Acetate Dependence of Tumors

Comerford, Sarah A., Huang, Zhiguang, Du, Xinlin, Wang, Yun, Cai, Ling, Witkiewicz, Agnes K., Walters, Holly, Tantawy, Mohammed N., Fu, Allie, Manning, H. Charles, Horton, Jay D., Hammer, Robert E., McKnight, Steven L., Tu, Benjamin P.·2014·Cell

DOI 10.1016/j.cell.2014.11.020

Cited by (678)

Items 101–200 of 678

Non-coding RNAs: the new central dogma of cancer biology
Phei Er Saw, Xiaoding Xu, Jianing Chen, Erwei Song · 2020 · Science China Life Sciences
Metabolic analysis as a driver for discovery, diagnosis, and therapy
Ralph J. DeBerardinis, Kayvan R. Keshari · 2022 · Cell
ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism
Zhi‐Guang Huang, Menglu Zhang, Abigail A. Plec, Sandi Jo Estill, Ling Cai, Joyce J. Repa, Steven Lanier McKnight, Benjamin P. Tu · 2018 · Proceedings of the National Academy of Sciences
Pyruvate and metabolic flexibility: illuminating a path toward selective cancer therapies
Olson, Kristofor A., Schell, John C., Rutter, Jared · 2016 · Trends in Biochemical Sciences
Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells
Yoshiaki Sunami, Artur Rebelo, Jorg H. Kleeff · 2017 · Cancers
ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition
Ming Lü, Wenwei Zhu, Xuan Wang, Jing-Jie Tang, Kaili Zhang, Guangyang Yu, Weiqing Shao, Zhifei Lin, Sheng-Hao Wang, Lu Lu et al. · 2019 · Cell Metabolism
β-catenin-activated hepatocellular carcinomas are addicted to fatty acids
Nadia Senni, Mathilde Savall, David Cabrerizo Granados, Marie‐Clotilde Alves‐Guerra, Chiara Sartor, Isabelle Lagoutte, Angélique Gougèlet, Benoît Terris, Hélène Gilgenkrantz, Christine Perret et al. · 2018 · Gut
ChREBP-Mediated Regulation of Lipid Metabolism: Involvement of the Gut Microbiota, Liver, and Adipose Tissue
Katsumi Iizuka, Ken Takao, Daisuke Yabe · 2020 · Frontiers in Endocrinology
The redox requirements of proliferating mammalian cells
Aaron M. Hosios, Matthew G. Vander Heiden · 2018 · Journal of Biological Chemistry
When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance
Ching‐Ying Kuo, David Kong Ann · 2018 · 癌症：英文版
The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells
Edward V. Prochownik, Huabo Wang · 2021 · Cells
Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization
Elias Björnson, Bani Mukhopadhyay, Anna Asplund, Nuša Pristovšek, Reşat Çınar, Stefano Romeo, Mathias Uhlén, George Kunos, Jens Nielsen, Adil Mardinoğlu · 2015 · Cell Reports
Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells
Javad Alizadeh, Amir A. Zeki, Nima Mirzaei, Sandipan Tewary, Adel Rezaei Moghadam, Aleksandra Głogowska, Pandian Nagakannan, Eftekhar Eftekharpour, Emilia Wiecheć, Joseph W. Gordon et al. · 2017 · Scientific Reports
VDAC Regulation: A Mitochondrial Target to Stop Cell Proliferation
Diana Fang, Eduardo N. Maldonado · 2018 · Advances in cancer research
Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism
Cunqi Ye, Benjamin P. Tu · 2018 · Trends in Endocrinology and Metabolism
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production
Kunlun Yin, Jordan Lee, Zhaoli Liu, Hyeoncheol Kim, David R Martin, Dandan Wu, Meilian Liu, Xiang Xue · 2021 · Cell Death and Differentiation
Tumour microenvironment factors shaping the cancer metabolism landscape
Dimitrios Anastasiou · 2016 · British Journal of Cancer
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc
