Hippo pathway in organ size control, tissue homeostasis, and cancer

Yu, Fa-Xing, Zhao, Bin, Guan, Kun-Liang·2015·Cell

Cited by (1,005)

Items 101–200 of 1,005

  1. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer
    Yang Tang, Ge‐Min Fang, Fenghua Guo, Hui Zhang, Xiaoxu Chen, Liwei An, Min Chen, Li Zhou, Wenjia Wang, Tiantian Ye et al. · 2020 · Cancer Cell
  2. The physics of cell-size regulation across timescales
    Clotilde Cadart, Larisa S. Venkova, Pierre Recho, Marco Cosentino Lagomarsino, Matthieu Piel · 2019 · Nature Physics
  3. Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer
    Shenghong Ma, Tracy Tzu-Ling Tang, Gary D. Probst, Andrei William Konradi, Chunyu Jin, Fulong Li, Jorge Silvio Gutkind, Xiang‐Dong Fu, Kun‐Liang Guan · 2022 · Nature Communications
  4. The Hippo pathway in tissue homeostasis and regeneration
    Yu Wang, Aijuan Yu, Fa‐Xing Yu · 2017 · Protein & Cell
  5. Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells
    Yang Sun, Lu Hu, Zhipeng Tao, Gopala K. Jarugumilli, Hannah Erb, Alka Singh, Qi Li, Jennifer L. Cotton, Patricia Greninger, Regina K. Egan et al. · 2022 · Nature Communications
  6. Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1
    Yuan Si, Xinyan Ji, Xiaolei Cao, Xiaoming Dai, Lingyi Xu, Hongxia Zhao, Xiaocan Guo, Huan Yan, Haitao Zhang, Chu Zhu et al. · 2017 · Cancer Research
  7. Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP
    Roberto Moreno-Vicente, Dácil María Pavón, Inés Martín-Padura, Mauro Català-Montoro, Alberto Díez-Sánchez, Antonio Quílez-Álvarez, Juan Antonio López, Miguel Sánchez‐Álvarez, Jesús Vázquez, Raffaele Strippoli et al. · 2018 · Cell Reports
  8. YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity
    Yuan, Yao, Park, Jeannie, Feng, Amber, Awasthi, Parirokh, Wang, Zhiyong, Chen, Qianming, Iglesias-Bartolome, Ramiro · 2020 · Nature Communications
  9. YAP/TAZ Initiates Gastric Tumorigenesis via Upregulation of MYC
    Wonyoung Choi, Jeongsik Kim, Jaeoh Park, Da-Hye Lee, Daehee Hwang, Jeong‐Hwan Kim, Hassan Ashktorab, Duane T. Smoot, Seon‐Young Kim, Chan Choi et al. · 2018 · Cancer Research
  10. The Crosstalk Between Hippo-YAP Pathway and Innate Immunity
    Shuai Wang, Lili Zhou, Li Ling, Xuli Meng, Feng Chu, Suping Zhang, Fangfang Zhou · 2020 · Frontiers in Immunology
  11. Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice
    Han-Byul Kim, Minchul Kim, Young-Soo Park, Intae Park, Tackhoon Kim, Sung Yeun Yang, Charles J. Cho, Daehee Hwang, Jin‐Hak Jung, Sanford D. Markowitz et al. · 2016 · Gastroenterology
  12. High mobility group protein B1 controls liver cancer initiation through yes‐associated protein ‐dependent aerobic glycolysis
    Ruochan Chen, Shan Zhu, Xuegong Fan, Haichao Wang, Michael T. Lotze, Herbert J. Zeh, Timothy R. Billiar, Rui Kang, Daolin Tang · 2017 · Hepatology
  13. YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation
    He, Lizhi, Pratt, Henry, Gao, Mingshi, Wei, Fengxiang, Weng, Zhiping, Struhl, Kevin · 2021 · eLife
  14. An overview of signaling pathways regulating YAP/TAZ activity
    Boon Chin Heng, Xuehui Zhang, Dominique Aubel, Yunyang Bai, Xiaochan Li, Wei Yan, Martin Fussenegger, Xuliang Deng · 2020 · Cellular and Molecular Life Sciences
  15. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma.
