The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618

IL-17 and th17 cells

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

The International IBD Genetics Consortium (IIBDGC), Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., et al. (2012) · Nature · doi:10.1038/nature11582 · Cited by 4,722

Intestinal mucosal barrier function in health and disease

Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541

Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Peterson, L. W., & Artis, D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3608 · Cited by 3,367

Points of control in inflammation

Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738

Cytokines in inflammatory bowel disease

Neurath, M. F. (2014) · Nature Reviews Immunology · doi:10.1038/nri3661 · Cited by 2,706

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024

Regional specialization within the intestinal immune system

Mowat, A. M., & Agace, W. W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3738 · Cited by 1,882

Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection

Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684

CX 3 CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M. L., Ploegh, H. L., Fox, J. G., et al. (2005) · Science · doi:10.1126/science.1102901 · Cited by 1,646

Retinoic acid imprints gut-homing specificity on T cells

Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C., & Song, S.-Y. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.011 · Cited by 1,541

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

Bernardo, M. E., & Fibbe, W. E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.006 · Cited by 1,423

Inflammation meets cancer, with NF-κB as the matchmaker

Ben‐Neriah, Y., & Karin, M. (2011) · Nature Immunology · doi:10.1038/ni.2060 · Cited by 1,412

A Special Population of Regulatory T Cells Potentiates Muscle Repair

Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234

Six-of-the-best: unique contributions of γδ T cells to immunology

Vantourout, P., & Hayday, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3384 · Cited by 1,232

Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit

von Moltke, J., Ji, M., Liang, H.-E., & Locksley, R. M. (2016) · Nature · doi:10.1038/nature16161 · Cited by 1,230

Diversity, topographic differentiation, and positional memory in human fibroblasts

Chang, H. Y., Chi, J., Dudoit, S., Bondre, C., van de Rijn, M., Botstein, D., & Brown, P. O. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162488599 · Cited by 1,151

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

Lindemans, C. A., Calafiore, M., Mertelsmann, A. M., O'Connor, M. H., Dudakov, J. A., Jenq, R. R., Velardi, E., Young, L. F., Smith, O. M., Lawrence, G., et al. (2015) · Nature · doi:10.1038/nature16460 · Cited by 1,144

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

Bouskra, D., Brézillon, C., Bérard, M., Werts, C., Varona, R., Boneca, I. G., & Eberl, G. (2008) · Nature · doi:10.1038/nature07450 · Cited by 1,107

Th17 cell induction by adhesion of microbes to intestinal epithelial cells

Atarashi, K., Tanoue, T., Ando, M., Kamada, N., Nagano, Y., Narushima, S., Suda, W., Imaoka, A., Setoyama, H., Nagamori, T., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.058 · Cited by 1,071

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

Mora, J. R., Bono, M. R., Manjunath, N., Weninger, W., Cavanagh, L. L., Rosemblatt, M. S., & von Andrian, U. H. (2003) · Nature · doi:10.1038/nature01726 · Cited by 1,068

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

Pickert, G., Neufert, C., Leppkes, M., Zheng, Y., Wittkopf, N., Warntjen, M., Lehr, H.-A., Hirth, S., Weigmann, B., Wirtz, S., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082683 · Cited by 1,043

The alarmin IL-33 promotes regulatory T-cell function in the intestine

Schiering, C., Krausgruber, T., Chomka, A., Fröhlich, A., Adelmann, K., Wohlfert, E. A., Pott, J., Griseri, T., Bollrath, J., Hegazy, A. N., et al. (2014) · Nature · doi:10.1038/nature13577 · Cited by 1,007

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

Gerbe, F., Sidot, E., Smyth, D. J., Ohmoto, M., Matsumoto, I., Dardalhon, V., Cesses, P., Garnier, L., Pouzolles, M., Brulin, B., et al. (2016) · Nature · doi:10.1038/nature16527 · Cited by 1,002

A Distinct Function of Regulatory T Cells in Tissue Protection

Arpaia, N., Green, J. A., Moltedo, B., Arvey, A., Hemmers, S., Yuan, S., Treuting, P. M., & Rudensky, A. Y. (2015) · Cell · doi:10.1016/j.cell.2015.08.021 · Cited by 991