Juhong Wang, Yannan Yang, Fei Shao, Ying Meng, Dong Sheng Guo, Jie He, Zhimin Lu · 2024 · Nature Metabolism
Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment
Barrie Peck, Almut Schulze · 2019 · Trends in cancer
Alternative fuels for cancer cells
Keenan, Melissa M., Chi, Jen-Tsan · 2015 · The Cancer Journal
Metabolic Reprogramming in Brain Tumors
Sriram Venneti, Craig B. Thompson · 2017 · Annual Review of Pathology Mechanisms of Disease
Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer
Katelyn D. Miller, Seamus O’Connor, Katherine A. Pniewski, Toshitha Kannan, Reyes Acosta, Gauri Mirji, Sara B. Papp, Michael Hulse, Dzmitry Mukha, Sabina I. Hlavaty et al. · 2023 · Nature Cancer
Nuclear metabolism and the regulation of the epigenome
Ruben Boon, Giórgia Gobbi da Silveira, Raúl Mostoslavsky · 2020 · Nature Metabolism
Long Noncoding RNA TINCR-Mediated Regulation of Acetyl-CoA Metabolism Promotes Nasopharyngeal Carcinoma Progression and Chemoresistance
Zi‐Qi Zheng, Zhi‐Xuan Li, Jia-Li Guan, Xu Liu, Junyan Li, Yue Chen, Li Ching Lin, Jia Kou, Jia‐Wei Lv, Lulu Zhang et al. · 2020 · Cancer Research
Serine catabolism generates liver NADPH and supports hepatic lipogenesis
Zhaoyue Zhang, Tara A. TeSlaa, Xincheng Xu, Xianfeng Zeng, Lifeng Yang, Gang Xing, Gregory J. Tesz, Michelle F. Clasquin, Joshua D. Rabinowitz · 2021 · Nature Metabolism
Androgen control of lipid metabolism in prostate cancer: novel insights and future applications
Lisa M. Butler, Margaret M. Centenera, Johannes V. Swinnen · 2016 · Endocrine Related Cancer
Acetate controls endothelial-to-mesenchymal transition
Xiaolong Zhu, Yunyun Wang, Ioana Soaita, Heon‐Woo Lee, Hosung Bae, Nabil E. Boutagy, Anna Bostwick, Rong‐Mo Zhang, Caitlyn E. Bowman, Yanying Xu et al. · 2023 · Cell Metabolism
Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets
Vera Miranda‐Gonçalves, Ana Lameirinhas, Rui Henrique, Cármen Jerónimo · 2018 · Frontiers in Genetics
Glucose Metabolic Dysfunction in Neurodegenerative Diseases—New Mechanistic Insights and the Potential of Hypoxia as a Prospective Therapy Targeting Metabolic Reprogramming
Han, Rongrong, Liang, Jing, Zhou, Bing · 2021 · International Journal of Molecular Sciences
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate
Peng Zhou, Wen-yi Chang, De-ao Gong, Jie Lai Xia, Wei Chen, Luyi Huang, Rui Liu, Yi Liu, Chang Chen, Kai Wang et al. · 2023 · Cell Metabolism
Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance
Kenta Masui, Kazuhiro Tanaka, Shiro Ikegami, Genaro R. Villa, Huijun Yang, William H. Yong, Timothy Francis Cloughesy, Kanato Yamagata, Nobutaka Arai, Webster K. Cavenee et al. · 2015 · Proceedings of the National Academy of Sciences
Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
Alexander Muir, Laura V. Danai, Matthew G. Vander Heiden · 2018 · Disease Models & Mechanisms
Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca 2+ –NFAT signaling
Joyce V. Lee, Corbett T. Berry, Karla Kim, Payel Sen, Taehyong Kim, Alessandro Carrer, Sophie Trefely, Steven Zhao, Sully Fernandez, Lauren E. Barney et al. · 2018 · Genes & Development
Non-invasive metabolic imaging of brain tumours in the era of precision medicine
Michelle M. Kim, Abhijit Parolia, Mark P. Dunphy, Sriram Venneti · 2016 · Nature Reviews Clinical Oncology
Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders
