Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

QIIME allows analysis of high-throughput community sequencing data

Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887

KEGG: Kyoto Encyclopedia of Genes and Genomes

Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173

Human Genetics Shape the Gut Microbiome

Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164

Data, information, knowledge and principle: back to metabolism in KEGG

Kanehisa, M. I., Goto, S., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1076 · Cited by 3,103

Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling

Luca, R. D., Arrè, V., Nardone, S., Incerpi, S., Giannelli, G., Trivedi, P., Anastasiadou, E., & Negro, R. (2025) · Gut · doi:10.1136/gutjnl-2025-334938 · Cited by 33

Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products

Castillo, P., Wanek, A. G., Kumar, P., An, X., Elsegeiny, W. A. W., Horne, W. T., Fitch, A. C., Burr, A. B. P., Gopalakrishna, K. P., Chen, K., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.042 · Cited by 27

Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18

Iyer, N. R., Grizotte-Lake, M., Duncan, K., Gordon, S., Palmer, A. C. S., Calvin, C., Zhong, G. G., Isoherranen, N., & Vaishnava, S. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008360 · Cited by 28

Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites

Mercer, K. E., Yeruva, L., Pack, L., Graham, J. L., Stanhope, K. L., Chintapalli, S. V., Wankhade, U. D., Shankar, K., Havel, P. J., Adams, S. H., et al. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00105.2020 · Cited by 27

Key Technologies for Progressing Discovery of Microbiome-Based Medicines

Young, R. B., Marcelino, V. R., Chonwerawong, M., Gulliver, E. L., & Forster, S. C. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.685935 · Cited by 30

The Milk Active Ingredient, 2′-Fucosyllactose, Inhibits Inflammation and Promotes MUC2 Secretion in LS174T Goblet Cells In Vitro

Yao, Q., Li, H., Gao, Y., Zheng, N., Delcenserie, V., & Wang, J. (2023) · Foods · doi:10.3390/foods12010186 · Cited by 26

Gut microbiota and their derivatives in the progression of colorectal cancer: Mechanisms of action, genome and epigenome contributions

Ahmad, A., Mahmood, N., Raza, M. A., Mushtaq, Z., Saeed, F., Afzaal, M., Hussain, M., Amjad, H., & Al-Awadi, H. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29495 · Cited by 32

The role of pyroptosis in cancer: key components and therapeutic potential

Liu, Z., Xu, S., Chen, L., Gong, J., & Wang, M. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01932-z · Cited by 32

Effects of psychological stress on inflammatory bowel disease via affecting the microbiota–gut–brain axis

Chen, Y., Chen, X., Lin, S., Huang, S., Li, L., Hong, M., Li­, ­., Ma, L., & Ma, J. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003389 · Cited by 30

The key players of inflammasomes and pyroptosis in sepsis-induced pathogenesis and organ dysfunction

Zhu, L., Hu, M., Xu, H., Xu, H., Ren, B., Xu, R., Guo, M., Chen, H., Zhang, D., & Fang, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1586364 · Cited by 31

Mulberroside A repairs high fructose diet‐induced damage of intestinal epithelial and blood–brain barriers in mice: A potential for preventing hippocampal neuroinflammatory injury

Yu, R., Wen, S., Wang, Q., Wang, C., Zhang, L., Wu, X., Li, J., & Kong, L. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15242 · Cited by 27

NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease

Mainz, R. E., Albers, S., Haque, M., Sonntag, R., Treichel, N. S., Clavel, T., Latz, E., Schneider, K. M., Trautwein, C., & Otto, T. (2022) · Cells · doi:10.3390/cells11020182 · Cited by 26

Small molecule modulators of immune pattern recognition receptors

Tsukidate, T., Hespen, C. W., & Hang, H. C. (2023) · RSC Chemical Biology · doi:10.1039/d3cb00096f · Cited by 26

Nod-Like Receptor Pyrin-Containing Protein 6 (NLRP6) Is Up-regulated in Ileal Crohn’s Disease and Differentially Expressed in Goblet Cells

Ranson, N., Veldhuis, M., Mitchell, B., Fanning, S. B., Cook, A. L., Kunde, D., & Eri, R. D. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.03.001 · Cited by 26

NLRP6 deficiency aggravates liver injury after allogeneic hematopoietic stem cell transplantation

Li, M., Chen, Y., Shi, J.-R., Ju, W., Qi, K., Fu, C., Li, Z., Zhang, X., Qiao, J., Xu, K., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105740 · Cited by 26

Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis

Spalinger, M. R., Schwarzfischer, M., Hering, L., Shawki, A., Sayoc, A., Santos, A. N., Gottier, C., Lang, S., Bäbler, K., Geirnaert, A., et al. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0201-1 · Cited by 25

Microbiota-Associated Therapy for Non-Alcoholic Steatohepatitis-Induced Liver Cancer: A Review

Chen, Y., Wu, W., & Wu, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175999 · Cited by 29

Effects of β-Glucans Ingestion on Alveolar Bone Loss, Intestinal Morphology, Systemic Inflammatory Profile, and Pancreatic β-Cell Function in Rats with Periodontitis and Diabetes

Silva, V. D. O., Lobato, R. V., Andrade, E. F., Orlando, D. R., Borges, B. D. B., Zangerônimo, M. G., de Sousa, R., & Pereira, L. J. (2017) · Nutrients · doi:10.3390/nu9091016 · Cited by 25

The clinical implications of the microbiome in the development of allergy diseases

Koidl, L., & Untersmayr, E. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1874353 · Cited by 25

Comparative Efficacy of Two Types of Antibiotic Mixtures in Gut Flora Depletion in Female C57BL/6 Mice

Goulding, D. R., Myers, P., Dickerson, A. B., Comins, M. M., Wiltshire, R. A., & Blankenship-Paris, T. L. (2021) · Comparative Medicine · doi:10.30802/aalas-cm-21-000023 · Cited by 24

Impact of gut microbiota on immune system

Riazi‐Rad, F., Behrouzi, A., Mazaheri, H., Katebi, A., & Ajdary, S. (2021) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/030.2021.01532 · Cited by 26

GWAS-associated bacteria and their metabolites appear to be causally related to the development of inflammatory bowel disease

Zhuang, Z., Li, N., Wang, J., Yang, R., Wang, W., Liu, Z., & Huang, T. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-022-01074-w · Cited by 26

Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential

Liu, J., Fan, G., Tao, N., & Sun, T. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s352563 · Cited by 26

Lacticaseibacillus rhamnosus GG Counteracts Rotavirus-Induced Ion Secretion and Enterocyte Damage by Inhibiting Oxidative Stress and Apoptosis Through Specific Effects of Living and Postbiotic Preparations

Buccigrossi, V., Poeta, M., Cioffi, V., Terranova, S., Nunziata, F., Vecchio, A. L., & Guarino, A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.854989 · Cited by 27

Autonomous immunity in mucosal epithelial cells: fortifying the barrier against infection

Ross, K. F., & Herzberg, M. C. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.03.008 · Cited by 26

Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF)

Ciaula, A. D., Stella, A., Bonfrate, L., Wang, D. Q. ‐., & Portincasa, P. (2020) · Genes · doi:10.3390/genes11091041 · Cited by 25

NLRP6 and Dysbiosis: Avoiding the Luring Attraction of Over-Simplification

Elinav, E., Henao-Mejia, J., Strowig, T., & Flavell, R. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.002 · Cited by 24

Interaction and Metabolic Pathways: Elucidating the Role of Gut Microbiota in Gestational Diabetes Mellitus Pathogenesis

Mao, L., Gao, B., Chang, H., & Shen, H. (2024) · Metabolites · doi:10.3390/metabo14010043 · Cited by 27

What we need to know about the germ-free animal models

Aghighi, F., & Salami, M. (2024) · AIMS Microbiology · doi:10.3934/microbiol.2024007 · Cited by 29

Applications of pyroptosis activators in tumor immunotherapy

Bao, X., Sun, M., Meng, L., Zhang, H., Yi, X., & Zhang, P. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101191 · Cited by 24

Gardnerella vaginalis induces matrix metalloproteinases in the cervicovaginal epithelium through TLR-2 activation

Gerson, K. D., Anton, L., Ferguson, B., Ravel, J., Burris, H. H., & Elovitz, M. A. (2022) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2022.103648 · Cited by 25

Alterations of the Gut Microbiota and Metabolomics Associated with the Different Growth Performances of Macrobrachium rosenbergii Families

Lan, X., Peng, X. X., Du, T., Xia, Z., Gao, Q., Tang, Q., Yi, S., & Yang, G. (2023) · Animals · doi:10.3390/ani13091539 · Cited by 25

NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice

Tran, L. S., Ying, L., D’Costa, K., Wray‐McCann, G., Kerr, G., Le, L., Allison, C. C., Ferrand, J., Chaudhry, H., Emery, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39487-1 · Cited by 24

