Diabetes, weight change, and pancreatic cancer risk
Open accessAbstract
Importance: Pancreatic cancer is the third-leading cause of cancer death in the United States; however, few high-risk groups have been identified to facilitate early diagnosis strategies. Objective: To evaluate the association of diabetes duration and recent weight change with subsequent risk of pancreatic cancer in the general population. Design, Setting, and Participants: This cohort study obtained data from female participants in the Nurses' Health Study and male participants in the Health Professionals Follow-Up Study, with repeated exposure assessments over 30 years. Incident cases of pancreatic cancer were identified from self-report or during follow-up of participant deaths. Deaths were ascertained through reports from the next of kin, the US Postal Service, or the National Death Index. Data collection was conducted from October 1, 2018, to December 31, 2018. Data analysis was performed from January 1, 2019, to June 30, 2019. Exposures: Duration of physician-diagnosed diabetes and recent weight change. Main Outcome and Measures: Hazard ratios (HRs) for subsequent development of pancreatic cancer. Results: Of the 112 818 women (with a mean [SD] age of 59.4 [11.7] years) and 46 207 men (with a mean [SD] age of 64.7 [10.8] years) included in the analysis, 1116 incident cases of pancreatic cancers were identified. Compared with participants with no diabetes, those with recent-onset diabetes had an age-adjusted HR for pancreatic cancer of 2.97 (95% CI, 2.31-3.82) and those with long-standing diabetes had an age-adjusted HR of 2.16 (95% CI, 1.78-2.60). Compared with those with no weight loss, participants who reported a 1- to 4-lb weight loss had an age-adjusted HR for pancreatic cancer of 1.25 (95% CI, 1.03-1.52), those with a 5- to 8-lb weight loss had an age-adjusted HR of 1.33 (95% CI, 1.06-1.66), and those with more than an 8-lb weight loss had an age-adjusted HR of 1.92 (95% CI, 1.58-2.32). Participants with recent-onset diabetes accompanied by weight loss of 1 to 8 lb (91 incident cases per 100 000 person-years [95% CI, 55-151]; HR, 3.61 [95% CI, 2.14-6.10]) or more than 8 lb (164 incident cases per 100 000 person-years [95% CI, 114-238]; HR, 6.75 [95% CI, 4.55-10.00]) had a substantially increased risk for pancreatic cancer compared with those with neither exposure (16 incident cases per 100 000 person-years; 95% CI, 14-17). Incidence rates were even higher among participants with recent-onset diabetes and weight loss with a body mass index of less than 25 before weight loss (400 incident cases per 100 000 person-years) or whose weight loss was not intentional judging from increased physical activity or healthier dietary choices (334 incident cases per 100 000 person-years). Conclusions and Relevance: This study demonstrates that recent-onset diabetes accompanied by weight loss is associated with a substantially increased risk for developing pancreatic cancer. Older age, previous healthy weight, and no intentional weight loss further elevate this risk.
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People who have new-onset diabetes plus an END-PAC score of 3 or more form a group whose PDAC risk is high enough that screening might help.
“One such cohort is subjects with new-onset diabetes and a high score (≥3) on the Enriching New-Onset Diabetes for Pancreatic Cancer (END-PAC) model.4”
From Radiomics-based Machine-learning Models Can Detect Pancreatic Cancer on Prediagnostic Computed Tomography Scans at a Substantial Lead Time Before Clinical Diagnosis (2022) · cites this paper as [4]
The Discussion (page unavailable) identifies recent-onset diabetes accompanied by weight loss as a higher-risk group and says whether that group should undergo pancreatic cancer surveillance warrants prospective study. The paper does not identify an END-PAC score of ≥3 as the criterion for that group or assess screening for people meeting that cutoff. (LLM, conf=0.86)
Experimental — accuracy not yet measuredDetecting PDAC earlier improves survival beyond the effect of lead time, since smaller tumors are more often resectable.
“Early detection offers survival benefit beyond lead time, as tumors are smaller in volume and more likely to be resectable when detected earlier.2-4”
From Radiomics-based Machine-learning Models Can Detect Pancreatic Cancer on Prediagnostic Computed Tomography Scans at a Substantial Lead Time Before Clinical Diagnosis (2022) · cites this paper as [4]
The Introduction reports earlier-stage diagnosis and longer survival among patients undergoing surveillance, and the Discussion says early-stage pancreatic cancer can be cured with aggressive treatment. The paper also describes a window in which some tumors are surgically resectable. It does not establish that the survival benefit exceeds lead-time effects or attribute greater resectability to smaller tumor volume. Page numbers are unavailable in our copy. (LLM, conf=0.84)
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Cites
Siegel, R. L., Miller, K. D., & Jemal, A. (2020) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21590 · Cited by 20,444 · see citing works
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202 · see citing works
Diagnosis and classification of diabetes mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc10-s062 · Cited by 5,491 · see citing works
(1996) · Institutional Research Information System University of Turin (University of Turin) · doi:10.1111/j · Cited by 5,486 · see citing works
FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer
Conroy, T., Hammel, P., Hebbar, M., Ben Abdelghani, M., Wei, A. C., Raoul, J.-L., Choné, L., Francois, E., Artru, P., Biagi, J. J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1809775 · Cited by 2,874 · see citing works
Ryan, D. P., Hong, T. S., & Bardeesy, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1404198 · Cited by 2,348 · see citing works
Kamisawa, T., Wood, L. D., Itoi, T., & Takaori, K. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00141-0 · Cited by 2,212 · see citing works
Prospective study of alcohol consumption and risk of coronary disease in men.