Stephen L. Pinkosky, Pieter H.E. Groot, Narendra D. Lalwani, Gregory R. Steinberg · 2017 · Trends in Molecular Medicine
Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis – Part 2: Acetate and ACSS2 in Health and Disease
John R. Moffett, Narayanan Puthillathu, Ranjini Vengilote, Diane M. Jaworski, Aryan M. A. Namboodiri · 2020 · Frontiers in Physiology
Inhibition of ACSS2-mediated histone crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence
Lingzhi Li, Ting Xiang, Jingjing Guo, Fan Guo, Yiting Wu, Han Feng, Jing Liu, Sibei Tao, Ping Fu, Liang Ma · 2024 · Nature Communications
Metformin-based nanomedicines for reprogramming tumor immune microenvironment
Jieyu Liu, Xiaoling Li, Yinggang Li, Qiyong Gong, Kui Luo · 2024 · Theranostics
The gut microbiome and cancer: from tumorigenesis to therapy
Amandine Nobels, Cédric van Marcke, Bénédicte F. Jordan, Matthias Van Hul, Patrice D. Cani · 2025 · Nature Metabolism
Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids
Yijia Li, Johannes Francois Fahrmann, Maryam Aftabizadeh, Qianqian Zhao, S. C. Tripathi, Chunyan Zhang, Yuan Yuan, David Kong Ann, Samir Hanash, Hua Yu · 2022 · Cell Reports
Short-chain fatty acids and cancer
Shan Li, Yixin Duan, Shudi Luo, Fangxin Zhou, Qingang Wu, Zhimin Lu · 2024 · Trends in cancer
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
Zongwei Li, Huan Liu, Jin He, Zhiqiang Wang, Zheng Yin, Gichun You, Zhiming Wang, Richard Eric Davis, Pei Lin, Peter Leif Bergsagel et al. · 2021 · Cell Metabolism
Metabolic effects of fasting on human and mouse blood in vivo
Federico Pietrocola, Yohann Demont, Francesca Castoldi, David Pierre Enot, Sylvère Durand, Michaëla Semeraro, Elisa Elena Baracco, Jonathan G. Pol, José Manuel Bravo‐San Pedro, Chloé Bordenave et al. · 2017 · Autophagy
Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers
Arimichi Okazaki, Paulo A. Gameiro, Danos C. Christodoulou, Laura A. Laviolette, Meike Schneider, Frances L. Chaves, Anat O Stemmer-Rachamimov, Stephanie A. Yazinski, Richard E. Lee Jr., Gregory N Stephanopoulos et al. · 2017 · Journal of Clinical Investigation
Acyl‐CoA synthetase short‐chain family member 2 (ACSS2) is regulated by SREBP‐1 and plays a role in fatty acid synthesis in caprine mammary epithelial cells
Huifen Xu, Jun Luo, Gongzhen Ma, Xueying Zhang, Dawei Yao, Ming Li, Juan J. Loor · 2017 · Journal of Cellular Physiology
Metabolic recoding of epigenetics in cancer
Yi‐Ping Wang, Qun‐Ying Lei · 2018 · 癌症：英文版
An epigenetic gateway to brain tumor cell identity
Stephen C. Mack, Christopher G. Hubert, Tyler E. Miller, Michael D. Taylor, Jeremy N. Rich · 2015 · Nature Neuroscience
HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding
Joshua James Gruber, Benjamin S. Geller, Andrew M. Lipchik, Justin Chen, Ameen Abdulla Salahudeen, Ashwin N. Ram, James M. Ford, Calvin Jay Kuo, Michael P. Snyder · 2019 · Molecular Cell
Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth
Katelyn D. Miller, Katherine A. Pniewski, Caroline E. Perry, Sara B. Papp, Joshua D. Shaffer, Jesse N. Velasco‐Silva, Jessica C. Casciano, Tomas M. Aramburu, Yellamelli V. V. Srikanth, Joel A. Cassel et al. · 2021 · Cancer Research
Acetate Fuels the Cancer Engine
Costas Andreas Lyssiotis, Lewis C. Cantley · 2014 · Cell
Metabolic reprogramming in tumors: Contributions of the tumor microenvironment