Deciphering the intricate linkage between the gut microbiota and Alzheimer's disease: Elucidating mechanistic pathways promising therapeutic strategies

Liang, J., Wang, Y., Liu, B., Dong, X., Cai, W., Zhang, N., & Zhang, H. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14704 · Cited by 27

Microbial contributions to chronic inflammation and metabolic disease

Shanahan, F., & Sheehan, D. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000282 · Cited by 24

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production

Bao, B., Wang, Y., Boudreau, P., Song, X., Wu, M., Chen, X., Patik, I., Tang, Y., Ouahed, J., Ringel, A., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.04.007 · Cited by 24

Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID

Yao, L., Devotta, H., Li, J., Lunjani, N., Sadlier, C., Lavelle, A., Albrich, W. C., Walter, J., O’Toole, P. W., & O’Mahony, L. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2429754 · Cited by 24

Molecular Mechanisms of Sepsis-Associated Acute Kidney Injury

Hato, T., & Dagher, P. C. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000809 · Cited by 24

Basic Definitions and Concepts: Organization of the Gut Microbiome

Quigley, E. M. M. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.002 · Cited by 23

The Influence of Bifidobacterium bifidum and Bacteroides fragilis on Enteric Glial Cell–Derived Neurotrophic Factors and Inflammasome

Yang, P., Li, X., Yang, Y., Qian, W., Li, S., Yan, C., Wang, J., Wang, Q. L., Hou, X.-H., & Dai, C. (2020) · Inflammation · doi:10.1007/s10753-020-01284-z · Cited by 23

Metagenomic Information Recovery from Human Stool Samples Is Influenced by Sequencing Depth and Profiling Method

Santiago-Rodríguez, T. M., Garoutte, A., Adams, E., Nasser, W., Ross, M. C., Reau, A. L., Henseler, Z. M., Ward, T., Knights, D., Petrosino, J. F., et al. (2020) · Genes · doi:10.3390/genes11111380 · Cited by 24

Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease

Xu, Q., Zhou, X., Strober, W., & Mao, L. (2021) · Molecules · doi:10.3390/molecules26061725 · Cited by 25

Role of microbiota and related metabolites in gastrointestinal tract barrier function in NAFLD

Fernández-Cantos, M. V., García-Morena, D., Iannone, V., El-Nezami, H. S., Kolehmainen, M., & Kuipers, O. P. (2021) · Tissue Barriers · doi:10.1080/21688370.2021.1879719 · Cited by 23

Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues

Liang, J., Liu, B., Dong, X., Wang, Y., Cai, W., Zhang, N., & Zhang, H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1242254 · Cited by 26

Intestinal Epithelial Cell–Derived LKB1 Suppresses Colitogenic Microbiota

Liu, X., Lü, J., Liu, Z., Zhao, J., Sun, H., Wu, N., Liu, H., Liu, W., Hu, Z., Meng, G., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700547 · Cited by 22

Integrating Pharmacology and Microbial Network Analysis with Experimental Validation to Reveal the Mechanism of Composite Sophora Colon‐Soluble Capsule against Ulcerative Colitis

Ding, Y., Chen, M., Wang, Q., Gao, L., Yang, F., Wang, S.-D., Song, Z., & Tong, Z. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/9521073 · Cited by 22

Interaction between gut microbiota and immunity in health and intestinal disease

Wang, Q., Meng, Q., Chen, Y., Liu, Y., Li, X., Zhou, J., Ma, Y., Yu, Z., & Chen, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1673852 · Cited by 34

Clostridium difficile, Aging, and the Gut: Can Microbiome Rejuvenation Keep Us Young and Healthy?

Fischer, N., & Relman, D. A. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix417 · Cited by 23

Milk Fat Globule Membrane Enhances Colonic–Mucus‐Barrier Function in a Rat Model of Short‐Bowel Syndrome

Yu, Z., Li, Y., Niu, Y., Tang, Q., & Wu, J. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1956 · Cited by 22

Antimicrobial therapy during cancer treatment: Beyond antibacterial effects

Ghanem, S., Kim, C. J., Dutta, D., Salifu, M. O., & Lim, S. H. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13238 · Cited by 23

Microbiome-Mediated Immune Signaling in Inflammatory Bowel Disease and Colorectal Cancer: Support From Meta-omics Data

Pratt, M., Forbes, J. D., Knox, N., Bernstein, C. N., & Domselaar, G. V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716604 · Cited by 23

