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The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity
Open accessAbstract
Leptin is required for normal energy and glucose homeostasis. The hypothalamic arcuate nucleus (ARH) has been proposed as an important site of leptin action. To assess the physiological significance of leptin signaling in the ARH, we used mice homozygous for a FLPe-reactivatable, leptin receptor null allele (Lepr(neo/neo) mice). Similar to Lepr(db/db) mice, these mice are obese, hyperglycemic, hyperinsulinemic, infertile, and hypoactive. To selectively restore leptin signaling in the ARH, we generated an adeno-associated virus expressing FLPe-recombinase, which was delivered unilaterally into the hypothalamus using stereotaxic injections. We found that unilateral restoration of leptin signaling in the ARH of Lepr(neo/neo) mice leads to a modest decrease in body weight and food intake. In contrast, unilateral reactivation markedly improved hyperinsulinemia and normalized blood glucose levels and locomotor activity. These data demonstrate that leptin signaling in the ARH is sufficient for mediating leptin's effects on glucose homeostasis and locomotor activity.
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In the citing paper
“unilateral, selective restoration of leptin signaling to the ARC was found to have only modest effects on food intake and body weight, while it markedly improved hyperinsulinemia and normalized blood glucose levels (40).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [40]
In the citing paper
“Genetic studies in mice suggest that the arcuate hypothalamic nucleus plays a major role in mediating effects of leptin on glucose balance and on voluntary locomotor activity (Coppari et al., 2005), however the specific arcuate neurons responsible remain unspecified.”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
In the citing paper
“Moreover, unilateral restoration of leptin receptor expression in the ARC of leptin receptor deficient Leprdb/db mice leads to long term reduction of body weight and food intake (Coppari et al., 2005)”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
In the citing paper
“Restoration of leptin-receptors in arcuate neurons greatly increases voluntary locomotor activity in Leprdb/db mice (Coppari et al., 2005), but the specific neurons mediating this action remain unknown.”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
In the citing paper
“unilateral, not bilateral, restoration of endogenous leptin receptors in arcuate neurons of leptin-receptor deficient mice (Coppari et al., 2005) results in a phenotype”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
In the citing paper
“and a normalization of serum glucose levels”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
In the citing paper
“and of locomotor activity (Coppari et al., 2005).”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
In the citing paper
“restoration of endogenous leptin receptors solely in the arcuate nucleus, accomplished by stereotaxic delivery of adeno viruses expressing FLPe-recombinase in otherwise leptin-receptor deficient mice, also results in a partial reduction in body weight and food intake”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
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Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
Self-citationObesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327
Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053
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Items 301–400 of 457
Vauthier, V., Roujeau, C., Chen, P. B., Sarkis, C., Migrenne, S., Hosoi, T., Ozawa, K., Rouillé, Y., Foretz, M., Mallet, J. J., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.009 · Cited by 19
Dissecting the Brain/Islet Axis in Metabesity
Fuente-Martín, E., Mellado‐Gil, J. M., Cobo‐Vuilleumier, N., Martín‐Montalvo, A., Romero‐Zerbo, S., Contreras, I. D., Hmadcha, A., Soria, B., Bermudo, F. M., Reyes, J. C., et al. (2019) · Genes · doi:10.3390/genes10050350 · Cited by 17
Central regulation of glucose metabolism in an insulin‐dependent and ‐independent manner
Fujikawa, T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12941 · Cited by 21
Franks, P. W., Loos, R. J. F., Brage, S., O’Rahilly, S., Wareham, N. J., & Ekelund, U. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01022.2006 · Cited by 18
Changes in environmental temperature influence leptin responsiveness in low- and high-fat-fed mice
Harris, R. B. S., Mitchell, T. D., Kelso, E. W., & Flatt, W. P. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00848.2006 · Cited by 18
Circulating leptin levels are associated with physical activity or physical fitness in Japanese
