NK cell recognition of Candida glabrata through binding of NKp46 and NCR1 to fungal ligands Epa1, Epa6, and Epa7
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Natural killer (NK) cells form an important arm of the innate immune system and function to combat a wide range of invading pathogens, ranging from viruses to bacteria. However, the means by which NK cells accomplish recognition of pathogens with a limited repertoire of receptors remain largely unknown. In the current study, we describe the recognition of an emerging fungal pathogen, Candida glabrata, by the human NK cytotoxic receptor NKp46 and its mouse ortholog, NCR1. Using NCR1 knockout mice, we observed that this receptor-mediated recognition was crucial for controlling C. glabrata infection in vitro and in vivo. Finally, we delineated the fungal ligands to be the C. glabrata adhesins Epa1, Epa6, and Epa7 and demonstrated that clearance of systemic C. glabrata infections in vivo depends on their recognition by NCR1. As NKp46 and NCR1 have been previously shown to bind viral adhesion receptors, we speculate that NKp46/NCR1 may be a novel type of pattern recognition receptor.
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Natural Killer cells play a role in combating C. glabrata infections.
“A recent study has highlighted the role of Natural Killer cells, which are effector lymphatic cells of the innate and adaptive immune system, in combating C. glabrata infections [145].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [145]
Epa1, Epa6, and Epa7 adhesins are specifically recognized by the NKp46/NCR1 receptor, resulting in clearance of disseminated infection.
“The Epa1, Epa6 and Epa7 adhesins were shown to be specifically recognized by the NKp46/NCR1 receptor, resulting in the clearance of disseminated infection [145].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [145]
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β1 Integrins Are Required To Mediate NK Cell Killing of Cryptococcus neoformans
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- Authors
- Vitenshtein, A., Charpak-Amikam, Y., Yamin, R., Bauman, Y., Isaacson, B., Stein, N., Berhani, O., Dassa, L., Gamliel, M., Gur, C., Glasner, A., Gomez, C., Ben-Ami, R., Osherov, N., Cormack, B. P., & Mandelboim, O.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Johns Hopkins University (US)
- Tel Aviv University (IL)
- Corresponding author
- Cormack, Brendan P.
- Mandelboim, Ofer
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 20
- Issue
- 4
- Pages
- 527-534
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC5492882
- OpenAlex
- W2531548495
- Cited by
- 96
- References
- 40
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 13 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 10 · 2019: 8 · 2018: 18 · 2017: 15 · 2016: 3
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Rosetrees Trust (M21-F1)
- National Institute of General Medical Sciences (R24GM098791, T32GM008752, U54GM062116)
- National Institute of Allergy and Infectious Diseases (R01AI046223)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- natural killer cells, NKp46, Candida glabrata, fungal adhesins, pattern recognition receptors, antifungal immunity
- MeSH terms
- Animals, Antigens, Ly, Candidiasis, Disease Models, Animal, Fungal Proteins, Humans, Killer Cells, Natural, Mice, Inbred BALB C, Mice, Knockout, Candida glabrata, Natural Cytotoxicity Triggering Receptor 1
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