Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Mäkelä, T. P., Alessi, D. R., & Hardie, D. G. (2003) · Journal of Biology · doi:10.1186/1475-4924-2-28 · Cited by 1,694

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.031 · Cited by 1,650

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I

El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

Lizcano, J. M., Göransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S. A., Udd, L., Mäkelä, T. P., Hardie, D. G., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600110 · Cited by 1,381

The specificities of protein kinase inhibitors: an update

BAIN, J., McLAUCHLAN, H., ELLIOTT, M., & COHEN, P. (2003) · Biochemical Journal · doi:10.1042/bj20021535 · Cited by 1,369

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264

The AMP-activated protein kinase pathway – new players upstream and downstream

Hardie, D. G. (2004) · Journal of Cell Science · doi:10.1242/jcs.01540 · Cited by 1,163

Minireview: Hey U(PS): Metabolic and Proteolytic Homeostasis Linked via AMPK and the Ubiquitin Proteasome System

Ronnebaum, S. M., Patterson, C., & Schisler, J. C. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1180 · Cited by 39

AMP-activated kinase mediates adipose stem cell-stimulated neuritogenesis of PC12 cells

Tan, B., Luan, Z., Wei, X., He, Y., Wei, G., Johnstone, B. H., Farlow, M. R., & Du, Y. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.038 · Cited by 37

Autophagy and Autophagy-Related Proteins in CNS Autoimmunity

Keller, C. W., & Lünemann, J. D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00165 · Cited by 38

Calcium signalling links MYC to NUAK1

Monteverde, T., Tait-Mulder, J., Hedley, A., Knight, J. R. P., Sansom, O. J., & Murphy, D. J. (2017) · Oncogene · doi:10.1038/onc.2017.394 · Cited by 38

Activation of AMPK by Medicinal Plants and Natural Products: Its Role in Type 2 Diabetes Mellitus

Francini, F., Schinella, G. R., & Ríos, J.-L. (2018) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666181128120726 · Cited by 37

Mitochondrial retrograde signalling in neurological disease

Granat, L., Hunt, R. J., & Bateman, J. M. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0415 · Cited by 37

Chronic high cytosolic calcium decreases AICAR-induced AMPK activity via calcium/calmodulin activated protein kinase II signaling cascade

Park, S., Scheffler, T. L., & Gerrard, D. E. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.05.009 · Cited by 37

AMPK in Lymphocyte Metabolism and Function

Andris, F., & Léo, O. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.969422 · Cited by 38

The Interplay of AMP-Activated Protein Kinase and Androgen Receptor in Prostate Cancer Cells

Shen, M., Zhang, Z., Ratnam, M., & Dou, Q. P. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24494 · Cited by 37

AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures

Eom, J.-W., Lee, J., Koh, J., & Kim, Y. H. (2016) · Molecular Brain · doi:10.1186/s13041-016-0194-6 · Cited by 38

Identification of Signaling Pathways by Which CD40 Stimulates Autophagy and Antimicrobial Activity against Toxoplasma gondii in Macrophages

Liu, E., Corcino, Y. L., Portillo, J. C., Miao, Y., & Subauste, C. S. (2016) · Infection and Immunity · doi:10.1128/iai.00101-16 · Cited by 37

Metformin augments doxorubicin cytotoxicity in mammary carcinoma through activation of adenosine monophosphate protein kinase pathway

El‐Ashmawy, N. E., Khedr, N. F., El‐Bahrawy, H. A., & Mansour, H. E. A. (2017) · Tumor Biology · doi:10.1177/1010428317692235 · Cited by 38

Relationship between Kinase Phosphorylation, Muscle Fiber Typing, and Glycogen Accumulation in Longissimus Muscle of Beef Cattle with High and Low Intramuscular Fat

Underwood, K. R., Tong, J., Zhu, M. J., Shen, Q. W., Means, W. J., Ford, S. P., Paisley, S. I., Hess, B. W., & Du, ‬. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071573z · Cited by 37

Sesamin ameliorates lipotoxicity and lipid accumulation through the activation of the estrogen receptor alpha signaling pathway

Pham, T. H., Lee, G. H., Jin, S. W., Lee, S. Y., Han, E. H., Kim, N. D., Choi, C. Y., Jeong, G.-S., Lee, S. K., Kim, H. S., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115768 · Cited by 36

CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing

McAloon, L. M., Muller, A. G., Nay, K., Lu, E. L., Smeuninx, B., Means, A. R., Febbraio, M. A., & Scott, J. W. (2024) · Essays in Biochemistry · doi:10.1042/ebc20240011 · Cited by 36