Lane, Andrew N., Higashi, Richard M., Fan, Teresa W-M. · 2020 · Genes & Diseases
The impact of the intestinal microbiota in therapeutic responses against cancer
Anne‐Gaëlle Goubet, Romain Daillère, Bertrand Routy, Lisa Derosa, Paula M. Roberti, Laurence Zitvogel · 2018 · Comptes Rendus Biologies
Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis
Divya Murthy, Kuldeep Singh Attri, Surendra Kumar Shukla, Ravi Kumar Thakur, Nina V. Chaika, Chunbo He, Dezhen Wang, Kanupriya Jha, Aneesha Dasgupta, Ryan J. King et al. · 2024 · Nature Cell Biology
ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease
Yingbin Lin, Anlan Lin, Lili Cai, Weibin Huang, Shanzhi Yan, Yuanxiang Wei, Xinglin Ruan, Wenting Fang, Xiaoman Dai, Jinbo Cheng et al. · 2023 · Molecular Neurodegeneration
A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors
Md Maksudul Alam, Sneha Lal, Keely E. FitzGerald, Zhang Li · 2016 · Clinical and Translational Medicine
The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target
Philippe Icard, Hubert Lincet · 2016 · Drug Resistance Updates
Press-pulse: a novel therapeutic strategy for the metabolic management of cancer
Thomas N. Seyfried, George W. Yu, Joseph C. Maroon, Dominic P. D’Agostino · 2017 · Nutrition & Metabolism
The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development
Arielle Elkrief, Reilly Pidgeon, Saman Maleki Vareki, Meriem Messaoudene, Bastien Castagner, Bertrand Routy · 2025 · Nature Reviews Drug Discovery
The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis
Koselny, Kristy, Green, Julianne, DiDone, Louis, Halterman, Justin P., Fothergill, Annette W., Wiederhold, Nathan P., Patterson, Thomas F., Cushion, Melanie T., Rappelye, Chad, Wellington, Melanie et al. · 2016 · Antimicrobial Agents and Chemotherapy
Targeting extracellular nutrient dependencies of cancer cells
Javier García‐Bermúdez, Robert T. Williams, Rohiverth Guarecuco, Kıvanç Birsoy · 2019 · Molecular Metabolism
Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development
Rui Ling, Gong Chen, Xiang Tang, Na Liu, Yuepeng Zhou, Deyu Chen · 2022 · Discover Oncology
Metabolic tricks of cancer cells
Kateřina Hönigová, Jiří Navrátil, Barbora Peltanová, Hana Holcova Polanska, Martina Raudenská, Michal Masařík · 2022 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
Li, Zhaoqi, Ji, Brian W., Dixit, Purushottam D., Tchourine, Konstantine, Lien, Evan C., Hosios, Aaron M., Abbott, Keene L., Rutter, Justine C., Westermark, Anna M., Gorodetsky, Elizabeth F. et al. · 2022 · Nature Metabolism
Metabolic pathway analysis using stable isotopes in patients with cancer
Caroline Bartman, Brandon Faubert, Joshua D. Rabinowitz, Ralph J. DeBerardinis · 2023 · Nature reviews. Cancer
ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection
Anna Vysochan, Arjun Sengupta, Aalim M. Weljie, James C. Alwine, Yongjun Yu · 2017 · Proceedings of the National Academy of Sciences
Caloric restriction promotes functional changes involving short-chain fatty acid biosynthesis in the rat gut microbiota
Tanca, Alessandro, Abbondio, Marcello, Palomba, Antonio, Fraumene, Cristina, Marongiu, Fabio, Serra, Monica, Pagnozzi, Daniela, Laconi, Ezio, Uzzau, Sergio · 2018 · Scientific Reports
The Heterogeneity of Lipid Metabolism in Cancer
