Cited by 191IL-33, ST2, and ILC PathwaysT-cell and B-cell ImmunologyImmune Response and Inflammation

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The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier

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Nowarski, Roni, Jackson, Ruaidhrí, Flavell, Richard A.·2017·Cell

DOI 10.1016/j.cell.2016.11.040

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Abstract

The immune system safeguards organ integrity by employing a balancing act of inflammatory and immunosuppressive mechanisms designed to neutralize foreign invaders and resolve injury. Maintaining or restoring a state of immune homeostasis is particularly challenging at barrier sites where constant exposure to immunogenic environmental agents may induce destructive inflammation. Recent studies underscore the role of epithelial and mesenchymal barrier cells in regulating immune cell function and local homeostatic and inflammatory responses. Here, we highlight immunoregulatory circuits engaging epithelial and mesenchymal cells in the intestine, airways, and skin and discuss how immune communications with hematopoietic cells and the microbiota orchestrate local immune homeostasis and inflammation.

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Pascual-Reguant, A., Bayat Sarmadi, J., Baumann, C., Noster, R., Cirera-Salinas, D., Curato, C., Pelczar, P., Huber, S., Zielinski, C.E., Löhning, M., et al. (in press). TH17 Cells Express ST2 and are Controlled by the Alarmin IL-33 in the Small Intestine. Mucosal Immunology.

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Authors: Nowarski, R., Jackson, R., & Flavell, R. A.
Affiliations: Yale University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Flavell, Richard A.
ORCID: Jackson, Ruaidhrí
Flavell, Richard A.
Venue: Cell
Publisher: Elsevier BV
Published: 2017-01
Volume: 168
Issue: 3
Pages: 362-375
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2016.11.040
OpenAlex: W2580798654
Cited by: 191
References: 129
Citations by year: 2026: 16 · 2025: 13 · 2024: 21 · 2023: 18 · 2022: 19 · 2021: 33 · 2020: 33 · 2019: 14 · 2018: 14 · 2017: 10
FWCI: 1.99
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 390 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: immune regulation, inflammation, immune homeostasis, epithelial cells, mesenchymal cells, hematopoietic cells, microbiota, intestinal immunity, airway immunity, skin immunity
MeSH terms: Animals, Epithelial Cells, Epithelium, Homeostasis, Humans, Infections, Inflammation, Intestines, Mesoderm, Respiratory System

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The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier

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