The NEXIS Study Group, Miyatake, N., Murakami, H., Kawakami, R., Tabata, I., & Miyachi, M. (2014) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-014-0398-2 · Cited by 17
Denroche, H. C., Glavas, M. M., Tudurí, E., Karunakaran, S., Quong, W. L., Philippe, M., Britton, H. M., Clee, S. M., & Kieffer, T. J. (2016) · Endocrinology · doi:10.1210/en.2015-1998 · Cited by 19
Anderson, B. M., Jacobson, L., Novakovic, Z. M., & Grasso, P. (2017) · Brain Research · doi:10.1016/j.brainres.2017.03.020 · Cited by 17
Chen, M., Wilson, E. A., Cui, Z., Sun, H., Shrestha, Y. B., Podyma, B., Le, C. H., Naglieri, B., Pacák, K., Gavrilova, O., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.04.005 · Cited by 16
Li, H., Yuan, W., Tian, Y., Tian, F., Wang, Y., Sun, X., & Gong, Y. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109269 · Cited by 17
Chmielewski, A., Hübert, T., Descamps, A., Mazur, D., Daoudi, M., Ciofi, P., Fontaine, C., Caiazzo, R. J., Pattou, F. N., Prévot, V., et al. (2019) · Obesity · doi:10.1002/oby.22465 · Cited by 17
Li, B., Lee, K., & Martin, R. J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.032 · Cited by 17
Teixeira, P. D. S., Ramos-Lobo, A. M., Furigo, I. C., & Donato, J. (2019) · Endocrinology · doi:10.1210/en.2019-00639 · Cited by 9
Circulating glucagon to ghrelin ratio as a determinant of insulin resistance in hyperthyroidism
Ağbaht, K., Erdoğan, M. F., Emral, R., Başkal, N., & Güllü, S. (2013) · Endocrine · doi:10.1007/s12020-013-9951-9 · Cited by 16
Nuclear Receptor Coactivator PNRC2 Regulates Energy Expenditure and Adiposity
Zhou, D., Shen, R., Ye, J. J., Li, Y., Tsark, W. M. K., Isbell, D., Tso, P., & Chen, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703234200 · Cited by 16
Elias, C. F. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00444.2013 · Cited by 17
Extranuclear signaling by ovarian steroids in the regulation of sexual receptivity
Micevych, P. E., & Sinchak, K. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.05.001 · Cited by 16
He, X., Wang, N., Zhao, J.-J., Wang, D., Wang, C.-J., Xie, L. Y., Zheng, H.-Y., Shi, S., He, J. N., Zhou, J., et al. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111004 · Cited by 17
Evaluation of Energy Homeostasis
Argmann, C., Champy, M., & Auwerx, J. H. (2006) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb29b01s73 · Cited by 16
Wiater, M. F., Li, A., Dinh, T. T., Jansen, H. T., & Ritter, S. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00032.2013 · Cited by 16
Perland, E., Hellsten, S. V., Schweizer, N., Arapi, V., Rezayee, F., Bushra, M., & Fredriksson, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186325 · Cited by 17
Heiston, E. M., & Malin, S. K. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12668-1_15 · Cited by 17
Beall, C., Hanna, L., & Ellacott, K. L. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160045 · Cited by 16
Central leptin signalling: Beyond the arcuate nucleus
Jovanović, Z., & Yeo, G. S. H. (2010) · Autonomic Neuroscience · doi:10.1016/j.autneu.2010.05.008 · Cited by 16
Sumita, T., Ono, H., Suzuki, T., Sakai, G., Inukai, K., Katagiri, H., Asano, T., Katayama, S., & Awata, T. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2013 · Cited by 16
Grasso, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.861350 · Cited by 15
Fuel homeostasis and locomotor behavior: role of leptin and melanocortin pathways
Ceccarini, G., Maffei, M., Vitti, P., & Santini, F. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0225-z · Cited by 16
Effects of 2-AG on the reinforcing properties of wheel activity in obese and lean Zucker rats
Smith, S. L., & Rasmussen, E. B. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833aec4d · Cited by 15
Murakami, H., Iemitsu, M., Fuku, N., Sanada, K., Gando, Y., Kawakami, R., & Miyachi, M. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.053 · Cited by 14
Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus
Desai, B. N., & Harris, R. B. S. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00501.2014 · Cited by 14
Tang, W., Zou, J., Chen, X., Zheng, J., Zeng, H., Liu, Z., & Shi, Y. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.84 · Cited by 14
Dudek, M., Kolodziejski, P. A., Pruszyńska‐Oszmałek, E., Ziarniak, K., & Sliwowska, J. H. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12453 · Cited by 14
Idelevich, A., Sato, K., Nagano, K., Rowe, G. C., Gori, F., & Baron, R. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3741 · Cited by 14
A reappraisal on the ability of leptin to induce fever
Steiner, A. A., Krall, C. M., & Liu, E. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.03.018 · Cited by 13
Fuller, P. M., Yamanaka, A., & Lazarus, M. (2015) · Temperature · doi:10.1080/23328940.2015.1075095 · Cited by 12
Leptin’s Immune Action: A Review Beyond Satiety
