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The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction
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“Specifically, mice with the p53 R72 variant developed islet hypertrophy, insulin resistance, and fatty liver disease.274”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [274]
In the citing paper
“In a humanized mouse model with p53 codon 72 variants fed a high-fat diet (HFD), mice with the p53 R72 variant exhibited more severe glucose intolerance and obesity than did mice with the p53 P72 variant.”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [274]
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Citations
Cites
The first 30 years of p53: growing ever more complex.
Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
Maddocks, O. D. K., Berkers, C. R., Mason, S. M., Zheng, L., Blyth, K., Gottlieb, E., & Vousden, K. H. (2013) · Nature · doi:10.1038/nature11743 · Cited by 1,007
Vousden, K. H., & Ryan, K. M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2715 · Cited by 959
Inflammasome is a central player in the induction of obesity and insulin resistance
Stienstra, R., van Diepen, J. A., Tack, C. J., Zaki, M. H., van de Veerdonk, F. L., Perera, D., Neale, G. A., Hooiveld, G. J., Hijmans, A., Vroegrijk, I., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100255108 · Cited by 727
Regulation of MCP-1 chemokine transcription by p53
Hacke, K., Rincon-Orozco, B., Buchwalter, G., Siehler, S. Y., Wasylyk, B., Wiesmüller, L., & Rösl, F. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-82 · Cited by 63
Tavana, O., Puebla-Osorio, N., Sang, M., & Zhu, C. (2010) · Diabetes · doi:10.2337/db09-0792 · Cited by 58
Research works printed but not linked: 53
- Abecasis, 2012, An integrated map of genetic variation from 1,092 human genomes, Nature, 491, 56, 10.1038/nature11632 · DOI · Paper page
- Antohe, 2012, Diabetes mellitus risk in rheumatoid arthritis: reduced incidence with anti-tumor necrosis factor α therapy, Arthritis Care Res. (Hoboken), 64, 215, 10.1002/acr.20657 · DOI
- Aravinthan, 2013, Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease, J. Hepatol., 58, 549, 10.1016/j.jhep.2012.10.031 · DOI · Paper page
- Azzam, 2013, CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest, PLoS ONE, 8, e74297, 10.1371/journal.pone.0074297 · DOI
- Bechmann, 2010, Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis, Liver Int., 30, 850, 10.1111/j.1478-3231.2010.02248.x · DOI
- Beckman, 1994, Is p53 polymorphism maintained by natural selection?, Hum. Hered., 44, 266, 10.1159/000154228 · DOI · Paper page
- Bergamaschi, 2006, iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53, Nat. Genet., 38, 1133, 10.1038/ng1879 · DOI · Paper page
- Burgdorf, 2011, Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans, PLoS ONE, 6, e15813, 10.1371/journal.pone.0015813 · DOI
- Carr, 2013, Temporal effects of ethanol consumption on energy homeostasis, hepatic steatosis, and insulin sensitivity in mice, Alcohol. Clin. Exp. Res., 37, 1091, 10.1111/acer.12075 · DOI
- Chang, 2012, Role of p53 in neurodegenerative diseases, Neurodegener. Dis., 9, 68, 10.1159/000329999 · DOI · Paper page
- Chen, 2015, Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL, Tumour Biol., 36, 4913, 10.1007/s13277-015-3602-0 · doi:10.1007/s13277-015-3602-0
- Danilova, 2008, p53 family in development, Mech. Dev., 125, 919, 10.1016/j.mod.2008.09.003 · DOI
- De Iuliis, 2015, Are pharmacogenomic biomarkers an effective tool to predict taxane toxicity and outcome in breast cancer patients? Literature review, Cancer Chemother. Pharmacol., 76, 679, 10.1007/s00280-015-2818-4 · DOI
- Dumont, 2003, The codon 72 polymorphic variants of p53 have markedly different apoptotic potential, Nat. Genet., 33, 357, 10.1038/ng1093 · DOI · Paper page
- Firneisz, 2014, Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?, World J. Gastroenterol., 20, 9072
- Frank, 2011, The codon 72 polymorphism of p53 regulates interaction with NF-kappaB and transactivation of genes involved in immunity and inflammation, Mol. Cell. Biol., 31, 1201, 10.1128/MCB.01136-10 · DOI
- Gaulton, 2008, Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes, Diabetes, 57, 3136, 10.2337/db07-1731 · DOI
- Gloria-Bottini, 2011, Is there a role of p53 codon 72 polymorphism in the susceptibility to type 2 diabetes in overweight subjects? A study in patients with cardiovascular diseases, Diabetes Res. Clin. Pract., 91, e64, 10.1016/j.diabres.2010.11.031 · doi:10.1016/j.diabres.2010.11.031
- Goldstein, 2012, Regulation of lipid metabolism by p53 - fighting two villains with one sword, Trends Endocrinol. Metab., 23, 567, 10.1016/j.tem.2012.06.007 · DOI
- Gruben, 2014, Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison?, Biochim. Biophys. Acta, 1842, 2329, 10.1016/j.bbadis.2014.08.004 · DOI
- Haukeland, 2006, Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2, J. Hepatol., 44, 1167, 10.1016/j.jhep.2006.02.011 · DOI · Paper page
- Kang, 2009, Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans, Proc. Natl. Acad. Sci. USA, 106, 9761, 10.1073/pnas.0904280106 · DOI · Paper page
- Khan, 2011, Maximum likelihood analysis of mammalian p53 indicates the presence of positively selected sites and higher tumorigenic mutations in purifying sites, Gene, 483, 29, 10.1016/j.gene.2011.05.011 · DOI
