How the 'slow' Ca2+ buffer parvalbumin affects transmitter release in nanodomain-coupling regimes
Open accessAbstract
Parvalbumin is thought to act in a manner similar to EGTA, but how a slow Ca(2+) buffer affects nanodomain-coupling regimes at GABAergic synapses is unclear. Direct measurements of parvalbumin concentration and paired recordings in rodent hippocampus and cerebellum revealed that parvalbumin affects synaptic dynamics only when expressed at high levels. Modeling suggests that, in high concentrations, parvalbumin may exert BAPTA-like effects, modulating nanodomain coupling via competition with local saturation of endogenous fixed buffers.
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Parvalbumin is a low-affinity calcium buffer that likely regulates neurotransmitter release.
“PV is a low-affinity calcium buffer that likely regulates neurotransmitter release (Eggermann and Jonas, 2012).”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Eggermann and Jonas, 2012
The demonstration that PV levels are decreased may indicate a shift in the E/I balance towards increased inhibition, taking into account the proven role of PV in synaptic transmission.
“In addition, the demonstration that PV levels are decreased may indicate a shift in the E/I balance towards an increased inhibition, taking into account the proven role of PV in synaptic transmission [52, 53, 55, 97, 98].”
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- Authors
- Eggermann, E., & Jonas, P.
- Affiliations
- University of Freiburg (DE)
- Venue
- Nature Neuroscience
- Published
- 2011-12-04
- Volume
- 15
- Issue
- 1
- Pages
- 20-22
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3631701
- OpenAlex
- W1976369723
- Cited by
- 119
- References
- 15
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 9 · 2020: 15 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 16 · 2014: 16 · 2013: 13 · 2012: 5
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- parvalbumin, calcium buffering, synaptic transmission, GABAergic synapses, hippocampus, cerebellum, paired recordings, EGTA, BAPTA, synaptic dynamics
- MeSH terms
- Animals, Cerebellum, gamma-Aminobutyric Acid, Hippocampus, Interneurons, Synaptic Transmission, Parvalbumins, Synapses, Rats, Inhibitory Postsynaptic Potentials
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