Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

QIIME allows analysis of high-throughput community sequencing data

Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887

KEGG: Kyoto Encyclopedia of Genes and Genomes

Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173

Human Genetics Shape the Gut Microbiome

Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164

Data, information, knowledge and principle: back to metabolism in KEGG

Kanehisa, M. I., Goto, S., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1076 · Cited by 3,103

Gut Microbiota and Osteoarthritis: From Pathogenesis to Novel Therapeutic Opportunities

Xi, Y., Wang, Z., Wei, Y., Xiao, N., Duan, L., Zhao, T., Zhang, X., Zhang, L., Wang, J., Li, Z., et al. (2025) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x2550003x · Cited by 17

Emerging concepts and shifting paradigms for understanding the microbial basis of inflammatory bowel diseases

Kennedy, M. S., & Chang, E. B. (2025) · Journal of Clinical Investigation · doi:10.1172/jci193969 · Cited by 17

The Gut-Brain Axis in Alzheimer’s Disease: Exploring Microbial Influences and Therapeutic Strategies

Mustafa, M. A., Vadia, N., Varma, P., Al‐Shaker, H., Mohanty, B., Dhyani, A., Kaur, I., Chauhan, A. S., & Garg, G. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05474-4 · Cited by 18

IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner

Zheng, X., Liu, L., Meng, G., Zhu, S., Zhou, R., & Jiang, W. (2021) · 中国科学通报：英文版 · doi:10.1016/j.scib.2021.01.025 · Cited by 18

Faecalibacterium prausnitzii Attenuates DSS‐Induced Colitis by Inhibiting the Colonization and Pathogenicity of Candida albicans

Mao, X., Ma, J., Jiao, C., Tang, N., Zhao, X., Wang, D., Zhang, Y., Ye, Z., Xu, C., Jiang, J., et al. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100433 · Cited by 16

Human Adult Microbiota in a Static Colon Model: AhR Transcriptional Activity at the Crossroads of Host–Microbe Interaction

Goya‐Jorge, E., Gonza, I., Bondue, P., Douny, C., Taminiau, B., Daube, G., Scippo, M., & Delcenserie, V. (2022) · Foods · doi:10.3390/foods11131946 · Cited by 17

NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner

Nascimento, M., Huot-Marchand, S., Fanny, M., Straube, M., Bert, M. L., Savigny, F., Apétoh, L., Snick, J. V., Trovero, F., Chamaillard, M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1224383 · Cited by 17

A Narrative Review of the IL-18 and IL-37 Implications in the Pathogenesis of Atopic Dermatitis and Psoriasis: Prospective Treatment Targets

Rusiñol, L., & Puig, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158437 · Cited by 18

Human Respiratory and Gut Microbiomes—Do They Really Contribute to Respiratory Health?

Durack, J., & Christophersen, C. T. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00528 · Cited by 18

Discrete role for maternal stress and gut microbes in shaping maternal and offspring immunity

Chen, H. J., Bischoff, A., Galley, J. D., Peck, L., Bailey, M. T., & Gur, T. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100480 · Cited by 16

An Intestinal Inflammasome – The ILC3–Cytokine Tango

Gonçalves, P., & Santo, J. P. D. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.02.008 · Cited by 15

Correlation, consequence, and functionality in microbiome‐immune interplay

Pabst, O. (2017) · Immunological Reviews · doi:10.1111/imr.12584 · Cited by 16

Overview of the Effect of Citrobacter rodentium Infection on Host Metabolism and the Microbiota

Hopkins, E. G. D., & Frankel, G. M. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1339-9_20 · Cited by 16

Upregulation of Intestinal NLRP6 Inflammasomes After Roux-en-Y Gastric Bypass Promotes Gut Immune Homeostasis

Wang, G., Wang, Q., Bai, J., Zhao, N., Wang, Y. H. D., Zhou, R., Kong, W., Zeng, T., Tao, K., Wang, G., et al. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04152-4 · Cited by 15

Fish oil extracted from Coregonus peled improves obese phenotype and changes gut microbiota in a high-fat diet-induced mouse model of recurrent obesity