Rimm, E. B., Giovannucci, E. L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B., & Stampfer, M. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)90542-w · Cited by 1,239 · see citing works
Self-citationPhysical activity and incidence of non-insulin-dependent diabetes mellitus in women
Manson, J. E., Stampfer, M. J., Colditz, G. A., Willett, W. C., Rosner, B., Hennekens, C. H., Speizer, F. E., Rimm, E. B., & Krolewski, A. S. (1991) · The Lancet · doi:10.1016/0140-6736(91)90664-b · Cited by 1,164 · see citing works
Self-citationType-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
Huxley, R., Ansary-Moghaddam, A., Berrington de González, A., Barzi, F., & Woodward, M. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602619 · Cited by 1,105 · see citing works
Regression Models in Clinical Studies: Determining Relationships Between Predictors and Response
Harre, F. E., Lee, K. L., & Pollock, B. G. (1988) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/80.15.1198 · Cited by 960 · see citing works
(2018) · doi:10.1001/jama · Cited by 932 · see citing works
Early Detection of Pancreatic Cancer: Opportunities and Challenges
Singhi, A. D., Koay, E. J., Chari, S. T., & Maitra, A. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.259 · Cited by 841 · see citing works
Physical Activity and Television Watching in Relation to Risk for Type 2 Diabetes Mellitus in Men
Hu, F. B., Leitzmann, M. F., Stampfer, M. J., Colditz, G. A., Willett, W. C., & Rimm, E. B. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.12.1542 · Cited by 828 · see citing works
Self-citationCanto, M. I., Harinck, F., Hruban, R. H., Offerhaus, G. J., Poley, J.-W., Kamel, I., Nio, Y., Schulick, R. S., Bassi, C., Kluijt, I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303108 · Cited by 784 · see citing works
The Nurses' Health Study: 20-Year Contribution to the Understanding of Health Among Women
Colditz, G. A., Manson, J. E., & Hankinson, S. E. (1997) · Journal of Women s Health · doi:10.1089/jwh.1997.6.49 · Cited by 739 · see citing works
Diabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies
Ben, Q., Xu, M., Ning, X., Liu, J., Hong, S., Huang, W., Zhang, H., & Li, Z. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.03.003 · Cited by 685 · see citing works
Mayers, J. R., Wu, C. H., Clish, C. B., Kraft, P., Torrence, M. E., Fiske, B. P., Yuan, C., Bao, Y., Townsend, M. K., Tworoger, S. S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3686 · Cited by 652 · see citing works
Self-citationProbability of Pancreatic Cancer Following Diabetes: A Population-Based Study
Chari, S. T., Leibson, C. L., Rabe, K. G., Ransom, J., de Andrade, M., & Petersen, G. M. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.007 · Cited by 603 · see citing works
Probability of Pancreatic Cancer Following Diabetes: A Population-Based Study
CHARI, S., LEIBSON, C., RABE, K., RANSOM, J., DEANDRADE, M., & PETERSEN, G. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.007 · Cited by 603 · see citing works
Hu, C., Hart, S. N., Polley, E. C., Gnanaolivu, R., Shimelis, H., Lee, K. Y., Lilyquist, J., Na, J., Moore, R., Antwi, S. O., et al. (2018) · JAMA · doi:10.1001/jama.2018.6228 · Cited by 577 · see citing works
Test of the National Death Index and Equifax Nationwide Death Search
Rich-Edwards, J. W., Corsano, K. A., & Stampfer, M. J. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117191 · Cited by 530 · see citing works
Self-citationChari, S. T., Leibson, C. L., Rabe, K. G., Timmons, L. J., Ransom, J. E., de Andrade, M., & Petersen, G. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.040 · Cited by 519 · see citing works
US Preventive Services Task Force, Owens, D. K., Davidson, K. W., Krist, A. H., Barry, M. J., Cabana, M., Caughey, A. B., Curry, S. J., Doubeni, C. A., Epling, J. W., et al. (2019) · JAMA · doi:10.1001/jama.2019.10232 · Cited by 419 · see citing works
Canto, M. I., Almario, J. A., Schulick, R. D., Yeo, C. J., Klein, A., Blackford, A., Shin, E. J., Sanyal, A., Yenokyan, G., Lennon, A. M., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.05.035 · Cited by 414 · see citing works
Model to determine risk of pancreatic cancer in patients with new-onset diabetes
Sharma, A., Kandlakunta, H., Nagpal, S. J. S., Feng, Z., Hoos, W., Petersen, G. M., & Chari, S. T. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.05.023 · Cited by 394 · see citing works
Vasen, H., Ibrahim, I., Ponce, C. G., Slater, E. P., Matthäi, E., Carrato, A., Earl, J., Robbers, K., van Mil, A. M., Potjer, T., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.0730 · Cited by 344 · see citing works
Boursi, B., Finkelman, B., Giantonio, B. J., Haynes, K., Rustgi, A. K., Rhim, A. D., Mamtani, R., & Yang, Y.-X. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.11.046 · Cited by 202 · see citing works
Pelaez-Luna, M., Takahashi, N., Fletcher, J. G., & Chari, S. T. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01480.x · Cited by 180 · see citing works
Altered exocrine function can drive adipose wasting in early pancreatic cancer
Danai, L. V., Babic, A., Rosenthal, M. H., Dennstedt, E. A., Muir, A., Lien, E. C., Mayers, J. R., Tai, K., Lau, A. N., Jones-Sali, P., et al. (2018) · Nature · doi:10.1038/s41586-018-0235-7 · Cited by 141 · see citing works
Self-citationNew-Onset Diabetes and Pancreatic Cancer
Gupta, S. N., Vittinghoff, E., Bertenthal, D., Corley, D. A., Shen, H., Walter, L. C., & McQuaid, K. R. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.06.024 · Cited by 137 · see citing works
Sah, R. P., Sharma, A., Nagpal, S. J. S., Patlolla, S. H., Sharma, A. K., Kandlakunta, H., Anani, V., Angom, R. S., Kamboj, A. K., Ahmed, N., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.039 · Cited by 136 · see citing works
Pancreatitis-Diabetes-Pancreatic Cancer
