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CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

Samelson, Avi J., Ariqat, Nabeela, McKetney, Justin, Rohanitazangi, Gita, Parra Bravo, Celeste, Bose, Rudra S., Travaglini, Kyle J., Lam, Victor L., Goodness, Darrin, Ta, Thomas, Dixon, Gary, Marzette, Emily, Jin, Julianne, Tian, Ruilin, Tse, Eric, Abskharon, Romany, Pan, Henry S., Carroll, Emma C., Lawrence, Rosalie E., Gestwicki, Jason E., Rexach, Jessica E., Eisenberg, David S., Kanaan, Nicholas M., Southworth, Daniel R., Gross, John D., Gan, Li, Swaney, Danielle L., Kampmann, Martin·2026·Cell
DOI 10.1016/j.cell.2025.12.038PMC PMC12978015

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Metadata

Authors
Samelson, A. J., Ariqat, N., McKetney, J., Rohanitazangi, G., Parra Bravo, C., Bose, R. S., Travaglini, K. J., Lam, V. L., Goodness, D., Ta, T., Dixon, G., Marzette, E., Jin, J., Tian, R., Tse, E., Abskharon, R., Pan, H. S., Carroll, E. C., Lawrence, R. E., Gestwicki, J. E., Rexach, J. E., Eisenberg, D. S., Kanaan, N. M., Southworth, D. R., Gross, J. D., Gan, L., Swaney, D. L., & Kampmann, M.
ORCID
Kampmann, Martin
Venue
Cell
Publisher
Elsevier BV
Published
2026-03
Volume
189
Issue
5
Pages
1517-1534.e19
ISSN
0092-8674
DOI
10.1016/j.cell.2025.12.038
PMC
PMC12978015
Cited by
36
References
27
Language
en
Licence
Funders
  • Rainwater Charitable Foundation (F32 AG063487)
  • The Chan Zuckerberg Initiative
  • Howard Hughes Medical Institute (U54AI170792, 1R01AG075802, F32AG076281, R01AG085357, NIAU19AG060909)
  • Tau Consortium (U24AG072458, U54NS100717, R01AG062359, U54NS123746, R01AG070895, R01AG082141)
  • Alzheimer's Association
  • National Institutes of Health
  • National Institute on Aging (F32 AG063487, F32AG076281, K99 AG080116-01)
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Allergy and Infectious Diseases
  • BrightFocus Foundation

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CoChat. (2026). Citation check: CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. https://app.cochat.ai/papers/10.1016/j.cell.2025.12.038
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Samelson, A. J., Ariqat, N., McKetney, J., Rohanitazangi, G., Parra Bravo, C., Bose, R. S., Travaglini, K. J., Lam, V. L., Goodness, D., Ta, T., Dixon, G., Marzette, E., Jin, J., Tian, R., Tse, E., Abskharon, R., Pan, H. S., Carroll, E. C., Lawrence, R. E., . . . Kampmann, M. (2026). CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. Cell. https://doi.org/10.1016/j.cell.2025.12.038

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