The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
TAFA4, a Chemokine-like Protein, Modulates Injury-Induced Mechanical and Chemical Pain Hypersensitivity in Mice
Open accessAbstract
C-low-threshold mechanoreceptors (C-LTMRs) are unique among C-unmyelinated primary sensory neurons. These neurons convey two opposite aspects of touch sensation: a sensation of pleasantness, and a sensation of injury-induced mechanical pain. Here, we show that TAFA4 is a specific marker of C-LTMRs. Genetic labeling in combination with electrophysiological recordings show that TAFA4+ neurons have intrinsic properties of mechano-nociceptors. TAFA4-null mice exhibit enhanced mechanical and chemical hypersensitivity following inflammation and nerve injury as well as increased excitability of spinal cord lamina IIi neurons, which could be reversed by intrathecal or bath application of recombinant TAFA4 protein. In wild-type C57/Bl6 mice, intrathecal administration of TAFA4 strongly reversed carrageenan-induced mechanical hypersensitivity, suggesting a potent analgesic role of TAFA4 in pain relief. Our data provide insights into how C-LTMR-derived TAFA4 modulates neuronal excitability and controls the threshold of somatic sensation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuronal circuitry for pain processing in the dorsal horn
Todd, A. J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2947 · Cited by 1,475
Coding of pleasant touch by unmyelinated afferents in humans
Löken, L. S., Wessberg, J., Morrison, I., McGlone, F., & Olausson, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2312 · Cited by 1,120
Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ
Malmberg, A. B., Chen, C., Tonegawa, S., & Basbaum, A. I. (1997) · Science · doi:10.1126/science.278.5336.279 · Cited by 690
Nociceptors: a phylogenetic view
Smith, E. S. J., & Lewin, G. R. (2009) · Journal of Comparative Physiology A · doi:10.1007/s00359-009-0482-z · Cited by 271
Mechanoreceptor activity from the human face and oral mucosa
Johansson, R. S., Trulsson, M., Olsson, K. Å., & Westberg, K. G. (1988) · Experimental Brain Research · doi:10.1007/bf00248518 · Cited by 256
Cited by
Discriminative and affective touch: Sensing and feeling.
McGlone, F., Wessberg, J., & Olausson, H. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.001 · Cited by 1,112
Neural circuits for pain: Recent advances and current views
Peirs, C., & Seal, R. P. (2016) · Science · doi:10.1126/science.aaf8933 · Cited by 478
Self-citationDorsal Horn Circuits for Persistent Mechanical Pain
Peirs, C., Williams, S.-P. G., Zhao, X., Walsh, C. E., Gedeon, J. Y., Cagle, N. E., Goldring, A. C., Hioki, H., Liu, Z., Marell, P. S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.029 · Cited by 327
Self-citationTouch neurons underlying dopaminergic pleasurable touch and sexual receptivity
Elias, L. J., Succi, I. K., Schaffler, M. D., Foster, W., Gradwell, M. A., Bohic, M., Fushiki, A., Upadhyay, A., Ejoh, L. L., Schwark, R., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.034 · Cited by 85
Transduction and encoding sensory information by skin mechanoreceptors
Hao, J., Bonnet, C., Amsalem, M., Ruel, J., & Delmas, P. (2015) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1651-7 · Cited by 71
Self-citation
Metadata
- Authors
- Delfini, M.-C., Mantilleri, A., Gaillard, S., Hao, J., Reynders, A., Malapert, P., Alonso, S., François, A., Barrere, C., Seal, R., Landry, M., Eschallier, A., Alloui, A., Bourinet, E., Delmas, P., Le Feuvre, Y., & Moqrich, A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 5
- Issue
- 2
- Pages
- 378-388
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2037755318
- Cited by
- 160
- References
- 5
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