Targeting AMPK in the treatment of malignancies

Vakana, E., Altman, J. K., & Platanias, L. C. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23369 · Cited by 37

Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase

Jiang, S., Park, D. W., Gao, Y., Ravi, S., Darley-Usmar, V. M., Abraham, E., & Zmijewski, J. W. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.02.024 · Cited by 41

The Glutamate Agonist Homocysteine Sulfinic Acid Stimulates Glucose Uptake through the Calcium-dependent AMPK-p38 MAPK-Protein Kinase C ζ Pathway in Skeletal Muscle Cells

Kim, J. H., Lee, J. O., Lee, S., Moon, J. W., You, G. Y., Kim, S. J., Park, S.-H., Park, J., Lim, S. Y., Suh, P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.149328 · Cited by 36

The regulation effect of AMPK in immune related diseases

Wang, J., Li, Z., Gao, L., Qi, Y., Zhu, H., & Qin, X. (2017) · Science China Life Sciences · doi:10.1007/s11427-017-9169-6 · Cited by 37

AMP ‐activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events

Jiang, S., Wang, Y., Luo, L., Shi, F., Zou, J., Lin, H., Ying, Y., Luo, Y., Zhan, Z., Liu, P., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14279 · Cited by 36

Lopinavir-Ritonavir Combination Induces Endoplasmic Reticulum Stress and Kills Urological Cancer Cells

Okubo, K., Isono, M., Asano, T., & Sato, A. (2019) · Anticancer Research · doi:10.21873/anticanres.13793 · Cited by 36

CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation

Chen, V., & Shtivelman, E. (2010) · Cell Cycle · doi:10.4161/cc.9.24.14230 · Cited by 36

BML-275, an AMPK inhibitor, induces DNA damage, G2/M arrest and apoptosis in human pancreatic cancer cells

Duong, H., Hwang, J. S., Kim, H. J., Seong, Y., & Bae, I. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1672 · Cited by 36

Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder

Scott, J. W., Park, E., Rodriguiz, R. M., Oakhill, J. S., Issa, S. M. A., O’Brien, M. T., Dite, T. A., Langendorf, C. G., Wetsel, W. C., Means, A. R., et al. (2015) · Scientific Reports · doi:10.1038/srep14436 · Cited by 36

Bone resorption: supporting immunometabolism

van Niekerk, G., Mitchell, M., & Engelbrecht, A. (2018) · Biology Letters · doi:10.1098/rsbl.2017.0783 · Cited by 37

AMPK activation by pterostilbene contributes to suppression of hepatic gluconeogenic gene expression and glucose production in H4IIE cells

Ren, G., Rimando, A. M., & Mathews, S. T. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.035 · Cited by 36

Exploring the Therapeutic Role of Flavonoids Through AMPK Activation in Metabolic Syndrome: A Narrative Review

Saikia, L., Talukdar, N. C., & Dutta, P. P. (2025) · Phytotherapy Research · doi:10.1002/ptr.8428 · Cited by 36

Activation of SAD Kinase by Ca2+/Calmodulin-Dependent Protein Kinase Kinase

Fujimoto, T., Yurimoto, S., Hatano, N., Nozaki, N., Sueyoshi, N., Kameshita, I., Mizutani, A., Mikoshiba, K., Kobayashi, R., & Tokumitsu, H. (2008) · Biochemistry · doi:10.1021/bi702528r · Cited by 35

Absence of RIP140 Reveals a Pathway Regulating glut4-Dependent Glucose Uptake in Oxidative Skeletal Muscle through UCP1-Mediated Activation of AMPK

Fritah, A., Steel, J. H., Parker, N., Nikolopoulou, E., Christian, M., Carling, D., & Parker, M. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032520 · Cited by 37

Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges

Yung, M. M. H., Ngan, H., & Chan, D. W. (2016) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv128 · Cited by 35

AMPK Activation of PGC-1α/NRF-1-Dependent SELENOT Gene Transcription Promotes PACAP-Induced Neuroendocrine Cell Differentiation Through Tolerance to Oxidative Stress

Abid, H., Cartier, D., Hamieh, A., François‐Bellan, A., Bucharles, C., Pothion, H., Manecka, D.-L., Leprince, J., Adriouch, S., Boyer, O., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1352-x · Cited by 37

Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction

Wang, L., Halliday, G., Huot, J. R., Satoh, T., Baust, J., Fisher, A. J., Cook, T. G., HU, J. L., Avolio, T., Goncharov, D. A., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313883 · Cited by 37

Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease

Song, X., Tsakiridis, E. E., Steinberg, G. R., & Pei, Y. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109704 · Cited by 36

Lycopene increases the proportion of slow-twitch muscle fiber by AMPK signaling to improve muscle anti-fatigue ability

Wen, W., Chen, X., Huang, Z., Chen, D., Yu, B., He, J., Zheng, P., Luo, Y., Yan, H., & Yu, J. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108750 · Cited by 37

AMPK and Pulmonary Hypertension: Crossroads Between Vasoconstriction and Vascular Remodeling

Zhao, Q., Song, P., & Zou, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.691585 · Cited by 37

Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity

Zhang, S., Qi, Q., Chan, C. B., Zhou, W., Chen, J., Luo, H. R., Appin, C., Brat, D. J., & Ye, K.-N. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.66 · Cited by 35

Visfatin, a novel adipokine, stimulates glucose uptake through the Ca2+-dependent AMPK–p38 MAPK pathway in C2C12 skeletal muscle cells

Lee, J. O., Kim, N., Lee, H., Lee, Y. W., Kim, J. K., Kim, H. I., Lee, S., Kim, S. J., Park, S. H., & Kim, H. S. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0274 · Cited by 35

Nanosecond pulsed electric fields activate AMP-activated protein kinase: Implications for calcium-mediated activation of cellular signaling

Morotomi‐Yano, K., Akiyama, H., & Yano, K. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.061 · Cited by 35

The AMPKyl subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia

Foretz, M., Hébrard, S., Guihard, S., Leclerc, J., Cruzeiro, M. D., Hamard, G., Niedergang, F., Gaudry, M., & Viollet, B. (2010) · The FASEB Journal · doi:10.1096/fj.10-169383 · Cited by 40

AMPK in the central nervous system: physiological roles and pathological implications

Segatto, M., Rosso, P., Fioramonti, M., Fracassi, A., Marangoni, M., Taglietti, V., & Siteni, S. (2016) · Research and Reports in Biology · doi:10.2147/rrb.s90858 · Cited by 35

Generation of Autonomous Activity of Ca2+/Calmodulin-Dependent Protein Kinase Kinase β by Autophosphorylation

Tokumitsu, H., Hatano, N., Fujimoto, T., Yurimoto, S., & Kobayashi, R. (2011) · Biochemistry · doi:10.1021/bi201005g · Cited by 35

Ghrelin’s Role as a Major Regulator of Appetite and Its Other Functions in Neuroendocrinology

Lim, C. T., Kola, B., Korbonits, M., & Grossman, A. B. (2010) · Progress in Brain Research · doi:10.1016/s0079-6123(10)82008-4 · Cited by 34

AMPK and Beyond: The Signaling Network Controlling RabGAPs and Contraction-Mediated Glucose Uptake in Skeletal Muscle

Peifer‐Weiß, L., Al‐Hasani, H., & Chadt, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031910 · Cited by 39

The ketone body β-hydroxybutyric acid influences agouti-related peptide expression via AMP-activated protein kinase in hypothalamic GT1-7 cells

Laeger, T., Pöhland, R., Metges, C. C., & Kuhla, B. (2012) · Journal of Endocrinology · doi:10.1530/joe-11-0457 · Cited by 36

Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics

Jiang, L. Q., Barbosa, T. D. C., Massart, J., Deshmukh, A. S., Löfgren, L., Duque-Guimaraes, D. E., Ozilgen, A., Osler, M. E., Chibalin, A., & Zierath, J. R. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00209.2015 · Cited by 35

ACitrus bergamiaExtract Decreases Adipogenesis and Increases Lipolysis by Modulating PPAR Levels in Mesenchymal Stem Cells from Human Adipose Tissue

Furno, D. L., Graziano, A. C. E., Avola, R., Giuffrida, R., Perciavalle, V., Bonina, F. P., Mannino, G., & Cardile, V. (2016) · PPAR Research · doi:10.1155/2016/4563815 · Cited by 34

AMPK allostery: A therapeutic target for the management/treatment of diabetic nephropathy

Ayinde, K. S., Olaoba, O. T., Boyenle, I. D., Du, L., Lü, Q., Yin, X., & Adelusi, T. I. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118455 · Cited by 34

Intravenous Administration of Lycopene, a Tomato Extract, Protects against Myocardial Ischemia-Reperfusion Injury

