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Diagnostic Yield From Screening Asymptomatic Individuals at High Risk for Pancreatic Cancer: A Meta-analysis of Cohort Studies
Open accessAbstract
Background & aims There have been few studies of abdominal imaging screening of individuals at high risk for pancreatic cancer (based on family history or genetic variants). We performed a meta-analysis of prospective cohort studies to determine the diagnostic yield and outcomes of abdominal imaging screening for asymptomatic individuals at high risk.Methods Through a systematic review of multiple electronic databases and conference proceedings through July 2017, we identified prospective cohort studies (>20 patients) of asymptomatic adults determined to be at high-risk of pancreatic cancer (lifetime risk >5%, including specific genetic-associated conditions) who were screened by endoscopic ultrasound (EUS) and/or magnetic resonance imaging (MRI) to detect pancreatic lesions. Our primary outcome was identification of high-risk pancreatic lesions (high-grade pancreatic intraepithelial neoplasia, high-grade dysplasia, or adenocarcinoma) at initial screening, and overall incidence during follow up. Summary estimates were reported as incidence rates per 100 patient-years.Results We identified 19 studies comprising 7085 individuals at high risk for pancreatic cancer; of these, 1660 patients were evaluated by EUS and/or MRI. Fifty-nine high-risk lesions were identified (43 adenocarcinomas: 28 during the initial exam and 15 during follow-up surveillance) and 257 patients underwent pancreatic surgery. Based on our meta-analysis, the overall diagnostic yield screening for high-risk pancreatic lesions was 0.74 (95% CI, 0.33-1.14), with moderate heterogeneity among studies. The number needed to screen to identify 1 patient with a high-risk lesion was 135 (95% CI, 88-303). The diagnostic yield was similar for patients with different genetic features that increased risk, and whether patients were screened by EUS or MRI.Conclusions Based on meta-analysis, 135 patients at high-risk for pancreatic cancer must be screened to identify 1 patient with a high-risk pancreatic lesion. Further studies are needed to determine whether screening reduces mortality and is cost effectiveness for individuals at high-risk of pancreatic cancer.
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“it is notable that these five cases represent a smaller proportion of resections for low-grade lesions than has been reported in prior studies14,15,29,30 and likely results from better selection of patients for surgery.”
From The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival (2022) · cites this paper as [15]
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“Recent evidence indicates that pancreas surveillance can downstage pancreatic cancers diagnosed in high-risk individuals (HRIs), although this is based upon only a few studies,12,14-16 with relatively few PDACs diagnosed, and only a small percentage of which were diagnosed with stage I disease.17”
From The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival (2022) · cites this paper as [15]
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Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Siegel, R. L., Miller, K. D., & Jemal, A. (2017) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21387 · Cited by 14,712
SEER Cancer Statistics Review, 1975-2003
Ries, L. A. G., Harkins, D., Krapcho, M. F., Mariotto, A. B., Miller, B., Feuer, E. J., Clegg, L. X., Eisner, M. P., Horner, M., Howlader, N., et al. (2006) · Digital Archive @ GSU · Cited by 11,404
Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
The National Lung Screening Trial Research Team (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102873 · Cited by 11,064
Six Hundred Fifty Consecutive Pancreaticoduodenectomies in the 1990s
