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Dissecting the Single-Cell Transcriptome Network Underlying Gastric Premalignant Lesions and Early Gastric Cancer
Open accessAbstract
Intestinal-type gastric cancer is preceded by premalignant lesions, including chronic atrophic gastritis and intestinal metaplasia. In this study, we constructed a single-cell atlas for 32,332 high-quality cells from gastric antral mucosa biopsies of patients spanning a cascade of gastric premalignant lesions and early gastric cancer (EGC) using single-cell RNA sequencing. We then constructed a single-cell network underlying cellular and molecular characteristics of gastric epithelial cells across different lesions. We found that gland mucous cells tended to acquire an intestinal-like stem cell phenotype during metaplasia, and we identified OR51E1 as a marker for unique endocrine cells in the early-malignant lesion. We also found that HES6 might mark the pre-goblet cell cluster, potentially aiding identification of metaplasia at the early stage. Finally, we identified a panel of EGC-specific signatures, with clinical implications for the precise diagnosis of EGC. Our study offers unparalleled insights into the human gastric cellulome in premalignant and early-malignant lesions.
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Transfer learning enables predictions in network biology
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“Totally, we curated single cell gene expression matrices of 13 human tissues, including lung[11], liver[12], ileum[13], rectum[13], blood[14], bone marrow[15], skin[16], spleen[17], esophagus[17], colon[18], eye[19], stomach[20] and”
A human cell atlas of fetal gene expression
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Metadata
- Authors
- Zhang, P., Yang, M., Zhang, Y., Xiao, S., Lai, X., Tan, A., Du, S., & Li, S.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 27
- Issue
- 6
- Pages
- 1934-1947.e5
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2944311410
- Cited by
- 478
- References
- 41
- FWCI
- 12.17
- Type
- journal article
- Language
- en
- Open access
- gold
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