Cited by 964Gut microbiota and healthInflammasome and immune disordersImmune Response and Inflammation

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Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

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Levy, Maayan, Thaiss, Christoph A., Zeevi, David, Dohnalová, Lenka, Zilberman-Schapira, Gili, Mahdi, Jemal Ali, David, Eyal, Savidor, Alon, Korem, Tal, Herzig, Yonatan, Pevsner-Fischer, Meirav, Shapiro, Hagit, Christ, Anette, Harmelin, Alon, Halpern, Zamir, Latz, Eicke, Flavell, Richard A., Amit, Ido, Segal, Eran, Elinav, Eran·2015·Cell

DOI 10.1016/j.cell.2015.10.048PMC PMC5665753

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Abstract

Host-microbiome co-evolution drives homeostasis and disease susceptibility, yet regulatory principles governing the integrated intestinal host-commensal microenvironment remain obscure. While inflammasome signaling participates in these interactions, its activators and microbiome-modulating mechanisms are unknown. Here, we demonstrate that the microbiota-associated metabolites taurine, histamine, and spermine shape the host-microbiome interface by co-modulating NLRP6 inflammasome signaling, epithelial IL-18 secretion, and downstream anti-microbial peptide (AMP) profiles. Distortion of this balanced AMP landscape by inflammasome deficiency drives dysbiosis development. Upon fecal transfer, colitis-inducing microbiota hijacks this microenvironment-orchestrating machinery through metabolite-mediated inflammasome suppression, leading to distorted AMP balance favoring its preferential colonization. Restoration of the metabolite-inflammasome-AMP axis reinstates a normal microbiota and ameliorates colitis. Together, we identify microbial modulators of the NLRP6 inflammasome and highlight mechanisms by which microbiome-host interactions cooperatively drive microbial community stability through metabolite-mediated innate immune modulation. Therefore, targeted "postbiotic" metabolomic intervention may restore a normal microenvironment as treatment or prevention of dysbiosis-driven diseases.

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QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164
Data, information, knowledge and principle: back to metabolism in KEGG
Kanehisa, M. I., Goto, S., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1076 · Cited by 3,103

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Liu, Z., Liu, M., Meng, J., Wang, L., & Chen, M. (2023) · Journal of Future Foods · doi:10.1016/j.jfutfo.2023.07.004 · Cited by 45
Microbiome-Metabolome Responses to a High-Grain Diet Associated with the Hind-Gut Health of Goats
Tao, S., Tian, P., Luo, Y., Tian, J., Hua, C., Geng, Y., Cong, R., Ni, Y., & Zhao, R. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01764 · Cited by 46
Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification
Shen, J., Chen, B., Zhai, X., Qiao, W., Wu, S., Liu, X., Zhao, Y., Ruan, C., Pan, H., Chu, P. K.-H., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.08.025 · Cited by 45
Focus on the Mechanisms and Functions of Pyroptosis, Inflammasomes, and Inflammatory Caspases in Infectious Diseases
Song, H., Yang, B., Li, Y., Qian, A., Kang, Y., & Shan, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2501279 · Cited by 51
Group III phospholipase A2 promotes colitis and colorectal cancer
Murase, R., Taketomi, Y., Miki, Y., Nishito, Y., Saito, M., Fukami, K., Yamamoto, K., & Murakami, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-12434-z · Cited by 44
The role of the gut microbiota in the pathology and prevention of liver disease
Altamirano-Barrera, A., Uribe, M., Chávez-Tapia, N. C., & Nuño‐Lámbarri, N. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.03.006 · Cited by 48
Microbe-metabolite-host axis, two-way action in the pathogenesis and treatment of human autoimmunity
Meng, X. L., Zhou, H., Shen, H., Lufumpa, E., Li, X., Guo, B., & Li, B. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.03.006 · Cited by 46
Anti-inflammatory effects of purple sweet potato anthocyanin extract in DSS-induced colitis: modulation of commensal bacteria and attenuated bacterial intestinal infection
Mu, J., Xu, J., Wang, L., Chen, C., & Chen, P. (2021) · Food & Function · doi:10.1039/d1fo02454j · Cited by 45
Gut microbiota-derived metabolites in inflammatory diseases based on targeted metabolomics
Xu, H., Pan, L., Yu, H., Han, P., Fu, J., Zhang, Z., Hu, J.-C., Yang, X., Keranmu, A., Zhang, H.-J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.919181 · Cited by 45
Surfactin Mitigates Dextran Sodium Sulfate-Induced Colitis and Behavioral Disorders in Mice by Mediating Gut–Brain-Axis Balance
Chen, X., Zhao, H., Lu, Y., Meng, F., Lu, Z., & Lu, Y. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c07369 · Cited by 44
Biology of the Microbiome 1
Smolińska, S., Groeger, D., & O’Mahony, L. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.004 · Cited by 45
Functional Classification of the Gut Microbiota: The Key to Cracking the Microbiota Composition Code
Rosen, C. E., & Palm, N. W. (2017) · BioEssays · doi:10.1002/bies.201700032 · Cited by 45
Association Between Gut Microbial Abundance and Sight-Threatening Diabetic Retinopathy
Khan, R., Sharma, A., Ravikumar, R., Parekh, A., Srinivasan, R., George, R. J., & Raman, R. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.7.19 · Cited by 44
Role of gut bacterial and non-bacterial microbiota in alcohol-associated liver disease: Molecular mechanisms, biomarkers, and therapeutic prospective
Zafari, N., Velayati, M., Fahim, M., Maftouh, M., Pourali, G., Khazaei, M., Nassiri, M., Hassanian, S. M., Ghayour‐Mobarhan, M., Ferns, G. A., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120760 · Cited by 45
Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis
Millet, V., Gensollen, T., Maltese, M., Serrero, M., Lesavre, N., Bourges, C., Pitaval, C., Cadra, S., Chasson, L., Manh, T. V., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-325792 · Cited by 44
Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice
Lum, G. R., Ha, S. M., Olson, C. A., Blencowe, M., Paramo, J., Reyes, B. L., Matsumoto, J. H., Yang, X., & Hsiao, E. Y. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113521 · Cited by 49
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Navabi, N., Whitt, J., Wu, S.-E., Woo, V., Moncivaiz, J. D., Jordan, M. B., Vallance, B. A., Way, S. S., & Alenghat, T. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.046 · Cited by 44
Host NLRP6 exacerbates graft-versus-host disease independent of gut microbial composition
Toubai, T., Fujiwara, H., Rossi, C., Riwes, M. M., Tamaki, H., Zajac, C. K., Liu, C., Mathew, A. V., Byun, J., Oravecz-Wilson, K. I., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0373-1 · Cited by 45
Predictive Metagenomic Analysis of Autoimmune Disease Identifies Robust Autoimmunity and Disease Specific Microbial Signatures
Volkova, A., & Ruggles, K. V. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.621310 · Cited by 45
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Zhu, Y., Gu, L., Lin, X., Zhang, J., Tang, Y., Zhou, X., Lu, B., Lin, X., Liu, C., Prochownik, E. V., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.150607 · Cited by 43
Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition
Gerrick, E. R., Zlitni, S., West, P. T., Carter, M. M., Mechler, C. M., Olm, M. R., Caffrey, E. B., Li, J. A., Higginbottom, S. K., Severyn, C. J., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.018 · Cited by 42
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease
Andary, C. M., Al, K. F., Chmiel, J. A., Gibbons, S., Daisley, B. A., Parvathy, S. N., Vareki, S. M., Bowdish, D. M. E., Silverman, M., & Burton, J. P. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.12.005 · Cited by 46
Epithelial mitochondrial fission-mediated PANoptosis is crucial for ulcerative colitis and its inhibition by saquinavir through Drp1
Ye, Z., Deng, M., Yang, Y., Song, Y., Weng, L., Qi, W., Ding, P., Huang, Y., Yu, C., Wang, Y., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107538 · Cited by 46
Effects of field conditions on fecal microbiota
Hale, V. L., Tan, C. L., Niu, K., Yang, Y., Cui, D., Zhao, H., Knight, R. D., & Amato, K. R. (2016) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2016.09.017 · Cited by 44
The multifaceted roles of inflammasome proteins in cancer
Pétrilli, V. (2016) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000346 · Cited by 43
Loss of NLRP6 expression increases the severity of acute kidney injury
Rivas, L. V., Cuarental, L., Núñez, G., Sanz, A. B., Ortíz, A., & Sánchez-Niño, M. D. (2019) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfz169 · Cited by 45
Mutual regulation between butyrate and hypoxia‐inducible factor‐1α in epithelial cell promotes expression of tight junction proteins
Yin, J., Zhou, C., Yang, K., Ren, Y., Qiu, Y., Xu, P., Xiao, W., & Yang, H. (2020) · Cell Biology International · doi:10.1002/cbin.11336 · Cited by 44

