Cited by 202Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsIntracerebral and Subarachnoid Hemorrhage Research

Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration

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Wilcock, Donna M, Munireddy, Sanjay K, Rosenthal, Arnon, Ugen, Kenneth E, Gordon, Marcia N, Morgan, Dave·2004·Neurobiology of Disease

Abstract

The mechanisms by which anti-Abeta antibodies clear amyloid plaques in Abeta depositing transgenic mice are unclear. In the current study, we demonstrate that inhibition of anti-Abeta antibody-induced microglial activation with anti-inflammatory drugs, such as dexamethasone, inhibits removal of fibrillar amyloid deposits. We also show that anti-Abeta F(ab')(2) fragments fail to activate microglia and are less efficient in removing fibrillar amyloid than the corresponding complete IgG. Diffuse Abeta deposits are cleared by antibodies under all circumstances. These data suggest that microglial activation is necessary for efficient removal of compact amyloid deposits with immunotherapy. Inhibition of this activation may result in an impaired clinical response to vaccination against Abeta.

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Registry

Crossref · 10.1016/j.nbd.2003.09.015

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42 of 42 references verified0 citation errors · 0 not checkable

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  • Anti-apoE antibody might modulate similar inflammatory responses, consistent with the effect of certain anti-Aβ antibodies.

    “This finding suggests that anti-apoE antibody might modulate similar inflammatory responses, which is consistent with the effect of certain anti-Aβ antibodies (Bard et al., 2000; Wilcock et al., 2004).”

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Authors
Wilcock, D. M., Munireddy, S. K., Rosenthal, A., Ugen, K. E., Gordon, M. N., & Morgan, D.
Affiliations
University of South Florida (US)
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2004-02
Volume
15
Issue
1
Pages
11-20
ISSN
0969-9961 (ISSN-L)
OpenAlex
W2063909850
Cited by
202
References
43
Citations by year
2026: 7 · 2025: 15 · 2024: 8 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 12 · 2014: 6 · 2013: 11 · 2012: 12
FWCI
8.07
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health
  • National Institute on Aging (R01AG018478, AG 15490, R01AG020227, AG20227, R01AG015490, AG18478)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
Keywords
microglial activation, amyloid plaques, plaque clearance, dexamethasone, anti-inflammatory agents, F(ab')2 fragments, Alzheimer's disease
MeSH terms
Alzheimer Disease, Animals, Anti-Inflammatory Agents, Antibodies, Brain, Dexamethasone, Disease Models, Animal, Encephalitis, Flurbiprofen, Gliosis, Immunoglobulin G, Mice, Transgenic, Peptide Fragments, Vaccines, Amyloid beta-Peptides, Leukocyte Common Antigens, Microglia, Mice, Plaque, Amyloid

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