ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE

Chang, T. Y.; Chang, Catherine C. Y.; Cheng, Dong

doi:10.1146/annurev.biochem.66.1.613

Cited by 440

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ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE

Chang, T. Y., Chang, Catherine C. Y., Cheng, Dong·1997·Annual Review of Biochemistry

DOI 10.1146/annurev.biochem.66.1.613

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Abstract

Due to its presumed role in regulating cellular cholesterol homeostasis, and in various pathophysiological conditions, acyl-coenzyme A:cholesterol acyltransferase (ACAT) has attracted much attention. Cloning the ACAT gene provides the necessary tool to advance molecular studies of this enzyme. The topics reviewed in this chapter include the pathophysiological roles of ACAT, the biochemistry and molecular biology of the ACAT protein and the ACAT gene, and the mode of regulation by sterol or nonsterol agents in mammalian cells. In addition, we present a working model linking the presumed allosteric property of ACAT with cholesterol trafficking into and out of the endoplasmic reticulum.

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Authors: Chang, T. Y., Chang, C. C. Y., & Cheng, D.
Affiliations: Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 1997-06
Volume: 66
Issue: 1
Pages: 613-638
ISSN: 0066-4154
1545-4509
DOI: 10.1146/annurev.biochem.66.1.613
Cited by: 440
References: 6
Language: en

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ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE

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