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Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences
Open accessAbstract
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. PAPERCLIP:
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“A causal role for the involvement of gut microbes is in part based on the fulfillment of one of Koch’s postulates - namely, the transmission of a disease related phenotype with transplantation of gut microbial organisms to a new host (Cho and Blaser, 2012; Cox et al., 2014; Dumas et al., 2006; Gregory et al., 2015; Koch, 1880; Sandhu and Chase, 1986).”
From Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis (2015) · cites this paper as Cox et al., 2014
In the citing paper
“Nonetheless, the gut microbiome is known to be remarkably dynamic and adaptive, including changes in response to different dietary inputs, as well as the presence versus absence of distinct diseases (Cox et al., 2014; Koren et al., 2011; Wu et al., 2011).”
From Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis (2015) · cites this paper as Cox et al., 2014
In the citing paper
“Similarly, recent studies by Blaser and colleagues (34) show that affecting microbiota in early windows of critical development can affect metabolism long term.”
From Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation (2015) · cites this paper as [34]
In the citing paper
“Specifically, they have identified several taxa transiently disrupted after low-dose penicillin administration at mouse weaning age to be linked to persistent metabolic alterations such as enhanced dietary-induced fat mass accumulation and decreased intestinal-based immunity (34).”
From Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation (2015) · cites this paper as [34]
In the citing paper
“FMT might modulate obesity and metabolism in humans and mice 29,30 , ameliorate metabolic syndrome in patients 31 , and contribute to the treatment of refractory immune checkpoint inhibitor (ICI)-associated colitis 32 and recurrent infections by Clostridium difficile 33 .”
From Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice (2019) · cites this paper as [30]
In the citing paper
“low dose penicillin (LDP) administration was shown to induce stronger physiological alterations if administered from the beginning of gestation, rather than at weaning”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [91]
In the citing paper
“while the expression of intestinal immune genes coding for proteins such asRegIIIγ, β-defensins, and IL-17 was decreased.”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [91]
In the citing paper
“following early LDP administration, body mass and fat content were increased in adulthood”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [91]
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Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
vegan: Community Ecology Package
Oksanen, J., Simpson, G. L., Blanchet, F. G., Kindt, R., Legendre, P., Minchin, P. R., O’Hara, R. B., Sólymos, P., Stevens, M. H. H., Szöcs, E., et al. (2001) · doi:10.32614/cran.package.vegan · Cited by 27,099
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
A new method for non-parametric multivariate analysis of variance
Anderson, M. J. (2001) · Austral Ecology · doi:10.1111/j.1442-9993.2001.01070.pp.x · Cited by 13,828
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Flagged first, then by citations
Research works printed but not linked: 2
- Beijerinck, 1901, Sur les ferments lactiques de l’industrie, Archives Néerlandaises des Sciences Exactes et Naturelles, 6, 212
- Leidy, 1849, On the existence of entophyta in healthy animals, as a natural condition, Proc. Acad. Nat. Sci. Philadelphia, 4, 225
Cited by
Sorted by citations
Items 301–400 of 1,002
Cheng, C., Wei, H., Xu, C., Xie, X., Jiang, S., & Peng, J. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.01047-18 · Cited by 123
Zhou, L., Qiu, W., Wang, J., Zhao, A., Zhou, C., Sun, T., Xiong, Z., Cao, P., Shen, W., Chen, J., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.05.022 · Cited by 134
