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RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss
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Mice with partial deficiencies in both OCN and GPR158 (Ocn+/−Gpr158+/−) exhibit age-related cognitive impairment, whereas mice with a partial deficiency in either Ocn or Gpr158 alone do not display such cognitive deficits.
“These observations are further supported by genetic evidence showing that mice with partial deficiencies in both OCN and GPR158 (Ocn+/−Gpr158+/−) exhibit age-related cognitive impairment, whereas mice with a partial deficiency in either Ocn (Ocn+/−) or Gpr158 (Gpr158+/−) alone do not display such cognitive deficits37–39.”
From MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity (2025) · cites this paper as [38]
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Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
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Self-citationMaternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions
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Self-citationHuman umbilical cord plasma proteins revitalize hippocampal function in aged mice
Castellano, J. M., Mosher, K. I., Abbey, R. J., McBride, A. A., James, M. L., Berdnik, D., Shen, J. C., Zou, B., Xie, X. S., Tingle, M., et al. (2017) · Nature · doi:10.1038/nature22067 · Cited by 445
Gpr158 mediates osteocalcin’s regulation of cognition
Khrimian, L., Obri, A., Ramos-Brossier, M., Rousseaud, A., Moriceau, S., Nicot, A.-S., Mera, P., Kosmidis, S., Karnavas, T., Saudou, F., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171320 · Cited by 308
Self-citationMolecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48
Pavlopoulos, E., Jones, S., Kosmidis, S., Close, M., Kim, C., Kovalerchik, O., Small, S. A., & Kandel, E. R. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006373 · Cited by 109 · cited 8×
“Since we have previously found an involvement of both RbAp48 and OCN proteins in age-related memory loss (Khrimian et al., 2017; Pavlopoulos et al., 2013), we wondered whether activation of OCN/GPR158 pathway can elevate RbAp48 levels in middle-aged animals and rescue any age-associated deficits in discrimination memo…”
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Metadata
- Authors
- Kosmidis, S., Polyzos, A., Harvey, L., Youssef, M., Denny, C. A., Dranovsky, A., & Kandel, E. R.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 25
- Issue
- 4
- Pages
- 959-973.e6
- ISSN
- 2211-1247
- PMC
- PMC7725275
- Cited by
- 74
- References
- 9
- Language
- en
- Licence
- Funders
- Howard Hughes Medical Institute
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