Zi‐Ning Lei, Tian Qin, Qiu‐Xu Teng, John N.D. Wurpel, Leli Zeng, Yihang Pan, Zhe‐Sheng Chen · 2023 · MedComm
Selenium and Selenoproteins in Health
Fan Zhang, Xue‐Lian Li, Yumiao Wei · 2023 · Biomolecules
Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism
Ding, Kaiyue, Liu, Chongbin, Li, Li, Yang, Ming, Jiang, Na, Luo, Shilu, Sun, Lin · 2023 · Chinese Medical Journal
The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells
Louandre, Christophe, Marcq, Ingrid, Bouhlal, Hicham, Lachaier, Emma, Godin, Corinne, Saidak, Zuzana, François, Catherine, Chatelain, Denis, Debuysscher, Véronique, Barbare, Jean-Claude et al. · 2015 · Cancer Letters
Lipid Metabolism and Ferroptosis
Lee, Ji-Yoon, Kim, Won Kon, Bae, Kwang-Hee, Lee, Sang Chul, Lee, Eun-Woo · 2021 · Biology
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Guang‐Hui Chen, Chang-Chun Song, Kostas Pantopoulos, Xiaolei Wei, Hua Zheng, Zhi Luo · 2022 · Free Radical Biology and Medicine