Cited by 1,589Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

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Hawley, Simon A., Pan, David A., Mustard, Kirsty J., Ross, Louise, Bain, Jenny, Edelman, Arthur M., Frenguelli, Bruno G., Hardie, D. Grahame·2005·Cell Metabolism

DOI 10.1016/j.cmet.2005.05.009

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Abstract

The AMP-activated protein kinase (AMPK) is a critical regulator of energy balance at both the cellular and whole-body levels. Two upstream kinases have been reported to activate AMPK in cell-free assays, i.e., the tumor suppressor LKB1 and calmodulin-dependent protein kinase kinase. However, evidence that this is physiologically relevant currently only exists for LKB1. We now report that there is a significant basal activity and phosphorylation of AMPK in LKB1-deficient cells that can be stimulated by Ca2+ ionophores, and studies using the CaMKK inhibitor STO-609 and isoform-specific siRNAs show that CaMKKbeta is required for this effect. CaMKKbeta also activates AMPK much more rapidly than CaMKKalpha in cell-free assays. K(+)-induced depolarization in rat cerebrocortical slices, which increases intracellular Ca2+ without disturbing cellular adenine nucleotide levels, activates AMPK, and this is blocked by STO-609. Our results suggest a potential Ca(2+)-dependent neuroprotective pathway involving phosphorylation and activation of AMPK by CaMKKbeta.

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Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights
Nyane, N. A., Tlaila, T. B., Malefane, T. G., Ndwandwe, D. E., & Owira, P. M. O. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.03.042 · Cited by 101
TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway
Zhang, P., Liu, X., Li, H., Chen, Z., Yao, X., Jin, J., & Ma, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-03230-w · Cited by 103
Role of AMP‐Activated Protein Kinase in Cancer Therapy
Rehman, G., Shehzad, A., Khan, A. L., & Hamayun, M. (2014) · Archiv der Pharmazie · doi:10.1002/ardp.201300402 · Cited by 107
AMP-Activated Kinase Restricts Rift Valley Fever Virus Infection by Inhibiting Fatty Acid Synthesis
Moser, T. S., Schieffer, D., & Cherry, S. R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002661 · Cited by 102
The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML
Obba, S., Hizir, Z., Boyer, L., Selimoglu-Buet, D., Pfeifer, A., Michel, G., Hamouda, M.-A., Gonçalvès, D., Cerezo, M., Marchetti, S., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1034406 · Cited by 100
Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD
Udi, S., Hinden, L., Earley, B. J., Drori, A., Reuveni, N., Hadar, R., Çınar, R., Nemirovski, A., & Tam, J. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016101085 · Cited by 102
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
Zhang, C., Li, M., Wang, Y., Li, X., Zong, Y., Long, S., Zhang, M., Feng, J.-W., Wei, X., Liu, Y., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00640-7 · Cited by 104
The Role of AMP-Activated Protein Kinase in Obesity
Kola, B., Grossman, A. B., & Korbonits, M. (2008) · KARGER eBooks · doi:10.1159/000115366 · Cited by 100
Activation of AMP-Activated Protein Kinase Prevents TGF-β1–Induced Epithelial-Mesenchymal Transition and Myofibroblast Activation
Thakur, S., Viswanadhapalli, S., Kopp, J. B., Shi, Q., Barnes, J. L., Block, K. L., Gorin, Y. C., & Abboud, H. E. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.04.014 · Cited by 100
Macroautophagy Signaling and Regulation
Esclatine, A., Chaumorcel, M., & Codogno, P. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-00302-8_2 · Cited by 101
AMP‐activated protein kinase: a core signalling pathway in the heart
Kim, A. S., Miller, E. J., & Young, L. H. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01978.x · Cited by 99
Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
Pelosse, M., Cottet‐Rousselle, C., Bidan, C. M., Dupont, A., Gupta, K., Berger, I., & Schlattner, U. (2019) · Nature Communications · doi:10.1038/s41467-019-08938-z · Cited by 99
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy
Wu, W., Wang, X., Sun, Y., Berleth, N., Deitersen, J., Schlütermann, D., Stuhldreier, F., Hieke, N., Mendiburo, M. J., Cox, J., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1899667 · Cited by 98
AMP‐activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function
Mayer, A., Denanglaire, S., Viollet, B., Léo, O., & Andris, F. (2008) · European Journal of Immunology · doi:10.1002/eji.200738045 · Cited by 99
Activation of AMP-activated Protein Kinase by Vascular Endothelial Growth Factor Mediates Endothelial Angiogenesis Independently of Nitric-oxide Synthase
Stahmann, N., Woods, A., Spengler, K., Heslegrave, A., Bauer, R., Krause, S., Viollet, B., Carling, D., & Heller, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.108688 · Cited by 100
AMPK regulates histone H2B O-GlcNAcylation
Xu, Q., Yang, C., Du, Y., Chen, Y., Liu, H., Deng, M., Zhang, H., Zhang, L., Liu, T., Liu, Q., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku236 · Cited by 106
Targeting LKB1 in Cancer – Exposing and Exploiting Vulnerabilities
Momcilovic, M., & Shackelford, D. B. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.261 · Cited by 97
Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects
Salvatore, T., Pafundi, P. C., Galiero, R., Rinaldi, L., Caturano, A., Vetrano, E., Aprea, C., Albanese, G., Di Martino, A., Ricozzi, C., et al. (2020) · Biomedicines · doi:10.3390/biomedicines9010003 · Cited by 97
Is TAK1 a Direct Upstream Kinase of AMPK?
Neumann, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082412 · Cited by 102
The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2
Lee, J. O., Lee, H. J., Lee, Y. W., Han, J. A., Kang, M. J., Moon, J., Shin, M.-J., Lee, H. J., Chung, J. H., Lee, J., et al. (2020) · FEBS Journal · doi:10.1111/febs.15301 · Cited by 97
Role of AMPK in pancreatic beta cell function
Fu, A., Eberhard, C. E., & Screaton, R. A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.020 · Cited by 103
Nicotine-induced Activation of AMP-activated Protein Kinase Inhibits Fatty Acid Synthase in 3T3L1 Adipocytes
An, Z., Wang, H., Song, P., Zhang, M., Geng, X., & Zou, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703701200 · Cited by 98
Retracted
Endothelial nitric oxide synthase: A potential therapeutic target for cerebrovascular diseases
Zhu, J., Song, W., Li, L., & Fan, X. (2016) · Molecular Brain · doi:10.1186/s13041-016-0211-9 · Cited by 96