Yeo, C. J., Cameron, J. L., Riall, T. S., Lillemoe, K. D., Pitt, H. A., Talamini, M. A., Hruban, R. H., Ord, S. E., Sauter, P. K., Coleman, J., et al. (1997) · Annals of Surgery · doi:10.1097/00000658-199709000-00004 · Cited by 1,781
Hereditary Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., DiMagno, E. P., Elitsur, Y., Gates, L. K., Perrault, J., Whitcomb, D. C., & International Hereditary Pancreatitis Study Group (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.6.442 · Cited by 988
Xiao, A., Tan, M. L., Wu, L. M., Asrani, V. M., Windsor, J. A., Yadav, D. K., & Petrov, M. S. (2016) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30004-8 · Cited by 824
Colonoscopy in Colorectal-Cancer Screening for Detection of Advanced Neoplasia
Reguła, J., Rupiński, M., Kraszewska, E., Polkowski, M., Pachlewski, J., Orłowska, J., Nowacki, M. P., & Butruk, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054967 · Cited by 785
Canto, M. I., Harinck, F., Hruban, R. H., Offerhaus, G. J., Poley, J.-W., Kamel, I., Nio, Y., Schulick, R. S., Bassi, C., Kluijt, I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303108 · Cited by 784
Ten-Year Experience With 733 Pancreatic Resections
Balcom, J. H. (2001) · Archives of Surgery · doi:10.1001/archsurg.136.4.391 · Cited by 772
Frequent detection of pancreatic lesions in asymptomatic high-risk individuals
Canto, M. I., Hruban, R. H., Fishman, E. K., Kamel, I. R., Schulick, R., Zhang, Z., Topazian, M., Takahashi, N., Fletcher, J., Petersen, G., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.01.005 · Cited by 648
Epidemiology and risk factors for pancreatic cancer
Lowenfels, A. B., & Maisonneuve, P. (2006) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2005.10.001 · Cited by 635
Chronic Pancreatitis and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis
Kirkegård, J., Mortensen, F. V., & Cronin-Fenton, D. P. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.218 · Cited by 551
Lower Cancer Incidence in Amsterdam-I Criteria Families Without Mismatch Repair Deficiency
Lindor, N. M., Rabe, K. G., Petersen, G. M., Haile, R. W., Casey, G., Baron, J. A., Gallinger, S., Bapat, B. V., Aronson, M. D., Hopper, J. L., et al. (2005) · JAMA · doi:10.1001/jama.293.16.1979 · Cited by 542
Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study
Canto, M. I., Goggins, M., Hruban, R. H., Petersen, G. M., Giardiello, F. M., Yeo, C., Fishman, E. K., Brune, K., Axilbund, J., Griffin, C., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.02.005 · Cited by 524
Allen, P. J., Kuk, D., Castillo, C. F.-D., Basturk, O., Wolfgang, C. L., Cameron, J. L., Lillemoe, K. D., Ferrone, C. R., Morales-Oyarvide, V., He, J., et al. (2017) · Annals of Surgery · doi:10.1097/sla.0000000000001763 · Cited by 485
Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach
Canto, M. I., Goggins, M., Yeo, C. J., Griffin, C., Axilbund, J. E., Brune, K., Ali, S. Z., Jagannath, S., Petersen, G. M., Fishman, E. K., et al. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00244-7 · Cited by 448
Lynch, S. M., Vrieling, A., Lubin, J. H., Kraft, P. L., Mendelsohn, J. B., Hartge, P. A., Canzian, F., Steplowski, E., Arslan, A. A., Gross, M., et al. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp134 · Cited by 395
Number needed to screen: development of a statistic for disease screening
Rembold, C. M. (1998) · BMJ · doi:10.1136/bmj.317.7154.307 · Cited by 385
The Concise Handbook of Family Cancer Syndromes
Lindor, N. M., Greene, M. H., & Program, M. F. C. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.14.1039 · Cited by 338
Poley, J. W., Kluijt, I., Gouma, D. J., Harinck, F., Wagner, A., Aalfs, C., van Eijck, C. H. J., Cats, A., Kuipers, E. J., Nio, Y., et al. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.276 · Cited by 257