Bardagi, A. A., Paschoal, C. D. S., Favero, G. G., Riccetto, L., Dias, M. L. A., Guerra‐Júnior, G., & Degasperi, G. R. (2022) · Immunological Investigations · doi:10.1080/08820139.2022.2129381 · Cited by 13
von Schnurbein, J., Remy, M., Brandt, S., Manzoor, J., Kohlsdorf, K., Mahmood, S., Hebebrand, J., & Wabitsch, M. (2023) · Pediatric Obesity · doi:10.1111/ijpo.13057 · Cited by 12
Insulin signaling in LepR cells modulates fat and glucose homeostasis independent of leptin
Borges, B. C., Han, X., Allen, S. J., García-Galiano, D., & Elias, C. F. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00287.2018 · Cited by 11
PROGRESS IN UREMIC TAXIN RESEARCH: Leptin and Uremic Protein‐Energy Wasting—The Axis of Eating
Yamamoto, T., Carrero, J. J., Lindholm, B., Stenvinkel, P., & Axelsson, J. (2009) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2009.00586.x · Cited by 12
Keeping the fat off with nesfatin
Myers, M. G. (2006) · Nature Medicine · doi:10.1038/nm1106-1248 · Cited by 12
Guzmán‐Ruiz, M. A., Jiménez, A., Cárdenas‐Rivera, A., Guerrero‐Vargas, N. N., Organista‐Juárez, D., & Guevara‐Guzmán, R. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01080-9 · Cited by 11
Qiu, W., Wu, Q., Zhang, K., Da, X., Tang, K., Yuan, N., Deng, L., Wu, M.-S., Zhang, Y., Quan, J., et al. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-03942-9 · Cited by 12
Role of hypothalamic autophagy in the control of whole body energy balance
Kim, M.-S., Quan, W., & Lee, M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9257-5 · Cited by 12
Yagmur, E., Jhaisha, S. A., Buendgens, L., Sapundzhieva, N., Brozat, J. F., Hohlstein, P., Pollmanns, M. R., Koek, G. H., Weiskirchen, R., Trautwein, C., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12123010 · Cited by 11
Schwanstecher, C., & Schwanstecher, M. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_1 · Cited by 11
Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative
Bandala, C., Cárdenas‐Rodríguez, N., Reyes-Long, S., Cortes-Altamirano, J. L., Garciadiego-Cázares, D., Lara‐Padilla, E., Ibáñez-Cervantes, G., Mancilla-Ramı́rez, J., Gómez‐Manzo, S., & Alfaro-Rodríguez, A. (2022) · Antioxidants · doi:10.3390/antiox11101972 · Cited by 12
Association of 25 (OH) Vitamin D and Leptin in Individuals with Insulin Resistance
Madhu, S. V., Aslam, M., Mishra, B. K., Gupta, A., & Jhamb, R. (2022) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_141_22 · Cited by 10
Qi, M., Fadool, D. A., & Storace, D. A. (2023) · The Journal of Comparative Neurology · doi:10.1002/cne.25518 · Cited by 10
Guo, T., Yin, R., Nie, R.-J., Chen, X., Yuan, B., & Lin, W. (2015) · Europe PMC (PubMed Central) · Cited by 10
LRP1 regulates food intake and energy balance in GABAergic neurons independently of leptin action
Kang, M., Seo, J. A., Lee, H., Üner, A. G., Yang, W., Rodrigues, K. C. D. C., Kim, H. J., Li, W. S., Campbell, J. N., Dagon, Y., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00399.2020 · Cited by 11
Gene expression atlas of energy balance brain regions
Rosa, M. C. D., Glover, H. J., Stratigopoulos, G., LeDuc, C. A., Su, Q., Shen, Y., Sleeman, M. W., Chung, W. K., Leibel, R. L., Altarejos, J. Y., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.149137 · Cited by 9
Talari, M., Nayak, T. K. S., Kain, V., Babu, P. P., Misra, P., & Parsa, K. V. L. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.12.014 · Cited by 10
Leptin and Insulin in COPD: Unveiling the Metabolic-Inflammatory Axis—A Narrative Review
Catană, O. M., Nemeş, A. F., Cioboată, R., Toma, C., Mitroi, D. M., Călăraşu, C., & Streba, C. T. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14082611 · Cited by 11
Liu, Y., Jiang, Q., Huang, Y., Zhang, X., Kang, H., Yu, C., Xia, Y., Liu, Y., & Zhang, H. (2025) · Cells · doi:10.3390/cells14221780 · Cited by 10
Kohno, D., Furusawa, K., & Kitamura, T. (2020) · Endocrine Journal · doi:10.1507/endocrj.ej19-0389 · Cited by 8
Harris, R. B. S. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00143.2021 · Cited by 9
Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering
Takanashi, M., Taira, Y., Okazaki, S., Takase, S., Kimura, T., Li, C. C., Xu, P., Noda, A., Sakata, I., Kumagai, H., et al. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.39552 · Cited by 9
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Schneider, J. E., & Watts, A. G. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00006-1 · Cited by 9
Benfato, I. D., Moretto, T. L., de Carvalho, F. P., Barthichoto, M., Ferreira, S. M., Júnior, J. M. C., Lazzarin, M. C., de Oliveira, F., Martinez, C., Carvalho, C. P. D. F., et al. (2017) · Experimental Physiology · doi:10.1113/ep086265 · Cited by 8
Balland, É., & Prévot, V. (2014) · médecine/sciences · doi:10.1051/medsci/20143006009 · Cited by 8
