Candida glabrata’s Genome Plasticity Confers a Unique Pattern of Expressed Cell Wall Proteins

López-Fuentes, Eunice; Gutiérrez-Escobedo, Guadalupe; Timmermans, Bea; Van Dijck, Patrick; De Las Peñas, Alejandro; Castaño, Irene

doi:10.3390/jof4020067

Cited by 35Antifungal resistance and susceptibilityFungal and yeast genetics researchYeasts and Rust Fungi Studies

Candida glabrata’s Genome Plasticity Confers a Unique Pattern of Expressed Cell Wall Proteins

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López-Fuentes, Eunice, Gutiérrez-Escobedo, Guadalupe, Timmermans, Bea, Van Dijck, Patrick, De Las Peñas, Alejandro, Castaño, Irene·2018·Journal of Fungi

DOI 10.3390/jof4020067PMC PMC6023349

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Abstract

Candida glabrata is the second most common cause of candidemia, and its ability to adhere to different host cell types, to microorganisms, and to medical devices are important virulence factors. Here, we consider three characteristics that confer extraordinary advantages to C. glabrata within the host. (1) C. glabrata has a large number of genes encoding for adhesins most of which are localized at subtelomeric regions. The number and sequence of these genes varies substantially depending on the strain, indicating that C. glabrata can tolerate high genomic plasticity; (2) The largest family of CWPs (cell wall proteins) is the EPA (epithelial adhesin) family of adhesins. Epa1 is the major adhesin and mediates adherence to epithelial, endothelial and immune cells. Several layers of regulation like subtelomeric silencing, cis-acting regulatory regions, activators, nutritional signaling, and stress conditions tightly regulate the expression of many adhesin-encoding genes in C. glabrata, while many others are not expressed. Importantly, there is a connection between acquired resistance to xenobiotics and increased adherence; (3) Other subfamilies of adhesins mediate adherence to Candida albicans, allowing C. glabrata to efficiently invade the oral epithelium and form robust biofilms. It is noteworthy that every C. glabrata strain analyzed presents a unique pattern of CWPs at the cell surface.

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The majority of Epa adhesins are encoded by sub-telomeric localized genes and regulated by epigenetic SIR-dependent transcriptional silencing.
“The majority of Epa adhesins are encoded by sub-telomeric localized genes and regulated by epigenetic SIR (Silent Information Regulator)-dependent transcriptional silencing [27,29,30,31].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [31]

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Authors: López-Fuentes, E., Gutiérrez-Escobedo, G., Timmermans, B., Van Dijck, P., De Las Peñas, A., & Castaño, I.
Affiliations: Institute for Scientific and Technological Research (MX)
Instituto Potosino de Investigación Científica y Tecnológica (IPICYT), División de Biología Molecular, Camino a la Presa San José 2055, San Luis Potosí, SLP 78216, Mexico
VIB-KU Leuven Center for Microbiology (BE)
KU Leuven, Laboratory of Molecular Cell Biology, Kasteelpark Arenberg 31 bus 2438, 3001 Leuven, Belgium
Corresponding author: Castaño, Irene
ORCID: López-Fuentes, Eunice
Gutiérrez-Escobedo, Guadalupe
Timmermans, Bea
Van Dijck, Patrick
De Las Peñas, Alejandro
Castaño, Irene
Venue: Journal of Fungi
Publisher: MDPI AG
Published: 2018-06-05
Volume: 4
Issue: 2
Pages: 67
ISSN: 2309-608X (ISSN-L)
DOI: 10.3390/jof4020067
PMC: PMC6023349
OpenAlex: W2805211771
Cited by: 35
References: 89
Citations by year: 2026: 5 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 3
FWCI: 0.55
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Journal of Fungi (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Lirias (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: FWO-Flanders / CONACYT (FWO-Flanders (VS.036.14N) / CONACYT-Mexico (219669))
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords: Candida glabrata, genome plasticity, cell wall proteins, adhesins, subtelomeric regions, gene expression regulation, xenobiotic resistance, adherence, biofilm formation, candidemia, virulence factors, host cell adhesion

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Candida glabrata’s Genome Plasticity Confers a Unique Pattern of Expressed Cell Wall Proteins

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