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Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

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Petitjean, Hugues, Pawlowski, Sophie Anne, Fraine, Steven Li, Sharif, Behrang, Hamad, Doulia, Fatima, Tarheen, Berg, Jim, Brown, Claire M., Jan, Lily-Yeh, Ribeiro-da-Silva, Alfredo, Braz, Joao M., Basbaum, Allan I., Sharif-Naeini, Reza·2015·Cell Reports

DOI 10.1016/j.celrep.2015.09.080PMC PMC6038918

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Abstract

Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and is characterized by spontaneous pain and mechanical hypersensitivity. Although loss of inhibitory tone in the dorsal horn of the spinal cord is a major contributor to neuropathic pain, the molecular and cellular mechanisms underlying this disinhibition are unclear. Here, we combined pharmacogenetic activation and selective ablation approaches in mice to define the contribution of spinal cord parvalbumin (PV)-expressing inhibitory interneurons in naive and neuropathic pain conditions. Ablating PV neurons in naive mice produce neuropathic pain-like mechanical allodynia via disinhibition of PKCγ excitatory interneurons. Conversely, activating PV neurons in nerve-injured mice alleviates mechanical hypersensitivity. These findings indicate that PV interneurons are modality-specific filters that gate mechanical but not thermal inputs to the dorsal horn and that increasing PV interneuron activity can ameliorate the mechanical hypersensitivity that develops following nerve injury.

