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The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes

Wei, Jian, Zhang, Ying-Yu, Luo, Jie, Wang, Ju-Qiong, Zhou, Yu-Xia, Miao, Hong-Hua, Shi, Xiong-Jie, Qu, Yu-Xiu, Xu, Jie, Li, Bo-Liang, Song, Bao-Liang·2017·Cell Reports
DOI 10.1016/j.celrep.2017.06.012
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  • Defective lysosomal homeostasis in the absence of POST1 causes massive accumulation of cholesterol and LBPA in the cell.

    “Defective lysosomal homeostasis in the absence of POST1 eventually caused massive accumulation of cholesterol and lyso-bis-phosphatidic acid (LBPA) in the cell (Fig. 6G and 6H), since lysosomal proteins such as NPC2 need M6P modification for lysosomal targeting (Wei et al., 2017).”

    From POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation (2021) · cites this paper as Wei et al., 2017

  • Lysosomal proteins such as NPC2 need M6P modification for lysosomal targeting.

    “since lysosomal proteins such as NPC2 need M6P modification for lysosomal targeting (Wei et al., 2017).”

    From POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation (2021) · cites this paper as Wei et al., 2017

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Cited by

Sorted by citations

Metadata

Authors
Wei, J., Zhang, Y.-Y., Luo, J., Wang, J.-Q., Zhou, Y.-X., Miao, H.-H., Shi, X.-J., Qu, Y.-X., Xu, J., Li, B.-L., & Song, B.-L.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2017-06
Volume
19
Issue
13
Pages
2823-2835
ISSN
2211-1247
DOI
10.1016/j.celrep.2017.06.012
Cited by
56
References
1
Language
en
Licence
Funders
  • Ministry of Science and Technology of the People's Republic of China (2016YFA0500100)
  • China Postdoctoral Science Foundation (2016M592380)
  • Natural Science Foundation of Hubei Province (2016CFA012)
  • Ministry of Education of the People's Republic of China (B16036)
  • National Natural Science Foundation of China (31230020, 31430044, 31600651, 31601147, 31690102)

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