The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Landscape of Circular RNA in Cancer
Open accessAbstract
SUMMARY Circular RNAs (circRNAs) are an intriguing class of RNA due to their covalently closed structure, high stability, and implicated roles in gene regulation. Here, we used an exome capture RNA sequencing protocol to detect and characterize circRNAs across >2,000 cancer samples. When compared against Ribo-Zero and RNase R, capture sequencing significantly enhanced the enrichment of circRNAs and preserved accurate circular-to-linear ratios. Using capture sequencing, we built the most comprehensive catalogue of circRNA species to date: MiOncoCirc, the first database to be composed primarily of circRNAs directly detected in tumor tissues. Using MiOncoCirc, we identified candidate circRNAs to serve as biomarkers for prostate cancer and were able to detect circRNAs in urine. We further detected a novel class of circular transcripts, termed read-through circRNAs, that involved exons originating from different genes. MiOncoCirc will serve as a valuable resource for the development of circRNAs as diagnostic or therapeutic targets across cancer types.
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Circular RNAs are abundant, conserved, and associated with ALU repeats
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Self-citationThe landscape of long noncoding RNAs in the human transcriptome
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Self-citationCirc-ZNF609 is a circular RNA that can be translated and functions in myogenesis
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Cited by
The role of non-coding RNAs in oncology
Slack, F. J., & Chinnaiyan, A. M. (2019) · Cell · doi:10.1016/j.cell.2019.10.017 · Cited by 1,619
Self-citationThe emerging roles of circRNAs in cancer and oncology
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The interplay between m6A RNA methylation and noncoding RNA in cancer
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Proteogenomic Characterization of Endometrial Carcinoma
Dou, Y., Kawaler, E. A., Cui Zhou, D., Gritsenko, M. A., Huang, C., Blumenberg, L., Karpova, A., Petyuk, V. A., Savage, S. R., Satpathy, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.026 · Cited by 485
“Discovery of a Potential Role for circRNAs in EMT Regulation Circular RNAs (circRNAs) have recently drawn interest for their role in tumor biology (Chen et al., 2019; Dragomir and Calin, 2018; Hansen et al., 2013; Kristensen et al., 2018; Vo et al., 2019).”
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Metadata
- Authors
- Vo, J. N., Cieslik, M., Zhang, Y., Shukla, S., Xiao, L., Zhang, Y., Wu, Y.-M., Dhanasekaran, S. M., Engelke, C. G., Cao, X., Robinson, D. R., Nesvizhskii, A. I., & Chinnaiyan, A. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 176
- Issue
- 4
- Pages
- 869-881.e13
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2912017471
- Cited by
- 1,738
- References
- 11
- FWCI
- 79.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vo, J. N., Cieslik, M., Zhang, Y., Shukla, S., Xiao, L., Zhang, Y., Wu, Y.-M., Dhanasekaran, S. M., Engelke, C. G., Cao, X., Robinson, D. R., Nesvizhskii, A. I., & Chinnaiyan, A. M. (2019). The Landscape of Circular RNA in Cancer. Cell. https://doi.org/10.1016/j.cell.2018.12.021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
