The DOI matches its Crossref record; 128 of the 129 references it cites were found in a registry or an index.
The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier
Open accessAbstract
The immune system safeguards organ integrity by employing a balancing act of inflammatory and immunosuppressive mechanisms designed to neutralize foreign invaders and resolve injury. Maintaining or restoring a state of immune homeostasis is particularly challenging at barrier sites where constant exposure to immunogenic environmental agents may induce destructive inflammation. Recent studies underscore the role of epithelial and mesenchymal barrier cells in regulating immune cell function and local homeostatic and inflammatory responses. Here, we highlight immunoregulatory circuits engaging epithelial and mesenchymal cells in the intestine, airways, and skin and discuss how immune communications with hematopoietic cells and the microbiota orchestrate local immune homeostasis and inflammation.
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“These three cell types, which we refer to as “structural cells”, have been shown to contribute in important ways to mammalian immunity7–11.”
From Structural cells are key regulators of organ-specific immune responses (2020) · cites this paper as [9]
Citations
Cites
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Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
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1 of the 129 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Pascual-Reguant, A., Bayat Sarmadi, J., Baumann, C., Noster, R., Cirera-Salinas, D., Curato, C., Pelczar, P., Huber, S., Zielinski, C.E., Löhning, M., et al. (in press). TH17 Cells Express ST2 and are Controlled by the Alarmin IL-33 in the Small Intestine. Mucosal Immunology.
Cited by
Sorted by citations
Type 2 immunity in tissue repair and fibrosis
Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055
The intestinal epithelium: central coordinator of mucosal immunity
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Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease
Kinchen, J., Chen, H. H., Parikh, K., Antanaviciute, A., Jagielowicz, M., Fawkner-Corbett, D., Ashley, N., Cubitt, L., Mellado-Gomez, E., Attar, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.067 · Cited by 745
Type 2 immunity in the skin and lungs
Akdiş, C. A., Arkwright, P. D., Brüggen, M., Busse, W. W., Gadina, M., Guttman‐Yassky, E., Kabashima, K., Mitamura, Y., Vian, L., Wu, J., et al. (2020) · Allergy · doi:10.1111/all.14318 · Cited by 594
López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499
Metadata
- Authors
- Nowarski, R., Jackson, R., & Flavell, R. A.
- Affiliations
- Yale University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Flavell, Richard A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 168
- Issue
- 3
- Pages
- 362-375
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2580798654
- Cited by
- 191
- References
- 129
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 21 · 2023: 18 · 2022: 19 · 2021: 33 · 2020: 33 · 2019: 14 · 2018: 14 · 2017: 10
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- immune regulation, inflammation, immune homeostasis, epithelial cells, mesenchymal cells, hematopoietic cells, microbiota, intestinal immunity, airway immunity, skin immunity
- MeSH terms
- Animals, Epithelial Cells, Epithelium, Homeostasis, Humans, Infections, Inflammation, Intestines, Mesoderm, Respiratory System
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