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BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965
Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
Coull, J. A. M., Boudreau, D., Bachand, K., Prescott, S. A., Nault, F., Attila Gabor, S. I. K., Koninck, P. D., & Koninck, Y. D. (2003) · Nature · doi:10.1038/nature01868 · Cited by 1,118
Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors
Alexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 1,019
Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord
Moore, K. A., Kohno, T., Karchewski, L. A., Scholz, J., Baba, H., & Woolf, C. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06724.2002 · Cited by 859
Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
Ernfors, P., Lee, K., Kučera, J., & Jaenisch, R. (1994) · Cell · doi:10.1016/0092-8674(94)90213-5 · Cited by 813
Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ
Malmberg, A. B., Chen, C., Tonegawa, S., & Basbaum, A. I. (1997) · Science · doi:10.1126/science.278.5336.279 · Cited by 690
Self-citation
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Duan, B., Cheng, L., Bourane, S., Britz, O., Padilla, C., Garcia-Campmany, L., Krashes, M., Knowlton, W., Velasquez, T., Ren, X., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.003 · Cited by 582
The impact of neuropathic pain on health-related quality of life
Jensen, M. P., Chodroff, M. J., & Dworkin, R. H. (2007) · Neurology · doi:10.1212/01.wnl.0000259085.61898.9e · Cited by 575
Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells
Cavanaugh, D. J., Chesler, A. T., Jackson, A. C., Sigal, Y. M., Yamanaka, H., Grant, R., O'Donnell, D., Nicoll, R. A., Shah, N. M., Julius, D., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6451-10.2011 · Cited by 542
Self-citation
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Celio, M. R., & Heizmann, C. W. (1981) · Nature · doi:10.1038/293300a0 · Cited by 486
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Braz, J. M., Solórzano, C., Wang, X., & Basbaum, A. I. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.018 · Cited by 446
Self-citation
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Scholz, J., Broom, D. C., Youn, D. H., Mills, C. D., Kohno, T., Suter, M. R., Moore, K. A., Décosterd, I., Coggeshall, R. E., & Woolf, C. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-05.2005 · Cited by 437
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Lan, J.-Y., Skeberdis, V. A., Jover, T., Grooms, S. Y., Lin, Y., Araneda, R. C., Zheng, X., Bennett, M. V. L., & Zukin, R. S. (2001) · Nature Neuroscience · doi:10.1038/86028 · Cited by 421
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Stirpe, F., Barbieri, L. L., Battelli, M. G., Soria, M. R., & Lappi, D. A. (1992) · Nature Biotechnology · doi:10.1038/nbt0492-405 · Cited by 410
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Torsney, C., & MacDermott, A. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4584-05.2006 · Cited by 407
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Kardon, A. P., Polgár, E., Hachisuka, J., Snyder, L. M., Cameron, D., Savage, S., Cai, X., Karnup, S., Fan, C. R., Hemenway, G. M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.046 · Cited by 369
Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch
Foster, E., Wildner, H., Tudeau, L., Haueter, S., Ralvenius, W. T., Jegen, M., Johannssen, H. C., Hösli, L., Haenraets, K., Ghanem, A., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.028 · Cited by 366
Remote Control of Neuronal Signaling
Rogan, S. C., & Roth, B. L. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003020 · Cited by 339
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Peirs, C., Williams, S.-P. G., Zhao, X., Walsh, C. E., Gedeon, J. Y., Cagle, N. E., Goldring, A. C., Hioki, H., Liu, Z., Marell, P. S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.029 · Cited by 327
Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis
Shields, S. D., Eckert, W. A., & Basbaum, A. I. (2003) · Journal of Pain · doi:10.1067/s1526-5900(03)00781-8 · Cited by 322
Self-citation
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Lü, Y., Dong, H., Gao, Y., Gong, Y., Ren, Y., Gu, N., Zhou, S., Xia, N., Sun, Y., Ji, R., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70026 · Cited by 287
GABA decreases in the spinal cord dorsal horn after peripheral neurectomy
Castro‐Lopes, J. M., Tavares, I., & Coimbra, A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90167-l · Cited by 266
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Cavanaugh, D. J., Chesler, A. T., Braz, J. M., Shah, N. M., Julius, D. J., & Basbaum, A. I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1299-11.2011 · Cited by 263
Self-citation
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Miraucourt, L. S., Dallel, R., & Voisin, D. L. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001116 · Cited by 227
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Prescott, S. A., Ma, Q., & De Koninck, Y. (2014) · Nature Neuroscience · doi:10.1038/nn.3629 · Cited by 210
D5 Dopamine Receptors Enhance Zn2+-Sensitive GABAA Currents in Striatal Cholinergic Interneurons through a PKA/PP1 Cascade
Yan, Z., & Surmeier, D. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80402-x · Cited by 195
Subpopulations of gabaergic neurons in laminae i–iii of rat spinal dorsal horn defined by coexistence with classical transmitters, peptides, nitric oxide synthase or parvalbumin
Laing, I., Todd, A. J., Heizmann, C. W., & Schmidt, H. H. H. W. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90065-5 · Cited by 177
Innocuous, Not Noxious, Input Activates PKCγ Interneurons of the Spinal Dorsal Horn via Myelinated Afferent Fibers
Neumann, S., Braz, J. M., Skinner, K., Llewellyn‐Smith, I. J., & Basbaum, A. I. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1259-08.2008 · Cited by 175
Self-citation
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Polgár, E., Gray, S., Riddell, J. S., & Todd, A. J. (2004) · Pain · doi:10.1016/j.pain.2004.06.011 · Cited by 158
Calcium‐binding proteins, parvalbumin‐ and calbindin‐D 28k‐immunoreactive neurons in the rat spinal cord and dorsal root ganglia: A light and electron microscopic study
Antal, M., Freund, T. F., & Polgár, E. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902950310 · Cited by 156
Morphological, neurochemical and electrophysiological features of parvalbumin‐expressing cells: a likely source of axo‐axonic inputs in the mouse spinal dorsal horn
Hughes, D. I., Sikander, S., Kinnon, C. M., Boyle, K. A., Watanabe, M., Callister, R. J., & Graham, B. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235655 · Cited by 151
Release of BDNF and GABA in the dorsal horn of neuropathic rats
Lever, I. J., Cunningham, J. R., Grist, J., Yip, P. K., & Malcangio, M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02848.x · Cited by 145
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Dong, S., Rogan, S. C., & Roth, B. L. (2010) · Nature Protocols · doi:10.1038/nprot.2009.239 · Cited by 143