Klimenko, N. S., Tyakht, A. V., Popenko, A. S., Vasiliev, A. S., Altukhov, I. A., Ischenko, D. S., Shashkova, T. I., Efimova, D. A., Nikogosov, D. A., Osipenko, D. A., et al. (2018) · Nutrients · doi:10.3390/nu10050576 · Cited by 123
Ferguson, J. F., Allayee, H., Gerszten, R. E., Ideraabdullah, F., Kris‐Etherton, P. M., Ordovás, J. M., Rimm, E. B., Wang, T. J., & Bennett, B. J. (2016) · Circulation Cardiovascular Genetics · doi:10.1161/hcg.0000000000000030 · Cited by 128
Early antibiotic exposure and development of asthma and allergic rhinitis in childhood
Ni, J., Friedman, H. L., Boyd, B., McGurn, A., Babinski, P., Markossian, T. W., & Dugas, L. R. (2019) · BMC Pediatrics · doi:10.1186/s12887-019-1594-4 · Cited by 121
The gut microbiome in cardio-metabolic health
Hansen, T. H., Gøbel, R. J., Hansen, T. F., & Pedersen, O. B. (2015) · Genome Medicine · doi:10.1186/s13073-015-0157-z · Cited by 132
Feng, Y., Weng, H., Ling, L., Zeng, T., Zhang, Y., Chen, D., & Li, H. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.242 · Cited by 122
Self-citationTowards a mechanistic understanding of reciprocal drug–microbiome interactions
Zimmermann, M., Patil, K. R., Typas, A., & Maier, L. (2021) · Molecular Systems Biology · doi:10.15252/msb.202010116 · Cited by 124
Rethinking heritability of the microbiome
van Opstal, E. J., & Bordenstein, S. R. (2015) · Science · doi:10.1126/science.aab3958 · Cited by 122
Autoimmune host–microbiota interactions at barrier sites and beyond
Ruff, W. E., & Kriegel, M. A. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.02.006 · Cited by 122
Ribeiro, C. F. A., Silveira, G. G. D. O. S., Cândido, E. D. S., Cardoso, M. H. E. S., Carvalho, C. M. E., & Franco, O. L. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00036 · Cited by 126
Dynamics of the preterm gut microbiome in health and disease
Cuna, A. C., Morowitz, M. J., Ahmed, I., Umar, S., & Sampath, V. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00399.2020 · Cited by 125
Aranda-Díaz, A., Ng, K. M., Thomsen, T., Real-Ramírez, I., Dahan, D., Dittmar, S., Gonzalez, C. G., Chavez, T. M., Vasquez, K. S., Nguyen, T. H., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2021.12.008 · Cited by 118
Shelton, C. D., Sing, E., Mo, J., Shealy, N. G., Yoo, W., Thomas, J., Fitz, G. N., Castro, P. R., Hickman, T. T., Torres, T. P., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.09.002 · Cited by 125
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Gerber, J. S., Bryan, M. W., Ross, R. K., Daymont, C. B., Parks, E. P., Localio, A. R., Grundmeier, R. W., Stallings, V. A., & Zaoutis, T. E. (2016) · JAMA · doi:10.1001/jama.2016.2395 · Cited by 119
Bacteriophages as potential new mammalian pathogens
Tetz, G. V., Ruggles, K. V., Zhou, H., Heguy, A., Tsirigos, A., & Tetz, V. (2017) · Scientific Reports · doi:10.1038/s41598-017-07278-6 · Cited by 121
Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader
van Muijlwijk, G. H., van Mierlo, G., Jansen, P. W. T. C., Vermeulen, M., Bleumink‐Pluym, N. M. C., Palm, N. W., van Putten, J. P. M., & de Zoete, M. R. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1966278 · Cited by 119
Steves, C. J., Bird, S., Williams, F. M. K., & Spector, T. D. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2765 · Cited by 125
Unveiling bifidobacterial biogeography across the mammalian branch of the tree of life
Milani, C., Mangifesta, M., Mancabelli, L., Lugli, G. A., James, K., Duranti, S., Turroni, F., Ferrario, C., Ossiprandi, M. C., van Sinderen, D., et al. (2017) · The ISME Journal · doi:10.1038/ismej.2017.138 · Cited by 117
Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity
Montgomery, T. L., Künstner, A., Kennedy, J. J., Fang, Q., Asarian, L., Culp‐Hill, R., D’Alessandro, A., Teuscher, C., Busch, H. S., & Krementsov, D. N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002817117 · Cited by 121
Liu, H., Rocha, C. S., Dandekar, S., & Wan, Y. Y. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.09.022 · Cited by 120