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Ramadori, G., & Coppari, R. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.02.002 · Cited by 8
Self-citationZhang, Y., & Ren, J. T. (2015) · Springer eBooks · doi:10.1007/978-3-319-19821-7_4 · Cited by 8
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Dam, J. (2018) · Biologie Aujourd hui · doi:10.1051/jbio/2018020 · Cited by 7
Harris, R. B. S. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.07.004 · Cited by 7
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Balthasar, N. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2008.042226 · Cited by 7
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Good, D. J., Zhang, H., Grange, R. W., & Braun, T. W. (2020) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000219 · Cited by 6
Light and chemical control of neuronal circuits: possible applications in neurotherapy
Whittle, A. J., Walsh, J. J., & de Lecea, L. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.948850 · Cited by 6
Rahman, T. U., Ullah, K., Ke, Z.-H., Guo, M.-X., Jin, L., Ren, J. T., Zhou, Y.-Z., Cheng, Y., Dong, X., Pang, H., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18519 · Cited by 6
Mancini, M., Hikima, T., Witkovsky, P., Patel, J. C., Stone, D. W., Affinati, A. H., & Rice, M. E. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1539-24.2025 · Cited by 7
Liu, X.-W., Yin, J., Ma, Q.-S., Qi, C., Mu, J.-Y., Zhang, L., Gao, L., & Jing, Y. (2017) · High Altitude Medicine & Biology · doi:10.1089/ham.2016.0141 · Cited by 5
Zieba, D. A., Biernat, W., Szczęsna, M., Kirsz, K., & Misztal, T. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1291997 · Cited by 5
Ahima, R. S., Scolaro, L. M., & Park, H.-K. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_24 · Cited by 5
Hypothalamic-mediated control of glucose balance in the presence and absence of insulin
Fujikawa, T., & Coppari, R. (2014) · Aging · doi:10.18632/aging.100641 · Cited by 5
Self-citationNeuroendocrine Control of Energy Stores
Cone, R. D., & Elmquist, J. K. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00035-3 · Cited by 5
Self-citationNeuroendocrine Regulation of Food Intake
Watts, A. G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10014-9 · Cited by 6
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Rupp, A. C., Tomlinson, A. J., Affinati, A. H., True, C. A., Lindsley, S. R., Kirigiti, M. A., MacKenzie, A., Li, C., Knudsen, L. B., Olson, D. P., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.10.472115 · Cited by 5
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Zhao, Y., Laule, C. F., & Rahmouni, K. (2025) · Clinical Science · doi:10.1042/cs20257748 · Cited by 5
Liu, Y., Ma, Q.-S., & Wu, Q. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.012 · Cited by 4
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Gougoula, C., Bielfeld, A. P., Pour, S. J., Sager, M., Krüssel, J.-S., Benten, W. P. M., & Baston-Büst, D. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219604 · Cited by 4
Cara, A. L., Myers, M. G., & Elias, C. F. (2020) · Endocrinology · doi:10.1210/endocr/bqaa110 · Cited by 4
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Metadata
- Authors
- Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., Tang, V., Liu, S. M., Ludwig, T., Chua, S. C., Lowell, B. B., & Elmquist, J. K.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Columbia University (US)
- Corresponding author
- Lowell, Bradford B.
- Elmquist, Joel K.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 1
- Issue
- 1
- Pages
- 63-72
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2017709986
- Cited by
- 457
- References
- 52
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 13 · 2022: 11 · 2021: 12 · 2020: 23 · 2019: 22 · 2018: 15 · 2017: 28 · 2016: 22 · 2015: 25 · 2014: 23 · 2013: 23 · 2012: 36
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Institute of Mental Health (R01MH061583, MH61583)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK56116, DK53301, P01DK056116, R01DK057621, DK57621, DK 26687, P30DK026687)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, arcuate nucleus, hypothalamus, glucose homeostasis, locomotor activity, leptin receptor, adeno-associated virus, hyperinsulinemia, obesity, dietary intake, body weight, hyperglycemia, infertility
- MeSH terms
- Alleles, Animals, Arcuate Nucleus of Hypothalamus, Body Composition, Body Weight, Cell Nucleus, DNA Nucleotidyltransferases, Fertility, Glucose, Homeostasis, Homozygote, Hypothalamus, Immunohistochemistry, Male, Mice, Inbred C57BL, Mice, Transgenic, Models, Genetic, Motor Activity, Neurons, Oxygen Consumption, Receptors, Cell Surface, Time Factors, Signal Transduction, Leptin, Green Fluorescent Proteins, Mice, Receptors, Leptin
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