Qin, N., Song, G., Ren, X., Zhang, L., Gao, J., Xia, X., & Zhu, B. (2020) · Food & Function · doi:10.1039/d0fo00911c · Cited by 17

Effect of gut microbiota on host whole metabolome

Moriya, T., Satomi, Y., Murata, S., Sawada, H., & Kobayashi, H. (2017) · Metabolomics · doi:10.1007/s11306-017-1240-9 · Cited by 15

Acute Infectious Diarrhea

Vecchio, A. L., Buccigrossi, V., Fedele, M. C., & Guarino, A. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_320 · Cited by 15

Inflammasomes as regulators of non-infectious disease

Okin, D. A., & Kagan, J. C. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101815 · Cited by 14

NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death

Radulovic, K., Ayata, C. K., Mak’Anyengo, R., Lechner, K., Wuggenig, P., Kaya, B., Hruz, P. L., de Agüero, M. G., Brož, P., Weigmann, B., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800938 · Cited by 14

Ubiquitination is a major modulator for the activation of inflammasomes and pyroptosis

Jiang, Q., Zhu, Z., & Mao, X. (2023) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2023.194955 · Cited by 13

Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice

Fan, T., Tchaptchet, S., Arsene, D., Mishima, Y., Liu, B., Sartor, R. B., Carroll, I. M., Miao, E. A., Fodor, A. A., & Hansen, J. J. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy244 · Cited by 15

Using Multiple Analytical Platforms to Investigate the Androgen Depletion Effects on Fecal Metabolites in a Mouse Model of Systemic Lupus Erythematosus

Yuan, F., Harder, J. W., Ma, J., Yin, X., Zhang, X., & Kosiewicz, M. M. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00558 · Cited by 14

Endothelial GSDMD underlies LPS-induced systemic vascular injury and lethality

Su, E., Song, X., Wei, L. S., Xue, J., Cheng, X., Xie, S., Jiang, H. X., & Liu, M. (2025) · JCI Insight · doi:10.1172/jci.insight.182398 · Cited by 15

Traditional Chinese medicine and gut microbiota: biotransformation, interaction, and implications for chronic disease treatment

Hao, X., Zhang, J., Ma, R., Yao, B., & Yang, W. (2025) · Drug Metabolism Reviews · doi:10.1080/03602532.2025.2520768 · Cited by 13

Immunomodulation by the Commensal Microbiome During Immune-Targeted Interventions: Focus on Cancer Immune Checkpoint Inhibitor Therapy and Vaccination

Reens, A. L., Cabral, D. J., Liang, X., Norton, J. E., Therien, A. G., Hazuda, D. J., & Swaminathan, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.643255 · Cited by 14

Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study

Chernevskaya, E., Zuev, E., Odintsova, V. Y., Meglei, A. Y., & Nv, B. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111113 · Cited by 13

Redox Regulation of Nucleotide-Binding and Oligomerization Domain-Like Receptors Inflammasome

Ferrara, F., Pecorelli, A., & Valacchi, G. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0180 · Cited by 13

Treatment of insulin resistance: straight from the gut

Zhang, X., Zheng, X., & Yuan, Y. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.06.016 · Cited by 13

Yak milk protects against alcohol-induced liver injury in rats

Wang, M., Jiang, Y., Wang, S., Fu, L., Liang, Z., Zhang, Y., Huang, X., Li, X., Feng, M., & Long, D. (2023) · Food & Function · doi:10.1039/d3fo03675h · Cited by 12

Disturbances of Ruminal Microbiota and Liver Inflammation, Mediated by LPS and Histamine, in Dairy Cows Fed a High-Concentrate Diet

Ma, N., Guo, J., Li, Z., Xu, L., Zhang, K., Xu, T., Chang, G., Loor, J. J., & Shen, X. (2024) · Animals · doi:10.3390/ani14101495 · Cited by 12

Postprandial Metabolomics Analysis Reveals Disordered Serotonin Metabolism in Post-Bariatric Hypoglycemia

