CoChat
Sign Up
Cited by 49HIV Research and TreatmentHIV-related health complications and treatmentsInfectious Diseases and Tuberculosis

Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection

Open access
Foster, Samuel B., Lu, Ming, Glaze, Daniel G., Reuben, James M., Harris, Lynnette L., Cohen, Evan N., Lee, Bang-Ning, Zhao, Enxu +15 more·2012·Clinical Immunology
DOI 10.1016/j.clim.2012.04.004PMC PMC3377781
Open this paper in CoChat — free account

Abstract

Youth infected with HIV at birth often have sleep disturbances, neurocognitive deficits, and abnormal psychosocial function which are associated with and possibly resulted from elevated blood cytokine levels that may lead to a decreased quality of life. To identify molecular pathways that might be associated with these disorders, we evaluated 38 HIV-infected and 35 uninfected subjects over 18-months for intracellular cytokine levels, sleep patterns and duration of sleep, and neurodevelopmental abilities. HIV infection was significantly associated with alterations of intracellular pro-inflammatory cytokines (TNF-α, IFN-γ, IL-12), sleep factors (total time asleep and daytime sleep patterns), and neurocognitive factors (parent and patient reported problems with socio-emotional, behavioral, and executive functions; working memory-mental fatigue; verbal memory; and sustained concentration and vigilance. By better defining the relationships between HIV infection, sleep disturbances, and poor psychosocial behavior and neurocognition, it may be possible to provide targeted pharmacologic and procedural interventions to improve these debilitating conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.clim.2012.04.004

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The cytokine-sleep relationship in RA is not secondary to classical disease symptoms, in particular pain.

    “further suggesting that the cytokine-sleep relationship is not secondary to classical disease symptoms, in particular pain (196).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [196]

  • Treatment with the IL-6 receptor inhibitor tocilizumab in RA patients with active disease improves self-reported sleep quality and daytime sleepiness.

    “Furthermore, treatment with an IL-6 receptor inhibitor (tocilizumab) in RA patients with active disease improved self-reported sleep quality (assessed by the PSQI) and daytime sleepiness.”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [196]

  • Observed sleep improvements with tocilizumab in active RA could not be explained by a reduction in disease activity.

    “Observed sleep improvements could not be explained by a reduction in disease activity”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [196]

  • Treatment of RA patients with IL-6 or TNF blockers improved sleep.

    “As described in section IID2, treatment of RA patients with IL-6 or TNF blockers improved sleep (196, 283, 535).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [196]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [9]Steele RG Nelson TD Cole BP Psychosocial functioning of children with AIDS and HIV infection: review of the literature from a socioecological framework J Dev Behav Pediatr 2007 28 58 69 17353739

Cited by

Sorted by citations

Related

Authors
Foster, S. B., Lu, M., Glaze, D. G., Reuben, J. M., Harris, L. L., Cohen, E. N., Lee, B.-N., Zhao, E., Paul, M. E., Schwarzwald, H., McMullen-Jackson, C., Clark, C., Armstrong, F. D., Brouwers, P. Y., Miller, T. L., Colin, A. A., Scott, G. B., Shahzeidi, S., Willen, E. J., Asthana, D., Lipshultz, S. E., Thompson, B. W., & Shearer, W. T.
Affiliations
  • Baylor College of Medicine (US)
  • Clinical Trials and Surveys Corporation (US)
  • The University of Texas MD Anderson Cancer Center (US)
  • University of Miami (US)
  • National Institutes of Health (US)
Corresponding author
Shearer, William T.
ORCID
Venue
Clinical Immunology
Publisher
Elsevier BV
Published
2012-07
Volume
144
Issue
1
Pages
13-23
ISSN
1521-6616 (ISSN-L)
DOI
10.1016/j.clim.2012.04.004
PMC
PMC3377781
OpenAlex
W2065194221
Cited by
49
References
46
Citations by year
2026: 1 · 2025: 6 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 6
FWCI
2.15
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL079533, R01-HL075933, R43HL075933)
  • National Institute of Allergy and Infectious Diseases (P30AI036211, T32AI007456)
  • National Center for Research Resources (RR 00188, K01RR000188, M01RR000188)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
Keywords
HIV infection, perinatal HIV infection, sleep disorders, neurocognitive function, inflammatory cytokines, TNF-α, interferon-gamma, IL-12, sleep duration, executive function, working memory, sustained attention, psychosocial behavior
MeSH terms
Adolescent, Child, Child Behavior Disorders, Cognition Disorders, Female, Humans, Male, Memory, Neuropsychological Tests, Sleep, Cohort Studies, CD4-Positive T-Lymphocytes, HIV Infections, Cytokines, CD8-Positive T-Lymphocytes, Executive Function

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review