Andersen, D. K., Andrén‐Sandberg, Å., Duell, E. J., Goggins, M., Korc, M., Petersen, G. M., Smith, J. P., & Whitcomb, D. C. (2013) · Pancreas · doi:10.1097/mpa.0b013e3182a9ad9d · Cited by 132 · see citing works
Pannala, R., Leibson, C. L., Rabe, K. G., Timmons, L. J., Ransom, J. E., de Andrade, M., Petersen, G. M., & Chari, S. T. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.253 · Cited by 120 · see citing works
Maitra, A., Sharma, A., Brand, R. E., Van Den Eeden, S. K., Fisher, W. E., Hart, P. A., Hughes, S. J., Mather, K. J., Pandol, S. J., Park, W. G., et al. (2018) · Pancreas · doi:10.1097/mpa.0000000000001169 · Cited by 93 · see citing works
Weight Loss Precedes Cancer-Specific Symptoms in Pancreatic Cancer-Associated Diabetes Mellitus
Hart, P. A., Kamada, P., Rabe, K. G., Srinivasan, S., Basu, A., Aggarwal, G., & Chari, S. T. (2011) · Pancreas · doi:10.1097/mpa.0b013e318220816a · Cited by 92 · see citing works
Predictors for Pancreatic Cancer Diagnosis Following New-Onset Diabetes Mellitus
Munigala, S., Singh, A., Gelrud, A., & Agarwal, B. (2015) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2015.44 · Cited by 73 · see citing works
A Glimmer of Hope for Pancreatic Cancer
Kindler, H. L. (2018) · New England Journal of Medicine · doi:10.1056/nejme1813684 · Cited by 52 · see citing works
Is screening for pancreatic cancer in high-risk individuals one step closer or a fool's errand?
Hart, P. A., & Chari, S. T. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.09.024 · Cited by 32 · see citing works
Metabolic Alterations as a Signpost to Early Pancreatic Cancer
Khalaf, N. I., & Wolpin, B. M. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.028 · Cited by 20 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors
Klein, A. P. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00457-x · Cited by 1,258 · see citing works
Advances in the epidemiology of pancreatic cancer: Trends, risk factors, screening, and prognosis
Cai, J., Chen, H., Lu, M., Zhang, Y., Lu, B., You, L., Zhang, T., Dai, M., & Zhao, Y. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.06.027 · Cited by 475 · see citing works
A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories
Placido, D., Yuan, B., Hjaltelin, J. X., Zheng, C., Haue, A. D., Chmura, P. J., Yuan, C., Kim, J., Umeton, R., Antell, G., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02332-5 · Cited by 349 · see citing works
Self-citationMukherjee, S., Patra, A., Khasawneh, H., Korfiatis, P., Rajamohan, N., Suman, G., Majumder, S., Panda, A., Johnson, M. P., Larson, N. B., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.066 · Cited by 187 · see citing works
Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact
Spitzberg, J. D., Ferguson, S. W., Yang, K. S., Peterson, H. M., Carlson, J., & Weissleder, R. (2023) · Nature Communications · doi:10.1038/s41467-023-36932-z · Cited by 157 · see citing works
Pancreatic cancer in 2021: What you need to know to win
Tonini, V., & Zanni, M. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i35.5851 · Cited by 126 · see citing works
Diabetes and pancreatic cancer: Exploring the two-way traffic
Roy, A., Sahoo, J., Kamalanathan, S., Naik, D., Mohan, P., & Kalayarasan, R. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i30.4939 · Cited by 104 · see citing works
The age-dependent association of risk factors with pancreatic cancer
Yuan, C., Kim, J., Wang, Q.-L., Lee, A. A., Babić, A., Amundadottir, L. T., Ardanáz, E., Arslan, A. A., Beane-Freeman, L. E., Bracci, P. M., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.03.276 · Cited by 83 · see citing works
Self-citationAdipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer
Babić, A., Rosenthal, M. H., Sundaresan, T. K., Khalaf, N. I., Lee, V., Brais, L. K., Loftus, M., Caplan, L. R., Denning, S. L., Gurung, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40024-3 · Cited by 77 · see citing works
Self-citationHu, Y., Zeng, N., Ge, Y., Wang, D., Qin, X., Zhang, W., Jiang, F., & Liu, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.847760 · Cited by 64 · see citing works
“Numerous studies have specified type 2 diabetes mellitus (T2DM) as a known risk factor for PC (4, 5).”
BackgroundShen, B., Li, Y., Sheng, C., Liu, L., Hou, T., Xia, N., Sun, S., Miao, Y., Pang, Y., Gu, K., et al. (2022) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2022.100596 · Cited by 63 · see citing works
Afghani, E., & Klein, A. P. (2022) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2022.07.002 · Cited by 54 · see citing works
A blood-based metabolomic signature predictive of risk for pancreatic cancer
Irajizad, E., Kenney, A., Tang, T. M., Vykoukal, J., Wu, R., Murage, E. N., Dennison, J. B., Sans, M., Long, J. P., Loftus, M., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101194 · Cited by 44 · see citing works
“Consequently, we were unable to evaluate the complementarity of the metabolite panel together with other risk models based on patient characteristics 62 for risk assessment of pancreatic cancer.”
Self-citationAssociations between genetically predicted levels of blood metabolites and pancreatic cancer risk
Zhong, H., Liu, S., Zhu, J., & Wu, L. (2023) · International Journal of Cancer · doi:10.1002/ijc.34466 · Cited by 39 · see citing works
Weight Loss as an Untapped Early Detection Marker in Pancreatic and Periampullary Cancer
Hue, J. J., Sugumar, K., Kyasaram, R. K., Shanahan, J., Lyons, J. L., Ocuin, L. M., Rothermel, L. D., Hardacre, J. M., Ammori, J. B., Rao, G., et al. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-09861-8 · Cited by 39 · see citing works
“A study from two large datasets found weight loss ([ 1 pound) was identified prediagnostically in 51% of subjects who developed pancreatic cancer; however, reported weights were surveybased, with measurements taken 2 years apart.(25) As a result, UWL may be underreported.”