Ferraz-Bannitz, R., Ozturk, B., Cummings, C., Efthymiou, V., Casanova Querol, P., Poulos, L., Wang, H., Navarrete, V., Saeed, H., Mulla, C. M., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180157 · Cited by 12

Microbial metabolites derived from colonic fermentation of non-digestible compounds

Tabernero, M., & de Cedrón, M. G. (2017) · Current Opinion in Food Science · doi:10.1016/j.cofs.2017.03.005 · Cited by 13

NLRP6 targeting suppresses gastric tumorigenesis via P14ARF–Mdm2–P53-dependent cellular senescence

Wang, H., Xu, G., Huang, Z., Li, W., Cai, H., Zhang, Y., Xiong, D., Liu, G., Wang, S., Xue, Z., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22876 · Cited by 12

SARS-CoV-2 infection of intestinal epithelia cells sensed by RIG-I and DHX-15 evokes innate immune response and immune cross-talk

Zhang, L., Zhang, Y., Wang, R., Liu, X., Zhao, J., Tsuda, M., & Li, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1035711 · Cited by 12

Proteome changes in the small intestinal mucosa of growing pigs with dietary supplementation of non-starch polysaccharide enzymes

Zhang, J., Gao, Y., Lu, Q., Sa, R., & Zhang, H. (2016) · Proteome Science · doi:10.1186/s12953-016-0109-6 · Cited by 12

Nucleotide-Binding Domain Leucine-Rich Repeat Containing Proteins and Intestinal Microbiota: Pivotal Players in Colitis and Colitis-Associated Cancer Development

Prossomariti, A., Sokol, H., & Ricciardiello, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01039 · Cited by 12

IL‐18Rα‐deficient CD4+ T cells induce intestinal inflammation in the CD45RBhi transfer model of colitis despite impaired innate responsiveness

Holmkvist, P., Pool, L., Hägerbrand, K., Agace, W. W., & Rivollier, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201545957 · Cited by 12

IL-18 in atopic dermatitis—a multifaceted driver of skin inflammation

Bähler, L., Schärli, S., Luther, F., Bertschi, N., Skabytska, Y., Roediger, B., & Schlapbach, C. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.07.025 · Cited by 14

The link between gut microbiota and multiple sclerosis from the perspective of barrier function

Ren, J., Niu, Z., Wang, J., Guo, J., Hao, H.-J., Gao, F., Liu, R., & Wang, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1652796 · Cited by 13

Modulation of Bovine Endometrial Cell Receptors and Signaling Pathways as a Nanotherapeutic Exploration against Dairy Cow Postpartum Endometritis

Oladejo, A. O., Li, Y.-J., Wu, X.-H., Imam, B. H., Yang, J., Ma, X., Yan, Z.-T., & Wang, S.-Y. (2021) · Animals · doi:10.3390/ani11061516 · Cited by 12

Inflammatory macrophages exploited by oral streptococcus increase IL-1B release via NLRP6 inflammasome

Metcalfe, S., Panasiewicz, M., & Kay, J. G. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad089 · Cited by 12

The role and application of three IFN-related reactions in psoriasis

He, J., Zhao, M., Ma, X., Li, D., Kong, J., & Yang, F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115603 · Cited by 12

Monoclonal Antibody Against Mature Interleukin-18 Ameliorates Colitis in Mice and Improves Epithelial Barrier Function

Ikegami, S., Maeda, K., Urano, T., Mu, J., Nakamura, M., Yamamura, T., Sawada, T., Ishikawa, E., Yamamoto, K., Muto, H., et al. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad292 · Cited by 11

Sustained mucosal colonization and fecal metabolic dysfunction by Bacteroides associates with fecal microbial transplant failure in ulcerative colitis patients

Zhang, B., Magnaye, K. M., Stryker, E., Anderson, J. M., Porsche, C. E., Hertz, S., McCauley, K. E., Smith, B. J., Zydek, M., Pollard, K. S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-62463-8 · Cited by 11

