Cited by 172Mitochondrial Function and PathologyAutophagy in Disease and TherapyCell death mechanisms and regulation

Power Grid Protection of the Muscle Mitochondrial Reticulum

Open access
Glancy, Brian, Hartnell, Lisa M., Combs, Christian A., Femnou, Armel, Sun, Junhui, Murphy, Elizabeth, Subramaniam, Sriram, Balaban, Robert S.·2017·Cell Reports

Abstract

Mitochondrial network connectivity enables rapid communication and distribution of potential energy throughout the cell. However, this connectivity puts the energy conversion system at risk, because damaged elements could jeopardize the entire network. Here, we demonstrate the mechanisms for mitochondrial network protection in heart and skeletal muscle (SKM). We find that the cardiac mitochondrial reticulum is segmented into subnetworks comprising many mitochondria linked through abundant contact sites at highly specific intermitochondrial junctions (IMJs). In both cardiac and SKM subnetworks, a rapid electrical and physical separation of malfunctioning mitochondria occurs, consistent with detachment of IMJs and retraction of elongated mitochondria into condensed structures. Regional mitochondrial subnetworks limit the cellular impact of local dysfunction while the dynamic disconnection of damaged mitochondria allows the remaining mitochondria to resume normal function within seconds. Thus, mitochondrial network security is comprised of both proactive and reactive mechanisms in striated muscle cells.

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Authors
Glancy, B., Hartnell, L. M., Combs, C. A., Femnou, A., Sun, J., Murphy, E., Subramaniam, S., & Balaban, R. S.
Affiliations
National Institutes of Health (US)
Corresponding author
Glancy, Brian
Venue
Cell Reports
Publisher
Elsevier BV
Published
2017-04
Volume
19
Issue
3
Pages
487-496
ISSN
2211-1247 (ISSN-L)
OpenAlex
W2606122737
Cited by
172
References
32
Citations by year
2026: 6 · 2025: 14 · 2024: 10 · 2023: 19 · 2022: 21 · 2021: 31 · 2020: 24 · 2019: 27 · 2018: 18 · 2017: 2
FWCI
7.93
Type
journal article
Language
en
Update notices
erratum (2018-05-29)
Open access
Locations
  • Cell Reports (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • PubMed Central (acceptedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • DIR NHLBI (1ZIAHL004610-09)
  • CCR, NCI (1ZIABC010278-19)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
mitochondrial reticulum, mitochondrial contact sites, mitochondrial dysfunction, myocardium, skeletal muscle, mitochondrial segregation, striated muscle cells, energy conversion
MeSH terms
Animals, Energy Metabolism, Male, Mice, Inbred C57BL, Mitochondria, Heart, Mitochondria, Muscle, Membrane Potential, Mitochondrial

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