Cited by 212Genetics, Aging, and Longevity in Model OrganismsPolyamine Metabolism and ApplicationsAutophagy in Disease and Therapy

Spermidine: A physiological autophagy inducer acting as an anti-aging vitamin in humans?

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Madeo, Frank, Bauer, Maria A., Carmona-Gutierrez, Didac, Kroemer, Guido·2019·Autophagy

Abstract

Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested. Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer. Here, we discuss nutritional and other possible routes to counteract the age-mediated decline of spermidine levels.

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Authors
Madeo, F., Bauer, M. A., Carmona-Gutierrez, D., & Kroemer, G.
Affiliations
  • University of Graz (AT)
  • Institute of Molecular Biosciences, University of Graz, Graz, Austria
  • Karolinska University Hospital (SE)
Corresponding author
  • Madeo, Frank
  • Kroemer, Guido
Venue
Autophagy
Published
2018-10-11
Volume
15
Issue
1
Pages
165-168
ISSN
  • 1554-8627 (ISSN-L)
  • 1554-8635
OpenAlex
W2896631314
Cited by
212
References
41
Citations by year
2026: 33 · 2025: 35 · 2024: 31 · 2023: 28 · 2022: 27 · 2021: 23 · 2020: 27 · 2019: 8
Type
journal article
Language
en
Open access
Locations
  • Autophagy (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
Funders
  • Agence Nationale de la Recherche (E-Rare-2, Projets blancs)
  • Austrian Science Fund (W1226, P29262)
  • Austrian Science Fund (AT) (F3012, I1000, P29203, P24381, P23490-B20, P27893)
  • Bundesministerium für Wissenschaft, Forschung und Wirtschaft (AT) (Unkonventionelle Forschung)
  • BioTechMed-Graz/NAWI Graz (EPIAge)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
spermidine, polyamines, macroautophagy, anti-aging, lifespan extension, healthspan, aging, dietary supplementation, mortality, cardiovascular disease, cancer, age-related decline
MeSH terms
Aging, Animals, Autophagy, Humans, Nematoda, Spermidine, Vitamins, Yeasts, Up-Regulation, Mice

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