Langer, P., Kann, P. H., Fendrich, V., Habbe, N., Schneider, M., Sina‐Frey, M., Slater, E. P., Heverhagen, J. T., Gress, T. M., Rothmund, Μ., et al. (2009) · Gut · doi:10.1136/gut.2008.171611 · Cited by 249
PancPRO: Risk Assessment for Individuals With a Family History of Pancreatic Cancer
Wang, W., Chen, S., Brune, K. A., Hruban, R. H., Parmigiani, G., & Klein, A. P. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.2452 · Cited by 216
Verna, E. C., Hwang, C., Stevens, P. D., Rotterdam, H., Stavropoulos, S. N., Sy, C. D., Prince, M. A., Chung, W. K., Fine, R. L., Chabot, J. A., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3209 · Cited by 201
Feasibility and Yield of Screening in Relatives From Familial Pancreatic Cancer Families
Ludwig, E., Olson, S. H., Bayuga, S., Simon, J. A., Schattner, M. A., Gerdes, H., Allen, P. J., Jarnagin, W. R., & Kurtz, R. C. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.65 · Cited by 165
Vasen, H. F. A., Wasser, M., van Mil, A., Tollenaar, R. A., Konstantinovski, M., Gruis, N. A., Bergman, W., Hes, F. J., Hommes, D. W., Offerhaus, G. J. A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.11.048 · Cited by 152
Screening for Pancreatic Cancer in a High-Risk Cohort: An Eight-Year Experience
Al-Sukhni, W., Borgida, A., Rothenmund, H., Holter, S., Semotiuk, K., Grant, R. C., Wilson, S. R., Moore, M. J., Narod, S. A., Jhaveri, K. S., et al. (2011) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-011-1781-6 · Cited by 150
Screening and surveillance for hereditary pancreatic cancer
Kimmey, M. B., Bronner, M. P., Byrd, D. R., & Brentnall, T. A. (2002) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(02)70092-8 · Cited by 134
Familial and second primary pancreatic cancers: A nationwide epidemiologic study from Sweden
Hemminki, K., & Li, X. (2002) · International Journal of Cancer · doi:10.1002/ijc.10863 · Cited by 128
Zhang, Y., Ding, H., Chen, T., Zhang, X., Chen, W., Li, Q., Yao, L., Korrapati, P., Jin, X.-J., Zhang, Y., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.04.038 · Cited by 109
Ogawa, Y., Tanaka, M., Inoue, K., Yamaguchi, K., Chijiiwa, K., Mizumoto, K., Tsutsu, N., & Nakamura, Y. (2002) · Cancer · doi:10.1002/cncr.10493 · Cited by 108
Singh, S., Tang, S., Sreenarasimhaiah, J., Lara, L. F., & Siddiqui, A. A. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1709-8 · Cited by 106
Inherited Pancreatic Cancer: Surveillance and Treatment Strategies for Affected Families
Rulyak, S. J., & Brentnall, T. A. (2001) · Pancreatology · doi:10.1159/000055851 · Cited by 98
Controversies in the management of pancreatic IPMN
Tanaka, M. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.193 · Cited by 94
Chiaro, M. D., Verbeke, C. S., Kartalis, N., Mucelli, R. P., Gustafsson, P., Hansson, J., Haas, S., Segersvärd, R., Andrén‐Sandberg, Å., & Löhr, M. J. (2015) · JAMA Surgery · doi:10.1001/jamasurg.2014.3852 · Cited by 92
Prevalence of familial pancreatic cancer in Germany
Bartsch, D. K., Kress, R., Sina‐Frey, M., Grützmann, R., Gerdes, B., Pilarsky, C. P., Heise, J., Schulte, K., Colombo‐Benkmann, M., Schleicher, C., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20210 · Cited by 90
Screening for pancreatic cancer in familial high-risk individuals: A systematic review
Lu, C. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i28.8678 · Cited by 85
Zubarik, R. S., Gordon, S. R., Lidofsky, S. D., Anderson, S. R., Pipas, J. M., Badger, G. J., Ganguly, E. K., & Vecchio, J. A. (2011) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2011.03.1235 · Cited by 80
Lucas, A. L., Frado, L. E., Hwang, C., Kumar, S., Khanna, L. G., Levinson, E. J., Chabot, J. A., Chung, W. K., & Frucht, H. (2014) · Cancer · doi:10.1002/cncr.28662 · Cited by 68
Matsubara, S., Tada, M., Akahane, M., Yagioka, H., Kogure, H., Sasaki, T., Arizumi, T., Togawa, O., Nakai, Y., Sasahira, N., et al. (2012) · Pancreas · doi:10.1097/mpa.0b013e31824f5970 · Cited by 67