Tong, C., Peng, C. X., Wang, L., Zhang, L., Yang, X., Xu, P. A., Li, J., Delplancke, T. D. J., Zhang, H., & Qi, H. (2016) · Nutrients · doi:10.3390/nu8030138 · Cited by 34

Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways

Wang, X. J., Yang, X. P., Wang, R. X., Jiao, H., Zhao, J. P., Song, Z., & Lin, H. (2016) · Bioscience Reports · doi:10.1042/bsr20160096 · Cited by 34

Liqustri lucidi Fructus inhibits hepatic injury and functions as an antioxidant by activation of AMP-activated protein kinase in vivo and in vitro

Seo, H. L., Baek, S. Y., Lee, E. H., Lee, J., Lee, S., Kim, K.-Y., Jang, M., Park, M.-H., Kim, J.-H., Kim, K., et al. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.11.031 · Cited by 34

AMP‐activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparation

Scharf, M. T., Mackiewicz, M., Naidoo, N. N., O'Callaghan, J. P., & Pack, A. I. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05182.x · Cited by 34

Energy dysfunction in Huntington’s disease: insights from PGC-1α, AMPK, and CKB

Ju, T., Lin, Y., & Chern, Y. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1025-2 · Cited by 34

AMPK-Independent LKB1 Activity Is Required for Efficient Epithelial Ovarian Cancer Metastasis

Buensuceso, A. V., Ramos-Valdes, Y., DiMattia, G. E., & Shepherd, T. G. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0530 · Cited by 35

Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

Eduful, B. J., O’Byrne, S. N., Temme, L., Asquith, C. R. M., Liang, Y., Picado, A., Pilotte, J. R., Hossain, M. A., Wells, C. I., Zuercher, W. J., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02274 · Cited by 33

Dihydromyricetin improves meat quality and promotes skeletal muscle fiber type transformations via AMPK signaling in growing–finishing pigs

Guo, Z., Chen, X., Huang, Z., Chen, D., Li, M., Yu, B., He, J., Luo, Y., Yan, H., & Zheng, P. (2022) · Food & Function · doi:10.1039/d1fo03391c · Cited by 33

The role of AMP-activated protein kinase in the androgenic potentiation of cannabinoid-induced changes in energy homeostasis

Borgquist, A., Meza, C., & Wagner, E. J. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00421.2014 · Cited by 33

Glucocorticoids retard skeletal muscle development and myoblast protein synthesis through a mechanistic target of rapamycin (mTOR)-signaling pathway in broilers (Gallus gallus domesticus)

Wang, X., Jia, Q., Xiao, J., Jiao, H., & Lin, H. (2015) · Stress · doi:10.3109/10253890.2015.1083551 · Cited by 33

Dynamics of Elongation Factor 2 Kinase Regulation in Cortical Neurons in Response to Synaptic Activity

Kenney, J. W., Sorokina, O., Genheden, M., Sorokin, A., Armstrong, J. D., & Proud, C. G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2866-14.2015 · Cited by 33

Effect of 24 h Fasting on Gene Expression of AMPK, Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks

Liu, L., & LiXian, Z. (2012) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2012.12153 · Cited by 33

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy

Yamada, E., Okada, S., Bastie, C. C., Vatish, M., Nakajima, Y., Shibusawa, R., Ozawa, A., Pessin, J. E., & Yamada, M. (2016) · Oncotarget · doi:10.18632/oncotarget.11916 · Cited by 33

Inhibition of Autophagy by Captopril Attenuates Prion Peptide-Mediated Neuronal Apoptosis via AMPK Activation

Moon, J.-H., Jeong, J., Hong, J., Seol, J., & Park, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1370-8 · Cited by 33

Restoration of energy homeostasis under oxidative stress: Duo synergistic AMPK pathways regulating arginine kinases

Zhang, N., Meng, X., Jiang, H., Ge, H., Qian, K., Zheng, Y., Park, Y., & Wang, J. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010843 · Cited by 32

BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation

Hawley, S. A., Russell, F. M., Ross, F. A., & Hardie, D. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010453 · Cited by 32

A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF

Borgdorff, V., Rix, U., Winter, G. E., Gridling, M., Müller, A. C., Breitwieser, F. P., Wagner, C., Colinge, J., Bennett, K. L., Superti‐Furga, G., et al. (2013) · Oncogene · doi:10.1038/onc.2013.185 · Cited by 32

