The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences
Open accessAbstract
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. PAPERCLIP:
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“A causal role for the involvement of gut microbes is in part based on the fulfillment of one of Koch’s postulates - namely, the transmission of a disease related phenotype with transplantation of gut microbial organisms to a new host (Cho and Blaser, 2012; Cox et al., 2014; Dumas et al., 2006; Gregory et al., 2015; Koch, 1880; Sandhu and Chase, 1986).”
From Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis (2015) · cites this paper as Cox et al., 2014
In the citing paper
“Nonetheless, the gut microbiome is known to be remarkably dynamic and adaptive, including changes in response to different dietary inputs, as well as the presence versus absence of distinct diseases (Cox et al., 2014; Koren et al., 2011; Wu et al., 2011).”
From Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis (2015) · cites this paper as Cox et al., 2014
In the citing paper
“Similarly, recent studies by Blaser and colleagues (34) show that affecting microbiota in early windows of critical development can affect metabolism long term.”
From Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation (2015) · cites this paper as [34]
In the citing paper
“Specifically, they have identified several taxa transiently disrupted after low-dose penicillin administration at mouse weaning age to be linked to persistent metabolic alterations such as enhanced dietary-induced fat mass accumulation and decreased intestinal-based immunity (34).”
From Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation (2015) · cites this paper as [34]
In the citing paper
“FMT might modulate obesity and metabolism in humans and mice 29,30 , ameliorate metabolic syndrome in patients 31 , and contribute to the treatment of refractory immune checkpoint inhibitor (ICI)-associated colitis 32 and recurrent infections by Clostridium difficile 33 .”
From Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice (2019) · cites this paper as [30]
In the citing paper
“low dose penicillin (LDP) administration was shown to induce stronger physiological alterations if administered from the beginning of gestation, rather than at weaning”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [91]
In the citing paper
“while the expression of intestinal immune genes coding for proteins such asRegIIIγ, β-defensins, and IL-17 was decreased.”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [91]
In the citing paper
“following early LDP administration, body mass and fat content were increased in adulthood”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [91]
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QIIME allows analysis of high-throughput community sequencing data
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featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
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An obesity-associated gut microbiome with increased capacity for energy harvest
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Flagged first, then by citations
Research works printed but not linked: 2
- Beijerinck, 1901, Sur les ferments lactiques de l’industrie, Archives Néerlandaises des Sciences Exactes et Naturelles, 6, 212
- Leidy, 1849, On the existence of entophyta in healthy animals, as a natural condition, Proc. Acad. Nat. Sci. Philadelphia, 4, 225
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Acylation, a Conductor of Ghrelin Function in Brain Health and Disease
Thomas, A. S., Sassi, M., Angelini, R., Morgan, A. H., & Davies, J. S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.831641 · Cited by 17
Liu, Z., Wei, S., Chen, X., Liu, L., Wei, Z., Liao, Z., Wu, J., Li, Z., Zhou, H., & Wang, D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.833365 · Cited by 10
Metadata
- Authors
- Cox, L. M., Yamanishi, S., Sohn, J., Alekseyenko, A. V., Leung, J. M., Cho, I., Kim, S. G., Li, H., Gao, Z., Mahana, D., Zárate Rodriguez, J. G., Rogers, A. B., Robine, N., Loke, P., & Blaser, M. J.
- Affiliations
- NYU Langone Health (US)
- Tufts University (US)
- New York Genome Center (US)
- VA NY Harbor Healthcare System (US)
- Corresponding author
- Blaser, Martin J.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 158
- Issue
- 4
- Pages
- 705-721
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4134513
- OpenAlex
- W2053039168
- Cited by
- 1,859
- References
- 81
- Citations by year
- 2026: 74 · 2025: 119 · 2024: 137 · 2023: 145 · 2022: 177 · 2021: 194 · 2020: 182 · 2019: 163 · 2018: 182 · 2017: 177 · 2016: 161 · 2015: 124 · 2014: 20
- FWCI
- 65.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- NYU Langone Medical Center
- New York Genome Center
- National Institutes of Health
- National Cancer Institute (P30CA016087)
- National Institute of Allergy and Infectious Diseases (R01AI093811)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090989)
- National Center for Research Resources (UL1RR029893)
- Argonne National Laboratory
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- gut microbiota, early-life antibiotic exposure, microbiota disruption, body composition, obesity, high-fat diet, ileal gene expression, immunity, germ-free mice, host-microbe metabolic interactions, developmental programming
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacteria, Disease Models, Animal, Female, Intestinal Mucosa, Intestines, Male, Mice, Inbred C57BL, Obesity, Penicillins, Mice, Microbiota
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