The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis
Open accessAbstract
Summary: Ferroptosis is a non-apoptotic mode of regulated cell death that is iron- and lipid peroxidation-dependent. As new mechanistic insight into ferroptotic effectors and how they are regulated in different disease contexts is uncovered, our understanding of the physiological and pathological relevance of this mode of cell death continues to grow. Along these lines, a host of pharmacological modulators of this pathway have been identified, targeting proteins involved in iron homeostasis; the generation and reduction of lipid peroxides; or cystine import and glutathione metabolism. Also, of note, many components of the ferroptosis cascade are target genes of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), indicating its critical role in mediating the ferroptotic response. In this review, we discuss the in vitro, in vivo, and clinical evidence of ferroptosis in disease, including a brief discussion of targeting upstream mediators of this cascade, including NRF2, to treat ferroptosis-driven diseases.
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Cites
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Amino acid metabolism in Mammalian cell cultures
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Ferroptosis: process and function
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
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Ferroptosis as a p53-mediated activity during tumour suppression
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Autophagy promotes ferroptosis by degradation of ferritin
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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
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Cited by
Targeting Ferroptosis as a Vulnerability in Cancer
Lei, G., Zhuang, L., & Gan, B. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00459-0 · Cited by 2,252
Ferroptosis: machinery and regulation
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Signaling pathways and defense mechanisms of ferroptosis
Liu, J., Kang, R., & Tang, D. (2022) · The FEBS Journal · doi:10.1111/febs.16059 · Cited by 787
Ferroptosis in cancer and cancer immunotherapy
Zhao, L., Zhou, X., Xie, F., Zhang, L., Yan, H., Huang, J., Zhang, C., Zhou, F., Chen, J., & Zhang, L. (2022) · Cancer Communications · doi:10.1002/cac2.12250 · Cited by 684
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Metadata
- Authors
- Anandhan, A., Dodson, M., Schmidlin, C. J., Liu, P., & Zhang, D. D.
- Venue
- Cell Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 27
- Issue
- 4
- Pages
- 436-447
- ISSN
- 2451-9448 (ISSN-L)
- 2451-9456
- OpenAlex
- W3015800932
- Cited by
- 442
- References
- 38
- FWCI
- 24.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Anandhan, A., Dodson, M., Schmidlin, C. J., Liu, P., & Zhang, D. D. (2020). Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis. Cell Chemical Biology. https://doi.org/10.1016/j.chembiol.2020.03.011
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