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

Mcdole, J. R., Wheeler, L. W., McDonald, K. G., Wang, B., Konjufca, V. H., Knoop, K. A., Newberry, R. D., & Miller, M. J. (2012) · Nature · doi:10.1038/nature10863 · Cited by 976

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Brestoff, J. R., Kim, B. S., Saenz, S. A., Stine, R. R., Monticelli, L. A., Sonnenberg, G. F., Thome, J. J., Farber, D. L., Lutfy, K., Seale, P., et al. (2015) · Nature · doi:10.1038/nature14115 · Cited by 968

Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling

Levy, M., Thaiss, C. A., Zeevi, D., Dohnalová, L., Zilberman-Schapira, G., Mahdi, J. A., David, E., Savidor, A., Korem, T., Herzig, Y., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.048 · Cited by 960

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

Kuperman, D. A., Huang, X., Koth, L. L., Chang, G. H., Dolganov, G., Zhu, Z., Elias, J. A., Sheppard, D., & Erle, D. J. (2002) · Nature Medicine · doi:10.1038/nm734 · Cited by 957

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

Halim, T. Y. F., Steer, C. A., Mathä, L., Gold, M. J., Martínez-González, I., McNagny, K. M., McKenzie, A. N. J., & Takei, F. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.011 · Cited by 950

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

Howitt, M. R., Lavoie, S., Michaud, M., Blum, A. M., Tran, S. V., Weinstock, J. V., Gallini, C. A., Redding, K., Margolskee, R. F., Osborne, L. C., et al. (2016) · Science · doi:10.1126/science.aaf1648 · Cited by 939

Interleukin-18 and IL-18 Binding Protein

Dinarello, C. A., Novick, D., Kim, S., & Kaplanski, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00289 · Cited by 938

Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2

Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002) · Science · doi:10.1126/science.1069094 · Cited by 936

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.004 · Cited by 922

Individual intestinal symbionts induce a distinct population of RORγ + regulatory T cells

Sefik, E., Geva-Zatorsky, N., Oh, S., Konnikova, L., Zemmour, D., McGuire, A. M., Burzyn, D., Ortiz-Lopez, A., Lobera, M., Yang, J., et al. (2015) · Science · doi:10.1126/science.aaa9420 · Cited by 879

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

Hecker, L., Vittal, R., Jones, T., Jagirdar, R., Luckhardt, T. R., Horowitz, J. C., Pennathur, S., Martinez, F. J., & Thannickal, V. J. (2009) · Nature Medicine · doi:10.1038/nm.2005 · Cited by 852

Respiratory epithelial cells orchestrate pulmonary innate immunity

Whitsett, J. A., & Alenghat, T. (2014) · Nature Immunology · doi:10.1038/ni.3045 · Cited by 846

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

Naik, S., Bouladoux, N., Linehan, J. L., Han, S.-J., Harrison, O. J., Wilhelm, C., Conlan, S., Himmelfarb, S., Byrd, A. L., Deming, C., et al. (2015) · Nature · doi:10.1038/nature14052 · Cited by 820

Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

Rimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G. M., Nespoli, A., Viale, G., Allavena, P., & Rescigno, M. (2005) · Nature Immunology · doi:10.1038/ni1192 · Cited by 815

Reparative inflammation takes charge of tissue regeneration

Karin, M., & Clevers, H. (2016) · Nature · doi:10.1038/nature17039 · Cited by 767

Muc5b is required for airway defence

Roy, M. G., Livraghi-Butrico, A., Fletcher, A. A., McElwee, M. M., Evans, S. E., Boerner, R. M., Alexander, S. N., Bellinghausen, L. K., Song, A. S., Petrova, Y. M., et al. (2014) · Nature · doi:10.1038/nature12807 · Cited by 764

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

Lee, J. S., Tato, C. M., Joyce-Shaikh, B., Gulen, M. F., Cayatte, C., Chen, Y., Blumenschein, W. M., Judo, M., Ayanoglu, G., McClanahan, T. K., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.003 · Cited by 760

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

Klose, C. S. N., Kiss, E. A., Schwierzeck, V., Ebert, K., Hoyler, T., d’Hargues, Y., Göppert, N., Croxford, A. L., Waisman, A., Tanriver, Y., et al. (2013) · Nature · doi:10.1038/nature11813 · Cited by 734