    Ayumi Kaneda, Toshihiro Seike, Tomohiro Danjo, Takahiro Nakajima, Nobumasa Otsubo, Daisuke Yamaguchi, Yoshiro Tsuji, Kaori Hamaguchi, Mai Yasunaga, Yoichi Nishiya et al. · 2020 · PubMed Central
  16. Cell Junctions in Hippo Signaling
    Ruçhan Karaman, Georg A. Halder · 2017 · Cold Spring Harbor Perspectives in Biology
  17. Surface Topography Guides Morphology and Spatial Patterning of Induced Pluripotent Stem Cell Colonies
    Giulio Abagnale, Antonio S. Sechi, Michael Steger, Qihui Zhou, Chao‐Chung Kuo, Gülcan Aydın, Carmen Schalla, Gerhard Müller‐Newen, Martin Zenke, Ivan G. Costa et al. · 2017 · Stem Cell Reports
  18. HIPPO SIGNALING CONTROLS NLRP3 ACTIVATION AND GOVERNS IMMUNOREGULATION OF MESENCHYMAL STEM CELLS IN MOUSE LIVER INJURY
    Changyong Li, Yuting Jin, Song Wei, Yi-Shuang Sun, Longfeng Jiang, Qiang Zhu, D. Farmer, R. Busuttil, J. Kupiec-Weglinski, B. Ke · 2019 · Hepatology
  19. Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network
    Shuguo Sun, Kenneth D. Irvine · 2016 · Trends in Cell Biology
  20. Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition
    Francisco, Jamie, Zhang, Yu, Jeong, Jae Im, Mizushima, Wataru, Ikeda, Shohei, Ivessa, Andreas, Oka, Shinichi, Zhai, Peiyong, Tallquist, Michelle D., Del Re, Dominic P. · 2020 · JACC: Basic to Translational Science
  21. ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells
    Evi Maria Morandi, Ralph Verstappen, Marit Zwierzina, Stephan Geley, G. Pierer, Christian Ploner · 2016 · Scientific Reports
  22. Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway
    Nianshuang Li, Yan Feng, Yi Hu, Cong He, Chuan Xie, Yaobin Ouyang, Stephen C. Artim, Deqiang Huang, Yin Zhu, Zhijun Luo et al. · 2018 · Journal of Experimental & Clinical Cancer Research
  23. S1P/S1PR3 axis promotes aerobic glycolysis by YAP/c-MYC/PGAM1 axis in osteosarcoma
    Yifei Shen, Shujie Zhao, Shenyu Wang, Xiaohui Pan, Yunkun Zhang, Jingwen Xu, Yuqing Jiang, Haibo Li, Qiang Zhang, Jianbo Gao et al. · 2018 · EBioMedicine
  24. Cardiac Regeneration
    Francisco X. Galdos, Yuxuan Guo, Sharon L. Paige, Nathan J. VanDusen, Sean M. Wu, William T. Pu · 2017 · Circulation Research
  25. SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK
    Sung Jun Bae, Lisheng Ni, Adam Osinski, Diana R. Tomchick, Chad A. Brautigam, Xuelian Luo · 2017 · eLife
  26. A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease
    Jing Cai, Xuewen Song, Wei Wang, Terry J. Watnick, York Pei, Feng Qian, Duojia Pan · 2018 · Genes & Development
  27. Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth
    Ja Hyun Koo, Steven W. Plouffe, Zhipeng Meng, Da-Hye Lee, Di Yang, Dae‐Sik Lim, Cun‐Yu Wang, Kun‐Liang Guan · 2019 · Genes & Development
  28. Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis
    Zhong, Guoheng, Su, Shuwen, Li, Juncong, Zhao, Hengli, Hu, Dongtu, Chen, Jun, Li, Shichao, Lin, Yingwen, Wen, Liming, Lin, Xiangjie et al. · 2023 · Science Advances
  29. Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function
    Congshan Sun, Vanessa De Mello, Abdalla D. Mohamed, Huascar Pedro Ortuste Quiroga, Amaya García-Muñoz, Abdullah Al Bloshi, Annie Tremblay, Alex von Kriegsheim, Elaina S.R. Collie-Duguid, Neil Vargesson et al. · 2017 · Stem Cells
  30. Role of Hippo signaling in regulating immunity
    Lixin Hong, Xun Li, Dawang Zhou, Jing Geng, Lanfen Chen · 2018 · Cellular and Molecular Immunology
  31. Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development
    Xiangmin Lv, Chunbo He, Cong Huang, Hongbo Wang, Guohua Hua, Zhengfeng Wang, Jin Rong Zhou, Xingcheng Chen, Bowen Ma, Barbara K. Timm et al. · 2019 · The FASEB Journal
  32. Mitochondria at Work: New Insights into Regulation and Dysregulation of Cellular Energy Supply and Metabolism
    Volker Schirrmacher · 2020 · Biomedicines
