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CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
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“Recently, we published a genome-wide CRISPRi screen for regulators of tau oligomerization 33 , which identified many m 6 A-regulating proteins, suggesting that targeting m 6 A can have upstream causal effects on the levels and/or misfolding of tau.”
From Tau is an m 6 A-associated RNA binding protein that causes RNA dysregulation in disease (2026) · cites this paper as [33]
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Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy
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Self-citationTau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers
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NEDD8 and ubiquitin ligation by cullin-RING E3 ligases
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X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
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Evolutionarily conserved regulators of tau identify targets for new therapies
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Cited by
Mohl, G. A., Dixon, G., Marzette, E., McKetney, J., Samelson, A. J., Serras, C. P., Jin, J., Ariqat, N., Keys, A., Chavira, C., et al. (2026) · npj Dementia · doi:10.1038/s44400-026-00076-w · Cited by 5
Self-citationTau is an m 6 A-associated RNA binding protein that causes RNA dysregulation in disease
Dixon, G., Keys, A., Rothamel, K., McKetney, J., Jiang, Y. X., Gordon, L. A., Page, M. L., Liu, C., Hou, K., Flanagan, K., et al. (2026) · doi:10.64898/2026.10.26.762095
Self-citationHINN prioritizes multi-omics biomarkers associated with cognitive decline
Vashishath, Y., Beaver, S. A., Saeed, F., & Bozdag, S. (2026) · Bioinformatics · doi:10.1093/bioinformatics/btag741
Metadata
- Authors
- Samelson, A. J., Ariqat, N., McKetney, J., Rohanitazangi, G., Parra Bravo, C., Bose, R. S., Travaglini, K. J., Lam, V. L., Goodness, D., Ta, T., Dixon, G., Marzette, E., Jin, J., Tian, R., Tse, E., Abskharon, R., Pan, H. S., Carroll, E. C., Lawrence, R. E., Gestwicki, J. E., Rexach, J. E., Eisenberg, D. S., Kanaan, N. M., Southworth, D. R., Gross, J. D., Gan, L., Swaney, D. L., & Kampmann, M.
- ORCID
- Kampmann, Martin
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2026-03
- Volume
- 189
- Issue
- 5
- Pages
- 1517-1534.e19
- ISSN
- 0092-8674
- PMC
- PMC12978015
- Cited by
- 36
- References
- 27
- Language
- en
- Licence
- Funders
- Rainwater Charitable Foundation (F32 AG063487)
- The Chan Zuckerberg Initiative
- Howard Hughes Medical Institute (U54AI170792, 1R01AG075802, F32AG076281, R01AG085357, NIAU19AG060909)
- Tau Consortium (U24AG072458, U54NS100717, R01AG062359, U54NS123746, R01AG070895, R01AG082141)
- Alzheimer's Association
- National Institutes of Health
- National Institute on Aging (F32 AG063487, F32AG076281, K99 AG080116-01)
- National Institute of Neurological Disorders and Stroke
- National Institute of Allergy and Infectious Diseases
- BrightFocus Foundation
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