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

Wlodarska, M., Thaiss, C. A., Nowarski, R., Henao-Mejia, J., Zhang, J.-P., Brown, E. M., Frankel, G., Levy, M., Katz, M. N., Philbrick, W. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.026 · Cited by 708

The light and dark sides of intestinal intraepithelial lymphocytes

Cheroutre, H., Lambolez, F., & Mucida, D. (2011) · Nature Reviews Immunology · doi:10.1038/nri3007 · Cited by 693

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

Lee, M.-W., Odegaard, J. I., Mukundan, L., Qiu, Y., Molofsky, A. B., Nussbaum, J. C., Yun, K. M., Locksley, R. M., & Chawla, A. (2014) · Cell · doi:10.1016/j.cell.2014.12.011 · Cited by 680

Control of TH17 cells occurs in the small intestine

Esplugues, E., Huber, S., Gagliani, N., Hauser, A. E., Town, T., Wan, Y. Y., O’Connor, W., Rongvaux, A., van Rooijen, N., Haberman, A. M., et al. (2011) · Nature · doi:10.1038/nature10228 · Cited by 660

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., et al. (2013) · Science · doi:10.1126/science.1237910 · Cited by 642

New insights into the development of lymphoid tissues

van de Pavert, S. A., & Mebius, R. E. (2010) · Nature reviews. Immunology · doi:10.1038/nri2832 · Cited by 616

Localization of Distinct Peyer's Patch Dendritic Cell Subsets and Their Recruitment by Chemokines Macrophage Inflammatory Protein (Mip)-3α, Mip-3β, and Secondary Lymphoid Organ Chemokine

Iwasaki, A., & Kelsall, B. L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1381 · Cited by 582

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Nowarski, R., Jackson, R. P., Gagliani, N., de Zoete, M. R., Palm, N. W., Bailis, W., Low, J. S., Harman, C. C. D., Graham, M. M., Elinav, E., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.072 · Cited by 582

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Schuijs, M. J., Willart, M. A., Vergote, K., Gras, D., Deswarte, K., Ege, M. J., Madeira, F. B., Beyaert, R., van Loo, G., Bracher, F., et al. (2015) · Science · doi:10.1126/science.aac6623 · Cited by 576

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

Parker, M. W., Rossi, D., Peterson, M., Smith, K. A., Sikström, K., White, E. S., Connett, J. E., Henke, C. A., Larsson, O. S., & Bitterman, P. B. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71386 · Cited by 572

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

Goto, Y., Obata, T., Kunisawa, J., Sato, S., Ivanov, I. I., Lamichhane, A., Takeyama, N., Kamioka, M., Sakamoto, M., Matsuki, T., et al. (2014) · Science · doi:10.1126/science.1254009 · Cited by 568

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

Birchenough, G. M. H., Nyström, E. E. L., Johansson, M. E. V., & Hansson, G. C. (2016) · Science · doi:10.1126/science.aaf7419 · Cited by 568

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

Pickard, J. M., Maurice, C. F., Kinnebrew, M. A., Abt, M. C., Schenten, D., Golovkina, T. V., Bogatyrev, S. R., Ismagilov, R. F., Pamer, E. G., Turnbaugh, P. J., et al. (2014) · Nature · doi:10.1038/nature13823 · Cited by 550

Stromal cell contributions to the homeostasis and functionality of the immune system

Mueller, S. N., & Germain, R. N. (2009) · Nature reviews. Immunology · doi:10.1038/nri2588 · Cited by 547

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

Sano, T., Huang, W., Hall, J. A., Yang, Y., Chen, A., Gavzy, S. J., Lee, J.-Y., Ziel, J. W., Miraldi, E. R., Domingos, A. I., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.061 · Cited by 547

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

Zaph, C., Troy, A. E., Taylor, B. C., Berman-Booty, L. D., Guild, K. J., Du, Y., Yost, E. A., Gruber, A. D., May, M. J., Greten, F. R., et al. (2007) · Nature · doi:10.1038/nature05590 · Cited by 496

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

Ramirez-Carrozzi, V., Sambandam, A., Luis, E., Lin, Z., Jeet, S., Lesch, J., Hackney, J., Kim, J., Zhou, M., Lai, J., et al. (2011) · Nature Immunology · doi:10.1038/ni.2156 · Cited by 477

An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice

Tieu, B. C., Lee, C., Sun, H., LeJeune, W. S., Recinos, A., Ju, X., Spratt, H. M., Guo, D., Milewicz, D. M., Tilton, R. G., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38308 · Cited by 474

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells

Diehl, G. E., Longman, R., Zhang, J.-X., Bréart, B., Galan, C., Cuesta, A., Schwab, S. R., & Littman, D. R. (2013) · Nature · doi:10.1038/nature11809 · Cited by 472

Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L. (2015) · Science · doi:10.1126/science.1260972 · Cited by 471

Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis.