The Host CYP1A1-Microbiota Metabolic Axis Promotes Gut Barrier Disruption in Methicillin-Resistant Staphylococcus aureus-Induced Abdominal Sepsis

Ma, X., Jin, H., Chu, X., Dai, W., Tang, W., Zhu, J., Wang, F., Yang, X., Li, W., Liu, G., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.802409 · Cited by 22

The emerging role of the gut mycobiome in liver diseases

Szóstak, N., Figlerowicz, M., & Philips, A. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2211922 · Cited by 22

When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD

van der Gracht, E. T. I., Zahner, S. P., & Kronenberg, M. (2016) · Mediators of Inflammation · doi:10.1155/2016/9765238 · Cited by 22

Taurine does not affect the composition, diversity, or metabolism of human colonic microbiota simulated in a single-batch fermentation system

Sasaki, K., Sasaki, D., Okai, N., Tanaka, K., Nomoto, R., Fukuda, I., Yoshida, K., Kondo, A., & Osawa, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180991 · Cited by 22

Act Locally, Act Globally—Microbiota, Barriers, and Cytokines in Atherosclerosis

Kurilenko, N., Fatkhullina, A. R., Mazitova, A., & Koltsova, E. K. (2021) · Cells · doi:10.3390/cells10020348 · Cited by 22

The effect of exercise on depression and gut microbiota: Possible mechanisms

Yao, M., Qu, Y., Zheng, Y., & Guo, H. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111130 · Cited by 26

Microbiota in Health and Disease—Potential Clinical Applications

Laudes, M., Geisler, C., Rohmann, N., Bouwman, J., Pischon, T., & Schlicht, K. (2021) · Nutrients · doi:10.3390/nu13113866 · Cited by 22

Insights into inflammasome regulation: cellular, molecular, and pathogenic control of inflammasome activation

Challagundla, N., Saha, B., & Agrawal-Rajput, R. (2022) · Immunologic Research · doi:10.1007/s12026-022-09286-9 · Cited by 22

The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease

Li, S., Xu, K., Cheng, Y., Chen, L., Yi, A., Xiao, Z., Zhao, X., Chen, M., Tian, Y., Wei, M., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1188455 · Cited by 24

Biomolecular Actions by Intestinal Endotoxemia in Metabolic Syndrome

Charitos, I. A., Aliani, M., Tondo, P., Venneri, M. G., Castellana, G., Scioscia, G., Castellaneta, F., Lacedonia, D., & Carone, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052841 · Cited by 26

Talking about cross-talk: the immune system and the microbiome

Zeevi, D., Korem, T., & Segal, E. (2016) · Genome biology · doi:10.1186/s13059-016-0921-4 · Cited by 21

Pyrin-only protein 2 limits inflammation but improves protection against bacteria

Periasamy, S., Porter, K. A., Atianand, M., Le, H. T., Earley, S., Duffy, E. B., Haller, M. C., Chin, H., & Harton, J. A. (2017) · Nature Communications · doi:10.1038/ncomms15564 · Cited by 21

Natterin an aerolysin-like fish toxin drives IL-1β-dependent neutrophilic inflammation mediated by caspase-1 and caspase-11 activated by the inflammasome sensor NLRP6

Lima, C., Falcão, M. A. P., Andrade‐Barros, A. I., Seni-Silva, A. C., Grund, L. Z., Balogh, E., Conceição, K., Queniaux, V. F., Ryffel, B., & Lopes‐Ferreira, M. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107287 · Cited by 21

The impact of novel probiotics isolated from the human gut on the gut microbiota and health

Caesar, R. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16129 · Cited by 22

Organoids as Next-Generation Models for Tumor Heterogeneity, Personalized Therapy, and Cancer Research: Advancements, Applications, and Future Directions

Madan, A., Saini, R., Dhiman, N., Juan, S., & Satapathy, M. K. (2025) · Organoids · doi:10.3390/organoids4040023 · Cited by 24

A Modern-World View of Host–Microbiota–Pathogen Interactions

Tan, C. Y., Ramirez, Z. E., & Surana, N. K. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100215 · Cited by 24

Genetic and environmental factors shape the host response to Helicobacter hepaticus: insights into IBD pathogenesis

Jeffery, R., Ilott, N. E., & Powrie, F. M. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.10.012 · Cited by 20

Multiomic Analysis of the Gut Microbiome in Psoriasis Reveals Distinct Host‒Microbe Associations

Chang, H.-W., Yan, D., Singh, R., Bui, A., Lee, K., Truong, A., Milush, J. M., Somsouk, M., & Liao, W. J. (2022) · JID Innovations · doi:10.1016/j.xjidi.2022.100115 · Cited by 20

