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Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors
Open accessAbstract
The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify aberrant DNA methylation and associated cis-transcriptional changes across >6,000 human tumors. Tumors exhibiting mutations of chromatin remodeling factors and Wnt signaling displayed DNA methylation instability, characterized by numerous hyper- and hypo-methylated loci. Most silenced and enhanced genes coalesced in specific pathways including apoptosis, DNA repair, and cell metabolism. Cancer-germline antigens (CG) were frequently epigenomically enhanced and their expression correlated with response to anti-PD-1, but not anti-CTLA4, in skin melanoma. Finally, we demonstrated the potential of our approach to explore DNA methylation changes in pediatric tumors, which frequently lack genetic drivers and exhibit epigenomic modifications. Our results provide a pan-cancer map of aberrant DNA methylation to inform functional and therapeutic studies.
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Cites
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F., Ben Miled, S., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,803
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
Comprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499
Integrated genomic analyses of ovarian carcinoma
Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,925
Comprehensive molecular characterization of gastric adenocarcinoma
The Cancer Genome Atlas Research Network (2014) · Nature · doi:10.1038/nature13480 · Cited by 6,498
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061
Integrated genomic characterization of endometrial carcinoma
The Cancer Genome Atlas Research Network, & Levine, D. A. (2013) · Nature · doi:10.1038/nature12113 · Cited by 5,784
Mutational heterogeneity in cancer and the search for new cancer-associated genes
Lawrence, M. S., Stojanov, P., Polak, P., Kryukov, G. V., Cibulskis, K., Sivachenko, A., Carter, S. L., Stewart, C., Mermel, C. H., Roberts, S. A., et al. (2013) · Nature · doi:10.1038/nature12213 · Cited by 5,461
Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
xCell: digitally portraying the tissue cellular heterogeneity landscape
Aran, D., Hu, Z., & Butte, A. J. (2017) · Genome Biology · doi:10.1186/s13059-017-1349-1 · Cited by 4,397
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017
Comprehensive genomic characterization of squamous cell lung cancers
The Cancer Genome Atlas Research Network (2012) · Nature · doi:10.1038/nature11404 · Cited by 3,994
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
Barbie, D. A., Tamayo, P., Boehm, J. S., Kim, S. Y., Moody, S. E., Dunn, I. F., Schinzel, A. C., Sandy, P., Meylan, E., Scholl, C., et al. (2009) · Nature · doi:10.1038/nature08460 · Cited by 3,890
Esteller, M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra072067 · Cited by 3,662
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
Hugo, W., Zaretsky, J. M., Sun, L., Song, C., Moreno, B. H., Hu-Lieskovan, S., Berent-Maoz, B., Pang, J., Chmielowski, B., Cherry, G., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.065 · Cited by 3,448
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W. K., Luna, A., La, K. C., Dimitriadoy, S., Liu, D. L., Kantheti, H. S., Saghafinia, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.035 · Cited by 3,201
Self-citationGenomic classification of cutaneous melanoma
Akbani, R., Akdemir, K. C., Aksoy, B. A., Albert, M., Ally, A., Amin, S. B., Arachchi, H., Arora, A., Auman, J. T., Ayala, B., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.044 · Cited by 3,151
