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Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections

Open access
Lv, Huibin, Wu, Nicholas C., Tsang, Owen Tak-Yin, Yuan, Meng, Perera, Ranawaka A.P.M., Leung, Wai Shing, So, Ray T.Y., Chan, Jacky Man Chun, Yip, Garrick K., Chik, Thomas Shiu Hong, Wang, Yiquan, Choi, Chris Yau Chung, Lin, Yihan, Ng, Wilson W., Zhao, Jincun, Poon, Leo L.M., Peiris, J.S. Malik, Wilson, Ian A., Mok, Chris K.P.·2020·Cell Reports
DOI 10.1016/j.celrep.2020.107725

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Abstract

The World Health Organization has declared the ongoing outbreak of COVID-19, which is caused by a novel coronavirus SARS-CoV-2, a pandemic. There is currently a lack of knowledge about the antibody response elicited from SARS-CoV-2 infection. One major immunological question concerns antigenic differences between SARS-CoV-2 and SARS-CoV. We address this question by analyzing plasma from patients infected by SARS-CoV-2 or SARS-CoV and from infected or immunized mice. Our results show that, although cross-reactivity in antibody binding to the spike protein is common, cross-neutralization of the live viruses may be rare, indicating the presence of a non-neutralizing antibody response to conserved epitopes in the spike. Whether such low or non-neutralizing antibody response leads to antibody-dependent disease enhancement needs to be addressed in the future. Overall, this study not only addresses a fundamental question regarding antigenicity differences between SARS-CoV-2 and SARS-CoV but also has implications for immunogen design and vaccine development.

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Metadata

Authors
Lv, H., Wu, N. C., Tsang, O. T.-Y., Yuan, M., Perera, R. A. P. M., Leung, W. S., So, R. T. Y., Chan, J. M. C., Yip, G. K., Chik, T. S. H., Wang, Y., Choi, C. Y. C., Lin, Y., Ng, W. W., Zhao, J., Poon, L. L. M., Peiris, J. S. M., Wilson, I. A., & Mok, C. K. P.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2020-06
Volume
31
Issue
9
Pages
107725
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2020.107725
OpenAlex
W3025553169
Cited by
407
References
8
FWCI
11.08
Type
journal article
Language
en
Open access
gold
Licence
Funders
National Institutes of Health

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CoChat. (2026). Citation check: Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections. https://app.cochat.ai/papers/10.1016/j.celrep.2020.107725
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Lv, H., Wu, N. C., Tsang, O. T.-Y., Yuan, M., Perera, R. A. P. M., Leung, W. S., So, R. T. Y., Chan, J. M. C., Yip, G. K., Chik, T. S. H., Wang, Y., Choi, C. Y. C., Lin, Y., Ng, W. W., Zhao, J., Poon, L. L. M., Peiris, J. S. M., Wilson, I. A., & Mok, C. K. P. (2020). Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections. Cell Reports. https://doi.org/10.1016/j.celrep.2020.107725

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