  33. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload
    Shohei Ikeda, Wataru Mizushima, Sebastiano Sciarretta, Maha Abdellatif, Peiyong Zhai, Risa Mukai, Nadezhda Fefelova, Shinichi Oka, Michinari Nakamura, Dominic P. Del Re et al. · 2019 · Circulation Research
  34. Activation of YAP1 by N6-Methyladenosine–Modified circCPSF6 Drives Malignancy in Hepatocellular Carcinoma
    Yunhao Chen, Zhenan Ling, Xianlei Cai, Yongfang Xu, Zhen Lv, Da Man, Jiangzhen Ge, Chengkuan Yu, Deguo Zhang, Yanpeng Zhang et al. · 2021 · Cancer Research
  35. The extracellular matrix and mechanotransduction in pulmonary fibrosis
    Zhenjun Deng, Mark William Fear, Yu Suk Choi, Fiona Melanie Wood, Amira Allahham, Steven Eugene Mutsaers, Cecilia M. Prêle · 2020 · The International Journal of Biochemistry & Cell Biology
  36. Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts
    Bikram Sharma, Lena Ho, Gretchen Hazel Ford, Heidi I. Chen, Andrew Brooks Goldstone, Yi-Ping Joseph Woo, Thomas Quertermous, Bruno Reversade, Kristy Red‐Horse · 2017 · Developmental Cell
  37. Discharge may not be the end of treatment: Pay attention to pulmonary fibrosis caused by severe COVID‐19
    Chi Zhang, Zhao Wu, Jia‐Wen Li, Kangan Tan, Wanna Yang, Hong Zhao, Gui‐Qiang Wang · 2020 · Journal of Medical Virology
  38. The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology
    Marjolaine Hugonnet, Pushpita Singh, Quentin Haas, Stephan von Gunten · 2021 · Frontiers in Immunology
  39. MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells
    Emad Heidary Arash, Ahmed Shiban, Siyuan Song, Liliana Attisano · 2017 · EMBO Reports
  40. Fusobacterium nucleatum induces chemoresistance in colorectal cancer by inhibiting pyroptosis via the Hippo pathway
    Ni Wang, Lu Zhang, Xiao-Xu Leng, Yile Xie, Zi‐Ran Kang, Licong Zhao, Linhong Song, Cheng‐Bei Zhou, Jing‐Yuan Fang · 2024 · Gut Microbes
  41. The role of Hippo/yes‐associated protein signalling in vascular remodelling associated with cardiovascular disease
    Jinlong He, Qiankun Bao, Yan Meng, Jing Liang, Yi Zhu, Chunjiong Wang, Ding Ai · 2017 · British Journal of Pharmacology
  42. STRIPAK integrates upstream signals to initiate the Hippo kinase cascade
    Rui Chen, Ruiling Xie, Zhipeng Meng, Shenghong Ma, Kun‐Liang Guan · 2019 · Nature Cell Biology
  43. Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
    Andrew Graham Cox, Allison Tsomides, Dean Yimlamai, Katie L. Hwang, Joel B. Miesfeld, Giorgio Giacomo Galli, Brendan H. Fowl, Michael W. Fort, Y. Kimberly, Mark R. Sullivan et al. · 2018 · The EMBO Journal
  44. The Emerging Roles of Exosomes as EMT Regulators in Cancer
    Hyunwoo Kim, Sung-Min Lee, Eunguk Shin, K. Seong, Y. Jin, Hyesook Youn, B. Youn · 2020 · Cells
  45. Drugs Targeting p53 Mutations with FDA Approval and in Clinical Trials
    Nishikawa, Shigeto, Iwakuma, Tomoo · 2023 · Cancers
  46. YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer
    Masafumi Horie, Akira Saito, Mitsuhiro Ohshima, Hiroshi I. Suzuki, Takahide Nagase · 2016 · Cancer Science
  47. The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number
    Alfonso Lavado, Jun Young Park, Joshua Paré, David Finkelstein, Haitao Pan, Beisi Xu, Yiping Fan, Ram Parikshan Kumar, Geoffrey A. M. Neale, Young Don Kwak et al. · 2018 · Developmental Cell
  48. Pathomechanisms in schwannoma development and progression
    Dario Lucas Helbing, Alexander Schulz, Helen Morrison · 2020 · Oncogene
  49. New Insights into Hippo/YAP Signaling in Fibrotic Diseases
    Masum M. Mia, Manvendra Kumar Singh · 2022 · Cells
  50. YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma
    Hirofumi Omori, Miki Nishio, Muneyuki Masuda, Yosuke Miyachi, Fumihito Ueda, Takafumi Nakano, Kuniaki Sato, Koshi Mimori, Kenichi Taguchi, Hiroki Hikasa et al. · 2020 · Science Advances