The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage

Boegli, A., Bernard, E. M., Lacante, L., Majeux, G., Hartenian, E., Mack, V., & Brož, P. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00637-4 · Cited by 13

Tissue-selective alternate promoters guide NLRP6 expression

Bracey, N. A., Platnich, J. M., Lau, A. N., Chung, H., Hyndman, M. E., MacDonald, J. A., Chun, J., Beck, P. L., Girardin, S. E., Gordon, P. M. K., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.202000897 · Cited by 12

Inflammasomes and Type 1 Diabetes

Pearson, J. A., Wong, F. S., & Li, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686956 · Cited by 11

A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals

Gerson, K. D., Liao, J., McCarthy, C., Burris, H. H., Korem, T., Levy, M., Ravel, J., & Elovitz, M. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-02304-0 · Cited by 11

The autoinflammation-associated NLRC4V341A mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Eeckhout, E., Asaoka, T., Gorp, H. V., Demon, D., Girard-Guyonvarc’h, C., Andries, V., Vereecke, L., Gabay, C., Lamkanfi, M., Loo, G., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1272639 · Cited by 12

Intestinal immune response is regulated by gut microbe

Tanemoto, S., Sujino, T., & Kanai∥, T. (2017) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.40.408 · Cited by 11

Danger-associated metabolic modifications during bacterial infection of macrophages

Dramé, M., Buchrieser, C., & Escoll, P. (2020) · International Immunology · doi:10.1093/intimm/dxaa035 · Cited by 11

NLRP6 negatively regulates type 2 immune responses in mice

Chenuet, P., Marquant, Q., Fauconnier, L., Youness, A., Mellier, M., Marchiol, T., Rouxel, N., Messaoud-Nacer, Y., Maillet, I., Ledru, A., et al. (2022) · Allergy · doi:10.1111/all.15388 · Cited by 11

Intestinal amino acid metabolic response and its roles in inflammatory bowel disease

Niu, Y., Wang, F., Liu, C. H., Liu, Z., & Hu, X. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02622-0 · Cited by 11

Protection against DSS-induced colitis in mice through FcεRIα deficiency: the role of altered Lactobacillus

Yin, Y., Wang, R., Li, Y.-N., Qin, W.-F., Pan, L., Yan, C., Hu, Y.-S., Wang, G.-Q., Ai, L.-Z., Mei, Q.-X., et al. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00563-z · Cited by 11

Cross-kingdom-mediated detection of intestinal protozoa through NLRP6

Winsor, N. J., Bayer, G., Singh, O., Chan, J. K., Li, L. Y., Lieng, B. Y., Foerster, E. G., Popovic, A., Tsankov, B. K., Maughan, H., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.02.008 · Cited by 10

Gut microbiota circadian rhythms: a key regulator of immunometabolic homeostasis

Zhao, Z., Wu, S., Wang, T., & Zhao, Y. L. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025220 · Cited by 11

Immune features of the peritumoral stroma in pancreatic ductal adenocarcinoma

Ahmed, A., Klotz, R., Köhler, S., Giese, N. A., Hackert, T., Springfeld, C., Jäger, D., & Halama, N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.947407 · Cited by 10

NLRP6 deficiency expands a novel CD103+ B cell population that confers immune tolerance in NOD mice

Pearson, J. A., Peng, J., Huang, J., Yu, X.-Q., Tai, N., Hu, Y., Sha, S., Flavell, R. A., Zhao, H., Wong, F. S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1147925 · Cited by 10

Toxin-linked mobile genetic elements in major enteric bacterial pathogens

Panwar, S., Kumari, S., Verma, J., Bakshi, S., Narendrakumar, L., Paul, D., & Das, B. (2023) · Gut Microbiome · doi:10.1017/gmb.2023.2 · Cited by 10

Research progress on the effects of gut microbiome on lung damage induced by particulate matter exposure

Qin, J., & Wang, J. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116162 · Cited by 10