Joshua K. Park, Nathan J. Coffey, Aaron Limoges, Anne Le · 2018 · Advances in experimental medicine and biology
Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell
Lars Kolster Petersen, Allan Beck Christensen, Jacob Andersen, Charlotta G. Folkesson, Ole Kristensen, Charlotte Andersen, Amaya Alzu, Frank A. Sløk, Peter Blakskjær, Daniel Hargbøll Madsen et al. · 2021 · Journal of the American Chemical Society
Limits of aerobic metabolism in cancer cells
Jorge Fernández-de-Cossio-Díaz, Alexei Vázquez · 2017 · Scientific Reports
NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex
Wěi Li, Junjie Kou, Junying Qin, Li Li, Zhenxi Zhang, Ying Pan, Yi Xue, Wenjing Du · 2021 · Nature Metabolism
Cancer Metabolism: A Modeling Perspective
Pouyan Ghaffari, Adil Mardinoğlu, Jens Nielsen · 2015 · Frontiers in Physiology
Exploring the Role of ATP-Citrate Lyase in the Immune System
Monica Dominguez, Bernhard Brüne, Dmitry Namgaladze · 2021 · Frontiers in Immunology
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
Robert L. Summers, Charisse Flerida A. Pasaje, João Pedro Pisco, Josefine Striepen, Madeline R. Luth, Krittikorn Kümpornsin, Emma F. Carpenter, Justin T. Munro, De Lin, Andrew Plater et al. · 2021 · Cell chemical biology
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death
Aleksandra A. Pandyra, Peter Mullen, Carolyn A. Goard, Elke Ericson, Piyush Sharma, Manpreet Kalkat, Rosemary Yu, Janice T. Pong, Kevin R. Brown, Traver Hart et al. · 2015 · Oncotarget
Modulation of Guard Cell Turgor and Drought Tolerance by a Peroxisomal Acetate–Malate Shunt
Huan Dong, Ling Bai, Yu Zhang, Guozeng Zhang, Yanqing Mao, Lulu Min, Fuyou Xiang, Dongdong Qian, Xiaohong Zhu, Chun‐Peng Song · 2018 · Molecular Plant
Importance of the Microbiota Inhibitory Mechanism on the Warburg Effect in Colorectal Cancer Cells
Majid Eslami, Sina Sadrifar, Mohsen Karbalaei, Masoud Keikha, Nazarii M. Kobyliak, Bahman Yousefi · 2019 · Journal of Gastrointestinal Cancer
Metabolic Cooperation of Glucose and Glutamine Is Essential for the Lytic Cycle of Obligate Intracellular Parasite Toxoplasma gondii
Richard Nitzsche, Vyacheslav Zagoriy, Richard Lucius, Nishith Gupta · 2015 · Journal of Biological Chemistry
VDAC–Tubulin, an Anti-Warburg Pro-Oxidant Switch
Eduardo N. Maldonado · 2017 · Frontiers in Oncology
Memory CD8+ T Cells Balance Pro- and Anti-inflammatory Activity by Reprogramming Cellular Acetate Handling at Sites of Infection
Maria Luisa Balmer, Eric H. Ma, Andrew J. Thompson, Raja Epple, Gunhild Unterstab, Jonas Lötscher, Philippe Dehio, Christian M. Schürch, Jan D. Warncke, Gaëlle Perrin et al. · 2020 · Cell Metabolism
Msn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth
Zheng Kuang, Sudarshan Pinglay, Hongkai Ji, Jef D. Boeke · 2017 · eLife
VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges
Kareem A. Heslop, Verónica Milesi, Eduardo N. Maldonado · 2021 · Frontiers in Physiology
The contributions of cancer cell metabolism to metastasis
Gloria Pascual, Diana Domínguez, Salvador Aznar Benitah · 2018 · Disease Models & Mechanisms
NF-Y activates genes of metabolic pathways altered in cancer cells
Paolo Benatti, Maria Luisa Chiaramonte, Mariangela Lorenzo, John Anthony Hartley, Daniel Hochhauser, Nerina Gnesutta, Roberto Mantovani, Carol Imbriano, Diletta Dolfini · 2015 · Oncotarget
Attacking the supply wagons to starve cancer cells to death
