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Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy

Jacquet, Rudy G., González Ibáñez, Fernando, Picard, Katherine, Funes, Lucy, Khakpour, Mohammadparsa, Gouras, Gunnar K., Tremblay, Marie-Ève, Maxfield, Frederick R., Solé-Domènech, Santiago·2024·Cell Reports
DOI 10.1016/j.celrep.2024.115052PMC PMC11760508
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Crossref · 10.1016/j.celrep.2024.115052

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  • LE is used by microglia to release cytokines, enzymes, and cargo into the extracellular space.

    “LE is used by microglia to release cytokines, enzymes, and cargo into the extracellular space (Dou et al. 2012; Jacquet et al. 2024; Kreher et al. 2021).”

    From The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human Microglia (2025) · cites this paper as Jacquet et al. 2024

    The Results sections on lysosomal synapses and Aβ fibril secretion report microglial lysosomal exocytosis of contents into extracellular compartments, including enzymes and previously endocytosed Aβ cargo. They do not report cytokine release by this mechanism; the Limitations of the study mentions cytokines only as components absent from the model aggregates. No page numbers are available in our copy. (LLM, conf=0.88)

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Research works printed but not linked: 68

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Metadata

Authors
Jacquet, R. G., González Ibáñez, F., Picard, K., Funes, L., Khakpour, M., Gouras, G. K., Tremblay, M.-È., Maxfield, F. R., & Solé-Domènech, S.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2024-12
Volume
43
Issue
12
Pages
115052
ISSN
2211-1247
DOI
10.1016/j.celrep.2024.115052
PMC
PMC11760508
Cited by
42
References
19
Language
en
Licence
Funders
  • National Institutes of Health (R01-HL093324, RF1-AG078244)
  • Cure Alzheimer's Fund (CAF-211540-02)
  • National Research Council Canada (CRC-2019-00407)
  • Swedish Research Council (637-2013-503/D0050301)
  • Canada Foundation for Innovation
  • Mexico State Government Mexican Council for Science and Technology
  • Leon Levy Foundation
  • Consejo Nacional de Humanidades, Ciencias y Tecnologías
  • Canada Research Chairs
  • Vanderbilt University Medical Center

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