Buurman, E. T., Timofeyeva, Y., Gu, J., Kim, J., Kodali, S., Liu, Y., Mininni, T., Moghazeh, S. L., Pavliakova, D., Singer, C. L., et al. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz062 · Cited by 118
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia
Dodiya, H. B., Lutz, H. L., Weigle, I. Q., Patel, P., Michalkiewicz, J., Roman-Santiago, C. J., Zhang, C. M., Liang, Y., Srinath, A., Zhang, X., et al. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20200895 · Cited by 120
Alemán, J. O., Bokulich, N. A., Swann, J. R., Walker, J. M., da Rosa, J. C., Battaglia, T., Costabile, A., Pechlivanis, A., Liang, Y., Breslow, J. L., et al. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1619-z · Cited by 120
Self-citationColonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants
Henrick, B. M., Chew, S., Casaburi, G., Brown, H. K., Frese, S. A., Zhou, Y., Underwood, M. A., & Smilowitz, J. T. (2019) · Pediatric Research · doi:10.1038/s41390-019-0533-2 · Cited by 117
Ma, H., Xiong, H., Zhu, X., Ji, C., Xue, J., Li, R., Ge, B., & Cui, H. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.209 · Cited by 100
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Stark, C. M., Susi, A., Emerick, J., & Nylund, C. M. (2019) · Gut · doi:10.1136/gutjnl-2017-314971 · Cited by 115
Warne, R. W., Kirschman, L. J., & Zeglin, L. H. (2019) · Journal of Animal Ecology · doi:10.1111/1365-2656.12973 · Cited by 117
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Abrahamsson, T., Wu, R., & Jenmalm, M. C. (2014) · Pediatric Research · doi:10.1038/pr.2014.165 · Cited by 116
Developmental Bisphenol A Exposure Modulates Immune-Related Diseases
Xu, J., Huang, G., & Guo, T. L. (2016) · Toxics · doi:10.3390/toxics4040023 · Cited by 116
Obata, F., Fons, C., & Gould, A. P. (2018) · Nature Communications · doi:10.1038/s41467-018-03070-w · Cited by 119
Lyu, Y., Wu, L., Wang, F., Shen, X., & Lin, D. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218763760 · Cited by 117
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Locantore, P., Gatto, V. D., Gelli, S., Paragliola, R. M., & Pontecorvi, A. (2020) · Mediators of Inflammation · doi:10.1155/2020/3686749 · Cited by 117
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Andermann, T. M., Peled, J. U., Ho, C. M., Reddy, P. R., Riches, M., Storb, R. F., Teshima, T., van den Brink, M. R. M., Alousi, A. M., Balderman, S., et al. (2018) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2018.02.009 · Cited by 113
Chen, L., Zhao, R., Shen, J., Liu, N., Zheng, Z., Yu, M., Zhu, J., Zhang, L., Wang, Y., Fang, H., et al. (2023) · Advanced Materials · doi:10.1002/adma.202306281 · Cited by 115
Wei, S., Mortensen, M. S., Stokholm, J., Brejnrod, A., Thorsen, J., Rasmussen, M. A., Trivedi, U., Bisgaard, H. F., & Sørensen, S. J. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.035 · Cited by 114
Calcium supplementation modulates gut microbiota in a prebiotic manner in dietary obese mice
Chaplin, A. M. L., Parra, P., Laraichi, S., Serra, F. A., & Palou, A. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500480 · Cited by 115
Zwittink, R. D., Renes, I. B., van Lingen, R. A., van Zoeren‐Grobben, D., Konstanti, P., Norbruis, O. F., Martı́n, R., Jebbink, L. J. G., Knol, J., & Belzer, C. (2018) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-018-3193-y · Cited by 111
Gold Nanoparticles Cure Bacterial Infection with Benefit to Intestinal Microflora
Li, J., Cha, R., Zhao, X., Guo, H., Luo, H., Wang, M., Zhou, F., & Jiang, X. (2019) · ACS Nano · doi:10.1021/acsnano.9b01002 · Cited by 111
Fan, Y., Qin, Y., Chen, M., Li, X., Wang, R., Huang, Z., Xu, Q., Yu, M., Zhang, Y., Han, X., et al. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121534 · Cited by 109
NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota
Huang, P., Jiang, A., Wang, X., Zhou, Y., Tang, W., Ren, C., Qian, X., Zhou, Z., & Gong, A. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.714604 · Cited by 110
Mother–infant transmission of human microbiota