Variation in Precursor Lesions of Pancreatic Cancer among High-Risk Groups
Potjer, T. P., Schot, I., Langer, P., Heverhagen, J. T., Wasser, M. N. J. M., Slater, E. P., Klöppel, G., Morreau, H. M., Bonsing, B. A., Cappel, W. H. D. V. T. N., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2730 · Cited by 67
Illés, D., Terzin, V., Holzinger, G., Kosár, K., Róka, R., Zsóri, G., Ábrahám, G., & Czakó, L. (2015) · Pancreatology · doi:10.1016/j.pan.2015.12.005 · Cited by 54
Shin, E. J., Topazian, M. D., Goggins, M., Syngal, S., Saltzman, J. R., Lee, J. H., Farrell, J. J., & Canto, M. I. (2015) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2015.02.028 · Cited by 52
PanGen-Fam: Spanish registry of hereditary pancreatic cancer
Mocci, E., Guillén‐Ponce, C., Earl, J., Márquez, M., Solera, J., Salazar-Lopez, M.-T., Calcedo-Arnáiz, C., Vázquez-Sequeiros, E., Montáns, J., Beltrán, M. M., et al. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.07.004 · Cited by 47
The use of EUS to diagnose cystic neoplasms of the pancreas
Brugge, W. R. (2009) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2008.12.029 · Cited by 47
Promising Outcomes of Screening for Pancreatic Cancer by Genetic Testing and Endoscopic Ultrasound
Sud, A., Wham, D., Catalano, M. F., & Guda, N. M. (2014) · Pancreas · doi:10.1097/mpa.0000000000000052 · Cited by 44
Stauffer, J. A., Onkendi, E., Wallace, M. B., Raimondo, M., Woodward, T. A., Lukens, F., & Asbun, H. J. (2017) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2017.01.033 · Cited by 14
Self-citationMccarthy, S. T., Hosmer, A. E., Scheiman, J. M., Raymond, V. M., Kwon, R. S., & Stoffel, E. M. (2015) · Gastroenterology · doi:10.1016/s0016-5085(15)30650-8 · Cited by 1
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Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment
Wood, L. D., Canto, M. I., Jaffee, E. M., & Simeone, D. M. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.03.056 · Cited by 918
Stoffel, E. M., Brand, R. E., & Goggins, M. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.02.012 · Cited by 565
Stoop, T. F., Javed, A. A., Oba, A., Koerkamp, B. G., Seufferlein, T. T. W., Wilmink, J. W., & Besselink, M. G. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00261-2 · Cited by 601
The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival
Dbouk, M., Katona, B. W., Brand, R. E., Chak, A., Syngal, S., Farrell, J. J., Kastrinos, F., Stoffel, E. M., Blackford, A. L., Rustgi, A. K., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.22.00298 · Cited by 247
Săftoiu, A., Hassan, C., Areia, M., Bhutani, M., Bisschops, R., Bories, E., Cazacu, I., Dekker, E., Deprez, P., Pereira, S., et al. (2020) · Endoscopy · doi:10.1055/a-1104-5245 · Cited by 187
Metadata
- Authors
- Corral, J. E., Mareth, K. F., Riegert-Johnson, D. L., Das, A., & Wallace, M. B.
- Affiliations
- Mayo Clinic (US)
- St. Joseph's Hospital and Medical Center (US)
- Corresponding author
- Wallace, Michael B.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 17
- Issue
- 1
- Pages
- 41-53
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2809523459
- Cited by
- 113
- References
- 49
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 13 · 2023: 19 · 2022: 14 · 2021: 16 · 2020: 14 · 2019: 10
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic cancer screening, high-risk individuals, endoscopic ultrasound, magnetic resonance imaging, diagnostic yield, pancreatic intraepithelial neoplasia, pancreatic ductal adenocarcinoma, pancreatic dysplasia, genetic susceptibility, family history (medicine), surveillance (medicine), number needed to screen
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Incidence, Early Detection of Cancer, Young Adult, Asymptomatic Diseases, Optical Imaging
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