BackgroundMellenthin, C., Balaban, D. V., Dugic, A., & Cullati, S. (2022) · Cancers · doi:10.3390/cancers14194684 · Cited by 47 · see citing works
“, JAMA Oncology, 2020 [30] USA Nurses’ Health Study (NHS), baseline 1978, Health Professionals Follow-Up Study (HPFS), baseline 1988 Two retrospective cohorts, female nurses and male physicians, without previous diagnosis of PDAC or DM.”
BackgroundProtein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer
Ben‐Ami, R., Wang, Q.-L., Zhang, J., Supplee, J., Fahrmann, J. F., Lehmann‐Werman, R., Brais, L. K., Nowak, J. A., Yuan, C., Loftus, M., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-331074 · Cited by 43 · see citing works
Self-citationCancer Diagnoses After Recent Weight Loss
Wang, Q.-L., Babić, A., Rosenthal, M. H., Lee, A. A., Zhang, Y., Zhang, X., Song, M., Rezende, L. F. M., Lee, D. H., Biller, L. H., et al. (2024) · JAMA · doi:10.1001/jama.2023.25869 · Cited by 35 · see citing works
Self-citationEarly Detection of Pancreatic Cancer: Current Advances and Future Opportunities
Lin, Z., Adeniran, E. A., Cai, Y., Qureshi, T. A., Li, D., Gong, J., Li, J., Pandol, S. J., & Jiang, Y. (2025) · Biomedicines · doi:10.3390/biomedicines13071733 · Cited by 34 · see citing works
“This association was consistent with prior findings from U.S. cohorts, such as the Nurses’ Health Study (NHS) and Health Professionals Follow-Up Study, where a more than two-fold increase in risk was observed in both recent-onset diabetes and longstanding diabetes [15].”
Risk of Pancreatic Cancer in Glycemically Defined New-Onset Diabetes: A Prospective Cohort Study
Chari, S. T., Wu, B. U., Lopez, C., Lustigova, E., Chen, Q., Eeden, S. K. V. D., Leimpeter, A. D., Fisher, W., Wood, A., Alexander, A. S., et al. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.06.025 · Cited by 33 · see citing works
Huang, Y. J., Liu, F., Chen, A., Yang, P., Peng, Y., Gong, J., Li, Z., & Zhong, G. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.09.037 · Cited by 31 · see citing works
The global, regional burden of pancreatic cancer and its attributable risk factors from 1990 to 2021
Yu, W., Zhou, D., Meng, F., Wang, J., Wang, B., Qiang, J., Shen, L., Wang, M., & Fang, H. (2025) · BMC Cancer · doi:10.1186/s12885-025-13471-y · Cited by 33 · see citing works
The timing of adiposity and changes in the life course on the risk of cancer
Fang, Z., & Giovannucci, E. L. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10054-2 · Cited by 28 · see citing works
Self-citationZhong, H., Liu, S., Zhu, J., Xu, T. H., Yu, H., & Wu, L. (2023) · International Journal of Cancer · doi:10.1002/ijc.34771 · Cited by 28 · see citing works
Tan, P. S., Garriga, C., Clift, A. K., Liao, W., Patone, M., Coupland, C. A. C., Bashford-Rogers, R. J. M., Sivakumar, S., & Hippisley‐Cox, J. (2022) · Gut · doi:10.1136/gutjnl-2021-326522 · Cited by 26 · see citing works
Early diagnosis of pancreatic cancer: What strategies to avoid a foretold catastrophe
Tonini, V., & Zanni, M. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i31.4235 · Cited by 27 · see citing works
Clift, A. K., Tan, P. S., Patone, M., Liao, W., Coupland, C. A. C., Bashford-Rogers, R. J. M., Sivakumar, S., & Hippisley‐Cox, J. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02693-9 · Cited by 25 · see citing works
“Although this association ’ s directionality and mechanisms are incompletely understood [4, 5], people with new-onset diabetes represent an important opportunity for identifying high-risk sub-populations suitable for further testing — new-onset ‘ T2DM ’ may in fact in some cases be type 3c…”
BackgroundZhang, B., Yuan, Q., Zhang, B., Li, S., Wang, Z., Liu, H., Meng, F., Chen, X., & Shang, D. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1078424 · Cited by 24 · see citing works
Jiang, Z., Zheng, X., Li, M., & Liu, M. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1050-6 · Cited by 24 · see citing works
Beetz, N. L., Geisel, D., Maier, C., Auer, T. A., Shnayien, S., Malinka, T., Neumann, C., Pelzer, U., & Fehrenbach, U. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092356 · Cited by 23 · see citing works
“In fact, 70% of patients are older than 65 [7].”
BackgroundYu, D.-W., Li, Q., Cheng, L., Yang, P., Sun, W., Peng, Y., Hu, J., Wu, J., Gong, J., & Zhong, G. (2021) · American Journal of Epidemiology · doi:10.1093/aje/kwab131 · Cited by 23 · see citing works
Lipidomics and pancreatic cancer risk in two prospective studies
Naudin, S., Sampson, J. N., Moore, S. C., Albanes, D., Freedman, N. D., Weinstein, S. J., & Stolzenberg‐Solomon, R. Z. (2023) · European Journal of Epidemiology · doi:10.1007/s10654-023-01014-3 · Cited by 22 · see citing works
“, diabetes or endocrine dysfunction [48]) or exogenous exposures (e.”