Self-citationComprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
The Cancer Genome Atlas Research Network (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1402121 · Cited by 3,148
DNA methylation-based classification of central nervous system tumours
Capper, D., Jones, D. T. W., Sill, M., Hovestadt, V., Schrimpf, D., Sturm, D., Koelsche, C., Sahm, F., Chavez, L., Reuss, D. E., et al. (2018) · Nature · doi:10.1038/nature26000 · Cited by 3,033
Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
A decade of exploring the cancer epigenome—biological and translational implications
Baylin, S. B., & Jones, P. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3130 · Cited by 2,871
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
Van Allen, E. M., Miao, D., Schilling, B., Shukla, S. A., Blank, C., Zimmer, L., Sucker, A., Hillen, U., Geukes Foppen, M. H., Goldinger, S. M., et al. (2015) · Science · doi:10.1126/science.aad0095 · Cited by 2,839
CpG island methylator phenotype in colorectal cancer
Toyota, M., Ahuja, N., Ohe-Toyota, M., Herman, J. G., Baylin, S. B., & Issa, J.-P. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8681 · Cited by 2,523
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
Noushmehr, H., Weisenberger, D. J., Diefes, K., Phillips, H. S., Pujara, K., Berman, B. P., Pan, F., Pelloski, C. E., Sulman, E. P., Bhat, K. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.017 · Cited by 2,337
Comprehensive Characterization of Cancer Driver Genes and Mutations
Bailey, M. H., Tokheim, C., Porta-Pardo, E., Sengupta, S., Bertrand, D., Weerasinghe, A., Colaprico, A., Wendl, M. C., Kim, J., Reardon, B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.060 · Cited by 2,256
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Malta, T. M., Sokolov, A., Gentles, A. J., Burzykowski, T., Poisson, L., Weinstein, J. N., Kamińska, B., Huelsken, J., Omberg, L., Gevaert, O., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.034 · Cited by 2,180
A Landscape of Pharmacogenomic Interactions in Cancer
Iorio, F., Knijnenburg, T. A., Vis, D. J., Bignell, G. R., Menden, M. P., Schubert, M., Aben, N., Gonçalves, E., Barthorpe, S., Lightfoot, H., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.017 · Cited by 2,090
Absolute quantification of somatic DNA alterations in human cancer
Carter, S. L., Cibulskis, K., Helman, E., McKenna, A., Shen, H., Zack, T., Laird, P. W., Onofrio, R. C., Winckler, W., Weir, B. A., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2203 · Cited by 2,053
A promoter-level mammalian expression atlas
The FANTOM Consortium and the RIKEN PMI and CLST (DGT) (2014) · Nature · doi:10.1038/nature13182 · Cited by 1,982
Cancer/testis antigens, gametogenesis and cancer
Simpson, A. J. G., Caballero, O. L., Jungbluth, A., Chen, Y.-T., & Old, L. J. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1669 · Cited by 1,582
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
Herman, J. G., Latif, F., Weng, Y., Lerman, M. I., Zbar, B., Liu, S., Samid, D., Duan, D. S., Gnarra, J. R., & Linehan, W. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9700 · Cited by 1,529
Induction of tumors in mice by genomic hypomethylation
Gaudet, F., Hodgson, J. G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J. W., Leonhardt, H., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083558 · Cited by 1,499 · cited 1×
“…a recently proposed stemness signature based on hypo-methylation of specific loci (Malta et al., 2018) and with the extent of chromosomal alterations in lung, prostate, stomach, and uterine carcinoma, supporting a link between DNA hypo-methylation and chromosomal instability (Gaudet et al., 2003).”
Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data
Racle, J., de Jonge, K., Baumgaertner, P., Speiser, D. E., & Gfeller, D. (2017) · eLife · doi:10.7554/elife.26476 · Cited by 1,384
Organization and function of the 3D genome
Bonev, B., & Cavalli, G. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.112 · Cited by 1,174
Charting histone modifications and the functional organization of mammalian genomes
Zhou, V. W., Goren, A., & Bernstein, B. E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2905 · Cited by 1,147
Epigenetic stem cell signature in cancer
Widschwendter, M., Fiegl, H., Egle, D., Mueller-Holzner, E., Spizzo, G., Marth, C., Weisenberger, D. J., Campan, M., Young, J., Jacobs, I., et al. (2007) · Nature Genetics · doi:10.1038/ng1941 · Cited by 1,143
CpG island methylator phenotype in cancer
Issa, J.-P. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1507 · Cited by 1,098
Dna Hypomethylation In Cancer Cells
Ehrlich, M. (2009) · Epigenomics · doi:10.2217/epi.09.33 · Cited by 1,060
Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution
Long, H. K., Prescott, S. L., & Wysocka, J. (2016) · Cell · doi:10.1016/j.cell.2016.09.018 · Cited by 945
Interplay between the Cancer Genome and Epigenome
Shen, H., & Laird, P. W. (2013) · Cell · doi:10.1016/j.cell.2013.03.008 · Cited by 910
Degli-Esposti, M. A., Dougall, W. C., Smolak, P. J., Waugh, J. Y., Smith, C. A., & Goodwin, R. G. (1997) · Immunity · doi:10.1016/s1074-7613(00)80399-4 · Cited by 821
DNA Methylation in Cancer and Aging
Klutstein, M., Nejman, D., Greenfield, R., & Cedar, H. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3278 · Cited by 810
MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
Weller, M., Stupp, R., Reifenberger, G., Brandes, A. A., van den Bent, M. J., Wick, W., & Hegi, M. E. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.197 · Cited by 778
Epigenetic gene silencing in cancer: the DNA hypermethylome
Esteller, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm018 · Cited by 725 · cited 6×
“, 2015), and (2) identification of mRNA silencing of genes of interest by hyper-methylation (Esteller, 2007; Cancer Genome Atlas Research Network, 2012).”
InfluentialEpigenetic reprogramming in cancer
Suvà, M. L., Riggi, N., & Bernstein, B. E. (2013) · Science · doi:10.1126/science.1230184 · Cited by 706
Self-citationMetabolic Regulation of Epigenetics
Lu, C., & Thompson, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.001 · Cited by 699
The NAD metabolome — a key determinant of cancer cell biology
Chiarugi, A., Dölle, C., Felici, R., & Ziegler, M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3340 · Cited by 639
Genome-scale analysis of aberrant DNA methylation in colorectal cancer
Hinoue, T., Weisenberger, D. J., Lange, C. P. E., Shen, H., Byun, H.-M., Van Den Berg, D., Malik, S., Pan, F., Noushmehr, H., van Dijk, C. M., et al. (2012) · Genome Research · doi:10.1101/gr.117523.110 · Cited by 601
Challa-Malladi, M., Lieu, Y. K., Califano, O., Holmes, A. B., Bhagat, G., Murty, V. V., Dominguez-Sola, D., Pasqualucci, L., & Dalla-Favera, R. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.11.006 · Cited by 439
CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens
Almeida, L. G., Sakabe, N. J., deOliveira, A. R., Silva, M. C. C., Mundstein, A. S., Cohen, T., Chen, Y.-T., Chua, R., Gurung, S., Gnjatic, S., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn673 · Cited by 433
Pencheva, N., Tran, H., Buss, C., Huh, D., Drobnjak, M., Busam, K., & Tavazoie, S. F. (2012) · Cell · doi:10.1016/j.cell.2012.10.028 · Cited by 415
Stevanović, S., Pasetto, A., Helman, S. R., Gartner, J. J., Prickett, T. D., Howie, B., Robins, H. S., Robbins, P. F., Klebanoff, C. A., Rosenberg, S. A., et al. (2017) · Science · doi:10.1126/science.aak9510 · Cited by 383
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor
Gadd, S., Huff, V., Walz, A. L., Ooms, A. H. A. G., Armstrong, A. E., Gerhard, D. S., Smith, M. A., Guidry Auvil, J. M., Meerzaman, D., Chen, Q.-R., et al. (2017) · Nature Genetics · doi:10.1038/ng.3940 · Cited by 367
Correlation of an epigenetic mitotic clock with cancer risk
Yang, Z., Wong, A., Kuh, D., Paul, D. S., Rakyan, V. K., Leslie, R. D., Zheng, S. C., Widschwendter, M., Beck, S., & Teschendorff, A. E. (2016) · Genome Biology · doi:10.1186/s13059-016-1064-3 · Cited by 325
Lachenmayer, A., Alsinet, C., Savic, R., Cabellos, L., Toffanin, S., Hoshida, Y., Villanueva, A., Minguez, B., Newell, P., Tsai, H.-W., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2322 · Cited by 306 · cited 1×
“These included enhanced expression of the glutamine synthetaseGLUL, a direct Wnt and Hippo target (Cox et al., 2016; Lachenmayer et al., 2012), and of the synovial sarcoma associated gene SSX1, recently implicated in Wnttarget activation (Cironi et al.”