  51. WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
    Sixian Qi, Yuwen Zhu, Xincheng Liu, Pengyue Li, Yebin Wang, Yan Jun Zeng, Aijuan Yu, Yu Wang, Zhao Sha, Zhenxing Zhong et al. · 2022 · Molecular Cell
  52. Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded
    Ting Su, Michael Z. Ludwig, Jiajie Xu, Richard G. Fehon · 2017 · Developmental Cell
  53. MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer
    Chunlin Ou, Zhenqiang Sun, Xiayu Li, Xiaoling Li, Weiguo Ren, Zailong Qin, Xuemei Zhang, Weitang Yuan, Jia Wang, Wentao Yu et al. · 2017 · Cancer Letters
  54. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration
    Xu Feng, Peng Liu, Xin Zhou, Meng-Tian Li, Fu-Long Li, Zhen Wang, Zhipeng Meng, Yi-Ping Sun, Ying Yu, Yue Xiong et al. · 2016 · Journal of Biological Chemistry
  55. Snail/Slug-YAP/TAZ complexes cooperatively regulate mesenchymal stem cell function and bone formation
    Yi Tang, Stephen J. Weiss · 2017 · Cell Cycle
  56. Pulmonary pericytes regulate lung morphogenesis
    Katsuhiro Kato, Rodrigo Diéguez‐Hurtado, Do Young Park, Seon Pyo Hong, Sakiko Kato-Azuma, Susanne Adams, Martin Stehling, Britta Trappmann, Jeffrey L. Wrana, Gou Young Koh et al. · 2018 · Nature Communications
  57. Role of the Hippo Pathway in Fibrosis and Cancer
    Cho-Long Kim, Sue-Hee Choi, Jung‐Soon Mo · 2019 · Cells
  58. The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications
    Xiaoyan Wang, Liming Chen, Jianming Wei, Hao Zheng, Ning Zhou, Xinjie Xu, Xin Deng, Tao Liu, Yunzeng Zou · 2025 · Signal Transduction and Targeted Therapy
  59. GNAQ and GNA11 mutations and downstream YAP activation in choroidal nevi
    Madeleine Vader, Michele C. Madigan, Marco Versluis, H M Suleiman, Gülçin Gezgin, Nelleke A. Gruis, Jacoba J. Out‐Luiting, W. Bergman, Robert M. Verdijk, Martine Johanna Jager et al. · 2017 · British Journal of Cancer
  60. FAK- and YAP/TAZ dependent mechanotransduction pathways are required for enhanced immunomodulatory properties of adipose-derived mesenchymal stem cells induced by aligned fibrous scaffolds
    Shuangyan Wan, Xiaoling Fu, Yi Ji, Man Li, Xuetao Shi, Yingjun Wang · 2018 · Biomaterials
  61. A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis
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  62. Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis
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  64. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity
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  65. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling
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  66. Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex
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  67. Multiphase coalescence mediates Hippo pathway activation
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  68. Heat stress activates YAP/TAZ to induce the heat shock transcriptome
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  69. Hippo pathway: Regulation, deregulation and potential therapeutic targets in cancer
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  70. YAP‐TEAD mediates PPAR α–induced hepatomegaly and liver regeneration in mice
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  71. Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity
    Thomas Mindos, Xin‐Peng Dun, Katherine North, Robin D. S. Doddrell, Alexander Schulz, Philip Edwards, James Russell, Bethany Gray, Sheridan L. Roberts, Aditya G. Shivane et al. · 2017 · The Journal of Cell Biology
  72. The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils
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  73. Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression
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  74. Astrocytic YAP Promotes the Formation of Glia Scars and Neural Regeneration after Spinal Cord Injury
