The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Toxoplasma Polymorphic Effectors Determine Macrophage Polarization and Intestinal Inflammation
Open accessAbstract
SUMMARY European and North American strains of the parasite Toxoplasma gondii belong to three distinct clonal lineages, type I, II and III, which differ in virulence. Understanding the basis of Toxoplasma strain differences and how secreted effectors work to achieve chronic infection is a major goal of current research. Here we show that type I and III infected macrophages, a cell type required for host immunity to Toxoplasma, are alternatively activated, while type II infected macrophages are classically activated. The Toxoplasma rhoptry kinase ROP16, which activates STAT6, is responsible for alternative activation. The Toxoplasma dense granule protein GRA15, which activates NF-κB, promotes classical activation by type II parasites. These effectors antagonistically regulate many of the same genes, and mice infected with type II parasites expressing type I ROP16 are protected against Toxoplasma-induced ileitis. Thus, polymorphisms in determinants that modulate macrophage activation influence the ability of Toxoplasma to establish a chronic infection.
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Cites
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107 · cited 4×
“M2 activation is promoted by STAT6 and PPARg transcription factors (Odegaard et al., 2007), and mice deficient in IL-4, a potent mediator of M2 polarization, aremore susceptible to acute Toxoplasma infection (Roberts et al.”
BackgroundInfluentialStumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V., Huang, Q., Yoshimura, A., Sehy, D., et al. (2006) · Nature Immunology · doi:10.1038/ni1376 · Cited by 955
Self-citationEl Kasmi, K. C., Qualls, J. E., Pesce, J. T., Smith, A. M., Thompson, R. W., Henao-Tamayo, M., Basaraba, R. J., König, T., Schleicher, U., Koo, M.-S., et al. (2008) · Nature Immunology · doi:10.1038/ni.1671 · Cited by 646 · cited 3×
“In keeping with an earlier report that Toxoplasma can induce the expression of Arg1 independently of STAT6 (El Kasmi et al., 2008), Toxoplasma elicited urea production in Stat6 / BMDMs, albeit at levels much lower than in wild-type BMDMs (Figure 3B).”
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Cited by
Macrophage Polarization in Inflammatory Diseases
Liu, Y.-C., Zou, X.-B., Chai, Y.-F., & Yao, Y.-M. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.8879 · Cited by 1,085
Toxoplasma Effectors Targeting Host Signaling and Transcription
Hakimi, M.-A., Olias, P., & Sibley, L. D. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00005-17 · Cited by 339
Muraille, E., Leo, O., & Moser, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00603 · Cited by 311
Modulators of the Balance between M1 and M2 Macrophages during Pregnancy
Zhang, Y.-H., He, M., Wang, Y., & Liao, A.-H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00120 · Cited by 292
Self-citationFox, B. A., Guevara, R. B., Rommereim, L. M., Falla, A., Bellini, V., Pètre, G., Rak, C., Cantillana, V., Dubremetz, J.-F., Cesbron-Delauw, M.-F., et al. (2019) · mBio · doi:10.1128/mbio.00589-19 · Cited by 89
Metadata
- Authors
- Jensen, K. D. C., Wang, Y., Wojno, E. D. T., Shastri, A. J., Hu, K., Cornel, L., Boedec, E., Ong, Y.-C., Chien, Y.-H., Hunter, C. A., Boothroyd, J. C., & Saeij, J. P. J.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 9
- Issue
- 6
- Pages
- 472-483
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2142939879
- Cited by
- 246
- References
- 7
- FWCI
- 13.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jensen, K. D. C., Wang, Y., Wojno, E. D. T., Shastri, A. J., Hu, K., Cornel, L., Boedec, E., Ong, Y.-C., Chien, Y.-H., Hunter, C. A., Boothroyd, J. C., & Saeij, J. P. J. (2011). Toxoplasma Polymorphic Effectors Determine Macrophage Polarization and Intestinal Inflammation. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2011.04.015
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