BackgroundRuze, R., Chen, Y., Xu, R., Song, J., Yin, X., Wang, C., & Xu, Q. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188844 · Cited by 19 · see citing works
Qi, J., Hart, P. A., Shi, N., Joseph, J. J., Donneyong, M., Conwell, D. L., Clinton, S. K., Cruz‐Monserrate, Z., Brasky, T. M., Tinker, L. F., et al. (2021) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-1478 · Cited by 20 · see citing works
“Conceptually, two different types of associations between glucose dysregulation and pancreatic cancer likely exist (38, 39).”
BackgroundShou, S., Liu, R., He, J., Jiang, X., Liu, F., Li, Y., Zhang, X., En, G., Pu, Z., Hua, B., et al. (2025) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2024-001544 · Cited by 22 · see citing works
IDO1 Is a Therapeutic Target for Pancreatic Cancer–Associated Depression
Hue, J. J., Graor, H. J., Zarei, M., Katayama, E., Ji, K., Hajihassani, O., Loftus, A. W., Gohar, A. V., & Winter, J. M. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-22-0055 · Cited by 18 · see citing works
Risk Assessment and Pancreatic Cancer: Diagnostic Management and Artificial Intelligence
Granata, V., Fusco, R., Setola, S. V., Galdiero, R., Maggialetti, N., Silvestro, L., Bellis, M. D., Girolamo, E. D., Grazzini, G., Chiti, G., et al. (2023) · Cancers · doi:10.3390/cancers15020351 · Cited by 19 · see citing works
Bureš, J., Kohoutová, D., Škrha, J., Bunganič, B., Ngo, O., Suchánek, Š., Škrha, P., & Zavoral, M. (2023) · Cancers · doi:10.3390/cancers15143669 · Cited by 19 · see citing works
Inherited Pancreatic Cancer Syndromes and High-Risk Screening
Biller, L. H., Wolpin, B. M., & Goggins, M. (2021) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2021.06.002 · Cited by 19 · see citing works
Self-citationPancreatic cancer risk predicted from disease trajectories using deep learningPreprint
Placido, D., Yuan, B., Hjaltelin, J. X., Zheng, C., Haue, A. D., Chmura, P. J., Yuan, C., Kim, J., Umeton, R., Antell, G. C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.27.449937 · Cited by 16 · see citing works
Self-citationIntegrated US-OCT-NIRF Tri-Modality Endoscopic Imaging System for Pancreaticobiliary Duct Imaging
Kong, R., Dai, C., Zhang, Q., Gao, L., Chen, Z., Song, Y., Wu, Z., Wang, J., Wang, S., Zheng, H., et al. (2022) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2022.3164777 · Cited by 15 · see citing works
Proteomics in pancreatic cancer
Cai, F., Gu, Y., Ling, Y., Yi, G., Zang, S., Su, T., Liu, Y., Li, A., Wang, D., Zhao, W., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00805-y · Cited by 14 · see citing works
“…high-risk cohorts (e.g., individuals with hereditary PDAC predisposition, pancreatic cystic lesions, and new-onset diabetes) may require distinct positivity thresholds compared with those applied in the general population, balancing sensitivity and specificity to optimize clinical utility [172].”
Machine Learning Predicts Patients With New-onset Diabetes at Risk of Pancreatic Cancer
Khan, S. A., & Bhushan, B. P. (2023) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001897 · Cited by 14 · see citing works
“31,32 Such a feature is vital to END-PAC and Boursi ’ s models.”
BackgroundWei, Y., Qin, Z., Liao, X., Zhou, X., Huang, H., Lan, C., Qin, W., Zhu, G., Su, H., & Peng, T. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1302436 · Cited by 14 · see citing works
“Cumulative risk effects for developing PC may arise from diabetes accompanied by weight loss (40).”
BackgroundSagami, R., Sato, T., Mizukami, K., Motomura, M., Okamoto, K., Fukuchi, S., Otsuka, Y., Abe, T., Ono, H., Mori, K., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12020377 · Cited by 14 · see citing works
Wu, B. U. (2021) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000763 · Cited by 14 · see citing works
Hjaltelin, J. X., Novitski, S. I., Jørgensen, I. F., Siggaard, T., Vulpius, S. A., Westergaard, D., Johansen, J. S., Chen, I. M., Jensen, L. J., & Brunak, S. (2023) · eLife · doi:10.7554/elife.84919 · Cited by 13 · see citing works
Papalamprakopoulou, Z., Dey, P., Frascati, R., & Fountzilas, C. K. (2025) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000832 · Cited by 12 · see citing works
Pancreatic cancer is associated with medication changes prior to clinical diagnosis
Zhang, Y., Wang, Q.-L., Yuan, C., Lee, A. A., Babić, A., Ng, K., Perez, K. J., Nowak, J. A., Lagergren, J., Stampfer, M. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38088-2 · Cited by 12 · see citing works
“In fact, hyperglycemia and weight loss commonly co-occur in patients who develop pancreatic cancer 4,43 .”
Self-citationLiu, X., Zhou, L., Chen, Y., Jiang, X., & Jiang, J. (2021) · Journal of Oncology · doi:10.1155/2021/6945046 · Cited by 10 · see citing works
“…race, diabetes, family history of PC, genetic factors, chronic infection, non-O blood type, and chronic pancreatitis are main risk factors in PC [2]. extremely poor prognosis in PC is primarily due to the early onset of metastasis, and therefore, surgical resection is thought to be the mainstay…”
Brewer, M. J., Doucette, J. T., Bar-Mashiah, A., Glickman, J. W., Kessel, E., Aronson, A., & Lucas, A. L. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.07.046 · Cited by 10 · see citing works
Mandic, M., Pulte, D. D., Safizadeh, F., Niedermaier, T., Hoffmeister, M., & Brenner, H. (2024) · Obesity Reviews · doi:10.1111/obr.13799 · Cited by 9 · see citing works
Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment
Ma, J., Bhardwaj, V., Lobie, P. E., & Pandey, V. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02620-x · Cited by 10 · see citing works
“Notably, new-onset diabetes in older adults significantly increases PDAC risk, with a 7–8-fold rise, and up to 80% of patients exhibit hyper-glycemia or diabetes at diagnosis [101–103].”