- Kung, 2015, Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes, Mol. Cancer Res., 13, 250, 10.1158/1541-7786.MCR-14-0385 · DOI
- Levine, 2011, The p53 family: guardians of maternal reproduction, Nat. Rev. Mol. Cell Biol., 12, 259, 10.1038/nrm3086 · DOI · Paper page
- Li, 2012, Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence, Cell, 149, 1269, 10.1016/j.cell.2012.04.026 · DOI · Paper page
- Liang, 2013, The regulation of cellular metabolism by tumor suppressor p53, Cell Biosci., 3, 9, 10.1186/2045-3701-3-9 · DOI
- Long, 2013, Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53, Mol. Cell, 50, 394, 10.1016/j.molcel.2013.03.016 · DOI
- Luo, 2001, Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool, Oncogene, 20, 320, 10.1038/sj.onc.1204080 · DOI
- Menendez, 2013, Interactions between the tumor suppressor p53 and immune responses, Curr. Opin. Oncol., 25, 85, 10.1097/CCO.0b013e32835b6386 · DOI
- Minamino, 2009, A crucial role for adipose tissue p53 in the regulation of insulin resistance, Nat. Med., 15, 1082, 10.1038/nm.2014 · DOI · Paper page
- Molchadsky, 2013, p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity, Cell Death Differ., 20, 774, 10.1038/cdd.2013.9 · DOI · Paper page
- Nomura, 2009, Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance, Am. J. Physiol. Endocrinol. Metab., 297, E1030, 10.1152/ajpendo.00343.2009 · DOI
- Ortega, 2014, Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression, Int. J. Obes., 38, 737, 10.1038/ijo.2013.163 · DOI
- Ota, 2013, Chemokine systems link obesity to insulin resistance, Diabetes Metab. J., 37, 165, 10.4093/dmj.2013.37.3.165 · DOI
- Park, 2013, Intestinal and hepatic niemann-pick c1-like 1, Diabetes Metab. J., 37, 240, 10.4093/dmj.2013.37.4.240 · DOI
- Park, 2014, Obesity and cancer--mechanisms underlying tumour progression and recurrence, Nat. Rev. Endocrinol., 10, 455, 10.1038/nrendo.2014.94 · DOI · Paper page
- Pim, 2004, p53 polymorphic variants at codon 72 exert different effects on cell cycle progression, Int. J. Cancer, 108, 196, 10.1002/ijc.11548 · DOI · Paper page
- Poyurovsky, 2010, P53 and aging: A fresh look at an old paradigm, Aging (Albany, N.Y.), 2, 380
- Puente, 2006, Comparative analysis of cancer genes in the human and chimpanzee genomes, BMC Genomics, 7, 15, 10.1186/1471-2164-7-15 · DOI
- Reiling, 2012, Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time, Eur. J. Hum. Genet., 20, 696, 10.1038/ejhg.2011.240 · DOI
- Reiling, 2014, Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition, Sci. Rep., 4, 4091, 10.1038/srep04091 · doi:10.1038/srep04091
- Sano, 2007, p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload, Nature, 446, 444, 10.1038/nature05602 · DOI · Paper page
- Sellayah, 2014, On the evolutionary origins of obesity: a new hypothesis, Endocrinology, 155, 1573, 10.1210/en.2013-2103 · DOI
- She, 2000, Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism, Mol. Cell. Biol., 20, 6508, 10.1128/MCB.20.17.6508-6517.2000 · doi:10.1128/mcb.20.17.6508-6517.2000 · Paper page
- Shi, 2009, Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia, Am. J. Hum. Genet., 84, 534, 10.1016/j.ajhg.2009.03.009 · DOI
- Speliotes, 2010, Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index, Nat. Genet., 42, 937, 10.1038/ng.686 · DOI · Paper page
- Sucheston, 2011, Natural selection and functional genetic variation in the p53 pathway, Hum. Mol. Genet., 20, 1502, 10.1093/hmg/ddr028 · DOI
- Thomas, 1999, Two polymorphic variants of wild-type p53 differ biochemically and biologically, Mol. Cell. Biol., 19, 1092, 10.1128/MCB.19.2.1092 · DOI · Paper page
- Tomita, 2012, p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice, J. Hepatol., 57, 837, 10.1016/j.jhep.2012.05.013 · DOI · Paper page
- Wang, 2005, Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men, Am. J. Clin. Nutr., 81, 555, 10.1093/ajcn/81.3.555 · DOI · Paper page
- Whibley, 2009, p53 polymorphisms: cancer implications, Nat. Rev. Cancer, 9, 95, 10.1038/nrc2584 · DOI · Paper page
- Zhang, 2014, Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion, Proc. Natl. Acad. Sci. USA, 111, 10684, 10.1073/pnas.1411026111 · DOI · Paper page
Cited by
Lacroix, M., Riscal, R., Arena, G., Linares, L. K., & Le Cam, L. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.10.002 · Cited by 373
p53: from understanding its structure to advances in therapeutic targeting
Wang, W., Liu, X., Liu, H., Abolhassani, H., Yan, H., Zhang, H., & Wang, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02549-5 · Cited by 30
Metadata
- Authors
- Kung, C.-P., Leu, J. I.-J., Basu, S., Khaku, S., Anokye-Danso, F., Liu, Q., George, D. L., Ahima, R. S., & Murphy, M. E.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 14
- Issue
- 10
- Pages
- 2413-2425
- ISSN
- 2211-1247
- Cited by
- 106
- References
- 6
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
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- Kung, C.-P., Leu, J. I.-J., Basu, S., Khaku, S., Anokye-Danso, F., Liu, Q., George, D. L., Ahima, R. S., & Murphy, M. E. (2016). The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction. Cell Reports. https://doi.org/10.1016/j.celrep.2016.02.037
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