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  75. The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis
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  76. Oxidative stress–CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway
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  77. CCNA2 acts as a novel biomarker in regulating the growth and apoptosis of colorectal cancer
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  78. FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis
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  79. Lactate and lactylation in cardiovascular diseases: current progress and future perspectives
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  80. The Roles of NDR Protein Kinases in Hippo Signalling
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  81. A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells
    Gernot Walko, Samuel Woodhouse, Angela Oliveira Pisco, Emanuel Rognoni, Kifayathullah Liakath‐Ali, Beate M. Lichtenberger, Ajay Mishra, Stéphanie B. Telerman, Priyalakshmi Viswanathan, Meike E. W. Logtenberg et al. · 2017 · Nature Communications
  82. lncRNA THAP9-AS1 Promotes Pancreatic Ductal Adenocarcinoma Growth and Leads to a Poor Clinical Outcome via Sponging miR-484 and Interacting with YAP
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  83. GPCR-Hippo Signaling in Cancer
    Jiaqian Luo, Fa‐Xing Yu · 2019 · Cells
  84. The Hippo Signaling Pathway in Pancreatic Cancer
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  85. O-GlcNAcylation and O-GlcNAc Cycling Regulate Gene Transcription: Emerging Roles in Cancer
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  86. YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling
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  87. YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis
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  88. Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention
    Toyokuni, Shinya · 2019 · Free Radical Biology and Medicine
  89. STRIPAK complexes in cell signaling and cancer
    Shi, Z, Jiao, S, Zhou, Z · 2016 · Oncogene
  90. Mediated nuclear import and export of TAZ and the underlying molecular requirements
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  91. Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction
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  92. Exosomes derived from hucMSC attenuate renal fibrosis through CK1δ/β-TRCP-mediated YAP degradation
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  93. A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
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  94. Alternative splicing in cancers: From aberrant regulation to new therapeutics
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  95. Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies
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  96. YAP/TAZ initiate and maintain Schwann cell myelination
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  97. miR-29c-3p regulates DNMT3B and LATS1 methylation to inhibit tumor progression in hepatocellular carcinoma
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  98. Microenvironmental sensing by fibroblasts controls macrophage population size
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  99. Retracted: Long non‐coding RNA XIST promotes osteosarcoma progression by targeting YAP via miR‐195‐5p
    Chao Yang, Ke Wu, Shan Wang, Guanghui Wei · 2018 · Journal of Cellular Biochemistry · Retracted
  100. YAP1 contributes to NSCLC invasion and migration by promoting Slug transcription via the transcription co-factor TEAD
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