BackgroundOncogenic roles of DNA hypomethylation through the activation of cancer-germline genes
Van Tongelen, A., Loriot, A., & De Smet, C. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.03.029 · Cited by 241
Epigenetic changes of DNA repair genes in cancer
Lahtz, C., & Pfeifer, G. P. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq053 · Cited by 217
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
Cox, A. G., Hwang, K. L., Brown, K. K., Evason, K. J., Beltz, S., Tsomides, A., O’Connor, K., Galli, G. G., Yimlamai, D., Chhangawala, S., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3389 · Cited by 215
Epigenetic inactivation of CHFR in human tumors
Toyota, M., Sasaki, Y., Satoh, A., Ogi, K., Kikuchi, T., Suzuki, H., Mita, H., Tanaka, N., Itoh, F., Issa, J.-P. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1337066100 · Cited by 199
Teschendorff, A. E., Jones, A., Fiegl, H., Sargent, A., Zhuang, J. J., Kitchener, H. C., & Widschwendter, M. (2012) · Genome Medicine · doi:10.1186/gm323 · Cited by 182
Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade
Shukla, S. A., Bachireddy, P., Schilling, B., Galonska, C., Zhan, Q., Bango, C., Langer, R., Lee, P. C., Gusenleitner, D., Keskin, D. B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.026 · Cited by 172
Alaminos, M., Dávalos, V., Ropero, S., Setién, F., Paz, M. F., Herranz, M., Fraga, M. F., Mora, J., Cheung, N. V., Gerald, W. L., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4283 · Cited by 154
Jiao, Y., Widschwendter, M., & Teschendorff, A. E. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu316 · Cited by 148
Hinoue, T., Weisenberger, D. J., Pan, F., Campan, M., Kim, M.-J., Young, J. P., Whitehall, V., Leggett, B., & Laird, P. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008357 · Cited by 146
Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies
Mina, M., Raynaud, F., Tavernari, D., Battistello, E., Sungalee, S., Saghafinia, S., Laessle, T., Sanchez-Vega, F., Schultz, N., Oricchio, E., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.06.010 · Cited by 129
Self-citationNovel Transcription Coactivator Complex Containing Activating Signal Cointegrator 1
Jung, D.-J., Sung, H.-S., Goo, Y.-W., Lee, H. M., Park, O. K., Jung, S. Y., Lim, J., Kim, H.-J., Lee, S., Kim, T. S., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5203-5211.2002 · Cited by 125
Multiple mechanisms of MYCN dysregulation in Wilms tumour
Williams, R. D., Chagtai, T., Alcaide-German, M., Apps, J. R., Wegert, J., Popov, S., Vujanic, G. M., van Tinteren, H., van den Heuvel‐Eibrink, M. M., Kool, M., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3377 · Cited by 106
Siebenkäs, C., Chiappinelli, K. B., Guzzetta, A. A., Sharma, A. R., Jeschke, J., Vatapalli, R. J., Baylin, S. B., & Ahuja, N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179501 · Cited by 100
Lü, C., & Allis, C. D. (2017) · Nature Genetics · doi:10.1038/ng.3779 · Cited by 93
Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas
Esposti, D. D., Sklias, A., Soares‐Lima, S. C., Divonne, S. B.-D. L. F., Cahais, V., Fernández‐Jiménez, N., Cros, M., Ecsedi, S., Cuenin, C., Bouaoun, L., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0419-z · Cited by 74
