Cited by 254Neuroscience and Neural EngineeringTactile and Sensory InteractionsVisual perception and processing mechanisms

Shape perception via a high-channel-count neuroprosthesis in monkey visual cortex

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Chen, Xing, Wang, Feng, Fernandez, Eduardo, Roelfsema, Pieter R.·2020·Science

Abstract

Restoring vision by stimulating the brain: Electrical stimulation of the visual cortex has long been proposed as an approach to restoring vision in blind people. Previous studies positioned electrodes on the surface of the brain and thus required delivery of relatively high currents. However, this approach limits the number of electrodes that can be safely stimulated simultaneously, and such surface electrodes activate several millimeters of cortex, which results in a low spatial resolution. Chen et al. demonstrated that the simultaneous stimulation of multiple intracortical electrodes in the monkey primary visual cortex gives rise to the perception of shape and successive stimulation to the perception of motion (see the Perspective by Beauchamp and Yoshor). This major improvement provides proof of concept for the use of electrical microstimulation to create a form of artificial vision in the blind. Science , this issue p. 1191 ; see also p. 1165

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Crossref · 10.1126/science.abd7435

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Authors
Chen, X., Wang, F., Fernandez, E., & Roelfsema, P. R.
Affiliations
  • Netherlands Institute for Neuroscience (NL)
  • Bioengineering Institute and CIBER-BBN, Miguel Hernández University of Elche, Elche, Spain.
Corresponding author
  • Chen, Xing
  • Roelfsema, Pieter R.
Venue
Science
Published
2020-12-04
Volume
370
Issue
6521
Pages
1191-1196
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W3106809839
Cited by
250
References
54
Citations by year
2026: 40 · 2025: 48 · 2024: 31 · 2023: 36 · 2022: 56 · 2021: 37 · 2020: 2
FWCI
15.00
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
  • VU Research Portal (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • FP7 Ideas: European Research Council (339490)
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (P15-42)
  • Human Brain Project (720270, 785907)
  • Friends Foundation, Netherlands Institute for Neuroscience
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
neural prostheses, visual prosthesis, blindness, electrical stimulation, visual cortex, area V1, area V4, receptive fields, shape perception, vision restoration
MeSH terms
Animals, Blindness, Electric Stimulation, Macaca mulatta, Male, Pattern Recognition, Visual, Phosphenes, Visual Cortex, Neural Prostheses

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