Pullan, R. D., Thomas, G. A. O., Rhodes, M. A., Newcombe, R. G., Williams, G. T., Allen, A., & Rhodes, J. M. (1994) · Gut · doi:10.1136/gut.35.3.353 · Cited by 467

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

Gibbs, J. E., Ince, L. M., Matthews, L. C., Mei, J., Bell, T., Yang, N., Saer, B., Begley, N., Poolman, T. M., Pariollaud, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3599 · Cited by 464

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

Westphalen, K., Gusarova, G. A., Islam, M. N., Subramanian, M., Cohen, T. S., Prince, A. S., & Bhattacharya, J. (2014) · Nature · doi:10.1038/nature12902 · Cited by 463

Requirement for Lymphoid Tissue-Inducer Cells in Isolated Follicle Formation and T Cell-Independent Immunoglobulin A Generation in the Gut

Tsuji, M., Suzuki, K., Kitamura, H., Maruya, M., Kinoshita, K., Ivanov, I. I., Itoh, K., Littman, D. R., & Fagarasan, S. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.014 · Cited by 462

Luminal Bacteria Recruit CD103+ Dendritic Cells into the Intestinal Epithelium to Sample Bacterial Antigens for Presentation

Farache, J., Koren, I., Milo, I., Gurevich, I., Kim, K.-W., Zigmond, E., Furtado, G. C., Lira, S. A., & Shakhar, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.009 · Cited by 456

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

Stark, K., Eckart, A., Haidari, S., Tirniceriu, A., Lorenz, M., von Brühl, M.-L., Gärtner, F., Khandoga, A. G., Legate, K. R., Pless, R., et al. (2013) · Nature Immunology · doi:10.1038/ni.2477 · Cited by 447

Understanding fibroblast heterogeneity in the skin

Driskell, R. R., & Watt, F. M. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.10.001 · Cited by 425

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

Willart, M. A. M., Deswarte, K., Pouliot, P., Braun, H., Beyaert, R., Lambrecht, B. N., & Hammad, H. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112691 · Cited by 418

Mesenchymal Cells of the Intestinal Lamina Propria

Powell, D. W., Pinchuk, I. V., Saada, J. I., Chen, X., & Mifflin, R. C. (2011) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100646 · Cited by 412

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

Chen, G., Korfhagen, T. R., Xu, Y. J., Kitzmiller, J. A., Wert, S. E., Maeda, Y., Gregorieff, A., Clevers, H. C., & Whitsett, J. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39731 · Cited by 403

Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

Hung, C. F., Linn, G. R., Chow, Y., Kobayashi, A., Mittelsteadt, K. L., Altemeier, W. A., Gharib, S. A., Schnapp, L. M., & Duffield, J. S. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201212-2297oc · Cited by 394

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

Barros, R. D. M., Roberts, N. A., Dart, R., Vantourout, P., Jandke, A., Nussbaumer, O., Deban, L., Cipolat, S., Hart, R., Iannitto, M. L., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.030 · Cited by 368

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

Fu, J., Wei, B., Wen, T., Johansson, M. E. V., Liu, X., Bradford, E., Thomsson, K. A., McGee, S., Mansour, L., Tong, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45538 · Cited by 366

Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning

Iliev, I. D., Mileti, E., Matteoli, G., Chieppa, M., & Rescigno, M. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.13 · Cited by 352

Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFκB

Lee, H., & Ziegler, S. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607305104 · Cited by 338

Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation

Kumar, P., Monin, L., Castillo, P., Elsegeiny, W., Horne, W., Eddens, T., Vikram, A., Good, M., Schoenborn, A. A., Bibby, K., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.007 · Cited by 326

Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo

Hammerschmidt, S. I., Ahrendt, M., Bode, U., Wahl, B., Kremmer, E., Förster, R., & Pabst, O. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080039 · Cited by 324

Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis

Cao, Z., Lis, R., Ginsberg, M. D., Chavez, D., Shido, K., Rabbany, S. Y., Fong, G., Sakmar, T. P., Rafii, S., & Ding, B. (2016) · Nature Medicine · doi:10.1038/nm.4035 · Cited by 293

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

Juncadella, I. J., Kadl, A., Sharma, A. K., Shim, Y. M., Hochreiter, A. E., Borish, L., & Ravichandran, K. S. (2012) · Nature · doi:10.1038/nature11714 · Cited by 290

The Ets-Domain Transcription Factor Spdef Promotes Maturation of Goblet and Paneth Cells in the Intestinal Epithelium

Gregorieff, A., Stange, D. E., Kujala, P., Begthel, H., van den Born, M., Korving, J., Peters, P. J., & Clevers, H. C. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.044 · Cited by 276

Pulmonary neuroendocrine cells function as airway sensors to control lung immune response

Branchfield, K., Nantie, L. B., Verheyden, J. M., Sui, P., Wienhold, M. D., & Sun, X. (2016) · Science · doi:10.1126/science.aad7969 · Cited by 270

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury

Brown, S. L., Riehl, T. E., Walker, M. R., Geske, M. J., Doherty, J. M., Stenson, W. F., & Stappenbeck, T. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29159 · Cited by 263

Tissue adaptation of regulatory and intraepithelial CD4 + T cells controls gut inflammation

Sujino, T., London, M., Hoytema van Konijnenburg, D. P., Rendon, T., Buch, T., Silva, H. M., Lafaille, J. J., Reis, B. S., & Mucida, D. (2016) · Science · doi:10.1126/science.aaf3892 · Cited by 250

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

Wu, C.-F., Chiang, W., Lai, C., Chang, F., Chen, Y., Chou, Y., Wu, T.-H., Linn, G. R., Ling, H., Wu, K., et al. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.09.009 · Cited by 247

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

Kim, Y., Kamada, N., Shaw, M. H., Warner, N. E., Chen, G., Franchi, L., & Núñez, G. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.013 · Cited by 242

Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine

Harrison, O. J., Srinivasan, N., Pott, J., Schiering, C., Krausgruber, T., Ilott, N. E., & Maloy, K. J. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.13 · Cited by 242

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease

Koyama, M., Kuns, R. D., Olver, S. D., Raffelt, N. C., Wilson, Y. A., Don, A. L. J., Lineburg, K. E., Cheong, M., Robb, R. J., Markey, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2597 · Cited by 240

Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity

Burkett, P. R., zu Hörste, G. M., & Kuchroo, V. K. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78085 · Cited by 225

MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts

Wang, D., Zhang, H., Li, M., Frid, M. G., Flockton, A. R., McKeon, B. A., Yeager, M. E., Fini, M. A., Morrell, N. W., Pullamsetti, S. S., et al. (2013) · Circulation Research · doi:10.1161/circresaha.114.301633 · Cited by 219

An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration

Chivukula, R. R., Shi, G., Acharya, A., Mills, E. W., Zeitels, L. R., Anandam, J., Abdelnaby, A. A., Balch, G. C., Mansour, J. C., Yopp, A. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.055 · Cited by 213

Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling

Hu, B., Castillo, E., Harewood, L., Ostano, P., Reymond, A., Dummer, R., Raffoul, W., Hoetzenecker, W., Hofbauer, G. F. L., & Dotto, G. P. (2012) · Cell · doi:10.1016/j.cell.2012.03.048 · Cited by 211

Protective mucosal immunity mediated by epithelial CD1d and IL-10

Olszak, T., Neves, J. F., Dowds, C. M., Baker, K., Glickman, J. N., Davidson, N. O., Lin, C., Jobin, C., Brand, S., Sotlar, K., et al. (2014) · Nature · doi:10.1038/nature13150 · Cited by 203

Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis

Mohapatra, A., Dyken, S. J. V., Schneider, C., Nussbaum, J. C., He, L., & Locksley, R. M. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.59 · Cited by 201

IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo

Koop, K., Backert, I., Wirtz, S. J., Hueber, A. J., Schett, G. A., Vieth, M. W., Probst, H. C., Bopp, T., Neurath, M. F., & Neufert, C. F. (2016) · Gut · doi:10.1136/gutjnl-2015-310374 · Cited by 192

Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection

Muñoz, M., Eidenschenk, C., Ota, N., Wong, K., Lohmann, U., Kühl, A. A., Wang, X., Manzanillo, P. S., Li, Y., Rutz, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.011 · Cited by 186

IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts

Suwara, M., Green, N. J., Borthwick, L. A., Mann, J., Mayer-Barber, K. D., Barron, L., Corris, P. A., Farrow, S. N., Wynn, T. A., Fisher, A., et al. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.87 · Cited by 171

Intrinsic Defense Mechanisms of the Intestinal Epithelium

Ramanan, D., & Cadwell, K. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.03.003 · Cited by 162

Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation

Rajavelu, P., Chen, G., Xu, Y. J., Kitzmiller, J. A., Korfhagen, T. R., & Whitsett, J. A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79422 · Cited by 159

IL13 activates autophagy to regulate secretion in airway epithelial cells

Dickinson, J. D., Alevy, Y. G., Malvin, N. P., Patel, K., Gunsten, S. P., Holtzman, M. J., Stappenbeck, T. S., & Brody, S. L. (2015) · Autophagy · doi:10.1080/15548627.2015.1056967 · Cited by 155

IL-22 Mediates Goblet Cell Hyperplasia and Worm Expulsion in Intestinal Helminth Infection

Turner, J., Stockinger, B., & Helmby, H. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003698 · Cited by 155

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

Denney, L., Byrne, A. J., Shea, T. J., Buckley, J., Pease, J. E., Herledan, G., Walker, S. A., Gregory, L. G., & Lloyd, C. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.012 · Cited by 153

NF-κB Mediates IL-1β– and IL-17A–Induced MUC5B Expression in Airway Epithelial Cells

Fujisawa, T., Chang, M. M.-J., Velichko, S., Thai, P., Hung, L., Huang, F., Phuong, N. S., Chen, Y., & Wu, R. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0313oc · Cited by 146

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

Pallangyo, C. K., Ziegler, P. K., & Greten, F. R. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150576 · Cited by 142

Intestinal CD103+CD11b− dendritic cells restrain colitis via IFN-γ-induced anti-inflammatory response in epithelial cells

Muzaki, A. R. B. M., Tetlak, P., Sheng, J., Loh, S.-C., Setiagani, Y. A., Poidinger, M., Zolezzi, F., Karjalainen, K., & Ruedl, C. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.64 · Cited by 139

Control of local immunity by airway epithelial cells

Weitnauer, M., Mijošek, V., & Dalpke, A. H. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.126 · Cited by 137

Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation

Reynolds, J. M., Lee, Y.-H., Shi, Y., Wang, X., Angkasekwinai, P., Nallaparaju, K. C., Flaherty, S., Chang, S. H., Watarai, H., & Dong, C. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.008 · Cited by 135

Epithelial Cell Contributions to Intestinal Immunity

Hooper, L. V. (2015) · Advances in immunology · doi:10.1016/bs.ai.2014.11.003 · Cited by 135

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer

Koliaraki, V., Pasparakis, M., & Kollias, G. A. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150542 · Cited by 132

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

Murthy, A., Shao, Y. W., Narala, S., Molyneux, S. D., Zúñiga‐Pflücker, J. C., & Khokha, R. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.005 · Cited by 129

Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice

Oh, K., Park, H.-B., Byoun, O.-J., Shin, D.-M., Jeong, E. M., Kim, Y. W., Kim, Y. S., Melino, G., Kim, I.-G., & Lee, D.-S. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101457 · Cited by 118

Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK

Neufert, C. F., Becker, C., Türeci, Ö., Waldner, M. J., Backert, I., Floh, K., Atreya, I., Leppkes, M., Jefremow, A., Vieth, M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci63748 · Cited by 117

Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers

Hsia, L.-T., Ashley, N., Ouaret, D., Wang, L. M., Wilding, J. L., & Bodmer, W. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603534113 · Cited by 100

Intestinal myofibroblast-specific Tpl2-Cox-2-PGE 2 pathway links innate sensing to epithelial homeostasis

Roulis, M., Nikolaou, C., Kotsaki, E., Kaffe, E., Karagianni, N., Koliaraki, V., Salpea, K. D., Ragoussis, J., Aidinis, V., Martini, E., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415762111 · Cited by 94

Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells

Vicente-Suarez, I., Larangé, A., Reardon, C., Matho, M. H., Feau, S., Chodaczek, G., Park, Y., Obata, Y., Gold, R. S., Wang-Zhu, Y., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.51 · Cited by 86

The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis.