Metabolic fingerprinting of carp and rainbow trout seminal plasma

Dietrich, M. A., Samczuk, P., Ciborowski, M., Nynca, J., Parfieniuk, E., Pietrowska, K., Kowalczyk, T., Kretowski, A. J., & Ciereszko, A. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.11.017 · Cited by 10

A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions

Li, R., Zan, Y., Wang, D., Chen, X., Wang, A. M., Tan, H., Zhang, G., Ding, S., Shen, C., Wu, H., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2321419121 · Cited by 10

Integrative Multiomics Profiling Unveils the Protective Function of Ulinastatin against Dextran Sulfate Sodium-Induced Colitis

Yu, T., Yan, J., Wang, R., Zhang, L., Hu, X., Xu, J., Li, F., & Sun, Q. (2024) · Antioxidants · doi:10.3390/antiox13020214 · Cited by 9

Gut Microbiome and Diet Interaction

Ogidi, O. I., & Felagha, I. (2024) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/979-8-3693-5528-2.ch012 · Cited by 9

Neuroimmune Crossroads: The Interplay of the Enteric Nervous System and Intestinal Macrophages in Gut Homeostasis and Disease

Lou, M., Heuckeroth, R. O., & Tjaden, N. E. B. (2024) · Biomolecules · doi:10.3390/biom14091103 · Cited by 11

Circulating hs-CRP, IL-18, Chemerin, Leptin, and Adiponectin Levels Reflect Cardiometabolic Dysfunction in Adults with Excess Weight

Lara-Guzmán, O. J., Arango-González, Á. M., Álvarez, R., Escobar, J. S., Muñoz-Durango, K., & Sierra, J. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031176 · Cited by 12

Butyrate-engineered yeast activates Nppa and Sgcg genes and reduces radiation-induced heart damage via the gut-heart axis

Wu, J., Ji, K., Kang, G., Zhang, M., Wang, J., Wang, L., Gao, M., Jia, X., Lu, X., Wang, Y., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107642 · Cited by 9

Targeting gut microbiota and its associated metabolites as a potential strategy for promoting would healing in diabetes

Xiong, L., Huang, Y.-X., Mao, L., Xu, Y., & Deng, Y. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i5.98788 · Cited by 10

The Role of the Gut-Brain Axis in Diseases

Chen, J. W., Xu, Y., & Cao, P. (2025) · Physiology · doi:10.1152/physiol.00016.2025 · Cited by 13

Chronic Morphine Induces IL-18 in Ileum Myenteric Plexus Neurons Through Mu-opioid Receptor Activation in Cholinergic and VIPergic Neurons

Muchhala, K. H., Köşeli, E., Gade, A. R., Woods, K., Minai, S., Kang, M., McQuiston, A. R., Dewey, W. L., & Akbarali, H. I. (2022) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10050-3 · Cited by 11

Childhood Microbial Experience, Immunoregulation, Inflammation, and Adult Susceptibility to Psychosocial Stressors and Depression

Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00002-7 · Cited by 9

Inflammasomes: Role in Disease Pathogenesis and Therapeutic Potential

Garanina, E. E., Martynova, E. V., Ivanov, K., Rizvanov, A. A., & Khaiboullina, S. F. (2020) · Učënye zapiski Kazanskogo universiteta. Seriâ Estestvennye nauki/Učënye zapiski Kazanskogo universiteta. Seriâ Estestvennye nauki/Učenye zapiski Kazanskogo gosudarstvennogo universiteta. Seriâ Estestvennye nauki · doi:10.26907/2542-064x.2020.1.80-111 · Cited by 10

Microorganisms and cardiovascular diseases: importance of gut bacteria

Noor, R., Naz, A., Maniha, S. M., Tabassum, N., Tabassum, T., Tabassum, T., Taniya, M. A., & Billah, M. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/4921 · Cited by 9

Epigenetic regulation by CpG methylation splits strong from retarded IFNγ-induced IL-18BP in epithelial versus monocytic cells

Bachmann, M., Pfeilschifter, J. M., & Mühl, H. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.01.020 · Cited by 9