Dissecting the role of aberrant DNA methylation in human leukaemia
Amabile, G., Ruscio, A. D., Müller, F., Welner, R. S., Yang, H. H., Ebralidze, A. K., Zhang, H., Levantini, E., Qi, L., Martinelli, G., et al. (2015) · Nature Communications · doi:10.1038/ncomms8091 · Cited by 73
Discovering causal signaling pathways through gene-expression patterns
Parikh, J. R., Klinger, B., Xia, Y., Marto, J. A., & Blüthgen, N. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq424 · Cited by 71
Sepulveda, J. L., Gutiérrez-Pajares, J. L., Luna, A. M., Yao, Y., Tobias, J. W., Thomas, S. M., Woo, Y., Giorgi, F. M., Komissarova, E. V., Califano, A., et al. (2016) · Modern Pathology · doi:10.1038/modpathol.2015.144 · Cited by 60
Borgal, L., Habbig, S., Hatzold, J., Liebau, M. C., Dafinger, C., Sacarea, I., Hammerschmidt, M., Benzing, T., & Schermer, B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.385658 · Cited by 56
Epigenetics and cancer without genomic instability
McKenna, E. S., & Roberts, C. W. M. (2009) · Cell Cycle · doi:10.4161/cc.8.1.7290 · Cited by 47
Ploeger, C., Waldburger, N., Fraas, A., Goeppert, B. F., Pusch, S., Breuhahn, K., Wang, X. W., Schirmacher, P., & Roessler, S. K. (2016) · Hepatology · doi:10.1002/hep.28684 · Cited by 44
Cironi, L., Petricevic, T., Vieira, V. F., Provero, P., Fusco, C., Buros, S. C., Fregni, G., Letovanec, I., Aguet, M., & Stamenkovic, I. (2016) · Scientific Reports · doi:10.1038/srep22113 · Cited by 40
Anastasakis, D. G., Skeparnias, I., Shaukat, A., Grafanaki, K., Κανέλλου, Α., Taraviras, S. L., Papachristou, D. J., Papakyriakou, A., & Stathopoulos, C. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw709 · Cited by 30
HSCARG Regulates NF-κB Activation by Promoting the Ubiquitination of RelA or COMMD1
Lian, M., & Zheng, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809752200 · Cited by 27
Swisher, E. M., Harrell, M. I., Lin, K., Coleman, R. L., Konecny, G. E., Tinker, A. V., O’Malley, D. M., McNeish, I. A., & Kaufmann, S. H. (2017) · Gynecologic Oncology · doi:10.1016/j.ygyno.2017.03.034 · Cited by 16
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Self-citationThe multi-factorial nature of clinical multidrug resistance in cancer
Assaraf, Y. G., Brozovic, A., Gonçalves, A. C., Jurkovicova, D., Linē, A., Machuqueiro, M., Saponara, S., Sarmento-Ribeiro, A. B., Xavier, C. P. R., & Vasconcelos, M. H. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100645 · Cited by 528
Zhang, C., Zhang, M., Ge, S., Huang, W., Lin, X., Gao, J., Gong, J., & Shen, L. (2019) · Cancer Medicine · doi:10.1002/cam4.2360 · Cited by 283
Liang, W.-W., Lu, R. J.-H., Jayasinghe, R. G., Foltz, S. M., Porta-Pardo, E., Geffen, Y., Wendl, M. C., Lazcano, R., Kolodziejczak, I., Song, Y., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.07.013 · Cited by 105
Metadata
- Authors
- Saghafinia, S., Mina, M., Riggi, N., Hanahan, D., & Ciriello, G.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 25
- Issue
- 4
- Pages
- 1066-1080.e8
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2897187982
- Cited by
- 357
- References
- 82
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- gold
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