Authors: Levy, M., Thaiss, C. A., Zeevi, D., Dohnalová, L., Zilberman-Schapira, G., Mahdi, J. A., David, E., Savidor, A., Korem, T., Herzig, Y., Pevsner-Fischer, M., Shapiro, H., Christ, A., Harmelin, A., Halpern, Z., Latz, E., Flavell, R. A., Amit, I., Segal, E., & Elinav, E.
Affiliations: Weizmann Institute of Science (IL)
Ben-Gurion University of the Negev (IL)
University of Bonn (DE)
Tel Aviv University (IL)
Howard Hughes Medical Institute (US)
Corresponding author: Segal, Eran
Elinav, Eran
ORCID: Levy, Maayan
Thaiss, Christoph A.
Zeevi, David
Dohnalová, Lenka
David, Eyal
Savidor, Alon
Korem, Tal
Herzig, Yonatan
Shapiro, Hagit
Christ, Anette
Harmelin, Alon
Halpern, Zamir
Latz, Eicke
Flavell, Richard A.
Amit, Ido
Segal, Eran
Elinav, Eran
Venue: Cell
Publisher: Elsevier BV
Published: 2015-12
Volume: 163
Issue: 6
Pages: 1428-1443
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2015.10.048
PMC: PMC5665753
OpenAlex: W2188593832
Cited by: 960
References: 51
Citations by year: 2026: 63 · 2025: 67 · 2024: 95 · 2023: 106 · 2022: 109 · 2021: 112 · 2020: 96 · 2019: 108 · 2018: 69 · 2017: 78 · 2016: 51 · 2015: 3
FWCI: 29.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Cancer Institute (P30CA016359)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034989)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: gut microbiota, NLRP6 inflammasome, host-microbiome interactions, taurine, histamine, spermine, IL-18, antimicrobial peptides, dysbiosis, colitis, fecal microbiota transplantation, postbiotics, innate immune modulation, intestinal epithelium
MeSH terms: Animals, Colitis, Colon, Germ-Free Life, Mice, Inbred C57BL, Receptors, Cell Surface, Taurine, Inflammatory Bowel Diseases, Signal Transduction, Interleukin-18, Antimicrobial Cationic Peptides, Mice, Inflammasomes, Microbiota, Dysbiosis

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Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

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