Anti-inflammatory Property of AMP-activated Protein Kinase

Noor, H. B., Mou, N. A., Salem, L., Shimul, M. F. A., Biswas, S., Akther, R., Khan, S., Raihan, S., Mohib, M. M., & Sagor, M. A. T. (2019) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523018666190830100022 · Cited by 34

Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors

Matheson, C. J., Casalvieri, K. A., Backos, D. S., Minhajuddin, M., Jordan, C. T., & Reigan, P. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112316 · Cited by 32

Rapid metabolic reprogramming mediated by the AMP-activated protein kinase during the lytic cycle of Toxoplasma gondii

Li, Y., Niu, Z., Yang, J., Yang, X., Chen, Y., Li, Y., Liang, X., Zhang, J., Fan, F., Wu, P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36084-0 · Cited by 32

CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem

Racioppi, L. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.004 · Cited by 32

The transcriptional activity of Gli1 is negatively regulated by AMPK through Hedgehog partial agonism in hepatocellular carcinoma

Xu, Q., Liu, X., Zheng, X. M., Yao, Y., Wang, M., & Liu, Q. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1847 · Cited by 32

New Candidate Targets of AMP-Activated Protein Kinase in Murine Brain Revealed by a Novel Multidimensional Substrate-Screen for Protein Kinases

Tuerk, R. D., Thali, R. F., Auchli, Y., Rechsteiner, H., Brunisholz, R., Schlattner, U., Wallimann, T., & Neumann, D. (2007) · Journal of Proteome Research · doi:10.1021/pr070160a · Cited by 35

Muscarinic Receptor Activation of AMP-activated Protein Kinase Inhibits Orexigenic Neuropeptide mRNA Expression

Thornton, C., Sardini, A., & Carling, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708987200 · Cited by 32

Revisiting the role of calcium in phagosome formation and maturation

Westman, J., Grinstein, S., & Maxson, M. E. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.mr1118-444r · Cited by 32

WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis

Zhang, P., Fu, H.-J., Lv, L.-X., Liu, C.-F., Han, C. L., Zhao, X., & Wang, J. (2023) · Communications Biology · doi:10.1038/s42003-023-04735-z · Cited by 31

Appetite and Metabolic Effects of Ghrelin and Cannabinoids: Involvement of AMP-Activated Protein Kinase

van Thuijl, H., Kola, B., & Korbonits, M. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)77006-6 · Cited by 31

Anti-neuroinflammatory Effect of a Novel Caffeamide Derivative, KS370G, in Microglial cells

Lu, D., Huang, B., Yeh, W., Lin, H., Huang, S., Liu, Y.-S., & Kuo, Y. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8474-y · Cited by 32

AMP-activated Protein Kinase Attenuates Nitric Oxide-induced β-Cell Death

Meares, G. P., Hughes, K. J., Jaimes, K. F., Salvatori, A., Rhodes, C. J., & Corbett, J. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047365 · Cited by 31

Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats

Aghanoori, M., Smith, D. R., Chowdhury, S. R., Sabbir, M. G., Calcutt, N. A., & Fernyhough, P. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.08.005 · Cited by 32

Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells

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AMPKα2deficiency uncovers time dependency in the regulation of contraction-induced palmitate and glucose uptake in mouse muscle

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Activation of the AMP-activated protein kinase–p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells

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A plant kinase plays roles in defense response against geminivirus by phosphorylation of a viral pathogenesis protein

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The mTOR Signaling Pathway in Pediatric Neuroblastoma

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IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells

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Sprinkler Technology Improves Broiler Production Sustainability: From Stress Alleviation to Water Usage Conservation: A Mini Review

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Metabolic Remodeling and Implicated Calcium and Signal Transduction Pathways in the Pathogenesis of Heart Failure

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Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

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AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension

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Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

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Dictyostelium, a microbial model for brain disease

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α-Lipoic acid as a triglyceride-lowering nutraceutical

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Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes

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A Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle

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CaMKK2 Suppresses Muscle Regeneration through the Inhibition of Myoblast Proliferation and Differentiation

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Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells

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HSF1 deficiency accelerates the transition from pressure overload-induced cardiac hypertrophy to heart failure through endothelial miR-195a-3p-mediated impairment of cardiac angiogenesis

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AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes

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Targeting the 5′-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer

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Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor

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Apoptotic Cells Activate AMP-activated Protein Kinase (AMPK) and Inhibit Epithelial Cell Growth without Change in Intracellular Energy Stores

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Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

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Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

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The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases

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5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

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AMP-activated protein kinase–mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β

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