Implications of gut microbiota in autoimmune liver diseases

Qian, Q., He, W., Tang, R., & Ma, X. (2021) · Minerva Gastroenterology · doi:10.23736/s2724-5985.21.02860-9 · Cited by 9

Interactions between the NLRP3-Dependent IL-1β and the Type I Interferon Pathways in Human Plasmacytoid Dendritic Cells

Bencze, D., Fekete, T., Pfliegler, W. P., Szöőr, Á., Csoma, E., Szántó, A., Tarr, T., Bácsi, A., Kemény, L. V., Veréb, Z., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012154 · Cited by 8

Gut microbial signatures are associated with Lynch syndrome (LS) and cancer history in Druze communities in Israel

Naddaf, R., Carasso, S., Levi, G. R., Hasnis, E., Qarawani, A., Maza, I., Gefen, T., Half, E., & Geva‐Zatorsky, N. (2023) · Scientific Reports · doi:10.1038/s41598-023-47723-3 · Cited by 8

Enterococcus durans 98D alters gut microbial composition and function to improve DSS-induced colitis in mice

Yu, L., Yan, Y., Zhong, J., Zhao, Y., Xu, Y., Zhang, T., Xiong, H., Chen, Y., Wang, X., & Zhang, K. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28486 · Cited by 8

Systematic Review and Meta‐Analysis: Taurine and Its Association With Colorectal Carcinoma

Sinha, A., Griffith, L., & Acharjee, A. (2024) · Cancer Medicine · doi:10.1002/cam4.70424 · Cited by 10

Inflammasomes: potential therapeutic targets in hematopoietic stem cell transplantation

Luo, J., Zhou, Y., Wang, M., Zhang, J. L., & Jiang, E. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01974-3 · Cited by 9

The Microbiome, Inflammation, and GVHD Axis: The Balance Between the “Gut” and the Bad

Pinzon-Leal, P., Gutiérrez-Barbosa, H., Medina-Moreno, S., & Zapata, J. C. (2025) · Immuno · doi:10.3390/immuno5010010 · Cited by 8

Decoding IBD progression: a dynamic biomarker atlas for personalized disease stratification

Tao, Y., Wang, L.-F., Pan, L., Sun, R., Li, Y.-J., Sun, M., Zhang, L.-J., Yang, L.-H., Jin, J.-J., & Zhong, X. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07024-x · Cited by 8

Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases

Wang, A., Guan, B., Zhang, H., & Xu, H. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106983 · Cited by 9

Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases

Patil, P., & Doshi, G. (2023) · Current Drug Targets · doi:10.2174/0113894501267496231102114410 · Cited by 10

Implications of the microbiome and metabolic intermediaries produced by bacteria in breast cancer

D’Afonseca, V., Valdés-Muñoz, E., Leal, A. L., Suazo, P., & Parra-Cid, C. (2024) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2023-0316 · Cited by 8

Brazilin-Rich Extract from Caesalpinia sappan L. Attenuated the Motor Deficits and Neurodegeneration in MPTP/p-Induced Parkinson’s Disease Mice by Regulating Gut Microbiota and Inhibiting Inflammatory Responses

Gao, W., Wu, X., Wang, Y., Lu, F., & Liu, F. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00679 · Cited by 9

Ding's herbal enema treats dextran sulfate sodium‑induced colitis in mice by regulating the gut microbiota and maintaining the Treg/Th17 cell balance

Tan, Y.-Y., Ding, Y., Zheng, X., Dai, G.-J., Zhang, S., Xu, Y., Xu, D., Chen, P., Zhang, J., Ma, J., et al. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10802 · Cited by 8

The important role of NLRP6 inflammasome in Pasteurella multocida infection

Wu, X.-P., Zeng, Z., Tian, H., Peng, L., Xu, D., Wang, Y., Ye, C., Peng, Y., & Fang, R. (2022) · Veterinary Research · doi:10.1186/s13567-022-01095-0 · Cited by 8

Taurine Inhibits TRPV-Dependent Activity to Overcome Oxidative Stress in Caenorhabditis elegans

