The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function
Open accessAbstract
Biomolecules are in constant motion. To understand how they function, and why malfunctions can cause disease, it is necessary to describe their three-dimensional structures in terms of dynamic conformational ensembles. Here, we demonstrate how nuclear magnetic resonance (NMR) spectroscopy provides an essential, dynamic view of structural biology that captures biomolecular motions at atomic resolution. We focus on examples that emphasize the diversity of biomolecules and biochemical applications that are amenable to NMR, such as elucidating functional dynamics in large molecular machines, characterizing transient conformations implicated in the onset of disease, and obtaining atomic-level descriptions of intrinsically disordered regions that make weak interactions involved in liquid-liquid phase separation. Finally, we discuss the pivotal role that NMR has played in driving forward our understanding of the biomolecular dynamics-function paradigm.
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Cites
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Hsp90-Tau complex reveals molecular basis for specificity in chaperone action
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Cited by
Bishop, A. C., Torres-Montalvo, G., Kotaru, S., Mimun, K., & Wand, A. J. (2023) · Nature Communications · doi:10.1038/s41467-023-37219-z · Cited by 16
Mapping Protein Conformational Landscapes from Crystallographic Drug Fragment Screens
Saeed, A. A., Klureza, M. A., & Hekstra, D. R. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c01380 · Cited by 9
Latham, A. P., Zhang, W., Tempkin, J. O. B., Otsuka, S., Ellenberg, J., & Sali, A. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2415674122 · Cited by 8
Metadata
- Authors
- Alderson, T. R., & Kay, L. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 184
- Issue
- 3
- Pages
- 577-595
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3128777856
- Cited by
- 224
- References
- 9
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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