How Gut Microbiota Are Shaped by Pattern Recognition Receptors in Colitis and Colorectal Cancer

Qing, F., Xie, T., Xie, L., Guo, T., & Liu, Z. (2022) · Cancers · doi:10.3390/cancers14153821 · Cited by 21

Dietary Polyphenols Alleviate Autoimmune Liver Disease by Mediating the Intestinal Microenvironment: Challenges and Hopes

Cheng, Z., Wang, Y., & Li, B. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c02654 · Cited by 20

Maternal Influence and Murine Housing Confound Impact of NLRP1 Inflammasome on Microbiome Composition

Ringel-Scaia, V. M., Qin, Y., Thomas, C. A., Huie, K. E., McDaniel, D. K., Eden, K. B., Wade, P. A., & Allen, I. C. (2019) · Journal of Innate Immunity · doi:10.1159/000495850 · Cited by 21

Host-microbe interactions and outcomes in multiple myeloma and hematopoietic stem cell transplantation

Pianko, M. J., & Golob, J. L. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10033-7 · Cited by 20

Mendelian randomization study for the roles of IL-18 and IL-1 receptor antagonist in the development of inflammatory bowel disease

Mi, J., Liu, Z., Pei, S., Wu, X., Zhao, N., Jiang, L., Zhang, Z., & Bai, X. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109020 · Cited by 18

The latest breakthrough on NLRP6 inflammasome

Li, R., Zan, Y., Sui, K., & Zhu, S. (2022) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbac022 · Cited by 19

Roles and Mechanisms of NLRP3 in Influenza Viral Infection

Niu, J., & Meng, G. (2023) · Viruses · doi:10.3390/v15061339 · Cited by 21

Regulatory functions and mechanisms of human microbiota in infectious diseases

Fang, Y., Lei, Z., Zhang, L., Liu, C. H., & Chai, Q. (2024) · hLife · doi:10.1016/j.hlife.2024.03.004 · Cited by 20

Gut Microbiomics—A Solution to Unloose the Gordian Knot of Biological Effects of Ionizing Radiation

Zhang, A., & Steen, T. Y. (2017) · Journal of Heredity · doi:10.1093/jhered/esx059 · Cited by 17

Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions

Varanasi, S. K., Rajasagi, N. K., Jaggi, U., & Rouse, B. T. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0058-8 · Cited by 19

Prognostic Role of Inflammasome Components in Human Colorectal Cancer

Domblides, C., Soubeyran, I., Lartigue, L., Mahouche, I., Lefort, F., Velasco, V., Barnetche, T., Blanco, P., Déchanet‐Merville, J., & Faustin, B. (2020) · Cancers · doi:10.3390/cancers12123500 · Cited by 19

Intragastric Administration of Casein Leads to Nigrostriatal Disease Progressed Accompanied with Persistent Nigrostriatal—Intestinal Inflammation Activited and Intestinal Microbiota—Metabolic Disorders Induced in MPTP Mouse Model of Parkinson’s Disease

Liu, X., Liu, S., Tang, Y., Pu, Z., Xiao, H., Gao, J., Yin, Q., Jia, Y., & Bai, Q. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03293-2 · Cited by 18

Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in Mice and Non-Human Primates Is Diminished upon Recovery of the Gut Microbiome

Swaminathan, G., Citron, M. P., Xiao, J., Norton, J. E., Reens, A. L., Topçuoğlu, B. D., Maritz, J. M., Lee, K.-J., Freed, D. C., Weber, T. M., et al. (2021) · Vaccines · doi:10.3390/vaccines9111340 · Cited by 19

The role of gut microbiota in infectious diseases

Cai, Y., Chen, L., Zhang, S., Zeng, L., & Zeng, G. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1551 · Cited by 18

Fecal microbiota and inflammatory and antioxidant status of obese and lean dogs, and the effect of caloric restriction

Vecchiato, C. G., Golinelli, S., Pinna, C., Pilla, R., Suchodolski, J. S., Tvarijonaviciute, A., Rubio, C. P., Dorato, E., Delsante, C., Stefanelli, C., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1050474 · Cited by 18

Interleukin‐1 family cytokines at the crossroads of microbiome regulation in barrier health and disease

Narros‐Fernández, P., Basavarajappa, S. C., & Walsh, P. T. (2023) · FEBS Journal · doi:10.1111/febs.16888 · Cited by 19

