Cited by 119Neuroscience and Neuropharmacology ResearchIon channel regulation and functionNeural dynamics and brain function

How the 'slow' Ca2+ buffer parvalbumin affects transmitter release in nanodomain-coupling regimes

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Eggermann, Emmanuel, Jonas, Peter·2012·Nature Neuroscience

Abstract

Parvalbumin is thought to act in a manner similar to EGTA, but how a slow Ca(2+) buffer affects nanodomain-coupling regimes at GABAergic synapses is unclear. Direct measurements of parvalbumin concentration and paired recordings in rodent hippocampus and cerebellum revealed that parvalbumin affects synaptic dynamics only when expressed at high levels. Modeling suggests that, in high concentrations, parvalbumin may exert BAPTA-like effects, modulating nanodomain coupling via competition with local saturation of endogenous fixed buffers.

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Authors
Eggermann, E., & Jonas, P.
Affiliations
University of Freiburg (DE)
Venue
Nature Neuroscience
Published
2011-12-04
Volume
15
Issue
1
Pages
20-22
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1976369723
Cited by
119
References
15
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 9 · 2020: 15 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 16 · 2014: 16 · 2013: 13 · 2012: 5
FWCI
4.77
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
parvalbumin, calcium buffering, synaptic transmission, GABAergic synapses, hippocampus, cerebellum, paired recordings, EGTA, BAPTA, synaptic dynamics
MeSH terms
Animals, Cerebellum, gamma-Aminobutyric Acid, Hippocampus, Interneurons, Synaptic Transmission, Parvalbumins, Synapses, Rats, Inhibitory Postsynaptic Potentials

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