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Cited by 524Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and TreatmentNeuroendocrine Tumor Research Advances

Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study

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Canto, Marcia Irene, Goggins, Michael, Hruban, Ralph H., Petersen, Gloria M., Giardiello, Francis M., Yeo, Charles, Fishman, Elliott K., Brune, Kieran +7 more·2006·Clinical Gastroenterology and Hepatology
DOI 10.1016/j.cgh.2006.02.005
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Abstract

Background & aims Individuals with a strong family history of pancreatic cancer and persons with Peutz-Jeghers syndrome (PJS) have an increased risk for pancreatic cancer. This study screened for early pancreatic neoplasia and compared the pancreatic abnormalities in high-risk individuals and control subjects.Methods High-risk individuals with PJS or a strong family history of pancreatic cancer were prospectively evaluated with baseline and 12-month computed tomography (CT) scan and endoscopic ultrasonography (EUS). If EUS was abnormal, EUS-fine-needle aspiration and endoscopic retrograde cholangiopancreatography (ERCP) were performed. Surgery was offered to patients with potentially neoplastic lesions. Radiologic findings and pathologic diagnoses were compared. Patients undergoing EUS and/or ERCP for benign non-pancreatic indications were concurrently enrolled as control subjects.Results Seventy-eight high-risk patients (72 from familial pancreatic cancer kindreds, 6 PJS) and 149 control patients were studied. To date, 8 patients with pancreatic neoplasia have been confirmed by surgery or fine-needle aspiration (10% yield of screening); 6 patients had 8 benign intraductal papillary mucinous neoplasms (IPMNs), 1 had an IPMN that progressed to invasive ductal adenocarcinoma, and 1 had pancreatic intraepithelial neoplasia. EUS and CT also diagnosed 3 patients with 5 extrapancreatic neoplasms. At EUS and ERCP abnormalities suggestive of chronic pancreatitis were more common in high-risk patients than in control subjects.Conclusions Screening EUS and CT diagnosed significant asymptomatic pancreatic and extrapancreatic neoplasms in high-risk individuals. IPMN should be considered a part of the phenotype of familial pancreatic cancer. Abnormalities suggestive of chronic pancreatitis are identified more commonly at EUS and ERCP in high-risk individuals.

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  • Medical imaging has been shown to detect precancerous tissue changes in the pancreas among individuals at high risk.

    “The ability to detect precancerous tissue changes in the pancreas using medical imaging among individuals at high risk has also been shown.110,122–125”

    From Early detection of pancreatic cancer (2020) · cites this paper as [123]

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Authors
Canto, M. I., Goggins, M., Hruban, R. H., Petersen, G. M., Giardiello, F. M., Yeo, C., Fishman, E. K., Brune, K., Axilbund, J., Griffin, C., Ali, S., Richman, J., Jagannath, S., Kantsevoy, S. V., & Kalloo, A. N.
Affiliations
  • Johns Hopkins University (US)
  • Mayo Clinic (US)
Corresponding author
Canto, Marcia Irene
ORCID
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2006-06
Volume
4
Issue
6
Pages
766-781
ISSN
1542-3565 (ISSN-L)
DOI
10.1016/j.cgh.2006.02.005
OpenAlex
W2159435688
Cited by
524
References
64
Citations by year
2026: 6 · 2025: 2 · 2024: 16 · 2023: 16 · 2022: 17 · 2021: 15 · 2020: 18 · 2019: 26 · 2018: 25 · 2017: 15 · 2016: 25 · 2015: 31 · 2014: 33 · 2013: 25 · 2012: 39
FWCI
21.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (M01440052)
  • National Cancer Institute (2P50 CA62924-10, P50CA062924)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
Keywords
pancreatic cancer screening, Peutz-Jeghers syndrome, familial pancreatic cancer, high-risk individuals, intraductal papillary mucinous neoplasm, pancreatic intraepithelial neoplasia, chronic pancreatitis, endoscopic ultrasound, computed tomography, endoscopic retrograde cholangiopancreatography, fine-needle aspiration, pancreatic ductal adenocarcinoma
MeSH terms
Adult, Aged, Cholangiopancreatography, Endoscopic Retrograde, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Peutz-Jeghers Syndrome, Risk Factors, Tomography, X-Ray Computed, Endosonography, Carcinoma, Pancreatic Ductal, Biopsy, Fine-Needle, Pancreatitis, Chronic

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