Kurashima, Y., Amiya, T., Fujisawa, K., Shibata, N., Suzuki, Y., Kogure, Y., Hashimoto, E., Otsuka, A., Kabashima, K., Sato, S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.014 · Cited by 79

Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity

Giacomin, P., Moy, R. H., Noti, M., Osborne, L. C., Siracusa, M. C., Alenghat, T., Liu, B., McCorkell, K. A., Troy, A. E., Rak, G. D., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141831 · Cited by 76

Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces

Nakahashi-Oda, C., Udayanga, K. G. S., Nakamura, Y., Nakazawa, Y., Totsuka, N., Miki, H., Iino, S., Tahara‐Hanaoka, S., Honda, S.-I., Shibuya, K., et al. (2016) · Nature Immunology · doi:10.1038/ni.3345 · Cited by 73

Epithelial Expression of the Cytosolic Retinoid Chaperone Cellular Retinol Binding Protein II Is Essential for in Vivo Imprinting of Local Gut Dendritic Cells by Lumenal Retinoids

McDonald, K. G., Leach, M. R., Brooke, K. W. M., Wang, C., Wheeler, L. W., Hanly, E. K., Rowley, C. W., Levin, M. S., Wagner, M., Li, E., et al. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.11.009 · Cited by 72

PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation

Sun, Q., Liu, L., Roth, M., Tian, J., He, Q., Zhong, B., Bao, R., Lan, X., Jiang, C., Sun, J., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402465 · Cited by 70

Inflammation, Innate Immunity, and the Intestinal Stromal Cell Niche: Opportunities and Challenges

Owens, B. M. J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00319 · Cited by 54

Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion

Shaker, A., Swietlicki, E. A., Wang, L., Jiang, S., Önal, B., Bala, S., DeSchryver, K., Newberry, R. D., Levin, M. S., & Rubin, D. C. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40676 · Cited by 51

Type 2 immunity in tissue repair and fibrosis

Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055

The intestinal epithelium: central coordinator of mucosal immunity

Allaire, J. M., Crowley, S. M., Law, H. T., Chang, S.-Y., Ko, H.-J., & Vallance, B. A. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.04.002 · Cited by 933

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

Kinchen, J., Chen, H. H., Parikh, K., Antanaviciute, A., Jagielowicz, M., Fawkner-Corbett, D., Ashley, N., Cubitt, L., Mellado-Gomez, E., Attar, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.067 · Cited by 745

Type 2 immunity in the skin and lungs

Akdiş, C. A., Arkwright, P. D., Brüggen, M., Busse, W. W., Gadina, M., Guttman‐Yassky, E., Kabashima, K., Mitamura, Y., Vian, L., Wu, J., et al. (2020) · Allergy · doi:10.1111/all.14318 · Cited by 594

Hallmarks of Health

López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499

Eavesdropping on the conversation between immune cells and the skin epithelium

Bukhari, S., Mertz, A. F., & Naik, S. (2019) · International Immunology · doi:10.1093/intimm/dxy088 · Cited by 12

The intestinal epithelial barrier in the control of homeostasis and immunity

Rescigno, M. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.003 · Cited by 361

Epithelial‐immune cell crosstalk for intestinal barrier homeostasis

Yao, Y., Shang, W., Bao, L., Peng, Z., & Wu, C. (2024) · European Journal of Immunology · doi:10.1002/eji.202350631 · Cited by 84

Epithelial-neuronal-immune cell interactions: Implications for immunity, inflammation, and tissue homeostasis at mucosal sites

Emanuel, E., Arifuzzaman, M., & Artis, D. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.02.004 · Cited by 26

A neuro-epithelial unit regulates immunohomeostasis at barrier surfaces

Jakob, M. O., Dohner, E., Forster, P. M., & Klose, C. S. N. (2026) · Mucosal Immunology · doi:10.1016/j.mucimm.2026.100363