Elizabeth M. Selwan, Brendan T. Finicle, Seong Min Kim, Aimee L. Edinger · 2016 · FEBS Letters
Imaging Cancer Metabolism: Underlying Biology and Emerging Strategies
Austin R. Pantel, Daniel Ackerman, Seung‐Cheol Lee, David A. Mankoff, Terence P.F. Gade · 2018 · Journal of Nuclear Medicine
Functional and regulatory profiling of energy metabolism in fission yeast
Michał Małecki, Danny A. Bitton, Maria Rodríguez‐López, Charalampos Rallis, Noelia Garcia Calavia, Graeme C. Smith, Jürg Bähler · 2016 · Genome biology
Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis
Wentao Dong, Mark A. Keibler, Gregory N Stephanopoulos · 2017 · Metabolic Engineering
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
Peter W. Stacpoole, Charles E. McCall · 2023 · Mitochondrion
Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors
David C. Montgomery, Alexander W. Sorum, Laura Guasch, Marc C. Nicklaus, Jordan L. Meier · 2015 · Chemistry & Biology
Enzymatic transfer of acetate on histones from lysine reservoir sites to lysine activating sites
Mariel R. Mendoza, Gabor Egervári, Simone Sidoli, Greg Donahue, Desi C. Alexander, Payel Sen, Benjamin Aaron Garcia, Shelley L. Berger · 2022 · Science Advances
Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma
Eyra Marien, Michael A. Meister, Thomas Muley, Teresa Gómez del Pulgar, Rita Derua, Jeffrey M. Spraggins, Raf Van de Plas, Frank Vanderhoydonc, Jelle Machiels, María Mercedes Binda et al. · 2016 · Oncotarget
Fatty Acids and Membrane Lipidomics in Oncology: A Cross-Road of Nutritional, Signaling and Metabolic Pathways
Carla Ferreri, Anna Sansone, Ferreri Rosaria, Javier Amézaga, Itziar Tueros · 2020 · Metabolites
Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers
Siqi Li, Hang Yuan, Liang Li, Qin Li, Ping Lin, Kai Li · 2025 · Antioxidants
Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia
Yang Li, Joshua James Gruber, Ulrike M. Litzenburger, Yiren Zhou, Yu Rebecca Miao, Edward L. LaGory, Albert Mao Li, Zhen Hu, Michaela Yip, Lori S. Hart et al. · 2020 · Cell Death and Disease
Metabolic reprogramming and interventions in angiogenesis
Yun Liu, Zifang Wu, Yikun Li, Yating Chen, Xuan Zhao, Miaomiao Wu, Yaoyao Xia · 2024 · Journal of Advanced Research
Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress
Ramya S. Kuna, Avi Kumar, Héctor Gálvez, Karl A. Wessendorf-Rodriguez, Courtney R. Green, Grace H. McGregor, Thekla Cordes, Reuben J. Shaw, Robert U Svensson, Christian M. Metallo · 2023 · Science Advances
A key role for transketolase-like 1 in tumor metabolic reprogramming
Santiago Díaz‐Moralli, Esther Aguilar, Silvia Marín, Johannes F. Coy, Mieke A. Dewerchin, Maciek R. Antoniewicz, Óscar Meca‐Cortés, Leen Notebaert, Bart Ghesquière, Guy Eelen et al. · 2016 · Oncotarget
Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth
Alexander J. Lakhter, James Hamilton, Raymond Lloyd Konger, Nickolay Brustovetsky, Hal E. Broxmeyer, Samisubbu R. Naidu · 2016 · Journal of Biological Chemistry
Acetate as a Metabolic and Epigenetic Modifier of Cancer Therapy
Diane M. Jaworski, Aryan M. A. Namboodiri, John R. Moffett · 2015 · Journal of Cellular Biochemistry
Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase
Kristy Koselny, Julianne Green, Lacey J. Favazzo, Virginia E. Glazier, Louis DiDone, Shea T. Ransford, Damian J. Krysan · 2016 · ACS Infectious Diseases