Authors: Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G.
Affiliations: University of Dundee (GB)
University at Buffalo, State University of New York (US)
Corresponding author: Hardie, D. Grahame
ORCID: Pan, David A.
Frenguelli, Bruno G.
Hardie, D. Grahame
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2005-07
Volume: 2
Issue: 1
Pages: 9-19
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2005.05.009
OpenAlex: W2067979493
Cited by: 1,589
References: 48
Citations by year: 2026: 41 · 2025: 38 · 2024: 57 · 2023: 53 · 2022: 64 · 2021: 78 · 2020: 90 · 2019: 64 · 2018: 84 · 2017: 82 · 2016: 84 · 2015: 92 · 2014: 77 · 2013: 84 · 2012: 118
FWCI: 27.73
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2974 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: AMPK, CaMKKβ, LKB1, AMPK activation, upstream kinases, calcium ionophore, STO-609, potassium depolarization, intracellular calcium, neuroprotection, energy metabolism
MeSH terms: Calcimycin, Acetyl-CoA Carboxylase, Adenosine Diphosphate, Adenosine Triphosphate, Animals, Benzimidazoles, Brain, Enzyme Activation, Fibroblasts, HeLa Cells, Humans, Isoquinolines, Multienzyme Complexes, Phosphoprotein Phosphatases, Phosphorylation, Substrate Specificity, Protein Serine-Threonine Kinases, RNA, Small Interfering, Mice, Rats, Naphthalimides, Calcium-Calmodulin-Dependent Protein Kinase Kinase, AMP-Activated Protein Kinases, In Vitro Techniques

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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

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