Browne, H. P., Shao, Y., & Lawley, T. D. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102173 · Cited by 117
Less is more: Antibiotics at the beginning of life
Stocker, M., Klingenberg, C., Navér, L., Nordberg, V., Berardi, A., el Helou, S., Fusch, G., Bliss, J. M., Lehnick, D., Dimopoulou, V., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38156-7 · Cited by 118
Wong, A. C.-N., Vanhove, A. S., & Watnick, P. I. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.023408 · Cited by 109
Cox, L. M., Sohn, J., Tyrrell, K. L., Citron, D. M., Lawson, P. A., Patel, N. B., Iizumi, T., Perez-Perez, G. I., Goldstein, E. J. C., & Blaser, M. J. (2017) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijsem.0.001793 · Cited by 110
Self-citationAntibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity
Zhang, X., Li, J., Krautkramer, K. A., Badri, M. H., Battaglia, T., Borbet, T. C., Koh, H., Ng, S., Sibley, R. A., Li, Y., et al. (2018) · eLife · doi:10.7554/elife.37816 · Cited by 111
Self-citationLiu, B., Zhu, X., Cui, Y., Wang, W., Liu, H., Li, Z., Guo, Z., Ma, S., Li, D., Wang, C., et al. (2021) · mSystems · doi:10.1128/msystems.00591-20 · Cited by 115
Gut microbiome and bone: To build, destroy, or both?
Yan, J., & Charles, J. F. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0382-z · Cited by 108
Lactobacillus paracasei feeding improves immune control of influenza infection in mice
Belkacem, N., Serafini, N., Wheeler, R., Derrien, M., Boucinha, L., Couesnon, A., Cerf-Bensussan, N., Gomperts Boneca, I., Di Santo, J. P., Taha, M.-K., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0184976 · Cited by 108
Yan, F., Liu, L., Cao, H., Moore, D. J., Washington, M. K., Wang, B., Peek, R. M., Acra, S. A., & Polk, D. B. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.43 · Cited by 106
Are Probiotics the New Calcium and Vitamin D for Bone Health?
Rizzoli, R., & Biver, E. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00591-6 · Cited by 112
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Rahman, M. S., Hassan, M. M., & Chowdhury, S. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07739 · Cited by 106
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Hsu, E., & Pacifici, R. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0321-0 · Cited by 106
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Touch, S., Clément, K., & André, S. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0900-5 · Cited by 109
Liu, Y., Qin, S., Song, Y., Feng, Y., Lv, N., Xue, Y., Liu, F., Wang, S., Zhu, B., Ma, J., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00598 · Cited by 109
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Charles‐Messance, H., Mitchelson, K. A. J., Castro, E. D. M., Sheedy, F. J., & Roche, H. M. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.013 · Cited by 121
Jian, C., Carpén, N., Helve, O., de Vos, W. M., Korpela, K., & Salonen, A. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103475 · Cited by 111
Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract
Fenneman, A. C., Weidner, M., Chen, L. A., Nieuwdorp, M., & Blaser, M. J. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00685-9 · Cited by 112
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Ibáñez, L., Rouleau, M., Wakkach, A., & Blin-Wakkach, C. (2019) · Joint Bone Spine · doi:10.1016/j.jbspin.2018.02.008 · Cited by 103
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Martinez, K. A., Devlin, J. C., Lacher, C., Yin, Y. S., Cai, Y., Wang, J., & Domínguez-Bello, M. G. (2017) · Science Advances · doi:10.1126/sciadv.aao1874 · Cited by 109
Gut microbiota as important modulator of metabolism in health and disease
Wang, X., Zhang, A., Miao, J.-H., Sun, H. J., Yan, G., Wu, F., & Wang, X.-J. (2018) · RSC Advances · doi:10.1039/c8ra08094a · Cited by 111
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Liu, Y., Luo, Y., Zeng, B., Gui, S., Zheng, P., Zheng, P., Pu, J., Wang, H., Wu, Y., Zhou, C., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-021-01689-w · Cited by 110