Uncovering the Carboxylated Metabolome in Gut Microbiota–Host Co-metabolism: A Chemical Derivatization-Molecular Networking Approach

Wang, Y., Chen, Y.-Y., Wu, X., Bai, P.-R., An, N., Liu, X.-L., Zhu, Q., & Feng, Y. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02353 · Cited by 17

Interleukin-18: The Bouncer at the Mucosal Bar

Hand, T. W. (2015) · Cell · doi:10.1016/j.cell.2015.11.041 · Cited by 19

Emerging Concepts in Innate Immunity

Pelka, K., & Nardo, D. D. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7519-8_1 · Cited by 19

Interkingdom Communication and Regulation of Mucosal Immunity by the Microbiome

Ethridge, A. D., Bazzi, M., Lukacs, N. W., & Huffnagle, G. B. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa748 · Cited by 20

The role of the intestinal microbiota in allogeneic HCT: clinical associations and preclinical mechanisms

Nguyen, C. L., Docampo, M. D., van den Brink, M. R. M., & Markey, K. A. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.11.007 · Cited by 17

Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid

Gregor, A., Pignitter, M., Trajanoski, S., Auernigg‐Haselmaier, S., Somoza, V., König, J. S., & Duszka, K. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1992236 · Cited by 19

Milk Fat Globules: 2024 Updates

Bagga, N., Mantry, H., Maheshwari, A., Rahman, M. M., Frydrysiak-Brzozowska, A., & Badarch, J. (2024) · Newborn · doi:10.5005/jp-journals-11002-0085 · Cited by 19

Mucin alleviates colonic barrier dysfunction by promoting spermine accumulation through enhanced arginine metabolism in Limosilactobacillus mucosae

Zhou, X., Xu, Q., Zhang, X., Wang, H., Bai, Y., Wu, Y., Liu, X., Wang, Z., Hu, J., Huang, M., et al. (2024) · mSystems · doi:10.1128/msystems.00246-24 · Cited by 19

NLRP6-associated host microbiota composition impacts in the intestinal barrier to systemic dissemination of Brucella abortus

Rungue, M., Melo, V., Martins, D., Campos, P. C., Leles, G., Galvão, I., de Almeida, V. M., Aganetti, M. A., Pedersen, A. S. B., Assis, N. R. G., et al. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009171 · Cited by 17

Metabolic regulators of enigmatic inflammasomes in autoimmune diseases and crosstalk with innate immune receptors

Jimenez‐Duran, G., & Triantafilou, M. (2021) · Immunology · doi:10.1111/imm.13326 · Cited by 17

Targeting Pyroptotic Cell Death Pathways in Retinal Disease

Zhao, M., Li, S., & Matsubara, J. A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.802063 · Cited by 17

Neuroimmune regulation in Hirschsprung’s disease associated enterocolitis

Ji, H., Lai, D., & Tou, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127375 · Cited by 17

Faecalibacterium prausnitzii promotes intestinal epithelial IL-18 production through activation of the HIF1α pathway

Fagundes, R. R., Bravo‐Ruiseco, G., Hu, S., Kierans, S. J., Weersma, R. K., Taylor, C. T., Dijkstra, G. D. H., Harmsen, H. J. M., & Faber, K. N. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1298304 · Cited by 19

Activation of the Innate Immune Receptors: Guardians of the Micro Galaxy

Nardo, D. D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5987-2_1 · Cited by 16

Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain bacteria, potentially causing sticky stool

Guo, Y., He, J., Li, S., Zou, S., Zhang, H., Yang, X., & Wang, J. (2025) · BMC Microbiology · doi:10.1186/s12866-024-03730-6 · Cited by 16

Maintaining the mucosal barrier in intestinal inflammation

Ray, K. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.217 · Cited by 4

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024

Microbiota-mediated fine-tuning of the threshold of intestinal inflammasome activation in host-microbial mutualism

Ronchi, F., Rupp, S., Steinert, A., Wyss, M., McCoy, K., & Macpherson, A. J. (2014) · Bern Open Repository and Information System (University of Bern)

Inflammasome shapes the microbiota

Papatriantafyllou, M. (2011) · Nature reviews. Immunology · doi:10.1038/nri3012 · Cited by 8

Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition.

Mamantopoulos, M., Ronchi, F., Hauwermeiren, F. V., Vieira‐Silva, S., Yilmaz, B., Martens, L., Saeys, Y., Drexler, S. K., Yazdi, A., Raes, J., et al. (2017) · Open Access CRIS of the University of Bern · doi:10.7892/boris.110305