Zhu, W., Chen, L., Aphinyanaphongs, Y., Kastrinos, F., Simeone, D. M., Pochapin, M. B., Stender, C., Razavian, N., & Gonda, T. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-89607-8 · Cited by 8 · see citing works
“Risk associations were developed based on the combination of several of these risk factors and their dynamic change during a period preceding the diagnosis of cancer 23,24 .”
Prävention des Pankreaskarzinoms
Scherübl, H. (2023) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-1975-2366 · Cited by 8 · see citing works
“BMI: Body-Mass-Index (angegeben in kg/m2) (nach Daten aus [27]).”
Weight loss during neoadjuvant therapy for pancreatic cancer does not predict poor outcomes
Hue, J. J., Markt, S. C., Sugumar, K., Kyasaram, R. K., Shanahan, J., Rothermel, L. D., Ammori, J. B., Hardacre, J. M., Winter, J. M., & Ocuin, L. M. (2021) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2021.10.001 · Cited by 8 · see citing works
New-onset Diabetes as a Signpost of Early Pancreatic Cancer: The Role of Screening
Khalaf, N. I., & Ali, B. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.02.015 · Cited by 7 · see citing works
Self-citationWeight Tracking as a Novel Prognostic Marker After Pancreatectomy
Hue, J. J., Ocuin, L. M., Kyasaram, R. K., Shanahan, J., Rao, G., Rothermel, L. D., Ammori, J. B., Hardacre, J. M., Winter, J. M., & Markt, S. C. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-11325-6 · Cited by 7 · see citing works
“This finding is similar to past reports on weight loss preceding a patient’s initial PDAC diagnosis, including a study by our group.(20,25) This insight may potentially improve time to diagnosis of recurrence.”
ResultLim, C. Y., Min, J. H., Hwang, J. A., Choi, S., & Ko, S. E. (2022) · European Radiology · doi:10.1007/s00330-022-08928-8 · Cited by 8 · see citing works
“Although DM was not a significant factor in the prediction model for malignancy, we should remind that it is associated with a substantially increased risk of developing PDAC [23].”
BackgroundDiabetic Ferroptosis and Pancreatic Cancer: Foe or Friend?
Li, L., Yu, X., Gao, L., Cheng, L., Sun, B., & Wang, G. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0101 · Cited by 7 · see citing works
Martínez-Gutiérrez, J., de Mendonça, L., Ly, P. T. T., Lee, A., Hunter, B., Manski-Nankervis, J.-A. E., Chima, S., Daly, D., Fishman, G., Lim, F. S., et al. (2024) · BJGP Open · doi:10.3399/bjgpo.2024.0025 · Cited by 6 · see citing works
“25,32 As an example, Nicholson et al identified men over 50 years old and people who smoked (currently or in the past) to be the populations at highest risk of cancer with PPVs over the required threshold for investigation of 3%.”
Current paradigm and futuristic vision on new-onset diabetes and pancreatic cancer research
Moreland, R., Arredondo, A., Dhasmana, A., Dhasmana, S., Shabir, S., Siddiqua, A., Banerjee, B., Yallapu, M. M., Behrman, S. W., Chauhan, S. C., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1543112 · Cited by 6 · see citing works
Nishikawa, M., Yamamoto, J., Einama, T., Hoshikawa, M., Iwasaki, T., Nakazawa, A., Takihara, Y., Tsunenari, T., & Kishi, Y. (2022) · Pancreas · doi:10.1097/mpa.0000000000002186 · Cited by 6 · see citing works
The Influence of Metabolic Syndrome on the Development of Gastrointestinal Malignant Tumors—A Review
Brzački, V., Rančić, A., Tešić-Rajković, S., Nagorni, I., Stamenković, M., Stanković, E., Milutinović, N., & Vukadinović, A. (2025) · Medicina · doi:10.3390/medicina61061025 · Cited by 6 · see citing works
Typ-2-Diabetes-mellitus und Krebsrisiko
Scherübl, H. (2021) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-1529-4521 · Cited by 6 · see citing works
“5-Fache, im Falle eines zusätzlichen Gewichtsverlustes sogar auf das 10–25-Fache an [20] (▶ Abb.”
BackgroundRajagopalan, A., Aroori, S., Russell, T. B., Labib, P. L. Z., Ausania, F., Pando, E., Roberts, K. J., Kausar, A., Mavroeidis, V. K., Marangoni, G., et al. (2024) · HPB · doi:10.1016/j.hpb.2024.04.010 · Cited by 10 · see citing works
He, R., Shen, Z., Chen, Q., Hu, H., Ding, X., Zheng, Z., Feng, Q., & Li, B. (2025) · BMC Cancer · doi:10.1186/s12885-025-13863-0 · Cited by 5 · see citing works
Liao, C.-Y., Schapiro, D., Mojdami, D., Sheffield, K. M., Hoog, M. M., Keni, R., Gathirua‐Mwangi, W. G., & Kan, H. J. (2025) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70104 · Cited by 5 · see citing works
Prediction of Pancreatic Cancer Risk in Patients with New-Onset Diabetes
Khan, S. (2025) · Visceral Medicine · doi:10.1159/000543479 · Cited by 5 · see citing works
“Long-standing diabetes doubles the risk of pancreatic cancer, new-onset diabetes triples the risk relative to the general population, and diabetes diagnosed within 1 year increases the risk sevenfold [10, 11].”