Romero, R. J., Chaemsaithong, P., Korzeniewski, S. J., Kusanovic, J. P., Docheva, N., Martínez‐Varea, A., Ahmed, A. I., Yoon, B. H., Hassan, S. S., Chaiworapongsa, T., et al. (2015) · Journal of Perinatal Medicine · doi:10.1515/jpm-2015-0044 · Cited by 104
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Nash, M. J., Frank, D. N., & Friedman, J. E. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00349 · Cited by 101
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He, S., Wang, Q., Li, S., Ran, C., Guo, X., Zhang, Z., & Zhou, Z. (2017) · Science China Life Sciences · doi:10.1007/s11427-016-9072-6 · Cited by 105
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Whitt, J., Woo, V., Lee, P. C., Moncivaiz, J. D., Haberman, Y., Denson, L. A., Tso, P., & Alenghat, T. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.04.017 · Cited by 100
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Ribado, J. V., Ley, C., Haggerty, T. D., Tkachenko, E., Bhatt, A. S., & Parsonnet, J. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707882 · Cited by 102
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Nogacka, A. M., Salazar, N., Arboleya, S., Suárez, M., Fernández, N., Sánchez, G. S., Reyes‐Gavilán, C. G. D. L., & Gueimonde, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2670-2 · Cited by 104
Skonieczna‐Żydecka, K., Łoniewski, I., Misera, A., Stachowska, E., Maciejewska, D., Marlicz, W. M., & Galling, B. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5102-6 · Cited by 103
Association between the gut and oral microbiome with obesity
Benahmed, A. G., Gasmi, A., Doşa, A., Chirumbolo, S., Mujawdiya, P. K., Aaseth, J., Dadar, M., & Bjørklund, G. (2020) · Anaerobe · doi:10.1016/j.anaerobe.2020.102248 · Cited by 102
Vallianou, N. G., Dalamaga, Μ., Stratigou, T., Karampela, Ι., & Tsigalou, C. (2021) · Current Obesity Reports · doi:10.1007/s13679-021-00438-w · Cited by 103
Association of Early-Life Antibiotic Use and Protective Effects of Breastfeeding
Korpela, K., Salonen, A., Virta, L. J., Kekkonen, R. A., & de Vos, W. M. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.0585 · Cited by 98
Miller, S. A., Wu, R., & Oremus, M. (2018) · Obesity Reviews · doi:10.1111/obr.12717 · Cited by 101
Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients
Wang, M., Chen, F., Wang, J., Zeng, Z., Yang, Q., & Shao, S. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.09.005 · Cited by 102
Korpela, K., Salonen, A., Saxén, H., Nikkonen, A., Peltola, V. T., Jaakkola, T., de Vos, W. M., & Kolho, K.-L. (2020) · Pediatric Research · doi:10.1038/s41390-020-0761-5 · Cited by 98
Gut microbiota in health and disease: an overview focused on metabolic inflammation
Nagpal, R., Kumar, M., Yadav, A. K., Hemalatha, R., Yadav, H., Marotta, F., & Yamashiro, Y. (2016) · Beneficial Microbes · doi:10.3920/bm2015.0062 · Cited by 97
Early-Life Host–Microbiome Interphase: The Key Frontier for Immune Development
Amenyogbe, N., Kollmann, T. R., & Ben-Othman, R. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00111 · Cited by 101
Is there any association between gut microbiota and type 1 diabetes? A systematic review
Jamshidi, P. K., Hasanzadeh, S., Tahvildari, A., Farsi, Y., Arbabi, M., Mota, J. F., Sechi, L. A., & Nasiri, M. J. (2019) · Gut Pathogens · doi:10.1186/s13099-019-0332-7 · Cited by 104
Roles of the gut microbiome in weight management
Carmody, R. N., & Bisanz, J. E. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00888-0 · Cited by 113
Song, S. J., Wang, J., Martino, C., Jiang, L., Thompson, W. K., Shenhav, L., McDonald, D. T., Marotz, C. A., Harris, P. R., Hernandez, C. D., et al. (2021) · Med · doi:10.1016/j.medj.2021.05.003 · Cited by 102
Gut microbiome interventions in human health and diseases
Nie, P., Li, Z., Wang, Y., Zhang, Y., Zhao, M., Luo, J., Du, S., Deng, Z., Chen, J., Wang, Y., et al. (2019) · Medicinal Research Reviews · doi:10.1002/med.21584 · Cited by 94