Different populations of parvalbumin‐ and calbindin‐D28k‐immunoreactive neurons contain GABA and accumulate 3 H‐D‐aspartate in the dorsal horn of the rat spinal cord
Antal, M., Polgár, E., Chalmers, J. P., Minson, J. B., Llewellyn‐Smith, I. J., Heizmann, C. W., & Somogyi, P. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903140111 · Cited by 140
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Cordero‐Erausquin, M., Coull, J. A. M., Boudreau, D., Rolland, M., & Koninck, Y. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1488-05.2005 · Cited by 125
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Miraucourt, L. S., Moisset, X., Dallel, R., & Voisin, D. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3923-08.2009 · Cited by 121
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Eggermann, E., & Jonas, P. (2012) · Nature Neuroscience · doi:10.1038/nn.3002 · Cited by 119
PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating
Lin, Y., Jover‐Mengual, T., Wong, J., Bennett, M. V. L., & Zukin, R. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609924104 · Cited by 118
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Zampieri, N., Jessell, T., & Murray, A. J. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.033 · Cited by 106
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Polgár, E., Sardella, T. C. P., Tiong, S. Y. X., Locke, S., Watanabe, M., & Todd, A. J. (2013) · Pain · doi:10.1016/j.pain.2013.05.001 · Cited by 96
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Polgár, E., & Todd, A. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.009 · Cited by 95
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Takazawa, T., & Macdermott, A. (2010) · Journal of Physiology · doi:10.1113/jphysiol.2010.188292 · Cited by 94
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Ng, T., Wong, J. H., & Wang, H. (2010) · Current Protein and Peptide Science · doi:10.2174/138920310790274662 · Cited by 76
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Bonin, R. P., & Koninck, Y. D. (2014) · Nature Neuroscience · doi:10.1038/nn.3758 · Cited by 72
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Leitner, J., Westerholz, S., Heinke, B., Forsthuber, L., Wunderbaldinger, G., Jäger, T., Gruber-Schoffnegger, D., Braun, K., & Sandkühler, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073370 · Cited by 68
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Tiong, S. Y., Polgár, E., van Kralingen, J. C., Watanabe, M., & Todd, A. J. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-36 · Cited by 66
Parvalbumin- and calbindin D28k-immunoreactive neurons in the superficial layers of the spinal cord dorsal horn of rat
Yamamoto, T., Carr, P. A., Baimbridge, K. G., & Nagy, J. I. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90195-0 · Cited by 63
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Hughes, D. I., Boyle, K. A., Kinnon, C. M., Bilsland, C., Quayle, J. A., Callister, R. J., & Graham, B. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.028 · Cited by 55
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Majdi, M., Ribeiro‐da‐Silva, A., & Cuello, A. C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05966.x · Cited by 42
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Peirs, C., Patil, S. S., Bouali‐Benazzouz, R., Artola, A., Landry, M., & Dallel, R. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23407 · Cited by 41
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Szabo, N. E., da Silva, R. V., Sotocinal, S. G., Zeilhofer, H. U., Mogil, J. S., & Kania, A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4690-14.2015 · Cited by 39
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Shumilla, J. A., Liron, T., Mochly-Rosen, D., Kendig, J. J., & Sweitzer, S. M. (2005) · The Journal of Pain · doi:10.1016/j.jpain.2005.03.005 · Cited by 38
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Franconville, R., Revet, G., Astorga, G., Schwaller, B., & Llano, I. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00133.2011 · Cited by 35
Control of Neuronal Excitability by Calcium Binding Proteins: A New Mathematical Model for Striatal Fast-Spiking Interneurons
Bischop, D. P., Orduz, D., Lambot, L., Schiffmann, S. N., & Gall, D. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00078 · Cited by 31
Protein kinase Cγ mediates ethanol withdrawal hyper‐responsiveness of NMDA receptor currents in spinal cord motor neurons
Li, H., Mochly‐Rosen, D., & Kendig, J. J. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706033 · Cited by 29
Neurochemical properties of enkephalinergic neurons in lumbar spinal dorsal horn revealed by preproenkephalin–green fluorescent protein transgenic mice
Huang, J. H., Chen, J., Wang, W., Wang, W., Koshimizu, Y., Wei, Y., Kaneko, T., Li, Y., & Wu, S. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06715.x · Cited by 27
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Authors: Petitjean, H., Pawlowski, S. A., Fraine, S. L., Sharif, B., Hamad, D., Fatima, T., Berg, J., Brown, C. M., Jan, L.-Y., Ribeiro-da-Silva, A., Braz, J. M., Basbaum, A. I., & Sharif-Naeini, R.
Affiliations: McGill University (CA)
Howard Hughes Medical Institute (US)
University of California, San Francisco (US)
ORCID: Petitjean, Hugues
Fraine, Steven Li
Sharif, Behrang
Hamad, Doulia
Berg, Jim
Brown, Claire M.
Jan, Lily-Yeh
Braz, Joao M.
Basbaum, Allan I.
Venue: Cell Reports
Publisher: Elsevier BV
Published: 2015-11
Volume: 13
Issue: 6
Pages: 1246-1257
ISSN: 2211-1247 (ISSN-L)
DOI: 10.1016/j.celrep.2015.09.080
PMC: PMC6038918
OpenAlex: W2132809690
Cited by: 326
References: 58
Citations by year: 2026: 28 · 2025: 14 · 2024: 22 · 2023: 41 · 2022: 38 · 2021: 34 · 2020: 42 · 2019: 38 · 2018: 28 · 2017: 23 · 2016: 18
FWCI: 16.94
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Cell Reports (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion, cc-by-nc-nd)
PubMed Central (acceptedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
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eScholarship (California Digital Library) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Funders: Wellcome Trust (102645, 102645/Z/13/Z)
Canadian Institutes of Health Research (MOP79411)
National Institute on Drug Abuse (R01DA029204, R01DA29204)
National Institute of Neurological Disorders and Stroke (R01NS069229, R37NS14627, R01NS014627, R37NS014627)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: neuropathic pain, parvalbumin interneurons, dorsal horn, spinal cord, disinhibition, mechanical allodynia, mechanical hypersensitivity, nerve injury, inhibitory interneurons, neuronal ablation
MeSH terms: Animals, Cells, Cultured, Hyperalgesia, Interneurons, Neuralgia, Parvalbumins, Protein Kinase C, Synapses, Touch, Mice, Spinal Cord Dorsal Horn

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Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

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