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Synaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain

Colom-Cadena, Martí, Davies, Caitlin, Sirisi, Sònia, Lee, Ji-Eun, Simzer, Elizabeth M., Tzioras, Makis, Querol-Vilaseca, Marta, Sánchez-Aced, Érika, Chang, Ya Yin, Holt, Kristjan, McGeachan, Robert I., Rose, Jamie, Tulloch, Jane, Wilkins, Lewis, Smith, Colin, Andrian, Teodora, Belbin, Olivia, Pujals, Sílvia, Horrocks, Mathew H., Lleó, Alberto, Spires-Jones, Tara L.·2023·Neuron
DOI 10.1016/j.neuron.2023.04.020

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  • With our technique, we do not observe somatic labelling of PSD95, rather we observe discrete puncta that are opposed to presynaptic terminal labelling.

    “There will be synaptic protein in cell bodies of neurons where they are produced before transport to synapses; however, with our technique, we do not observe somatic labelling of PSD95, rather we observe discrete puncta that are opposed to presynaptic terminal labelling [12].”

    From Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease (2024) · cites this paper as [12]

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Research works printed but not linked: 58

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Metadata

Authors
Colom-Cadena, M., Davies, C., Sirisi, S., Lee, J.-E., Simzer, E. M., Tzioras, M., Querol-Vilaseca, M., Sánchez-Aced, É., Chang, Y. Y., Holt, K., McGeachan, R. I., Rose, J., Tulloch, J., Wilkins, L., Smith, C., Andrian, T., Belbin, O., Pujals, S., Horrocks, M. H., Lleó, A., & Spires-Jones, T. L.
Venue
Neuron
Publisher
Elsevier BV
Published
2023-07
Volume
111
Issue
14
Pages
2170-2183.e6
ISSN
0896-6273
DOI
10.1016/j.neuron.2023.04.020
Cited by
224
References
22
Language
en
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