Rassy, E., Delaloge, S., Slaouti, Y., Pudlarz, T., Lekens, B., Boilève, A., Michiels, S., & Karimi, M. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03172-5 · Cited by 5 · see citing works
“The independent association between dyslipidemia and PDAC adds to the growing body of literature linking metabolic disorders and PDAC [19].”
Severe insulin resistance in a patient with diabetes after treatment with brentuximab vedotin
Peeters, G., & Verhaegen, A. A. (2024) · BMJ Case Reports · doi:10.1136/bcr-2022-251867 · Cited by 5 · see citing works
The critical need for guidance in managing glycaemic control in patients with cancer
Giovannucci, E. L. (2021) · Diabetic Medicine · doi:10.1111/dme.14624 · Cited by 5 · see citing works
Self-citationTime to Neoadjuvant Chemotherapy Initiation Is not Associated With Survival in Pancreatic Cancer
Hue, J. J., Sugumar, K., Elshami, M., Rothermel, L. D., Ammori, J. B., Hardacre, J. M., Winter, J. M., & Ocuin, L. M. (2022) · Journal of Surgical Research · doi:10.1016/j.jss.2022.03.013 · Cited by 5 · see citing works
Wang, X., Wang, H., Zhang, M., Li, H., Liu, Y., Huang, H., Pei, J., Huang, J., Zang, F., Zhang, Y., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0323 · Cited by 4 · see citing works
Xiao, X., Yi, X., Soe, N. N., Latt, P. M., Lin, L., Chen, X., Song, H., Sun, B., Zhao, H., & Xu, X. (2024) · Annals of Epidemiology · doi:10.1016/j.annepidem.2024.12.003 · Cited by 4 · see citing works
Current Approaches of Pancreatic Cancer Surveillance in High-Risk Individuals
Heller, M., Mann, D. A., & Katona, B. W. (2025) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-025-01184-1 · Cited by 4 · see citing works
“Diabetes For individuals with long-standing type 2 diabetes mellitus (DM), the risk for PC is roughly 2-fold higher than the general population [43–45].”
Typ-2-Diabetes mellitus und gastrointestinale Krebsvorsorge
Scherübl, H. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1821-9108 · Cited by 4 · see citing works
“5-fache, im Falle eines zusätzlichen Gewichtsverlustes sogar auf das 10bis 25-fache an [43] (▶ Abb.”
Cai, J., Chen, H., Lu, M., Zhang, Y., Lu, B., Luo, C., Feng, X., You, L., Dai, M., & Zhao, Y. (2022) · Cancers · doi:10.3390/cancers14143403 · Cited by 4 · see citing works
“Much attention has been paid to the risks of PC in patients with diabetes in many studies [20,21], and our research suggests that glycemic changes in people without diabetes, both increases and decreases in FBG, are also worth monitoring to identify PC risk.”
BackgroundAfghani, E., Lau, B. M., Becker, L. K., Goggins, M., & Klein, A. P. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-099488 · Cited by 4 · see citing works
“31 Based on our study, the younger individuals with a new diabetes diagnosis had a higher HR compared with older individuals.”
Verhoeff, K. K., & Shapiro, A. M. J. (2025) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2025.101414 · Cited by 3 · see citing works
Pancreatic Cancer and Diabetes: Insights, Hypotheses, and Next Steps
Hill, J. L. E., Hill, T. G., Parslow, D., & Hill, D. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110245 · Cited by 4 · see citing works
Clinical and Imaging Predictors of Pancreatic Cancer in Patients Hospitalized for Acute Pancreatitis
Luong, T. Q., Chen, Q., Tran, T. M., Zhou, Y., Lustigova, E., Chen, W., & Wu, B. U. (2022) · Gastro Hep Advances · doi:10.1016/j.gastha.2022.07.009 · Cited by 3 · see citing works
“18 Although weight loss coupled with new-onset diabetes in patients older than 50 years has been linked to increased short-term risk of pancreatic cancer in previous studies, 19,20 we did not identify such an association with recent-onset diabetes among patients with AP.”
BackgroundSun, Y., Wan, H., Xiong, J., Cao, K., Yang, D., & Huang, J. X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1559909 · Cited by 2 · see citing works
“The strong association between chronic subclinical in fl ammation triggered by metabolic syndrome and pancreatic cancer has been widely acknowledged (28).”
Tao, L. V., Karasinska, J. M., Souza, V. G. P., Loree, J. M., Johnson, J. D., Renouf, D. J., & Schaeffer, D. F. (2026) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2025.1645459 · Cited by 3 · see citing works
“…loss at PDAC diagnosis compared to weight prior to diabetes onset had a higher adjusted odds ratio in PDAC-associated diabetes individuals compared to T2D (93), while age-adjusted hazard risk for PDAC-associated diabetes increased with increasing weight loss in NOD individuals compared to T2D (26).”
Yang, J., Cao, B., Yuemaierabola, A., Gong, Y., Guo, Y., Zhong, H., Zhang, K., Wang, S., Huang, Q., Li, J., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07767-1 · Cited by 3 · see citing works
“Among individuals with NODM, the 3-year cumulative incidence of PC after NODM was 0.51%, corresponding to a 4.6-fold higher risk based on the standardized incidence ratio [17, 18].”
InfluentialBogdanski, A. M., Onnekink, A. M., Inderson, A., Boekestijn, B., Bonsing, B. A., Vasen, H. F. A., van Hooft, J. E., Boonstra, J. J., Mieog, J. S. D., Wasser, M. N. J. M., et al. (2024) · Pancreas · doi:10.1097/mpa.0000000000002335 · Cited by 2 · see citing works
Shan, Y., Teng, Y., Guan, C., Zhenbiao, M., Lu, C., Ding, W., & Zhang, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34028 · Cited by 2 · see citing works
“In addition to realizing early diagnosis based on clinical examination or biomarkers, it is very important to identify relevant risk factors and populations for those who are at high risk of PC [20,21].”
