Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation

Vasen, Hans F.A.; Wasser, Martin; van Mil, Anneke; Tollenaar, Rob A.; Konstantinovski, Marja; Gruis, Nelleke A.; Bergman, Wilma; Hes, Frederik J.; Hommes, Daniel W.; Offerhaus, G. Johan A.; Morreau, Hans; Bonsing, Bert A.; de Vos tot Nederveen Cappel, Wouter H.

doi:10.1053/j.gastro.2010.11.048

Cited by 152Pancreatic and Hepatic Oncology ResearchMRI in cancer diagnosisPancreatitis Pathology and Treatment

Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation

Vasen, Hans F.A., Wasser, Martin, van Mil, Anneke, Tollenaar, Rob A., Konstantinovski, Marja, Gruis, Nelleke A., Bergman, Wilma, Hes, Frederik J. +5 more·2011·Gastroenterology

DOI 10.1053/j.gastro.2010.11.048

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Abstract

Background & aims Surveillance of high-risk groups for pancreatic cancer might increase early detection and treatment outcomes. Individuals with germline mutations in p16-Leiden have a lifetime risk of 15% to 20% of developing pancreatic cancer. We assessed the feasibility of detecting pancreatic cancer at an early stage and investigated the outcomes of patients with neoplastic lesions.Methods Individuals with germline mutations in p16-Leiden (N = 79; 31 male; mean age, 56 years; range, 39-72 years) were offered annual surveillance by magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP). Those found to have neoplastic lesions were offered options for surgery or intensive follow-up. Individuals found to have possible neoplastic lesions were examined again by MRI/MRCP within 2 to 4 months.Results After a median follow-up period of 4 years (range, 0-10 years), pancreatic cancer was diagnosed in 7 patients (9%). The mean age at diagnosis was 59 years (range, 49-72 years). Three of the tumors were present at the first examination, and 4 were detected after a negative result in the initial examination. All 7 patients had a resectable lesion; 5 underwent surgery, 3 had an R0 resection, and 2 had lymph node metastases. Possible precursor lesions (ie, duct ectasias, based on MRCP) were found in 9 individuals (11%).Conclusions MRI/MRCP detects small, solid pancreatic tumors and small duct ectasias. Although surveillance increases the rate of resectability, carriers of a p16-Leiden mutation develop aggressive tumors.

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The CAPS5 study results differ from the Dutch Familial Pancreatic Cancer Surveillance Study Group report, which had a PDAC resectability rate of only 60%, possibly due to predominance of CDKN2A mutation carriers.
“The CAPS5 study results differ in some respects from the recent report of the Dutch Familial Pancreatic Cancer Surveillance Study Group.16 This study reported a PDAC resectability rate of only 60%, which may be a function of the predominance of CDKN2A mutation carriers in their high-risk cohort”
From The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival (2022) · cites this paper as [24]

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Authors: Vasen, H. F. A., Wasser, M., van Mil, A., Tollenaar, R. A., Konstantinovski, M., Gruis, N. A., Bergman, W., Hes, F. J., Hommes, D. W., Offerhaus, G. J. A., Morreau, H., Bonsing, B. A., & de Vos tot Nederveen Cappel, W. H.
Affiliations: Leiden University Medical Center (NL)
University Medical Center Utrecht (NL)
Corresponding author: Vasen, Hans F.A.
ORCID: Vasen, Hans F.A.
Wasser, Martin
Tollenaar, Rob A.
Gruis, Nelleke A.
Hes, Frederik J.
Offerhaus, G. Johan A.
Morreau, Hans
Bonsing, Bert A.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2011-03
Volume: 140
Issue: 3
Pages: 850-856
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2010.11.048
OpenAlex: W2066851924
Cited by: 152
References: 19
Citations by year: 2026: 3 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 10 · 2021: 5 · 2020: 7 · 2019: 11 · 2018: 13 · 2017: 11 · 2016: 14 · 2015: 16 · 2014: 17 · 2013: 9 · 2012: 19
FWCI: 5.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords: pancreatic cancer, germline mutation carriers, cancer surveillance, early detection, magnetic resonance imaging, magnetic resonance cholangiopancreatography, duct ectasia, tumor resectability, lymph node metastasis
MeSH terms: Adenocarcinoma, Adult, Aged, Feasibility Studies, Female, Humans, Magnetic Resonance Imaging, Male, Mass Screening, Middle Aged, Neoplasm Staging, Netherlands, Pancreas, Pancreatic Neoplasms, Phenotype, Precancerous Conditions, Predictive Value of Tests, Prognosis, Registries, Time Factors, Germ-Line Mutation, Genes, p16, Genetic Predisposition to Disease, Cholangiopancreatography, Magnetic Resonance, Early Detection of Cancer

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Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation

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