Cited by 28Visual perception and processing mechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region

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Morales-Gregorio, Aitor, Kurth, Anno C., Ito, Junji, Kleinjohann, Alexander, Barthélemy, Frédéric V., Brochier, Thomas, Grün, Sonja, van Albada, Sacha J.·2024·Cell Reports

Published version of a preprint

Abstract

High-dimensional brain activity is often organized into lower-dimensional neural manifolds. However, the neural manifolds of the visual cortex remain understudied. Here, we study large-scale multi-electrode electrophysiological recordings of macaque (Macaca mulatta) areas V1, V4, and DP with a high spatiotemporal resolution. We find that the population activity of V1 contains two separate neural manifolds, which correlate strongly with eye closure (eyes open/closed) and have distinct dimensionalities. Moreover, we find strong top-down signals from V4 to V1, particularly to the foveal region of V1, which are significantly stronger during the eyes-open periods. Finally, in silico simulations of a balanced spiking neuron network qualitatively reproduce the experimental findings. Taken together, our analyses and simulations suggest that top-down signals modulate the population activity of V1. We postulate that the top-down modulation during the eyes-open periods prepares V1 for fast and efficient visual responses, resulting in a type of visual stand-by state.

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Crossref · 10.1016/j.celrep.2024.114371

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  • Electrically evoked responses were confined to a low-dimensional neural manifold.

    “Similar to observations in visually evoked activity [52] and other brain regions [53], electrically evoked responses were confined to a low-dimensional neural manifold, quantified using latent factor analysis [54, 55] (Methods 4.10).”

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Authors
Morales-Gregorio, A., Kurth, A. C., Ito, J., Kleinjohann, A., Barthélemy, F. V., Brochier, T., Grün, S., & van Albada, S. J.
Affiliations
  • Forschungszentrum Jülich (DE)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Morales-Gregorio, Aitor
Venue
Cell Reports
Publisher
Elsevier BV
Published
2024-07
Volume
43
Issue
7
Pages
114371
ISSN
2211-1247 (ISSN-L)
OpenAlex
W4400009614
Cited by
28
References
88
Citations by year
2026: 12 · 2025: 10 · 2024: 5 · 2023: 1
FWCI
6.58
Type
journal article
Language
en
Open access
Locations
  • Cell Reports (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
Funders
  • European Union
  • Ministerium fur Kultur und Wissenschaft des Landes Nordrhein-Westfalen
  • Horizon 2020 Framework Programme (945539)
  • Deutsche Forschungsgemeinschaft (368482240/GRK2416)
  • Centre National de la Recherche Scientifique (491111487)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neural manifolds, primary visual cortex, top-down signals, V4, fovea, eyelid closure, population activity, macaque, visual cortex
MeSH terms
Animals, Computer Simulation, Fovea Centralis, Macaca mulatta, Male, Models, Neurological, Neurons, Visual Cortex

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