Li, Y., Su, X., Gao, Y., Lv, C., Gao, Z., Liu, Y., Wang, Y., Li, S., & Wang, Z. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165764 · Cited by 92
Self-citationThe connection between microbiome and schizophrenia
Golofast, B., & Vales, K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.011 · Cited by 92
Rate of establishing the gut microbiota in infancy has consequences for future health
Dogra, S. K., Sakwińska, O., Soh, S., Ngom‐Bru, C., Brück, W. M., Berger, B. W., Brüssow, H., Karnani, N., Lee, Y. S., Yap, F. K. P., et al. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1078051 · Cited by 95
Li, D., Chen, H., Ferber, J. R., & Odouli, R. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30281-9 · Cited by 98
Helicobacter pylori infection is associated with an altered gastric microbiota in children
Brawner, K. M., Kumar, R., Serrano, C. A., Ptacek, T., Lefkowitz, E. J., Morrow, C. D., Zhi, D., Kyanam-Kabir-Baig, K., Smythies, L. E., Harris, P. R., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.131 · Cited by 96
Akbar, S., Gu, L., Sun, Y., Zhou, Q., Zhang, L., Lyu, K., Huang, Y., & Yang, Z. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135827 · Cited by 98
On the origin of species: Factors shaping the establishment of infant's gut microbiota
van Best, N., Hornef, M. W., Savelkoul, P. H. M., & Penders, J. (2015) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21113 · Cited by 96
Jin, Y., Wu, Y., Zeng, Z., Jin, C., Wu, S., Wang, Y., & Fu, Z. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw150 · Cited by 93
Microbiota–drug interactions: Impact on metabolism and efficacy of therapeutics
Wilkinson, E. M., Ilhan, Z. E., & Herbst‐Kralovetz, M. M. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.03.012 · Cited by 95
Xu, R., Zhang, Y., Chen, S., Zeng, Y., Fu, X., Chen, T., Luo, S., & Zhang, X. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2044286 · Cited by 96
Antibiotics, gut microbiome and obesity
Leong, K. S. W., Derraik, J. G. B., Hofman, P. L., & Cutfield, W. S. (2017) · Clinical Endocrinology · doi:10.1111/cen.13495 · Cited by 98
Spatial disturbances in altered mucosal and luminal gut viromes of diet‐induced obese mice
Kim, M., & Bae, J. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.13182 · Cited by 95
Zhou, W., Xu, H., Zhan, L., Lu, X., & Zhang, L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00232 · Cited by 90
Metadata
- Authors
- Cox, L. M., Yamanishi, S., Sohn, J., Alekseyenko, A. V., Leung, J. M., Cho, I., Kim, S. G., Li, H., Gao, Z., Mahana, D., Zárate Rodriguez, J. G., Rogers, A. B., Robine, N., Loke, P., & Blaser, M. J.
- Affiliations
- NYU Langone Health (US)
- Tufts University (US)
- New York Genome Center (US)
- VA NY Harbor Healthcare System (US)
- Corresponding author
- Blaser, Martin J.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 158
- Issue
- 4
- Pages
- 705-721
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4134513
- OpenAlex
- W2053039168
- Cited by
- 1,859
- References
- 81
- Citations by year
- 2026: 74 · 2025: 119 · 2024: 137 · 2023: 145 · 2022: 177 · 2021: 194 · 2020: 182 · 2019: 163 · 2018: 182 · 2017: 177 · 2016: 161 · 2015: 124 · 2014: 20
- FWCI
- 65.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- NYU Langone Medical Center
- New York Genome Center
- National Institutes of Health
- National Cancer Institute (P30CA016087)
- National Institute of Allergy and Infectious Diseases (R01AI093811)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090989)
- National Center for Research Resources (UL1RR029893)
- Argonne National Laboratory
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- gut microbiota, early-life antibiotic exposure, microbiota disruption, body composition, obesity, high-fat diet, ileal gene expression, immunity, germ-free mice, host-microbe metabolic interactions, developmental programming
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacteria, Disease Models, Animal, Female, Intestinal Mucosa, Intestines, Male, Mice, Inbred C57BL, Obesity, Penicillins, Mice, Microbiota
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