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Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons

De Pace, Raffaella, Britt, Dylan J., Mercurio, Jeffrey, Foster, Arianne M., Djavaherian, Lucas, Hoffmann, Victoria, Abebe, Daniel, Bonifacino, Juan S.·2020·Cell Reports
DOI 10.1016/j.celrep.2020.107775PMC PMC7478246
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  • KO mice for the vast majority of genes that play fundamental roles in lysosomal positioning in both retrograde and anterograde directions are lethal or die immediately after birth.

    “KO mice for the vast majority of genes that play fundamental roles in this process, in both the retrograde and anterograde directions, are lethal or die immediately after birth.”

    From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as De Pace et al., 2020

    The Results section reports that homozygous BORCS5 (myrlysin) knockout pups died within an hour of birth. The Discussion also reports neonatal death for BORCS7-null mice and respiratory failure after birth for KIF1Bβ and KIF5A knockout mice. These examples do not establish that the vast majority of genes involved in lysosomal positioning have lethal knockouts, or cover both retrograde and anterograde directions; the paper also says the organelle deficiency responsible for myrlysin-KO lethality remains undetermined. No page numbers were available in our copy. (LLM, conf=0.88)

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Metadata

Authors
De Pace, R., Britt, D. J., Mercurio, J., Foster, A. M., Djavaherian, L., Hoffmann, V., Abebe, D., & Bonifacino, J. S.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2020-06
Volume
31
Issue
11
Pages
107775
ISSN
2211-1247
DOI
10.1016/j.celrep.2020.107775
PMC
PMC7478246
Cited by
87
References
4
Language
en
Licence
Funders
National Institutes of Health

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