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Cited by 478

The DOI matches its Crossref record; 208 of the 208 references it cites were found in a registry or an index.

Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration

Open access
Afshinnekoo, Ebrahim, Scott, Ryan T., MacKay, Matthew J., Pariset, Eloise, Cekanaviciute, Egle, Barker, Richard, Gilroy, Simon, Hassane, Duane, Smith, Scott M., Zwart, Sara R., Nelman-Gonzalez, Mayra, Crucian, Brian E., Ponomarev, Sergey A., Orlov, Oleg I., Shiba, Dai, Muratani, Masafumi, Yamamoto, Masayuki, Richards, Stephanie E., Vaishampayan, Parag A., Meydan, Cem, Foox, Jonathan, Myrrhe, Jacqueline, Istasse, Eric, Singh, Nitin, Venkateswaran, Kasthuri, Keune, Jessica A., Ray, Hami E., Basner, Mathias, Miller, Jack, Vitaterna, Martha Hotz, Taylor, Deanne M., Wallace, Douglas, Rubins, Kathleen, Bailey, Susan M., Grabham, Peter, Costes, Sylvain V., Mason, Christopher E., Beheshti, Afshin·2020·Cell
DOI 10.1016/j.cell.2020.10.050
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Abstract

Research on astronaut health and model organisms have revealed six features of spaceflight biology which guide our current understanding of fundamental molecular changes that occur during space travel. The features include oxidative stress, DNA damage, mitochondrial dysregulation, epigenetics (including gene regulation), telomere length alterations, and microbiome shifts. Here we review the known hazards of human spaceflight, how spaceflight affects living systems through these six fundamental features, and the associated health risks of space exploration. We also discuss the essential issues related to the health and safety of astronauts involved in future missions, especially planned long-duration and Martian missions.

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Metadata

Authors
Afshinnekoo, E., Scott, R. T., MacKay, M. J., Pariset, E., Cekanaviciute, E., Barker, R., Gilroy, S., Hassane, D., Smith, S. M., Zwart, S. R., Nelman-Gonzalez, M., Crucian, B. E., Ponomarev, S. A., Orlov, O. I., Shiba, D., Muratani, M., Yamamoto, M., Richards, S. E., Vaishampayan, P. A., Meydan, C., Foox, J., Myrrhe, J., Istasse, E., Singh, N., Venkateswaran, K., Keune, J. A., Ray, H. E., Basner, M., Miller, J., Vitaterna, M. H., Taylor, D. M., Wallace, D., Rubins, K., Bailey, S. M., Grabham, P., Costes, S. V., Mason, C. E., & Beheshti, A.
Venue
Cell
Publisher
Elsevier BV
Published
2020-11
Volume
183
Issue
5
Pages
1162-1184
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2020.10.050
OpenAlex
W3107984511
Cited by
478
References
208
FWCI
25.52
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration. https://app.cochat.ai/papers/10.1016/j.cell.2020.10.050
The paper
Afshinnekoo, E., Scott, R. T., MacKay, M. J., Pariset, E., Cekanaviciute, E., Barker, R., Gilroy, S., Hassane, D., Smith, S. M., Zwart, S. R., Nelman-Gonzalez, M., Crucian, B. E., Ponomarev, S. A., Orlov, O. I., Shiba, D., Muratani, M., Yamamoto, M., Richards, S. E., Vaishampayan, P. A., . . . Beheshti, A. (2020). Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration. Cell. https://doi.org/10.1016/j.cell.2020.10.050

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.