Risk of Pancreatic Cancer in Patients With Pancreatic Cysts and Family History of Pancreatic Cancer
Abstract
Background & aims A diagnosis of pancreatic cancer in a first-degree relative increases an individuals' risk of this cancer. However, it is not clear whether this cancer risk increases in individuals with pancreatic cystic lesions who have a first-degree relative with pancreatic cancer. The Fukuoka criteria are used to estimate risk of pancreatic cancer for patients with pancreatic cystic lesions: individuals with cysts with high risk or worrisome features (Fukuoka positive) have a higher risk of pancreatic cancer than individuals without these features (Fukuoka negative). We aimed to compare the risk of pancreatic cancer and surgery based on presence or absence of pancreatic cystic lesions and a first-degree relative with pancreatic cancer.Methods We performed a retrospective study of patients seen at the Mayo Clinic in Rochester, Minnesota, from January 1, 2000, through December 31, 2012. We identified individuals with: pancreatic cystic lesions and first-degree relative with pancreatic cancer (group 1, n = 269), individuals with pancreatic cystic lesions but no first-degree relative with pancreatic cancer (group 2, n = 1195), and individuals without pancreatic cystic lesions but with a first-degree relative with pancreatic cancer (group 3, n = 720). We compared, among groups, as well among patients with cysts classified according to Fukuoka criteria, proportions of individuals who developed pancreatic cancer or underwent pancreatic surgery within a 5-year period.Results A significantly higher proportion of individuals in group 1 developed pancreatic cancer during the 5-year period than in group 3 (6.64% vs 1.69%; P = .03); there was no significant difference between the percentage of individuals in group 1 vs group 2 who developed pancreatic cancer (6.64% vs 4.05%; P = .41). There was no significant difference in pancreatic cancer development among individuals with Fukuoka-positive cysts with vs without a family history of pancreatic cancer (P = .39). There was no significant difference in the proportion of patients in group 1 vs group 2 who underwent pancreatic surgery for their pancreatic cyst over the 5-year period (14.37% vs 11.80%; P = .59). Among patients with Fukuoka-negative cysts, a significantly higher proportion underwent surgery in group 1 than in group 2 (10.90% vs 5.90%; P = .03). However, among patients with Fukuoka-positive cysts, there was no difference in proportions of patients who underwent surgery between groups 1 and 2 (P = .66).Conclusions In a retrospective study of patients with pancreatic cysts and/or cancer, we found that a family history of pancreatic cancer does not affect 5-year risk of pancreatic cancer in patients with pancreatic cystic lesions. Despite this, among patients with Fukuoka-negative cysts, a higher proportion of those with a family history of pancreatic cancer undergo surgery than patients without family history of pancreatic cancer.
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Family history of pancreatic cancer is also a risk factor for patients with incidentally detected pancreatic cysts.
“Family history of pancreatic cancer is also a risk factor for patients identified as having incidentally detected pancreatic cysts.”
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- Authors
- Mukewar, S. S., Sharma, A., Phillip, N., Gupta, R., Aryal-Khanal, A., de Pretis, N., Anani, V., Enders, F. T., Larson, J. J., Takahashi, N., Levy, M. J., Topazian, M., Pearson, R. K., Vege, S. S., & Chari, S. T.
- Affiliations
- Mayo Clinic (US)
- Stanford University (US)
- Corresponding author
- Chari, Suresh T.
- ORCID
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 16
- Issue
- 7
- Pages
- 1123-1130.e1
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2785448859
- Cited by
- 26
- References
- 15
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 2
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Clinic
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Keywords
- pancreatic cancer, pancreatic cysts, family history of cancer, first-degree relatives, pancreatic surgery, cancer risk, hereditary cancer predisposition
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Male, Medical History Taking, Middle Aged, Minnesota, Pancreatic Cyst, Pancreatic Neoplasms, Retrospective Studies, Risk Assessment
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