BackgroundYang, M., Luo, J., Zheng, Y., & Chen, Q. (2025) · International Journal of Endocrinology · doi:10.1155/ije/7734237 · Cited by 2 · see citing works
“Type 2 diabetes mellitus (T2DM) is recognized globally as a chronic ailment [3].”
The Diabetes-Pancreatic Cancer Risk Relationship over Time: A Systematic Review and Meta-Analysis
Fuentes, A., Montserrat-Capdevila, J., Florensa, D., Godoy, S., Serrano, J., & Godoy, P. (2025) · Diabetology · doi:10.3390/diabetology6110131 · Cited by 2 · see citing works
Diabetogenic liver metastasis from pancreatic cancer: a case report
Kiritani, S., Ono, Y., Takamatsu, M., Oba, A., Sato, T., Ito, H., Inoue, Y., & Takahashi, Y. (2022) · Surgical Case Reports · doi:10.1186/s40792-022-01582-8 · Cited by 2 · see citing works
The Role of Diabetes Mellitus in the Malignant Pancreatic Cyst Neoplasm Diagnosis and Prognosis
Deng, J., Guo, Y., Gu, J., Du, J., Kong, L., Tao, B., Li, J., & Fu, D. (2022) · Cancer Management and Research · doi:10.2147/cmar.s355365 · Cited by 2 · see citing works
“According to the data from previous studies, the definition of new-onset diabetes mellitus (NODM) is DM diagnosed within four years from PCN diagnosis.(17,18) DM patients who had DM for more than four years were taken into the long-standing diabetes mellitus (LSDM) group.”
MethodBasaldúa-Maciel, V., Martínez–Esquivias, F., & Guzmán‐Flores, J. M. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673352470250312082922 · Cited by 1 · see citing works
Zhao, L., Tu, J., Zuo, H., Yin, F., Gao, T., Lu, M., Xie, L., & Zhang, C. (2025) · Gut Medicine · doi:10.1002/gtm2.70001 · Cited by 1 · see citing works
Post-surgery weight changes in pancreatic cancer: a prospective study on factors and survival impact
Cui, L., Zhang, L., Yu, H., Sun, Q., Jiang, K., Wei, J., & Fang, X. (2026) · World Journal of Surgical Oncology · doi:10.1186/s12957-026-04202-z · Cited by 1 · see citing works
“Additionally, weight was primarily self-reported, which may introduce differential measurement error—especially if severely affected patients under-report—a common concern in observational studies [37].”
Martínez-Gutiérrez, J., Somasundaram, K., Bernardes, C. M., Rafiq, M., Schrader, S., Jordan, S. J., Chima, S., Mendonca, L. D., Huckvale, K., Hunter, B., et al. (2026) · JMIR Formative Research · doi:10.2196/79209 · Cited by 1 · see citing works
Advancing precision medicine in pancreatic cancer using novel biomarkers and clinical targets
Murthy, D., Seyhan, A. A., den Hollander, P., Lu, S., Kuburich, N. A., Gould, C., Karam, A., Sun, K., Schupp, P. G., Safran, H., et al. (2026) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2026.101476 · Cited by 2 · see citing works
Huang, K., Huang, Z., He, Y., Zhao, P., & Hu, X. (2026) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.70205 · Cited by 1 · see citing works
Li, M., Gu, A., Li, J.-T., Tang, N.-N., Matin, M., Zhang, G., & Atanasov, A. G. (2026) · Food & medicine homology. · doi:10.26599/fmh.2027.9420153 · Cited by 1 · see citing works
Unintentional Weight Loss as a Marker of Malignancy Across Body Weight Categories
Hue, J. J., Ufholz, K. E., Winter, J. M., & Markt, S. C. (2021) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-021-00674-8 · Cited by 1 · see citing works
Krebsrisiko bei Prädiabetes und Typ-2-Diabetes mellitus
Scherübl, H. (2022) · Diabetologie und Stoffwechsel · doi:10.1055/a-1837-2035 · Cited by 1 · see citing works
- Authors
- Yuan, C., Babic, A., Khalaf, N., Nowak, J. A., Brais, L. K., Rubinson, D. A., Ng, K., Aguirre, A. J., Pandharipande, P. V., Fuchs, C. S., Giovannucci, E. L., Stampfer, M. J., Rosenthal, M. H., Sander, C., Kraft, P., & Wolpin, B. M.
- Affiliations
- Harvard University (US)
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts
- Michael E. DeBakey VA Medical Center (US)
- Brigham and Women's Hospital (US)
- Yale Cancer Center (US)
- Corresponding author
- Yuan, Chen
- ORCID
- Venue
- JAMA Oncology
- Publisher
- American Medical Association (AMA)
- Published
- 2020-10-08
- Volume
- 6
- Issue
- 10
- Pages
- e202948
- ISSN
- 2374-2437 (ISSN-L)
- PMC
- PMC7426876
- OpenAlex
- W3048739465
- Cited by
- 150
- References
- 40
- Citations by year
- 2026: 28 · 2025: 31 · 2024: 17 · 2023: 24 · 2022: 28 · 2021: 22
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (K08CA218420, R01CA205406)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- pancreatic cancer risk, diabetes duration, weight loss, recent-onset diabetes, long-standing diabetes, diabetes and cancer association, cancer risk factors, prospective cohort, Nurses' Health Study, Health Professionals Follow-up Study, early cancer detection, obesity and cancer risk, cancer screening guidelines, cancer survivorship, cancer survivorship support services, survivorship care
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Cohort Studies, Weight Loss, Body Mass Index, Incidence, Diabetes Complications
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