Moriuchi, M., Nakano, Y., Tsurekawa, Y., Piruzyan, M., Matsuyama, S., Nohara, H., Suico, M. A., Shuto, T., & Kai, H. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00370 · Cited by 10

Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment

Fung, K. Y., Nguyen, P. M., & Putoczki, T. L. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-38315-2_5 · Cited by 8

Acute Infectious Diarrhea

Poeta, M., Bene, M. D., Vecchio, A. L., & Guarino, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-58572-2_9 · Cited by 7

The major biogenic amine metabolites in mood disorders

Yang, H. J., Yuan, M., & Zhang, W. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1460631 · Cited by 8

Therapeutic systems based on natural gut microbiota modulators: the latest advances in the treatment of inflammatory bowel disease

Guan, Z., Niu, P., Tan, Q., Wang, Y., Deng, S., Wang, D., Dong, K., Xing, J., & You, C. (2025) · Materials Advances · doi:10.1039/d4ma00896k · Cited by 7

Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience

Arnesen, H., Birkeland, S., Stendahl, H., Neuhaus, K., Masopust, D., Boysen, P., & Carlsen, H. (2025) · Discovery Immunology · doi:10.1093/discim/kyaf002 · Cited by 7

Dietary Selenium Deficiency Accelerates the Onset of Aging‐Related Gut Microbial Changes in Aged Telomere‐Humanized Mice, With Akkermansia muciniphila Being the Most Prominent and Alleviating Selenium Deficiency‐Induced Type 2 Diabetes

Huang, Y., Lu, H., Zhang, L., Olivier, A. K., Wu, T., Hsu, C., LeGrand, C., Zeng, H., Curran, S., Wang, Q., et al. (2025) · Aging Cell · doi:10.1111/acel.70130 · Cited by 7

Ganoderma lucidum sporoderm-broken spore powder alleviates kidney aging by modulating gut microbiota

Liu, X., Zhao, J., Liu, J., Deng, W., Yan, L., Huang, Y., Zhang, L., Liu, Z., Cui, M., Xiao, H., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120344 · Cited by 9

Aging-caused the changes of the gut microbiota drive intestinal barrier dysfunction and increase sepsis susceptibility

Liang, H., Ding, X., liu, S., Tong, S., Wang, X., Zhang, Z., Wang, W., Zhang, X. L., Yuan, Y., Jiang, Y., et al. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2630475 · Cited by 7

The gut microbiome changes in wild type and IL-18 knockout mice after 9.0 Gy total body irradiation

Cui, W., Hull, L., Zizzo, A., Wang, L., Lin, B., Zhai, M., & Xiao, M. (2023) · Animal Microbiome · doi:10.1186/s42523-023-00262-8 · Cited by 7

The role of NLRP6 in the development and progression of neurological diseases

Guo, Y., Song, J., Yan, M., Chen, Y., Huang, L., Liu, J., He, Y., Yang, L., & Yu, W. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09293-z · Cited by 7

Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function

Mu, J., Maeda, K., Ohashi, A., Urano, T., Nariai, Y., Kamino, H., Nakamura, M., Yamamura, T., Sawada, T., Ishikawa, E., et al. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08453-2 · Cited by 8

Maintaining the mucosal barrier in intestinal inflammation

Ray, K. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.217 · Cited by 4

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024

Microbiota-mediated fine-tuning of the threshold of intestinal inflammasome activation in host-microbial mutualism

Ronchi, F., Rupp, S., Steinert, A., Wyss, M., McCoy, K., & Macpherson, A. J. (2014) · Bern Open Repository and Information System (University of Bern)

Inflammasome shapes the microbiota

Papatriantafyllou, M. (2011) · Nature reviews. Immunology · doi:10.1038/nri3012 · Cited by 8

Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition.

Mamantopoulos, M., Ronchi, F., Hauwermeiren, F. V., Vieira‐Silva, S., Yilmaz, B., Martens, L., Saeys, Y., Drexler, S. K., Yazdi, A., Raes, J., et al. (2017) · Open Access CRIS of the University of Bern · doi:10.7892/boris.110305