Cited by 118Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

Increased plasma levels of 8-iso-PGF2α and IL-6 in an elderly population with depression

Dimopoulos, Nikolaos, Piperi, Christina, Psarra, Vassiliki, Lea, Robert W., Kalofoutis, Anastasios·2008·Psychiatry Research

Abstract

Oxidative damage and immune-inflammatory activation have been suggested to play a role in depression. The purpose of the study was to investigate possible associations and interactions of these pathophysiological mechanisms in geriatric depression by determining the levels of plasma 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) and interleukin-6 (IL-6) in elderly depressed individuals. Subjects over 60 years of age with depression and controls were randomly selected from a population in the community after screening with the Geriatric Depression Scale. Plasma concentrations of 8-iso-PGF2alpha and IL-6 were measured in both groups. Depressed patients had significantly higher mean (+/-S.D.) 8-iso-PGF2alpha levels compared to healthy controls (245.01+/-179.92 pg/ml vs 97.64+/-42.72 pg/ml, respectively). Similarly, the same groups demonstrated significantly elevated IL-6 levels compared with controls (58.73+/-39.90 pg/ml vs 15.41+/-9.27 pg/ml). This study indicates an association between increased levels of plasma 8-iso-PGF2alpha and IL-6 with depressive symptomatology in elderly individuals and indicates the necessity for further investigation, possibly within the framework of an integrated involvement of oxidative damage and inflammation in the pathophysiology of depression in the elderly.

Integrity signals

Registry

Crossref · 10.1016/j.psychres.2007.07.019

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Dimopoulos, N., Piperi, C., Psarra, V., Lea, R. W., & Kalofoutis, A.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • University of Lancashire (GB)
Corresponding author
Dimopoulos, Nikolaos
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2008-10
Volume
161
Issue
1
Pages
59-66
ISSN
0165-1781 (ISSN-L)
OpenAlex
W2013247338
Cited by
118
References
40
Citations by year
2025: 7 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 8
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
  • CLOK (University of Central Lancashire) (acceptedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
geriatric depression, 8-isoprostane, interleukin-6, oxidative stress, inflammation, plasma biomarkers, older adults, depression pathophysiology, lipid peroxidation
MeSH terms
Age Factors, Aged, Depressive Disorder, Female, Humans, Inflammation, Male, Middle Aged, Reference Values, Risk Factors, Lipid Peroxidation, Dinoprost, Interleukin-8, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review