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eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

Liang, YongTian, Piao, Chengji, Beuschel, Christine B., Toppe, David, Kollipara, Laxmikanth, Bogdanow, Boris, Maglione, Marta, Lützkendorf, Janine, See, Jason Chun Kit, Huang, Sheng, Conrad, Tim O.F., Kintscher, Ulrich, Madeo, Frank, Liu, Fan, Sickmann, Albert, Sigrist, Stephan J.·2021·Cell Reports
DOI 10.1016/j.celrep.2021.108941
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  • In Drosophila, hypusination deficiency due to heterozygous mutation or knockdown of deoxyhypusine synthase abolishes lifespan extension by spermidine supplementation.

    “Moreover, in Drosophila , hypusination deficiency due to a heterozygous mutation or knockdown of deoxyhypusine synthase abolished lifespan extension by spermidine supplementation 121 .”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [121]

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Metadata

Authors
Liang, Y., Piao, C., Beuschel, C. B., Toppe, D., Kollipara, L., Bogdanow, B., Maglione, M., Lützkendorf, J., See, J. C. K., Huang, S., Conrad, T. O. F., Kintscher, U., Madeo, F., Liu, F., Sickmann, A., & Sigrist, S. J.
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2021-04
Volume
35
Issue
2
Pages
108941
ISSN
2211-1247
DOI
10.1016/j.celrep.2021.108941
Cited by
130
References
9
Language
en
Licence
Funders
  • Stiftung Charité
  • Karl-Franzens-Universität Graz (BMWFW-80.109/0001-WF/V/3b/2015)
  • Bundesministerium für Bildung, Wissenschaft und Forschung
  • Bundesministerium für Bildung und Forschung (3FO18501)
  • Austrian Science Fund (F3012, P27893, P29203, P29262, P31727, SFB LIPOTOX F3007, W1226)
  • Bundesministerium für Bildung und Frauen
  • Deutsches Zentrum für Herz-Kreislaufforschung (DFG – KI 712/10-1)
  • Deutsche Forschungsgemeinschaft (327654276, 445178831)

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